| Entry |
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| Symbol |
ARHGEF12
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| Name |
(RefSeq) rho guanine nucleotide exchange factor 12 isoform X1
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| KO |
| K07532 | Rho guanine nucleotide exchange factor 12 |
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| Organism |
shr Sarcophilus harrisii (Tasmanian devil)
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| Pathway |
| shr04270 | Vascular smooth muscle contraction |
| shr04625 | C-type lectin receptor signaling pathway |
| shr04810 | Regulation of actin cytoskeleton |
| shr05163 | Human cytomegalovirus infection |
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| Brite |
KEGG Orthology (KO) [BR:shr00001]
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
100913854 (ARHGEF12)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
100913854 (ARHGEF12)
04625 C-type lectin receptor signaling pathway
100913854 (ARHGEF12)
09153 Circulatory system
04270 Vascular smooth muscle contraction
100913854 (ARHGEF12)
09158 Development and regeneration
04360 Axon guidance
100913854 (ARHGEF12)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100913854 (ARHGEF12)
05205 Proteoglycans in cancer
100913854 (ARHGEF12)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
100913854 (ARHGEF12)
09171 Infectious disease: bacterial
05135 Yersinia infection
100913854 (ARHGEF12)
05152 Tuberculosis
100913854 (ARHGEF12)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:shr04131]
100913854 (ARHGEF12)
Membrane trafficking [BR:shr04131]
Others
Rho GTPase associated proteins
Rho guanine nucleotide exchange factors (GEFs)
100913854 (ARHGEF12)
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| Position |
3:360606283..360770508
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| AA seq |
1537 aa
MSGTQPTITDRFPLKKPIRHASILTRESPTDKKQKVERSTSHDFDPTDSSSKKTKSSSEE
SRSETYGLVQRCVIIQKDDNGFGLTVSGDNPVFVQSVKEDGAAMRAGVQTGDRIIKVNGT
LVTHSNHLEVVKLIKSGSYVALTVQGRPPGSPQIPLADSEVEPAAFGHMSPIMTSPHSPG
TSGNTERITSPVLMGEENNVVHNQKVEILRKMLQQEQERLQFLQEDYSRTPAQRLLKEIQ
EAKKHIPQLQEQLSKATGSTQDGAVVLSSKTSGDSLPLSEVEADSGDGLGRIDYSSGDGS
RPNSDIADSPRSGLKERIYLEESPEKSEMIPDNDTQSNIGSPLIRTAPQIIGAEDDDFGT
EHEQINGQCSCFQSIELLRSRPAHLAAFLHHVVSQFDPATLLCYLYSDLYKQTNSKETRR
IFLEFHQFFLDRAAHLKVSVPDEISLDLEKRRPELIPEDLHRHYVQTMQDKVYPEVQKHL
EDFRQKRSMGLTLAESELTKLDAERDRDRVILEKERACAEQIITKIEELLMTAQAVEEDK
SSTMQYVILMYMKHLGVRVKEPRNLEHKRGRIGFLPKIKQSIKKDREGEEKVKRRGFPSI
LGPPRRPSRHDSSAIGRAMELQKQRHPKHLSTPSSVSPEPQDSAKLRQSGISSDAADVMY
MPPNPMSSLTSGTSASQDGGKENEMGSKQIGEGPASGDSTDGTPRTPNTVFDFPAPPLDQ
LQEEEGEIERFPEHGTPKSFRKLDSIAFGESQSEDEQFENDLETDPPNWQQLVSREVLLG
LKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSSSELRRIFSNLEEILQ
