Entry |
|
Symbol |
PLCB3
|
Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
|
KO |
|
Organism |
shr Sarcophilus harrisii (Tasmanian devil)
|
Pathway |
shr04070 | Phosphatidylinositol signaling system |
shr04072 | Phospholipase D signaling pathway |
shr04261 | Adrenergic signaling in cardiomyocytes |
shr04270 | Vascular smooth muscle contraction |
shr04613 | Neutrophil extracellular trap formation |
shr04621 | NOD-like receptor signaling pathway |
shr04723 | Retrograde endocannabinoid signaling |
shr04750 | Inflammatory mediator regulation of TRP channels |
shr04919 | Thyroid hormone signaling pathway |
shr04925 | Aldosterone synthesis and secretion |
shr04927 | Cortisol synthesis and secretion |
shr04928 | Parathyroid hormone synthesis, secretion and action |
shr04933 | AGE-RAGE signaling pathway in diabetic complications |
shr04935 | Growth hormone synthesis, secretion and action |
shr04961 | Endocrine and other factor-regulated calcium reabsorption |
shr04973 | Carbohydrate digestion and absorption |
shr05022 | Pathways of neurodegeneration - multiple diseases |
shr05163 | Human cytomegalovirus infection |
|
Module |
shr_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
Brite |
KEGG Orthology (KO) [BR:shr00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
100922938 (PLCB3)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
100922938 (PLCB3)
04310 Wnt signaling pathway
100922938 (PLCB3)
04070 Phosphatidylinositol signaling system
100922938 (PLCB3)
04072 Phospholipase D signaling pathway
100922938 (PLCB3)
04071 Sphingolipid signaling pathway
100922938 (PLCB3)
04022 cGMP-PKG signaling pathway
100922938 (PLCB3)
09133 Signaling molecules and interaction
04082 Neuroactive ligand signaling
100922938 (PLCB3)
04081 Hormone signaling
100922938 (PLCB3)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
100922938 (PLCB3)
04613 Neutrophil extracellular trap formation
100922938 (PLCB3)
04062 Chemokine signaling pathway
100922938 (PLCB3)
09152 Endocrine system
04911 Insulin secretion
100922938 (PLCB3)
04922 Glucagon signaling pathway
100922938 (PLCB3)
04929 GnRH secretion
100922938 (PLCB3)
04915 Estrogen signaling pathway
100922938 (PLCB3)
04921 Oxytocin signaling pathway
100922938 (PLCB3)
04926 Relaxin signaling pathway
100922938 (PLCB3)
04935 Growth hormone synthesis, secretion and action
100922938 (PLCB3)
04918 Thyroid hormone synthesis
100922938 (PLCB3)
04919 Thyroid hormone signaling pathway
100922938 (PLCB3)
04928 Parathyroid hormone synthesis, secretion and action
100922938 (PLCB3)
04924 Renin secretion
100922938 (PLCB3)
04925 Aldosterone synthesis and secretion
100922938 (PLCB3)
04927 Cortisol synthesis and secretion
100922938 (PLCB3)
09154 Digestive system
04970 Salivary secretion
100922938 (PLCB3)
04971 Gastric acid secretion
100922938 (PLCB3)
04972 Pancreatic secretion
100922938 (PLCB3)
04973 Carbohydrate digestion and absorption
100922938 (PLCB3)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
100922938 (PLCB3)
09156 Nervous system
04724 Glutamatergic synapse
100922938 (PLCB3)
04725 Cholinergic synapse
100922938 (PLCB3)
04728 Dopaminergic synapse
100922938 (PLCB3)
04726 Serotonergic synapse
100922938 (PLCB3)
04720 Long-term potentiation
100922938 (PLCB3)
04730 Long-term depression
100922938 (PLCB3)
