Sarcophilus harrisii (Tasmanian devil): 100914746
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Entry
100914746 CDS
T02286
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2 isoform X1
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
shr
Sarcophilus harrisii (Tasmanian devil)
Pathway
shr05012
Parkinson disease
shr05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
shr00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
100914746 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
100914746 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
shr01001
]
100914746 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
shr04131
]
100914746 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
shr04147
]
100914746 (LRRK2)
Enzymes [BR:
shr01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
100914746 (LRRK2)
Protein kinases [BR:
shr01001
]
Serine/threonine kinases: TKL group
LRRK family
100914746 (LRRK2)
Membrane trafficking [BR:
shr04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
100914746 (LRRK2)
Exosome [BR:
shr04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
100914746 (LRRK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
PK_Tyr_Ser-Thr
Pkinase
LRR_8
Roc
LRR_4
COR-B
COR-A
Ras
LRR_14
LRR_9
Ank_2
Arf
LRR_NXF1-5
T2SSE
PduV-EutP
Beta-prop_RSE1_2nd
nSTAND3
AAA_7
LRR_13
GTP_EFTU
AAA_16
AAA_22
Arm
MMR_HSR1
Septin
NACHT
Beta-prop_EML_2
SRPRB
ABC_tran
Kdo
MobB
FtsK_SpoIIIE
nSTAND_NTPase5
AAA_29
cobW
TsaE
SRP54
Motif
Other DBs
NCBI-GeneID:
100914746
NCBI-ProteinID:
XP_012406304
Ensembl:
ENSSHAG00000016549
UniProt:
G3WVN1
LinkDB
All DBs
Position
5:68166212..68343584
Genome browser
AA seq
2526 aa
AA seq
DB search
MASSRSLRSEEKEEESLKKLIVRLQNVQEGKQIETLIQILEDMLMLTYSDRASKLFQGKN
VHMPLLVVLDSYMRVAGVQQVGWSLICKLTEICPDIMQSLMGPQDVGKDWEILGVHQLIL
KMLTVHNANITLSLIGLKALDQLLTSDLMTLRILEEDCSDVFTLIFDAMHTFITNEEIQK
FGCKILHVLFQKVSEEQLTEFIENKDYMFLLNALKRFNHEEEVVLHVLHSLHSLALPCSN
VEVLMSGNVRCYNIVVEAMKMFSSSEKIQEVGCCLLHRLTLDNFFNILVLNEVHEIIVKA
VKKYSENATLQIAALSCLALLTETIILNQDLEEKKKNQDDDEDNKLYWLEASYTALKLHK
KNTYVQEAACWALNNLFMYQRNLHENIGDEDDQYPVHREILLSMLMHSSTKEVFQATANA
LSTLSEQNVNIRKALLSKGIYWNVMRFMMKHLDFPEVAESGCKMLNHLLEGSNLHVDVMT
SVTSHIIKVMKSHKTSSTVQLEALRTILHIIVPDSKKEPEEDVSLNINLKVVKNQCLLND
IHRLVLSALNKFIGNPGIQICGLKIISSLANCSGALEMFSQEGALDSILHTLQMYPDNRV
IQYVGLSLLGCLITKKNLCTETQDLLANILVSSLQRFKDVAEVQISGFQTTLAILELSLS
FAKLLLSHHSYDSLIFYQMSRCFNEQADHQFRNLCCKFFAKITCDDDIKNILLARACAEN