LHIGLNEQMKAVRKRNETSVIDEIGEDLLIWFSGSGEEKLKHAAATFCSNQPFALEMIKS
RQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTERPKEREKV
KKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSNLKLSEYPNVEELRNLDLTKRKM
IHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVI
KLNTVLVRQVATDNKALFVISMSDNGAQIYELVAQTVSEKAVWQDLIGRMALTVKEQSTK
PIPLPESPPCEGEREEEEASKLKEESHDVSTSSLQSPEKQMGAETSLMSKPQSPSSVISG
KSEISDLLAERQFEKEQMEETSKESGMDFQSTIPEPHLPVCEERWALDALRNLGLLKQLL
VQQLGLTEKRTPEDWPHFSRFRTSSQGVQVESPGVSQNVLDHSENNKTSQFGEGHTSLQT
RTGQIACYSPRTSIESPVPQDYMELASQDSRASNLLVMDHMIMTPEPSSAELEGGPDDSG
EHFFDAREAHSDDNPSESDGTERKEEEALQLRISGNVLILDGFETVQESSTEEEGVSNLP
SVGWAHQQQSVLNPRSDGGGSPFTPEFLVQQRWRPGEESGFSAQSPSSSADSHSQIMQYI
RKIEADLEHLKKVEESYMTLCQRLAGSALTEEHSDKS |
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| NT seq |
4614 nt +upstreamnt +downstreamnt
atgagtggcacacagcctactatcacggacaggtttcccctcaaaaaacctataaggcat
gcaagtattttgacccgagagtctccaacagacaagaagcagaaagttgaacgcagtaca
tcacatgactttgaccccacagacagctcctccaagaagacaaagtctagttcagaggag
agtagatcggagacatatggtcttgttcagcgctgtgtgataatccagaaggatgacaat
ggatttgggctgacagtcagtggagacaatccagtcttcgtacagtctgttaaagaagat
ggagcagccatgcgggctggagtacaaacaggtgatcgaatcatcaaggtaaatggaact
ctagtgactcattcaaaccatttggaagtggtaaagctgatcaaatcgggttcctatgta
gctctcactgttcagggacgcccacctgggtcgccccagatcccattagctgattctgaa
gtggagccagcagcctttggacatatgtctcccatcatgacatcaccccattcacctgga
acatctggaaatacagagagaatcaccagtccagtgttgatgggggaagaaaacaatgtg
gttcacaaccagaaagtagaaatactgagaaagatgctacagcaagagcaggaacggcta
cagttcttacaagaagattatagccgcacacctgctcagcgattgcttaaggagattcag
gaggccaagaaacatattcctcagttgcaggaacagttatccaaagcaacaggctcaact
caggatggagctgtagttctatccagcaagacttctggtgactcccttccactcagtgaa
gtagaagcagacagtggtgatgggttaggcagaattgattatagtagtggagatggttct
cgacccaatagtgacattgcggatagtcccagaagtggcttgaaggaaaggatttatcta
gaagaaagtccagagaaaagtgagatgataccagataatgacactcaatcaaacattggt
agtcccttaattcgaacagcacctcagatcattggagcggaagatgatgactttggcact
gaacatgaacagattaatggacaatgcagctgcttccaaagtattgaactgctgagatcc
cgccctgctcacctagctgcattcctacaccatgtagtttcacagttcgaccctgcaaca
ctgctctgttatctttattcagatttatataaacaaaccaattccaaggagactcggcgc
attttccttgagtttcatcagttctttttggaccgagcagcacacttgaaggtttctgtt
ccagatgaaatatctctagacctggagaagagaaggccagaacttattcctgaagatttg
caccgacattatgtccaaactatgcaagataaagtttatcctgaagttcagaaacatttg
gaagattttaggcagaaacgtagtatggggctaaccttagctgaaagtgagctgaccaaa
cttgatgcagaacgagaccgtgaccgtgtaatcttggagaaagaacgagcatgtgcagag
cagatcattaccaaaattgaagaattattgatgacagctcaggctgttgaagaagataag
agttcaacaatgcaatatgtgatcctcatgtacatgaaacatttgggagtcagagtaaaa
gagcctcggaatttggagcataagcgaggtcgcattggatttctgccaaaaatcaagcaa
agtataaagaaagatagggaaggcgaagaaaaagtaaagagaagaggattcccaagcatt
ttaggacccccaaggaggccaagccgtcatgacagcagtgcaattggcagagccatggaa
ttacaaaaacaacgccatcctaagcacttatccacaccctcatcagtgagtcctgaacct
