KEGG   Sarcophilus harrisii (Tasmanian devil): 100915362
Entry
100915362         CDS       T02286                                 
Symbol
TBK1
Name
(RefSeq) serine/threonine-protein kinase TBK1 isoform X1
  KO
K05410  TANK-binding kinase 1 [EC:2.7.11.10]
Organism
shr  Sarcophilus harrisii (Tasmanian devil)
Pathway
shr04014  Ras signaling pathway
shr04137  Mitophagy - animal
shr04140  Autophagy - animal
shr04620  Toll-like receptor signaling pathway
shr04621  NOD-like receptor signaling pathway
shr04622  RIG-I-like receptor signaling pathway
shr04623  Cytosolic DNA-sensing pathway
shr04657  IL-17 signaling pathway
shr04936  Alcoholic liver disease
shr05014  Amyotrophic lateral sclerosis
shr05022  Pathways of neurodegeneration - multiple diseases
shr05135  Yersinia infection
shr05160  Hepatitis C
shr05161  Hepatitis B
shr05162  Measles
shr05163  Human cytomegalovirus infection
shr05164  Influenza A
shr05165  Human papillomavirus infection
shr05167  Kaposi sarcoma-associated herpesvirus infection
shr05168  Herpes simplex virus 1 infection
shr05169  Epstein-Barr virus infection
shr05170  Human immunodeficiency virus 1 infection
shr05171  Coronavirus disease - COVID-19
shr05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:shr00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    100915362 (TBK1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100915362 (TBK1)
   04137 Mitophagy - animal
    100915362 (TBK1)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    100915362 (TBK1)
   04621 NOD-like receptor signaling pathway
    100915362 (TBK1)
   04622 RIG-I-like receptor signaling pathway
    100915362 (TBK1)
   04623 Cytosolic DNA-sensing pathway
    100915362 (TBK1)
   04657 IL-17 signaling pathway
    100915362 (TBK1)
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    100915362 (TBK1)
   05161 Hepatitis B
    100915362 (TBK1)
   05160 Hepatitis C
    100915362 (TBK1)
   05171 Coronavirus disease - COVID-19
    100915362 (TBK1)
   05164 Influenza A
    100915362 (TBK1)
   05162 Measles
    100915362 (TBK1)
   05168 Herpes simplex virus 1 infection
    100915362 (TBK1)
   05163 Human cytomegalovirus infection
    100915362 (TBK1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100915362 (TBK1)
   05169 Epstein-Barr virus infection
    100915362 (TBK1)
   05165 Human papillomavirus infection
    100915362 (TBK1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100915362 (TBK1)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    100915362 (TBK1)
   05022 Pathways of neurodegeneration - multiple diseases
    100915362 (TBK1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100915362 (TBK1)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    100915362 (TBK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:shr01001]
    100915362 (TBK1)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:shr04131]
    100915362 (TBK1)
Enzymes [BR:shr01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     100915362 (TBK1)
Protein kinases [BR:shr01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   100915362 (TBK1)
Membrane trafficking [BR:shr04131]
 Autophagy
  Xenophagy
   Other xenophagy associated proteins
    100915362 (TBK1)
SSDB
Motif
Pfam: TBK1_CCD1 Pkinase TBK1_ULD PK_Tyr_Ser-Thr Pkinase_fungal Kinase-like CEP63 ABC1 DUF713 COG6_N DUF4200
Other DBs