NSVMAECLLLLGADINKVTGKTSLICQVCEKESSPKLVELLLDNGPREQEIRKALMISIK
KNNSHIISLLLRKLGLDLANSSICLGGFCMGKIEPSWLSPLFPDKASNLRKQTNTGSSLA
RMVLRYQLKSLSEDEPISGSDGSFPEDDLDKFGDWTFIPDSSLDCVFGQSDDLDSEGSEG
SIFMKKKSSSFNVGDLYRDPALQHGSPTLERHPNSMEASFDREELLKQKRDLKFSSDDSV
QGSSKLQSHLRQSESFFSLTLEREYIKSLDLSANELEDIDGISKKSCLNDHLIHLEKLEL
HQNALTRIPQQLCETLKCLTYLDLHSNKITSIPAYLLKMNSIANLDISRNDIGPSIILDP
SIRCPTLKQLNLSYNQLYSVPEHLADVTENLEQLFLEGNKISEIHSPLCLKELKFLNLSK
NHILSITEDFFEACRKLETFSARMNSLVAVPFLPSSITILNLSQNKFTCIPEVILNLPHL
RSLDLSSNEIHNLPGPVHWKSLNLRELLFNHNQISILDLSEKACAWSRMEKLHLSHNKLK
EIPPEIGFLENLTSLDVSYNLELRSFPNEMGKLTKIWDLPLDELHLNIDFKHIGCKTKDI
IRFLQQRLKKAVPYNRMKLMVVGNTGSGKTTLLQQLMKYKKTDLSTLSTTVGIDVKDWSI
QLRSKGKKELILNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGHAEVDAMKPWLFNI
KARASSSPVILIGTHLDVSDEKQRKASISKITRELLNKRGFPEIRDYHFVNATEHEALVK
LRKSIIKESLNFKIRDQPVVGQLIPDCYLELEKKILLERKNVPTEFPVISQKRLVQLVKE
NHLQLDENELPHAIHFLNESGVLLHFQDPALQLSDLYFVEPRWLCKMMAQILTVKVEGFA
KYPKGIIQRSDVEKFLSKKSKFPKNYMSQYFKLLEKFQIALPIGEEHLLVPSSLSDQRPV
IELPHCENSEVIVRLYEMPYFPMGFWSRLISRLLEISPYILSGRERALRPNRMYWRQGIY
LNWSPEAYCLVESSILDNSSESILKITAPSCRKGCIILGQVVDHIDSLMEEWFPGLLEID
VCGEGETLLKKWALYSFNDGEEQQKILLDDLMKKTEEGDLLINPDQPRLTIPIGHIAPDL
ILADLPRNIILNHDELEFEQAPEFLLGDGGFGSVYRASYKGEEVAVKIFNKHTSLRLLRQ
ELVVLCHLHHPSLISLLAAGIRPRMLVMELAPKGSLDRLLQQDKASLTRTLQHRIALHVA
DGLRYLHASMIIYRDLKPHNVLLFTLYPNSAIIAKIADYGIAQYCCRMGIKTSEGTAGFR
APEVARGNVIYNQQADVYSFGLLLYDILTTGGRILEGLKFPNEFDELAIHGKLPDPVKEY
GCTPWPKVENLIKKCLKENPQERPTSAQVYEILNSAELICLMRYILIPKLFVAECMVATN
QNNKNAVVWLGSGNNARGQLSCLEINTERHISKDVTDSRILCLALVYIHVEKESWIVAGT
QSGILLAVKTDDDKKSHMLQRMTDSVTCLYCNSFSKQSTQKNFLLVGTADGRLAIFEDKN
VKFEGAPPLKTLNIGNVSTPLMCLNESIYSSEKNIIWGGCGTKIFSLSNDFSIQKLIETK
TNQLFSYATFSDSNIISIVVDKAIYIAKKNSHFVEVWDKKTEKLCVLIDCVQFLKEHIGS
KESKHKMTYSGRVKTLCLQKNTALWIGTGGGHILLVDLSTHRIIHIIQNFCNSVRALMTV
QLGSLKNVMLVLGYSQKSNENTQDQKEMESCLSVWDINLPHEVENLEKHTEVRKELAEKM
KSISMD
NT seq
7581 nt
NT seq
+upstream
nt +downstream
nt
atggccagtagccgcagcctgcgcagtgaagaaaaagaagaggaatctttgaaaaagttg
atagttagactgcaaaatgtccaggaaggaaaacagatagaaaccctgatccaaatccta
gaggatatgctgatgttaacgtacagtgatcgcgcttccaagttatttcaaggcaaaaat
gtccatatgcctttgctcgttgttttggattcctacatgagagtcgcaggtgtgcaacag
gtgggttggtcacttatctgtaaattgacagaaatttgtcctgatataatgcaaagctta
atgggtccccaggatgttggaaaagattgggaaatccttggtgttcaccagctgattctt
aaaatgctcactgttcacaatgccaatataaccctttcattgattggactaaaggcatta
gatcagctcctgacttcagatttgatgactttgcggatcttggaagaagattgcagtgat
