KEGG   Sarcophilus harrisii (Tasmanian devil): 100913901
Entry
100913901         CDS       T02286                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
shr  Sarcophilus harrisii (Tasmanian devil)
Pathway
shr01521  EGFR tyrosine kinase inhibitor resistance
shr01522  Endocrine resistance
shr04010  MAPK signaling pathway
shr04012  ErbB signaling pathway
shr04068  FoxO signaling pathway
shr04270  Vascular smooth muscle contraction
shr04650  Natural killer cell mediated cytotoxicity
shr04720  Long-term potentiation
shr04726  Serotonergic synapse
shr04730  Long-term depression
shr04810  Regulation of actin cytoskeleton
shr04910  Insulin signaling pathway
shr04914  Progesterone-mediated oocyte maturation
shr04928  Parathyroid hormone synthesis, secretion and action
shr05010  Alzheimer disease
shr05022  Pathways of neurodegeneration - multiple diseases
shr05034  Alcoholism
shr05160  Hepatitis C
shr05161  Hepatitis B
shr05200  Pathways in cancer
shr05205  Proteoglycans in cancer
shr05208  Chemical carcinogenesis - reactive oxygen species
shr05210  Colorectal cancer
shr05211  Renal cell carcinoma
shr05212  Pancreatic cancer
shr05213  Endometrial cancer
shr05214  Glioma
shr05215  Prostate cancer
shr05218  Melanoma
shr05219  Bladder cancer
shr05220  Chronic myeloid leukemia
shr05221  Acute myeloid leukemia
shr05223  Non-small cell lung cancer
shr05224  Breast cancer
shr05225  Hepatocellular carcinoma
shr05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:shr00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100913901 (ARAF)
   04012 ErbB signaling pathway
    100913901 (ARAF)
   04068 FoxO signaling pathway
    100913901 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100913901 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    100913901 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100913901 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    100913901 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    100913901 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    100913901 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    100913901 (ARAF)
   04720 Long-term potentiation
    100913901 (ARAF)
   04730 Long-term depression
    100913901 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100913901 (ARAF)
   05205 Proteoglycans in cancer
    100913901 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    100913901 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100913901 (ARAF)
   05212 Pancreatic cancer
    100913901 (ARAF)
   05225 Hepatocellular carcinoma
    100913901 (ARAF)
   05226 Gastric cancer
    100913901 (ARAF)
   05214 Glioma
    100913901 (ARAF)
   05221 Acute myeloid leukemia
    100913901 (ARAF)
   05220 Chronic myeloid leukemia
    100913901 (ARAF)
   05218 Melanoma
    100913901 (ARAF)
   05211 Renal cell carcinoma
    100913901 (ARAF)
   05219 Bladder cancer
    100913901 (ARAF)
   05215 Prostate cancer
    100913901 (ARAF)
   05213 Endometrial cancer
    100913901 (ARAF)
   05224 Breast cancer
    100913901 (ARAF)
   05223 Non-small cell lung cancer
    100913901 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    100913901 (ARAF)
   05160 Hepatitis C
    100913901 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100913901 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    100913901 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    100913901 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100913901 (ARAF)