NCBI-GeneID: 100915362
NCBI-ProteinID: XP_031796767
Ensembl: ENSSHAG00000006325
LinkDB
Position
5:complement(74891689..74945400)
AA seq 729 aa
MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAVKVFNSISFLRPVDVQMREFEVLK
KLNHKNIVKLFAIEEETTTRHKVLVMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV
GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARVLEDDEQFVSLYGTEEYL
HPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG
KPSGAISGVQKAENGPIDWSADMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA
ETSDILHRMIVHVFSLQQMTAHKIYIHSCNTATVFHDLVYKQTKIVSSNQELIYEGRRLV
LEPGRLAQHFPKTTEENPIIVISREPMSIVGLMYEKISLPKVHPRYDLDGDASMAKVITG
VVCYACRVASTLLLYQELMRKGIRWLIELIKEDYNETIHKKTEVVIALDFCIRNIEKTVK
IYEKLMQIDLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIKSKLSPGGLLADTWANQE
GTHPKDRNVEKLQVLLNCITEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYFYATKAMSH
FTDECVEKYETFLDKAEEWMRKMLHLRKQLSSLTNQCFDMEEEVSKYQDYTNELQETLPQ
KLFAASSGIKHTMAPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGALTMD
GGLRNVDCL
NT seq 2190 nt   +upstreamnt  +downstreamnt
atgcagagtacttctaatcatctgtggctcctatctgatatcctagggcaaggagccact
gcaaatgtttttcgtggaagacataagaaaactggtgatttatttgcagtcaaggtattt
aatagcataagtttccttcgtcctgtggatgttcaaatgagagaatttgaagtcttaaaa
aaattaaaccacaagaatattgtcaaattgtttgctattgaagaagagacaaccacaaga
cataaagtacttgttatggaattttgcccatgtggtagtttatatactgttttagaagaa
ccatctaatgcctatggactaccagaatcagaatttttaattgtgttgagagatgtggtg
ggtggaatgaatcacctccgagaaaatggaatagtgcaccgtgatatcaagccgggcaac
atcatgcgtgttataggggaagatggacaatctgtttacaaactgacagattttggtgct
gctagagtattagaagatgacgaacagtttgtttctttgtatggcacagaagagtatttg
catcctgatatgtacgaacgagcagtgctaaggaaagatcatcagaagaaatatggtgca
acagttgatctttggagcattggagtaacattttaccatgctgcaacagggtcactaccc
tttcgcccttttgaaggacctagacgaaacaaagaagtcatgtataaaataattactgga
aaaccttctggtgcaatatcaggagtacaaaaagcagaaaatgggccaattgactggagt
gcagatatgcctgtttcttgtagtctttctaggggtctgcaagtcctacttactcctgtt
ctagcaaacattcttgaagctgaccaggaaaaatgctggggttttgaccagttttttgcc
gaaactagtgatatacttcaccggatgatagtgcatgttttttctttacaacaaatgaca
gcccacaagatttatattcatagttgtaatactgctactgtgttccatgatttggtttat
aaacaaaccaaaattgtttcttcaaatcaagaattgatttatgaaggacgacgattagtg
ctcgaacctggaagactagcacagcattttcctaaaactactgaagaaaatcccatcatt
gtaataagccgggaacctatgagcattgttggattaatgtatgaaaaaatttcactcccc
aaagtacatccacgttatgatttggatggtgatgcaagtatggctaaggtaataacaggt
gtcgtctgttatgcctgtagagttgccagtaccttgctgctttatcaggaattgatgcga
aaaggaatacgatggctgattgaactgattaaagaagattataatgaaacaatacacaaa
aagacagaagttgtgattgctctggatttctgtatcagaaacattgaaaaaactgtgaaa
atatatgaaaaattgatgcagattgatttggaagcagcagagctgggtgagatttcagac
atacacactaaattattgcgactctccagctcacagggaacaatagaaactagtcttcag
gatatcaaaagcaaattatctcctggaggattattggcagatacctgggcaaatcaggaa
ggaacacatccaaaggaccgaaatgtagaaaaactgcaagtcctgctaaattgcattaca
gagatttactatcagttcaaaaaagacaaagcagaacggagactagcttataatgaagaa
cagattcacaaatttgacaagcagaaactgtatttttatgcaacaaaagctatgagccac
tttactgatgagtgtgttgaaaaatatgaaacctttttggacaaggcagaagagtggatg
agaaagatgcttcacctaaggaaacagctgtcatctctaactaatcagtgttttgatatg
gaggaagaagtatcaaaataccaggattatactaatgagttacaggaaactttacctcag
aaattgtttgcagcttccagtggcataaaacataccatggcccccatttatccaagctcc
aatacactagtggagatgactcttggtatgaagaaattgaaggaagagatggaaggtgtt
gttaaagaacttgctgaaaataatcatattttagagagatttggcgctttgactatggat
ggcggacttcggaatgttgattgtctctaa

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