gtgttcacattaatttttgatgccatgcatacatttatcactaatgaagaaatccaaaaa
tttgggtgtaaaattttacatgtgctttttcagaaagtttcagaagagcagttgactgaa
tttattgaaaacaaagattatatgtttttgttgaatgcattaaaaagatttaatcacgaa
gaagaagttgttcttcatgttcttcacagtttgcattccctagcactcccatgcagtaat
gttgaagtcctaatgagtggaaatgtcagatgttacaatattgtggtagaagccatgaaa
atgttctctagcagtgaaaaaattcaagaagttggctgctgtttattacataggcttaca
ttggataatttctttaatatcctggtcttaaatgaagttcatgagataattgtgaaagct
gtcaaaaaatattcagaaaatgcaaccttgcagatcgcggcactgagctgtttggctctc
ctcactgaaactatcatattaaaccaagatttagaagaaaagaaaaagaatcaggatgat
gatgaggacaacaaattatactggttagaagccagttacacagcattgaaattacataaa
aagaacacctatgtgcaggaagctgcatgctgggctttgaacaatctatttatgtatcaa
agaaatttacatgaaaatattggtgatgaagatgaccagtatccagtgcatagagaaata
ctactctccatgctgatgcattcttcaacaaaagaagtatttcaggccactgctaatgca
ttgtcaactctttcagaacaaaatgttaatatcagaaaagccctgttatcaaaaggaata
tactggaatgtaatgcgatttatgatgaagcatttagactttcctgaagtagctgaaagt
ggatgtaaaatgttaaatcatcttttggaaggaagtaaccttcatgtagatgtaatgaca
tcagtgacatctcacataataaaagttatgaaaagtcacaaaacctcatcaacagtgcaa
ctggaggcactccgaactattttacatattattgtgccagactcaaagaaggaacctgaa
gaagatgtttcattaaatataaatctaaaagtggttaaaaatcaatgcctattgaatgac
attcacagactggttctgagtgctttaaataagtttattggaaatcctggaattcaaata
tgtggattaaaaataatctcttctttagcaaattgttctggtgcattagaaatgttttct
caagaaggggctcttgattcaatacttcatacattacagatgtatccagataatagagta
attcagtatgtgggtttgagtctactgggatgtttgataacaaaaaagaatttgtgcaca
gaaactcaggatctgcttgcaaatattctggtttccagcttacaacgatttaaagatgtt
gctgaagtacagataagtggatttcaaacaactctggcaatacttgaattatcacttagc
tttgcaaagctgctgttaagccatcattcgtatgattcactcattttctatcagatgtcc
aggtgtttcaatgaacaagcagatcatcagtttaggaatctttgttgcaaattctttgcc
aaaataacttgtgatgacgatattaaaaatatcctactggcaagagcttgtgcagaaaac
aatagcgttatggcggaatgccttctccttttgggagctgatattaataaagtgactgga
aaaacttctttaatctgccaggtttgtgaaaaagaaagcagtcctaaactagtggaactc
ttattagataatggaccacgggaacaagagattaggaaagcattgatgatcagcataaag
aaaaataatagtcatatcatcagtttactattaaggaagcttggcctggatcttgccaat
agcagcatttgtcttggaggattttgcatgggaaaaattgaaccttcatggctcagtcct
ttatttccagataaagcatctaatttaagaaaacaaacaaacacaggatcttcattggca
agaatggtattaagatatcagttaaaaagtttatcagaagatgaaccaatatcaggcagt
gatggaagttttcctgaagatgatcttgataaatttggtgattggacttttattcctgat
tcttctttggactgtgtatttggacagagtgatgatcttgatagtgaaggaagtgaaggt
tcaatttttatgaaaaagaaatcgagttcttttaatgtgggagatctttatagagatcct
gccctacagcatggctcaccaactttggaaaggcatcctaattcaatggaagccagtttt
gaccgtgaagaattgttgaagcaaaaaagagacttaaaattttcttctgatgattctgtc
