KEGG   Sarcophilus harrisii (Tasmanian devil): 100928932
Entry
100928932         CDS       T02286                                 
Symbol
IKBKB
Name
(RefSeq) inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1
  KO
K07209  inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
Organism
shr  Sarcophilus harrisii (Tasmanian devil)
Pathway
shr01523  Antifolate resistance
shr04010  MAPK signaling pathway
shr04014  Ras signaling pathway
shr04062  Chemokine signaling pathway
shr04064  NF-kappa B signaling pathway
shr04068  FoxO signaling pathway
shr04150  mTOR signaling pathway
shr04151  PI3K-Akt signaling pathway
shr04210  Apoptosis
shr04380  Osteoclast differentiation
shr04620  Toll-like receptor signaling pathway
shr04621  NOD-like receptor signaling pathway
shr04622  RIG-I-like receptor signaling pathway
shr04623  Cytosolic DNA-sensing pathway
shr04625  C-type lectin receptor signaling pathway
shr04657  IL-17 signaling pathway
shr04658  Th1 and Th2 cell differentiation
shr04659  Th17 cell differentiation
shr04660  T cell receptor signaling pathway
shr04662  B cell receptor signaling pathway
shr04668  TNF signaling pathway
shr04722  Neurotrophin signaling pathway
shr04910  Insulin signaling pathway
shr04920  Adipocytokine signaling pathway
shr04930  Type II diabetes mellitus
shr04931  Insulin resistance
shr04932  Non-alcoholic fatty liver disease
shr04936  Alcoholic liver disease
shr05010  Alzheimer disease
shr05132  Salmonella infection
shr05135  Yersinia infection
shr05142  Chagas disease
shr05145  Toxoplasmosis
shr05160  Hepatitis C
shr05161  Hepatitis B
shr05162  Measles
shr05163  Human cytomegalovirus infection
shr05164  Influenza A
shr05165  Human papillomavirus infection
shr05166  Human T-cell leukemia virus 1 infection
shr05167  Kaposi sarcoma-associated herpesvirus infection
shr05168  Herpes simplex virus 1 infection
shr05169  Epstein-Barr virus infection
shr05170  Human immunodeficiency virus 1 infection
shr05171  Coronavirus disease - COVID-19
shr05200  Pathways in cancer
shr05206  MicroRNAs in cancer
shr05208  Chemical carcinogenesis - reactive oxygen species
shr05212  Pancreatic cancer
shr05215  Prostate cancer
shr05220  Chronic myeloid leukemia
shr05221  Acute myeloid leukemia
shr05222  Small cell lung cancer
shr05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
shr05417  Lipid and atherosclerosis
shr05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:shr00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100928932 (IKBKB)
   04014 Ras signaling pathway
    100928932 (IKBKB)
   04064 NF-kappa B signaling pathway
    100928932 (IKBKB)
   04668 TNF signaling pathway
    100928932 (IKBKB)
   04068 FoxO signaling pathway
    100928932 (IKBKB)
   04151 PI3K-Akt signaling pathway
    100928932 (IKBKB)
   04150 mTOR signaling pathway
    100928932 (IKBKB)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    100928932 (IKBKB)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    100928932 (IKBKB)
   04621 NOD-like receptor signaling pathway
    100928932 (IKBKB)
   04622 RIG-I-like receptor signaling pathway
    100928932 (IKBKB)
   04623 Cytosolic DNA-sensing pathway
    100928932 (IKBKB)
   04625 C-type lectin receptor signaling pathway
    100928932 (IKBKB)
   04660 T cell receptor signaling pathway
    100928932 (IKBKB)
   04658 Th1 and Th2 cell differentiation
    100928932 (IKBKB)
   04659 Th17 cell differentiation
    100928932 (IKBKB)
   04657 IL-17 signaling pathway
    100928932 (IKBKB)
   04662 B cell receptor signaling pathway
    100928932 (IKBKB)
   04062 Chemokine signaling pathway
    100928932 (IKBKB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100928932 (IKBKB)
   04920 Adipocytokine signaling pathway
    100928932 (IKBKB)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    100928932 (IKBKB)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    100928932 (IKBKB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100928932 (IKBKB)
   05206 MicroRNAs in cancer
    100928932 (IKBKB)
   05208 Chemical carcinogenesis - reactive oxygen species
    100928932 (IKBKB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100928932 (IKBKB)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    100928932 (IKBKB)
   05221 Acute myeloid leukemia
    100928932 (IKBKB)
   05220 Chronic myeloid leukemia
    100928932 (IKBKB)
   05215 Prostate cancer
    100928932 (IKBKB)
   05222 Small cell lung cancer
    100928932 (IKBKB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100928932 (IKBKB)
   05170 Human immunodeficiency virus 1 infection
    100928932 (IKBKB)