caggactctgccaagttacgccagagtgggatctccagtgatgcagcagatgttatgtat
atgcctcctaatcccatgtcttctttgacttcagggactagtgcctcccaagatggagga
aaagagaatgaaatggggtcaaaacagattggagaaggaccagcttccggagattctaca
gatggtacaccacgaactcctaatacagtctttgattttccagctccaccattagaccaa
ttgcaggaggaggaaggtgaaatagaaaggttccctgaacatggaacaccaaaatctttt
cggaagcttgatagtatagcttttggggaaagtcagagtgaagatgagcagtttgaaaat
gacttagaaacagatccaccaaattggcagcagcttgttagcagagaggtgctcttgggg
ctaaaaccttgtgagatcaaacggcaggaagtgatcaatgagttgttctacacagagcga
gctcatgtccggacactgaaagttctagatcaggtgttctaccagcgagtatcccgagag
gggattctgtcatcgtcagaactgagaagaatcttctccaatctagaagagattcttcag
cttcacattgggttgaatgaacaaatgaaagctgttcgaaagaggaatgagacttctgta
attgatgagattggagaagatttattgatctggttcagtggatcaggagaggagaagttg
aaacatgcagctgccaccttctgtagtaaccagccttttgccctggaaatgatcaaatct
cgtcagaaaaaggactctcgattccagacttttgtgcaggatgctgagagtaatccacta
tgccgtcgactgcagctaaaggatattattcctactcaaatgcagaggctcactaaatat
ccccttctgctggataatattgctaaatatacagaacggccaaaggaaagagaaaaggta
aagaaagcagcagatcactgtcgtcaaatcctaaattatgtgaatcaagctgtcaaggag
gcagagaacaaacagcgcttagaagattatcagcgccgccttgatacatctaacttgaag
ctgtcagagtatccaaatgttgaagagctcaggaatttggatttaacaaagaggaagatg
attcatgaaggaccattagtgtggaaggtgaatagagataagaccattgatctttacaca
ttgctgttggaagacatccttgtattgttacaaaagcaggatgatagactggtgttgagg
tgtcatagtaaaattctagcatctacagcagatagcaaacacacattcagccctgtaatc
aaattgaataccgtgttggttcgacaagttgcaacagataacaaagcattattcgtcatc
tctatgtcagacaatggagcccaaatttatgaattggtggcacagacagtttctgaaaaa
gcagtctggcaggacttgattggcaggatggccctgacagtaaaggaacagtctacaaag
cccatcccattaccagagtcacccccctgcgaaggggaacgtgaggaagaagaagcttca
aagctgaaggaggaatcgcatgatgtttctacctctagtcttcagagtccagaaaaacaa
atgggagcagaaacttctttaatgtcaaaacctcagtccccttcatcagttatatctgga
aaatcagaaatcagtgatctactggctgaaagacagtttgaaaaggaacaaatggaagag
acatctaaagagtctggaatggactttcagagtactatcccagagccacatctccctgtt
tgtgaagagcgctgggcactggatgcactcaggaacttgggtctgttgaagcagttgctg
gtacagcagctaggtttgactgagaagaggactcctgaagactggccacatttttccagg
tttaggacatcttctcagggggtgcaagtagaaagtccaggtgtgagccaaaatgtcttg
gaccactctgaaaataataagaccagccagtttggtgaagggcatacgtccctccaaacc
agaactggccaaattgcatgttacagcccaaggacttcaattgaatctccagttccacag
gattatatggaactggcatctcaagatagcagggcaagtaatcttttagtcatggaccac
atgatcatgaccccagagccgtctagtgcagagctagaagggggtcctgatgacagcgga
gagcacttttttgatgcccgtgaagcccacagtgatgataatccttcagaaagtgatggg
acagaaagaaaggaagaggaagctcttcagttacggatctcaggaaatgttctgatcctt
gatggctttgaaacagttcaggaaagctctacggaggaagaaggtgtttcaaacctccct
tctgtgggctgggctcaccagcagcaatctgttctcaatccccggtctgatggaggaggt
tctccattcactcctgaattcctagtccagcagcgctggagacctggagaggagtctggc
ttcagtgcccagagtccctcttcctctgcagattcacacagccagatcatgcagtacatt
cggaagatagaggctgaccttgaacacttaaagaaagtggaggaaagttacatgactctt
tgccaaaggctggctggatcagccctcacagaggagcactcagataaaagttaa |
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