caaggatcttcaaaactccagtcccatttgagacaatcagagagctttttttctctaacc
ttagaaagagaatatataaagtcattagacctttcagcaaatgaactagaggacattgat
ggtataagcaagaaaagctgtttaaatgatcatttaatacaccttgagaaactggagctt
catcagaatgcacttacaagaattccacaacaactctgtgaaactttaaaatgtttgaca
tatttggacttacacagtaacaaaatcacttcaattcctgcctatttgctgaaaatgaat
agcattgcaaatcttgatatctcccgtaacgatattggaccttctataattttggatcca
tctatcagatgtccaactttgaagcaacttaatctctcatacaatcaactatattctgtc
cctgaacatcttgcagatgtcacagaaaatctagaacagctctttctagaaggaaacaaa
atatcagaaatacactcaccattgtgcttaaaggagttgaagtttttaaaccttagtaaa
aaccacatattatccataactgaagatttttttgaggcatgtaggaaactggaaactttt
agtgccagaatgaattctcttgttgctgtgcctttcttgccgtctagcataacaatttta
aatttgtcacaaaacaaatttacatgtattccagaagtaattctcaaccttccacatttg
cggtcattagatttgagcagcaatgaaattcacaacctacctgggcctgtacactggaaa
tcattaaacttaagggaacttttgtttaatcataatcagatcagcattttggacttaagt
gaaaaagcatgtgcatggtcacggatggagaaactacacttatcccataataaattaaag
gagattcctcctgaaatcggttttcttgaaaatttaacatctcttgatgtgagttacaat
ttggagctgagatcctttcctaatgaaatggggaaattaactaaaatctgggaccttcct
ttggatgaattgcatcttaatattgattttaagcatataggttgcaagactaaggacatc
ataaggtttcttcaacagagattaaagaaggcagtgccatacaatcgaatgaaacttatg
gttgtgggaaatactggcagtggaaaaactacattgttgcaacagttgatgaagtataaa
aaaacagatttgagcaccctgagcactacagtaggcatagatgtaaaagactggtctatc
cagctgaggagcaaagggaagaaagagctaatcctaaatgtctgggattttgcaggacga
gaagagttctatagcactcatcctcactttatgacacaacgagcattatatcttgctgta
tatgatcttagcaaaggacatgctgaagtagatgctatgaagccatggcttttcaacata
aaggctcgggcttcttcctcaccagtgattctaattggtacacatttggatgtttctgat
gaaaaacaacgaaaggcctccataagcaaaatcaccagggagctattaaacaaaagaggg
ttccctgaaatacgtgattaccattttgtgaatgctacagaacatgaggcattagtaaaa
cttcggaaaagtatcataaaagagagtctgaacttcaagatcagagaccaacctgttgta
ggacagctaattccagattgctacttggaactcgagaagaaaattttattggagcgaaag
aatgtccccactgaatttccagtaatcagtcagaaacgattggtacagttagtaaaagaa
aatcatctgcagttggatgagaatgaacttcctcatgcaattcacttcctaaatgaatca
ggtgttctgctacattttcaagacccagcattgcagttaagtgacttatattttgtggaa
cctagatggctatgcaaaatgatggcacagattttgacagtgaaagtagaaggctttgct
aaatatcctaagggtattattcaacgttcagatgtggaaaagttcctttcaaagaaaagc
aaatttcccaagaattacatgtctcaatactttaaactccttgaaaaatttcagattgct
ttgccaataggagaagagcatttactagttccaagcagtttgtctgatcagagacctgtg
atagaacttccacactgtgaaaactctgaagttattgttaggttgtatgaaatgccttat
tttcctatgggattttggtccagactgatcagtcgattacttgaaatttctccttacata
ctctcaggcagagaacgggcccttcgccctaacagaatgtattggagacaaggaatctac
ctaaattggtctcctgaagcctattgtctagtagaatcttcgattttggacaacagctca
