KEGG   Sturnira hondurensis: 118995662
Entry
118995662         CDS       T07222                                 
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
shon  Sturnira hondurensis
Pathway
shon00562  Inositol phosphate metabolism
shon01100  Metabolic pathways
shon01521  EGFR tyrosine kinase inhibitor resistance
shon01522  Endocrine resistance
shon01524  Platinum drug resistance
shon04012  ErbB signaling pathway
shon04014  Ras signaling pathway
shon04015  Rap1 signaling pathway
shon04024  cAMP signaling pathway
shon04062  Chemokine signaling pathway
shon04066  HIF-1 signaling pathway
shon04068  FoxO signaling pathway
shon04070  Phosphatidylinositol signaling system
shon04071  Sphingolipid signaling pathway
shon04072  Phospholipase D signaling pathway
shon04081  Hormone signaling
shon04140  Autophagy - animal
shon04150  mTOR signaling pathway
shon04151  PI3K-Akt signaling pathway
shon04152  AMPK signaling pathway
shon04210  Apoptosis
shon04211  Longevity regulating pathway
shon04213  Longevity regulating pathway - multiple species
shon04218  Cellular senescence
shon04360  Axon guidance
shon04370  VEGF signaling pathway
shon04380  Osteoclast differentiation
shon04510  Focal adhesion
shon04550  Signaling pathways regulating pluripotency of stem cells
shon04611  Platelet activation
shon04613  Neutrophil extracellular trap formation
shon04620  Toll-like receptor signaling pathway
shon04625  C-type lectin receptor signaling pathway
shon04630  JAK-STAT signaling pathway
shon04650  Natural killer cell mediated cytotoxicity
shon04660  T cell receptor signaling pathway
shon04662  B cell receptor signaling pathway
shon04664  Fc epsilon RI signaling pathway
shon04666  Fc gamma R-mediated phagocytosis
shon04668  TNF signaling pathway
shon04670  Leukocyte transendothelial migration
shon04722  Neurotrophin signaling pathway
shon04725  Cholinergic synapse
shon04750  Inflammatory mediator regulation of TRP channels
shon04810  Regulation of actin cytoskeleton
shon04910  Insulin signaling pathway
shon04914  Progesterone-mediated oocyte maturation
shon04915  Estrogen signaling pathway
shon04917  Prolactin signaling pathway
shon04919  Thyroid hormone signaling pathway
shon04923  Regulation of lipolysis in adipocytes
shon04926  Relaxin signaling pathway
shon04929  GnRH secretion
shon04930  Type II diabetes mellitus
shon04931  Insulin resistance
shon04932  Non-alcoholic fatty liver disease
shon04933  AGE-RAGE signaling pathway in diabetic complications
shon04935  Growth hormone synthesis, secretion and action
shon04960  Aldosterone-regulated sodium reabsorption
shon04973  Carbohydrate digestion and absorption
shon05010  Alzheimer disease
shon05017  Spinocerebellar ataxia
shon05020  Prion disease
shon05100  Bacterial invasion of epithelial cells
shon05132  Salmonella infection
shon05135  Yersinia infection
shon05142  Chagas disease
shon05146  Amoebiasis
shon05160  Hepatitis C
shon05161  Hepatitis B
shon05162  Measles
shon05163  Human cytomegalovirus infection
shon05164  Influenza A
shon05165  Human papillomavirus infection
shon05166  Human T-cell leukemia virus 1 infection
shon05167  Kaposi sarcoma-associated herpesvirus infection
shon05168  Herpes simplex virus 1 infection
shon05169  Epstein-Barr virus infection
shon05170  Human immunodeficiency virus 1 infection
shon05171  Coronavirus disease - COVID-19
shon05200  Pathways in cancer
shon05203  Viral carcinogenesis
shon05205  Proteoglycans in cancer
shon05206  MicroRNAs in cancer
shon05207  Chemical carcinogenesis - receptor activation
shon05208  Chemical carcinogenesis - reactive oxygen species
shon05210  Colorectal cancer
shon05211  Renal cell carcinoma
shon05212  Pancreatic cancer
shon05213  Endometrial cancer
shon05214  Glioma
shon05215  Prostate cancer
shon05218  Melanoma
shon05220  Chronic myeloid leukemia
shon05221  Acute myeloid leukemia
shon05222  Small cell lung cancer
shon05223  Non-small cell lung cancer
shon05224  Breast cancer
shon05225  Hepatocellular carcinoma
shon05226  Gastric cancer
shon05230  Central carbon metabolism in cancer
shon05231  Choline metabolism in cancer
shon05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
shon05415  Diabetic cardiomyopathy
shon05417  Lipid and atherosclerosis
shon05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:shon00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    118995662
