KEGG   Sarcophilus harrisii (Tasmanian devil): 100915970
Entry
100915970         CDS       T02286                                 
Name
(RefSeq) steroid 17-alpha-hydroxylase/17,20 lyase isoform X1
  KO
K00512  steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:1.14.14.19 1.14.14.32]
Organism
shr  Sarcophilus harrisii (Tasmanian devil)
Pathway
shr00140  Steroid hormone biosynthesis
shr01100  Metabolic pathways
shr04913  Ovarian steroidogenesis
shr04917  Prolactin signaling pathway
shr04927  Cortisol synthesis and secretion
shr04934  Cushing syndrome
Module
shr_M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
shr_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
shr_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
shr_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:shr00001]
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    100915970
   04917 Prolactin signaling pathway
    100915970
   04927 Cortisol synthesis and secretion
    100915970
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100915970
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:shr00199]
    100915970
Enzymes [BR:shr01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.19  steroid 17alpha-monooxygenase
     100915970
    1.14.14.32  17alpha-hydroxyprogesterone deacetylase
     100915970
Cytochrome P450 [BR:shr00199]
 Cytochrome P450, animal type
  CYP17 family
   100915970
SSDB
Motif
Pfam: p450 Syntaphilin
Other DBs
NCBI-GeneID: 100915970
NCBI-ProteinID: XP_003755460
Ensembl: ENSSHAG00000018660
UniProt: G3X2Z0
LinkDB
Position
2:complement(558878474..558887908)
AA seq 502 aa
MWWFLIASLLTLLYYLWQKLGTLGKKYPTCLPHLPILGSLPYLNSSDQAHIFFTKLKEKY
GHIYAFWLGPSYSVVVNQFSLAKEVLLKKGKDFASRPRMVTTDILSGSGKGIAFSQYGPQ
WRMYRKLVQSTFSLFKDRSQNFEKIICQEATSLCKSLAATQGQAMDPAMDFFLASANVIC
QFCFSSSWKQDDKDIEVMMNFSDTIIKNLAKDSLVDIFPWAQLFPNKELTQLKESVMLRN
KLLEKKLKIQKEKFNIDSVNNLLDTLLKAKVNHNGQVTQELEITDEHILMTVGDIFGAGV
ETTSSVVKWCIAYLLHYPQVKEKIQKEIDQKIGFSRTPVLSDRNQLLYLESTIREILRIR
PVAPLLIPHMACADSSIGEYTIPKGTRIYINLWSIHHDPTEWDEPEKFKPERFLDKNKEQ
LIMPTASYFPFGCGPRVCIGEFLARAELFLFLSWILQRFDLEVPDDGELPSLEGEFGVVY
QIVPFKLKFKLRKSWREAQLSA
NT seq 1509 nt   +upstreamnt  +downstreamnt
atgtggtggttcctcatcgcctccctgctgaccctgctatactacttgtggcagaagctg
gggactctgggcaagaaatatcccacttgtctgccccatctgcccatcctggggagcctt
ccctatctgaactcctctgaccaagcacacatcttcttcaccaagcttaaagagaagtac
ggccacatctatgccttttggctggggccttcgtactctgtggtagtgaaccagttctca
ctggccaaggaagtgcttctcaagaaaggcaaggattttgccagccgcccccgaatggta
accacagacatcctgagcggctcgggcaagggcatcgccttcagccagtacggcccccag
tggcgaatgtatcggaagctggtgcagtccaccttctccttgtttaaggatcgctcccag
aactttgagaagatcatctgccaagaggccacttcgctctgtaagtccctggccgccacg
caaggccaggccatggacccagctatggatttcttcctggcttccgccaatgtcatctgc
cagttttgcttcagcagctcctggaagcaggacgacaaagacatcgaggtcatgatgaac
ttcagcgacaccatcatcaaaaatctggccaaggacagcctggttgacatctttccctgg
gctcagctgttccccaacaaagaattgacacagttgaaggagagcgtcatgttacggaat
aagctactggagaaaaaacttaaaattcaaaaggagaaattcaacatagattctgtcaac
aacctcctggatacgctactgaaagccaaggtgaaccacaatggccaagtgacccaggag
ctagagatcacagatgagcacatcctgatgacagtgggtgacatttttggagctggtgtg
gagactaccagtagtgttgtcaagtggtgcattgcctacctgctgcactatcctcaggta
aaggagaagatccagaaggaaattgaccagaaaattggctttagccgaacacctgtactc
agtgacaggaatcaacttctttacctggagtccacaatacgtgaaatactccgcatacgg
ccagtggctcccttgctcatccctcacatggcatgtgctgacagcagcattggagaatat
accatccctaaaggcaccaggatctacatcaatctatggtctatccaccatgaccctaca
gaatgggatgagccagaaaagtttaagccagaacgattcctggacaagaataaggagcag
ctcatcatgccaactgccagctattttccttttggatgtggacctcgagtctgtattggg
gagttcttggctcgagcagagttgtttctctttctgtcctggatcctccaaagatttgac
ctggaagtacctgatgatggagaactaccctccttagagggggaatttggggtggtatat
cagatcgttcccttcaagttaaagttcaaactacggaagtcctggagggaggctcagctg
agtgcttag

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