04723 Retrograde endocannabinoid signaling
100922938 (PLCB3)
09157 Sensory system
04742 Taste transduction
100922938 (PLCB3)
04750 Inflammatory mediator regulation of TRP channels
100922938 (PLCB3)
09159 Environmental adaptation
04713 Circadian entrainment
100922938 (PLCB3)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100922938 (PLCB3)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
100922938 (PLCB3)
09174 Infectious disease: parasitic
05146 Amoebiasis
100922938 (PLCB3)
05142 Chagas disease
100922938 (PLCB3)
05143 African trypanosomiasis
100922938 (PLCB3)
09164 Neurodegenerative disease
05010 Alzheimer disease
100922938 (PLCB3)
05016 Huntington disease
100922938 (PLCB3)
05017 Spinocerebellar ataxia
100922938 (PLCB3)
05022 Pathways of neurodegeneration - multiple diseases
100922938 (PLCB3)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
100922938 (PLCB3)
05415 Diabetic cardiomyopathy
100922938 (PLCB3)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
100922938 (PLCB3)
04934 Cushing syndrome
100922938 (PLCB3)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:shr04131]
100922938 (PLCB3)
Enzymes [BR:shr01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
100922938 (PLCB3)
Membrane trafficking [BR:shr04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
100922938 (PLCB3)
Endocytosis
Macropinocytosis
Phospholipase C
100922938 (PLCB3)
|
SSDB |
|
Motif |
|
Other DBs |
|
LinkDB |
|
Position |
6:complement(242802795..242818733)
|
AA seq |
1214 aa
MAGARPGVHALQLEPPAVAEILRRGSKFIKWDEEASSRNLVTLRVDSHGFFLYWTGPNME
VDTLDISSIRDTRTGRYARLPKDPKIREILGFGGPETKPEDKLVTIVAGPDPVNTTFLNF
MAVQEDTAKVWADELFKLAMNILAQNASRNTFLKKAYTKLKLQVNQDGRIPVKNILKMFS
ADKKRVETALESCGLNFNRSQSIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY
LTLEQLLDFVNQKQRDPRLNEVLYPPLRPAQARLLIEKYEPNQQFLERDQMSMEGFSRYL
GGEENSILPPETLDLSNDMTQPLSSYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC
VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPFPVILSFENHVDSAK
QQAKMAEYCRTIFGDALLIDPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHHPPLNLGEG
SVRKRPLEQSNSALSESSVVTEPSSPQLGSPSSEACSTLSNEEDLLGANPEPRKSIDREA
ESEEEEEEEPPDPKKTSTDEGTASSEVNATEEMSTLVNYVEPVKFKSFEVARKRNKSYEM
SSFVETKALEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNAGCQLVALNFQ
TLDLPMQLNAGVFEYNGRSGYLLKPEFMRRQDKSFDPFTEGIVDGIVANALRVKVISGQF
LSDRKVSIYVEVDLFGLPADTRRKYRTRPSQGNSFNPVWDEEPFDFPKVVLPTLASLRVA
AFEEGGKFVGHRILPVSAIRSGYHYICLRNEANQPLCLPALLIYTEASDYIPDDHQDYAE
ALSNPIKHVSLMDQRSKQLAALMGESEAAPETSEDLPSQRPDRPPPKRSIHGCPEFVPSQ
PPGSGTSPTSPVINRPGQCDELVASILGEVSVVPLEELRAHKSLGKLRSRQERDLRELQK
KHQRKAVAFTRRLLGALAQHRGEMEKRRKSGGPEEEEEEEMRKYRELQKQQFQCLLDFRE
AQADAEAERRQEHLRQVQQRLRELVLETHASQLKKLKETSDKEKKELQKILDRKRHNSIS
EAKTREKHKKEAELNEINRRHITESVNSIRRLEDAQKQRQERVLSEQQQVQEQLDKEEPK
ATAQLAQECQAQRAQLAQEIRRSLPGELLPDDDDEPLGTGNGHPLGRASNGHPLGSASNG
HAPGSERQEENTQF |
NT seq |
3645 nt +upstreamnt +downstreamnt
atggccggcgcccggcccggggtgcacgcgctgcaactggagcctccggcggtggccgag
atcttaagacggggcagcaagttcatcaagtgggatgaggaggcttccagtcggaacctg
gtcacgctccgggtggattcccatggcttcttcctctactggactggacccaacatggaa
gtggacacgctggacatcagctcgatccgggacacgcgcacgggccgctacgcccggctg
cccaaggaccccaagatcagggaaatcctgggtttcggaggtccggagacgaagccggag
gacaagctggtgaccatcgtggctggccccgaccccgtgaacactactttcctcaacttc
atggctgtgcaggaagacactgccaaggtctgggccgatgagctcttcaagttggccatg