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    118995662
   04014 Ras signaling pathway
    118995662
   04015 Rap1 signaling pathway
    118995662
   04370 VEGF signaling pathway
    118995662
   04630 JAK-STAT signaling pathway
    118995662
   04668 TNF signaling pathway
    118995662
   04066 HIF-1 signaling pathway
    118995662
   04068 FoxO signaling pathway
    118995662
   04070 Phosphatidylinositol signaling system
    118995662
   04072 Phospholipase D signaling pathway
    118995662
   04071 Sphingolipid signaling pathway
    118995662
   04024 cAMP signaling pathway
    118995662
   04151 PI3K-Akt signaling pathway
    118995662
   04152 AMPK signaling pathway
    118995662
   04150 mTOR signaling pathway
    118995662
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    118995662
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    118995662
  09143 Cell growth and death
   04210 Apoptosis
    118995662
   04218 Cellular senescence
    118995662
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    118995662
   04550 Signaling pathways regulating pluripotency of stem cells
    118995662
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    118995662
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    118995662
   04613 Neutrophil extracellular trap formation
    118995662
   04620 Toll-like receptor signaling pathway
    118995662
   04625 C-type lectin receptor signaling pathway
    118995662
   04650 Natural killer cell mediated cytotoxicity
    118995662
   04660 T cell receptor signaling pathway
    118995662
   04662 B cell receptor signaling pathway
    118995662
   04664 Fc epsilon RI signaling pathway
    118995662
   04666 Fc gamma R-mediated phagocytosis
    118995662
   04670 Leukocyte transendothelial migration
    118995662
   04062 Chemokine signaling pathway
    118995662
  09152 Endocrine system
   04910 Insulin signaling pathway
    118995662
   04923 Regulation of lipolysis in adipocytes
    118995662
   04929 GnRH secretion
    118995662
   04915 Estrogen signaling pathway
    118995662
   04914 Progesterone-mediated oocyte maturation
    118995662
   04917 Prolactin signaling pathway
    118995662
   04926 Relaxin signaling pathway
    118995662
   04935 Growth hormone synthesis, secretion and action
    118995662
   04919 Thyroid hormone signaling pathway
    118995662
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    118995662
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    118995662
  09156 Nervous system
   04725 Cholinergic synapse
    118995662
   04722 Neurotrophin signaling pathway
    118995662
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    118995662
  09158 Development and regeneration
   04360 Axon guidance
    118995662
   04380 Osteoclast differentiation
    118995662
  09149 Aging
   04211 Longevity regulating pathway
    118995662
   04213 Longevity regulating pathway - multiple species
    118995662
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    118995662
   05206 MicroRNAs in cancer
    118995662
   05205 Proteoglycans in cancer
    118995662
   05207 Chemical carcinogenesis - receptor activation
    118995662
   05208 Chemical carcinogenesis - reactive oxygen species
    118995662
   05203 Viral carcinogenesis
    118995662
   05230 Central carbon metabolism in cancer
    118995662
   05231 Choline metabolism in cancer
    118995662
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    118995662
  09162 Cancer: specific types
   05210 Colorectal cancer
    118995662
   05212 Pancreatic cancer
    118995662
   05225 Hepatocellular carcinoma
    118995662
   05226 Gastric cancer
    118995662
   05214 Glioma
    118995662
   05221 Acute myeloid leukemia
    118995662
   05220 Chronic myeloid leukemia
    118995662
   05218 Melanoma
    118995662
   05211 Renal cell carcinoma
    118995662
   05215 Prostate cancer
    118995662
   05213 Endometrial cancer
    118995662
   05224 Breast cancer
    118995662
   05222 Small cell lung cancer
    118995662
   05223 Non-small cell lung cancer
    118995662
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    118995662
   05170 Human immunodeficiency virus 1 infection
    118995662
   05161 Hepatitis B
    118995662
   05160 Hepatitis C
    118995662