gagagtatcttgaaaattacagcaccttcatgcagaaaaggctgtatcattttgggacaa
gttgtagatcacatagattctctgatggaagaatggtttcctggtttattggaaatagat
gtctgtggtgaaggagaaacactgttaaagaaatgggctttatatagttttaatgatggt
gaagaacaacaaaaaatattacttgatgatttaatgaagaaaactgaagaaggagatctc
ttaattaatccagatcaaccaaggcttactatcccaataggccatattgcgcctgattta
attttggctgatttacctagaaatatcatattgaatcatgatgagttggaatttgaacaa
gcaccagaatttcttttaggtgatggtggttttggatccgtttatcgagcatcctataaa
ggagaagaagtggctgtgaagatttttaataaacatacatctcttcggctattaagacaa
gaattagtagtgctttgccatctccatcaccctagtctgatatctttgcttgctgctggt
attcgtccccggatgttggtaatggaattagccccaaaaggttctctagatcggttgctt
caacaagacaaagctagcttaaccagaacactccaacacaggatagcattacatgttgct
gatggcttaagatatctccatgcatcaatgattatataccgagatttgaagcctcataat
gtactgctttttaccctgtatcctaattctgcaatcattgccaagattgcagactatgga
atcgctcagtactgttgcagaatgggtataaagacatctgaaggaacagcaggatttcgt
gcacctgaagttgccagaggaaatgtcatttataatcaacaggctgatgtttattccttt
ggcttattgctttatgacattttgacaacaggaggtagaattctagaaggactgaaattc
ccaaatgagtttgatgagttagctatacatgggaaattaccagatccagtgaaggaatat
ggttgtactccgtggcctaaggtagaaaacttaatcaaaaagtgtctgaaagaaaatcct
caggaaaggccaacatctgcgcaggtatatgaaattttgaactcagctgaattaatatgt
ctaatgagatatattttaataccaaaattatttgtagcagaatgcatggttgctacaaac
caaaacaacaagaatgcagttgtctggctgggtagcgggaacaatgccaggggacaacta
tcctgtcttgagataaatactgaaagacatatctctaaggatgtgacagatagtagaata
ttgtgccttgcccttgtatacatacatgttgaaaaggaaagctggatcgtggcaggaaca
cagtctggtatcctattggcagtcaagacagatgatgataaaaagagccatatgcttcaa
agaatgactgactctgttacatgtttatactgcaattcattttctaaacaaagcacacaa
aagaattttcttctagtgggaactgcagatgggagactagctatttttgaagacaaaaat
gttaagtttgaaggagctcctcctttaaagacattaaatataggaaatgtcagcactcca
ttaatgtgtttaaatgaatctatatattcatcagaaaaaaacataatctggggaggatgt
ggcaccaagattttctcactttctaatgatttctccattcagaaacttattgagacaaag
acaaatcaactgttttcttatgcaacattcagtgattctaacatcatttcaattgtggtg
gacaaagctatctacatagctaagaaaaacagtcattttgttgaagtatgggacaagaag
acggagaaactttgtgtactaatagactgtgtgcagtttttaaaggagcatataggaagc
aaggaatcaaaacataaaatgacttattctggaagagtgaaaaccctctgtctgcagaaa
aacactgccctttggataggtacaggaggaggtcacattttactagttgatctttcaaca
catcgcatcatacacataattcagaacttttgtaattctgttagagcgctgatgacagtc
cagttagggagcctaaaaaatgtcatgctggttttggggtacagccagaaaagtaatgaa
aatactcaggaccaaaaagaaatggagtcttgtttgtctgtgtgggacattaacctacca
catgaggtggaaaatttggagaagcacacagaagttagaaaagaattagctgaaaaaatg
aaaagtatttccatggattaa
DBGET
integrated database retrieval system