   01522 Endocrine resistance
    100913901 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:shr01001]
    100913901 (ARAF)
Enzymes [BR:shr01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     100913901 (ARAF)
Protein kinases [BR:shr01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   100913901 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like Pkinase_fungal ABC1 C1_2 TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 100913901
NCBI-ProteinID: XP_012408875
Ensembl: ENSSHAG00000006228
UniProt: G3VVG4
LinkDB
Position
X:81728868..81734945
AA seq 624 aa
MMRRGPTATPVGSSRSLTAAEDPAATPSSSSRVGGTVKVYLPNQQRTVVTARDGMTVSDS
LDKALKVRGLNQDCCAVYHLVQGRKTATAWDAAIAPLHGEELTVEVRADVPLAAAHNFAR
KTFLAPTFCDFCRRFLFHGFRCQTCGYKFHQHCSARVPTVCVDMATARQPCYRSVQDLTG
GPGAPEPQSGGQALCESHTPKSPRTQTPASHGETFAFPGSGGPPLQRIRSTSTPNVHMIS
TTMPVDSRLVQQAAQAFTAEGTGGERTPQSSPSPSLVSPPGRKSPHPKFSSEPLERKSSA
SADDKKKVKSLGYRDSGYYWEVAPGEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQP
TAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPDFAIITQWCEGSSLYHHLHVADTHFDM
VQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQQV
EQPTGSVLWMASEVIRMQDKNPYSFQSDVYAYGVVLYELMSGSLPYSHINNRDQIIFMVG
RGYLSPDLTKVSNNCPKAMKKLLADCLRFQREERPLFPEILVTIELLQRVLPKIERSASE
PSLHRAQTEELPSSLLGALRLFGP
NT seq 1875 nt   +upstreamnt  +downstreamnt
atgatgagacgaggcccaactgccacccccgtaggatcctccaggagcctaaccgcagca
gaagatcctgctgcgaccccttcgagcagcagtcgggtagggggcactgtgaaggtctat
ctgcccaaccagcagcgtacagtggtaaccgcccgggatggaatgaccgtctccgactca
ctggacaaggcactgaaggtgcggggactgaaccaagactgctgtgctgtctatcacctt
gtacagggccggaagacagcaacggcctgggatgcagccattgctcctttgcatggggaa
gaactgacggtcgaggtccgggctgatgttccactcgcagctgcccacaactttgcccgg
aagacattcctggctcccaccttctgcgacttctgccgccgcttcctctttcatggcttc
cgctgccagacatgtggctacaagttccaccaacactgcagtgcccgggtccccaccgtc
tgtgttgacatggctaccgcccgccaaccttgctaccgcagtgtccaggacttgactgga
ggccctggtgctcctgagccccagtctggaggccaggctctgtgtgagtcccacacccca
aagagtcccaggacacaaacaccagcctcccacggggagacttttgctttccctgggtct
ggaggcccacccctccagaggatccgctctacatccacacccaatgtgcacatgatcagc
accacgatgcctgtggacagtaggctcgtacagcaggcagcccaggccttcactgctgaa
ggaacaggtggggaaaggaccccccaaagcagtcctagccccagccttgtgtccccccct
ggaaggaaatccccacaccccaagttttcatcagagccccttgagcgcaagtcctcagct
tcagctgatgataagaagaaagtgaagtccctgggttaccgagactcaggctactactgg
gaggtggccccaggggaggtgcagctgctgaagaggatcgggacgggctcctttgggacc
gtgttccgtggacgatggcacggagacgtggccgtgaaggtgctaaaggtggcacagccc
acggctgagcaagcacaggccttcaagaacgagatgcaggtcctcaggaagacgcgccac
gtgaacatccttttgttcatgggcttcatgacaaggcccgactttgccatcatcacccag
tggtgtgagggttccagcctctaccaccacctgcacgtggctgacactcactttgacatg
gtacagctcattgacgtggcgcgacagacggctcagggcatggattacctccatgccaag
aacatcattcaccgagacctcaagtccaacaatatcttcctacacgagggactgacggtg
aagatcggagactttgggctggccactgtcaagactaggtggagtggcgcccagcaagtg
gaacagcccactggctctgtgctctggatggcctctgaagtgatccgcatgcaggacaag
aacccctacagcttccagtctgacgtctatgcctatggcgtcgttctctatgagctcatg
agtggcagtcttccctatagccacatcaacaacagagatcagatcatcttcatggtgggc
agaggctatctgtcgccagacctcaccaaggtgtccaacaactgccccaaagccatgaag
aagctgctggccgactgtctgcgcttccagcgggaagagcggcccctctttcctgagatc
ctggtcaccatagagctgctgcaacgggtgctgcctaagatcgagcgcagcgcatcggaa
ccgtcgctgcaccgggctcagacggaggagctgccttcgtccctgctgggagccctgcgc
ctctttgggccgtag

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