Sarcophilus harrisii (Tasmanian devil): 100920427
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Entry
100920427 CDS
T02286
Symbol
FPGS
Name
(RefSeq) folylpolyglutamate synthase, mitochondrial isoform X1
KO
K01930
folylpolyglutamate synthase [EC:
6.3.2.17
]
Organism
shr
Sarcophilus harrisii (Tasmanian devil)
Pathway
shr00790
Folate biosynthesis
shr01100
Metabolic pathways
shr01240
Biosynthesis of cofactors
shr01523
Antifolate resistance
shr04981
Folate transport and metabolism
Brite
KEGG Orthology (KO) [BR:
shr00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
100920427 (FPGS)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
100920427 (FPGS)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
100920427 (FPGS)
Enzymes [BR:
shr01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.17 tetrahydrofolate synthase
100920427 (FPGS)
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Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Motif
Other DBs
NCBI-GeneID:
100920427
NCBI-ProteinID:
XP_031810549
Ensembl:
ENSSHAG00000018333
UniProt:
A0A7N4PJ82
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Position
2:478954416..478977929
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AA seq
600 aa
AA seq
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MATANLAPGFLGGMSWARCRALHAALRLAAGPLGIGPARRGFSARPVPQEPGMEYQDAVR
TLNTLQTNASFLEQIKQERGNPQVQLEAMKDYLVRSGLQIEDLDRLKIIHVTGTKGKGST
CAFTERILRGYGLKTGFYSSPHLVQVRERIRINGEPISPELFTKYFWRLYHRLEETKDDT
CVSMPPYFRFLTIMAFHVFLQEKVDLAVVEVGIGGAYDCTNIVRKPVVCGISSLGIDHTS
ILGDTIEKIAWQKAGIFKPGVPAFTVSQPDSPLEVLKDQARQLLCPLYLCPSLEAFEEEA
QPLQLGLAGDHQRSNAALALQLARCWLQRQGHKGIGELRATRLTSQQSLPLAPVFHPTWI
MKQGLWHTEWLGRTQVLRRGALTWYLDGAHTTSSIQAGIKWFRRAVLNQEKSINGPEVRV
LLFNATGERDTAALLKLLQSCQFDYAVFCPNLTEMSPVGNADQQNFTVTLDHMLTRCLEN
QKQWNQLAEEKAGQDPWLAQAPEPSTGPLHGPLLLVPPAPRPLNTNSLVFSCISHALQWI
SQGRDPHFRPSSSPRGLHSHPVASSGAVLLKEASSIQVLVTGSLHLVGGVLKLLDPTLSQ
NT seq
1803 nt
NT seq
+upstream
nt +downstream
nt
atggctactgcaaacctcgctcccggcttccttggcgggatgtcttgggcccgctgccga
gccctgcacgcggcgctgcggctcgcggctgggccgctggggatcgggccggcgaggcgg
ggcttcagtgcacggccggtgccgcaggagcccgggatggagtaccaggatgctgtgcgg
accctcaacacccttcagaccaatgctagcttcctagagcaaatcaagcaagaacgggga
aacccacaggtccagctagaagccatgaaggattatttggtccgaagtgggctgcagata
gaggatttagatcgactgaagattatccatgtgactgggactaaagggaagggctccact
tgtgccttcacagaacgtattctccgtggctacggtctgaaaactggattctacagctct
cctcatctggtgcaggtccgggagcgaatccgtattaatggggaacccatcagcccggag
ctctttaccaaatacttctggcggctctaccaccggttggaggaaactaaggatgacact
tgtgtcagcatgcccccttatttccgcttccttaccatcatggccttccacgtgtttctc
caagagaaggtggacctagcagtggtggaggttggcattggtggtgcttatgactgtacc
aatattgtcaggaagccagtggtctgtgggatatcctctctgggcatagaccacaccagc
atcctgggtgacactattgagaagattgcatggcagaaagcaggcatctttaagcctgga
gttccggccttcactgtgtcccagccagactcccccctggaggtcctgaaggaccaagcc
cgacagttgctgtgtccactgtacttgtgcccctcactggaggccttcgaggaagaagcg
cagccacttcaactggggctggcaggtgatcaccagcggagcaacgctgccctggccctg
cagctggcccggtgctggctccaacgacagggccacaagggtattggggaactgagggca
accaggctgacctcccagcaatctctgcccttggctcctgtgttccatcccacctggatt
atgaagcaggggctttggcacacagaatggctaggccggacacaggtactgagacgagga
gccctcacctggtacttggatggggcacacaccactagcagtatccaggctgggataaag
tggttccgccgggcagtacttaaccaggagaagtctatcaatggccccgaggttcgggtt
ttgctcttcaatgccactggagaacgggatacagcggcactactcaaactgctgcagtca
tgccagtttgattatgctgtcttctgccctaatctgactgaaatgtctcctgtagggaat
gcagaccagcagaactttacagtcaccctggaccacatgctgacacggtgtctagaaaac
cagaaacagtggaaccagctggcagaggagaaggcaggacaggatccctggttggcgcag
gccccagaacccagcactggacccttgcacgggcctcttctcctggtccccccagctcct
cggcctctcaacaccaactcccttgtcttcagctgcatttcccatgccctgcaatggatc
agccagggccgggacccccactttcggccctctagttctccacggggacttcactcccac
cctgtggccagtagtggggctgtcctcctcaaggaagcctcctctatccaggtgctggtc
actggcagtcttcacctggtgggtggggtcttaaagctcctcgatcccaccctgtcccag
taa
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