   05171 Coronavirus disease - COVID-19
    118995662
   05164 Influenza A
    118995662
   05162 Measles
    118995662
   05168 Herpes simplex virus 1 infection
    118995662
   05163 Human cytomegalovirus infection
    118995662
   05167 Kaposi sarcoma-associated herpesvirus infection
    118995662
   05169 Epstein-Barr virus infection
    118995662
   05165 Human papillomavirus infection
    118995662
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    118995662
   05135 Yersinia infection
    118995662
   05100 Bacterial invasion of epithelial cells
    118995662
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    118995662
   05142 Chagas disease
    118995662
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    118995662
   05017 Spinocerebellar ataxia
    118995662
   05020 Prion disease
    118995662
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    118995662
   05418 Fluid shear stress and atherosclerosis
    118995662
   05415 Diabetic cardiomyopathy
    118995662
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    118995662
   04932 Non-alcoholic fatty liver disease
    118995662
   04931 Insulin resistance
    118995662
   04933 AGE-RAGE signaling pathway in diabetic complications
    118995662
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    118995662
   01524 Platinum drug resistance
    118995662
   01522 Endocrine resistance
    118995662
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:shon04131]
    118995662
Enzymes [BR:shon01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     118995662
Membrane trafficking [BR:shon04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    118995662
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase DUF2321 ABC1 Ribosomal_S15 Retrotran_gag_4
Other DBs
NCBI-GeneID: 118995662
NCBI-ProteinID: XP_036914671
LinkDB
Position
Unknown
AA seq 570 aa
MKCKENHIKYYFILQSTRLARDNELRENDKEQLRAICTRDPLSEITEQEKDFLWSHRHYC
VTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRC
LEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEMHNK
TVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQ
MRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNE
IIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRSSHTIM
QIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHN
SNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQECTKTREFE
RFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEY
FMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 1713 nt   +upstreamnt  +downstreamnt
atgaagtgcaaagaaaatcatataaaatattactttattttacagagtaccagactagcc
agagacaacgaattaagggaaaatgataaagaacagctccgagcaatttgtacccgagat
cctctatctgaaatcactgagcaagagaaagattttctatggagccacagacactattgt
gtaactatccctgaaattctacccaaattgcttctgtctgttaaatggaattctagagat
gaagtagctcagatgtactgtttggtgaaagattggcctcccatcaaacccgaacaggct
atggagcttctggactgcaactacccggatcctatggttcgaggttttgctgttcgatgc
ctggaaaaatatttaacagatgacaaactttctcagtacctaattcagctagtacaggtc
ctaaaatatgaacaatatttggataatctgcttgtgagatttttactcaaaaaagcattg
actaatcaaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaa
acagtcagtcagaggtttggcctacttttggaatcctattgtcgtgcgtgcgggatgtat
ttgaagcacctgaacaggcaagttgaggctatggaaaagctcatcaacttaaccgacatt
ctcaagcaagagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaa
atgcggcgaccagatttcatggatgctctacagggctttctatctcctctaaatcctgct
catcagttaggaaatctcaggcttgaagagtgtcgcattatgtcttccgcaaaaaggcca
ctgtggttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgag
atcatctttaaaaatggggatgatttacggcaagacatgctaacacttcagattattcgc
attatggaaaatatctggcaaaatcaaggtctcgatcttcggatgttgccttacggctgt
ctgtcgattggtgactgtgtgggacttatagaggtggtgagaagttctcacactatcatg
cagattcagtgcaaagggggcctgaagggtgcactgcagttcaacagccacacgctccat
cagtggctcaaagacaagaacaaaggagagatatacgatgcagccattgacctgttcaca
cgttcatgtgctggatattgtgtcgcgaccttcattttgggaattggagatcgtcacaat
agtaacatcatggttaaagatgatggacaactgtttcatatagattttggacactttttg
gatcacaagaagaaaaaatttggttataaacgggaacgtgtgccatttgttttgacacag
gatttcttaatagtgatcagtaaaggagcccaagaatgcacaaagacaagagaattcgag
aggtttcaggagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttc
ataaatcttttctcaatgatgcttggctctggaatgccagaactacagtcttttgatgat
attgcatacattcgaaagaccctagctttagataaaacagagcaagaggctttggaatat
ttcatgaaacaaatgaatgatgcacaccatggtggctggacaacaaaaatggactggatc
ttccacacaattaagcagcatgctttgaactga

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