aacatcctggcccagaacgcgtcccgaaacaccttcctcaaaaaagcgtacaccaagtta
aagcttcaggtgaaccaagatgggcgaatcccggtcaaaaacatccttaagatgttctct
gctgacaagaagcgtgtggagacggcgctggagtcttgtggcctcaattttaaccggagc
cagtcgatccggccagacgagttttccctggagatctttgagagattcctcaataaactg
tgtctccggcccgacatagacaagatcctgctggagattggtgctaaggggaagccgtac
ctgaccttggagcagctcctggactttgtcaaccagaagcagcgggacccgaggctgaat
gaggtcctgtaccccccgcttcggccggcccaggcccgcctgctcatcgagaaatacgag
cccaaccagcagttcctggagcgagaccagatgtccatggaaggcttcagccgctacctg
ggcggggaggagaacagcatcctgcccccggagactctggacctgagcaacgacatgacg
cagcccctcagctcctacttcatcaattcctcacacaacacctacctcacagcggggcag
ctggcgggaacctcctcggtggagatgtaccggcaggcgctgctctggggctgccgctgc
gtggagctggatgtgtggaagggccgaccgccggaggaggagcccttcatcacgcacggc
ttcaccatgaccaccgaggtgccgctgcgcgacgtgctggaggccatcgccgagacggcc
ttcaagacctcacccttccccgtcatcctctcctttgagaatcacgtggactcggcgaag
cagcaggccaagatggccgagtactgccgcaccatcttcggggacgccctgctcatagac
ccgctggacaagtacccgctggcgccgggggtccccctgcccagcccgcaggacctgatg
ggccggatcctggtgaaaaacaaaaagcggcaccatccacccctgaacctcggcgagggc
tcggtgcgcaagcggcccctggagcagagtaactcggccctgagtgagagctccgtggtc
acggagccctcctccccgcagctcggctcccccagctcggaggcctgctccactctgagc
aatgaggaggatctcctgggcgccaatcctgagccccgaaaatccattgaccgagaggcc
gaaagcgaggaggaggaggaggaggagccgcccgaccccaagaagacctccacagatgag
ggcacggccagcagcgaggtgaacgccaccgaggagatgtccacgctggtcaactacgtc
gagcctgtcaagttcaagtcctttgaggtggcccggaagcggaacaagagctacgagatg
tcgtccttcgtggagaccaaggccctggagcagctcaccaagagccccatggagtttgtg
gagtacaacaagcagcagctgagccgcatctaccccaagggcacacgagtggactcctcc
aactacatgccgcagctcttctggaacgcgggctgccagctcgtggccctcaacttccag
acgctcgacctccccatgcagctgaacgccggcgtgttcgagtacaacgggcgcagcggg
tacctgctcaagcccgagttcatgcggcgccaggacaagtccttcgaccccttcaccgag
ggcatcgtggacggcatcgtggccaacgctctgcgggtcaaggtgatctcgggccagttc
ttgtcggacaggaaggtcagcatctacgtggaggtggatctcttcggcctccccgcggac
acgcggcgcaaatatcgcacgcggccctcccaggggaactccttcaacccggtctgggac
gaggagccctttgacttccccaaggtggtgctgcccacgctggcctctctccgggtggcc
gcctttgaggaagggggcaagtttgtggggcaccggatcctgcccgtctctgccatccgc
tcagggtaccattacatctgcctgaggaatgaagccaaccagccgctgtgtctgccggct
ctgctcatctacacggaggcttccgactacatccctgatgatcaccaggactacgccgag
gctttgtccaaccccatcaagcacgtcagcctcatggaccagaggtcaaagcagctggcg
gcgctgatgggggagagcgaggccgctcccgagacctcagaggacctgccttctcaaagg
ccggaccgcccaccgcccaaacggtccatccacggctgccccgagtttgtgccctcccag
ccccccggctctgggacctcccccaccagccccgtcataaacagaccaggtcagtgtgac
gagctcgtcgccagcatcctgggagaggtgtccgtggtccccctggaggagcttcgggcc
cacaagtccctggggaagcttcgcagccgccaggagcgggacctgcgggagctgcagaag
aagcatcagcgaaaggcggtggcgttcacgcggcggctcctcggcgccctggcccagcac
cggggggagatggaaaagaggcgcaagagcgggggcccggaggaggaggaggaagaagag
atgcggaagtaccgggagctgcagaagcagcagttccagtgtctgctggacttcagggag
gctcaggcggatgcagaagcggagcggcgccaggaacacctgagacaggtccagcagcgg
cttcgggagcttgtcctggagacgcacgcgagccagctgaaaaagctcaaggagaccagt
gacaaggagaagaaggagctgcagaagatcctggaccgcaagaggcacaacagcatttcc
gaggcgaagacccgcgagaaacacaagaaagaggcggagctgaacgagatcaaccggagg
cacatcacggaatccgtcaactccatccgaaggctggaagacgcgcagaagcagcggcag
gagcgggtgctgagcgagcagcagcaggtccaggagcagctggacaaggaggagcccaag
gccacggcccagctggcccaggagtgccaggcgcagcgcgcgcagctggcccaggagatc
cggcggagcctgccgggggagctgctcccggacgacgacgacgagcccctgggcaccggc
aacgggcacccgctgggcagagccagcaacgggcacccgctgggcagcgccagcaacggg
cacgccccggggagcgagaggcaggaggagaacacccagttctga |