   05161 Hepatitis B
    100928932 (IKBKB)
   05160 Hepatitis C
    100928932 (IKBKB)
   05171 Coronavirus disease - COVID-19
    100928932 (IKBKB)
   05164 Influenza A
    100928932 (IKBKB)
   05162 Measles
    100928932 (IKBKB)
   05168 Herpes simplex virus 1 infection
    100928932 (IKBKB)
   05163 Human cytomegalovirus infection
    100928932 (IKBKB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100928932 (IKBKB)
   05169 Epstein-Barr virus infection
    100928932 (IKBKB)
   05165 Human papillomavirus infection
    100928932 (IKBKB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100928932 (IKBKB)
   05135 Yersinia infection
    100928932 (IKBKB)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    100928932 (IKBKB)
   05142 Chagas disease
    100928932 (IKBKB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100928932 (IKBKB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100928932 (IKBKB)
   05418 Fluid shear stress and atherosclerosis
    100928932 (IKBKB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100928932 (IKBKB)
   04936 Alcoholic liver disease
    100928932 (IKBKB)
   04932 Non-alcoholic fatty liver disease
    100928932 (IKBKB)
   04931 Insulin resistance
    100928932 (IKBKB)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    100928932 (IKBKB)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:shr01001]
    100928932 (IKBKB)
Enzymes [BR:shr01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     100928932 (IKBKB)
Protein kinases [BR:shr01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   100928932 (IKBKB)
SSDB
Motif
Pfam: IKBKB_SDD Pkinase PK_Tyr_Ser-Thr IKKbetaNEMObind Pkinase_fungal Kdo ubiquitin YrbL-PhoP_reg APH Glyco_hydro_65m
Other DBs
NCBI-GeneID: 100928932
NCBI-ProteinID: XP_003758080
Ensembl: ENSSHAG00000017794
UniProt: G3WZY2
LinkDB
Position
2:129206148..129277400
AA seq 757 aa
MSWPPSLQIQTCGSWEMKERLGTGGFGNVIRWHNEETGEQIAIKQCRQELSLRNRERWCL
EIQIMRRLNHPNVVAARDVPEGMQKLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREE
AVLTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEKRLIHKIIDLGYAKELDQGSLCT
SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
LDIVVSEDLTGGVKFSSSLPYPNNLNSILIQRLEKWLQLMLMWQPRQRGMDPTYGPNGCF
KALDDILNLKLVHILNMVTGTVYTYPIMEKESLQSLKARIEADTGIPEEDQELLQEAGLA
LFSDKPAMQCIVDGKLNDDRILDMDLIFLFDNRKITYETQISPRPPPESVSCILQEPKRN
LPFFQLRKVWGQVWHTIRTLKEDCSQLQQGQRAAMMNLLRNNSSLSKMKNLMASMSQQLK
AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRETDVKLLVEQMMAL
QTDIVDLQRSPMSRKQGGTLDDLEEQARELYRRLREKPRDQRTDGDSQEMVRLLLQAIQS
FEKKVRAIYMQLSKTMVCKQKALELLPQVEEVVNLMNEDEKTVVQLQEKRQKELWNLLKI
ACSKVRGPVSGSPDSMNASRLSNPSQLLSQPPAAPYSLPESIKKSEELVMETQTLCTQLQ
NAMEDTMKKQDQSFMTLDWTWLHSEDGEQNGVEQSQI
NT seq 2274 nt   +upstreamnt  +downstreamnt
atgagctggccaccttctcttcaaatacagacttgtgggtcctgggaaatgaaagaacgg
cttggaactgggggatttggaaatgtcataaggtggcacaatgaggaaacgggagaacag
attgccataaaacaatgtcggcaggaattaagtcttcggaatcgcgagaggtggtgcctg
gaaatacagatcatgagaagactcaatcatcccaatgtagtggctgcccgggatgtccct
gaagggatgcagaaattagcacccaatgatcttcccctgctggctatggaatattgccag
ggtggagacctccgaaagtacctgaaccagtttgagaactgctgtggtcttcgggaagaa
gccgtcctcactctgctttctgacattgcctcagcacttagatatcttcatgaaaaccga
atcatccatcgggacctgaagcctgaaaacatagttctgcaacaaggagaaaaaaggtta
atacacaagatcattgacctaggatacgctaaagagctggaccaaggcagtctttgcact
tcctttgtggggacactgcagtacctggctccagagctgctggaacaacagaagtacacg
gtcaccgtggactactggagttttgggaccctggcctttgagtgtatcacagggtttagg
ccattcctccctaactggcagccagtgcaatggcattcaaaagtccgacagaagagtgaa
ctagatattgttgttagtgaagacttgactggaggagtaaaattctcaagcagtttaccc
taccctaataaccttaacagtattctgattcagagactagaaaagtggctgcagttgatg
ttaatgtggcaacctcgacagaggggcatggaccctacttatggcccaaatggctgcttc
aaagcactggacgacatcttgaacctgaagttggttcacatcttgaatatggtaactggc
actgtgtatacctatcccataatggagaaggaaagcttgcagagcttgaaggccaggata
gaggctgacacgggcatcccagaggaggaccaggagctattgcaggaagctggcctggcc
ctgttctctgacaaaccagccatgcagtgtattgtggatggcaagctaaatgatgaccga
atattggacatggatctcatttttctctttgacaacagaaaaatcacctatgagactcag
atctccccgaggcccccaccagaaagcgtcagctgtatccttcaagagcccaagcggaat
ctcccttttttccagctgaggaaagtatggggtcaggtatggcacaccatccggaccctg
aaggaagactgcagccagctgcagcaaggccagagagctgccatgatgaacctcctccga
aataacagcagcctttccaagatgaaaaacttaatggcgtccatgtctcagcagctcaag
gctaagctggatttctttaaaaccagcatccagattgacctggagaagtacagcgagcag
accgagtttgggatcacgtcagacaaattgctgctggcctggcgggagatggagcaggct
gtggagctctgcggacgggaaacagatgtgaaacttctggtggaacagatgatggcattg
cagacagatattgtggacctacagaggagcccaatgagccggaaacaagggggaaccttg
gatgatcttgaagaacaagcaagagaactttatcggcgattaagggaaaaaccaagagat
caacgaactgatggagacagtcaagaaatggtacggctactccttcaggccatccagagc
tttgagaagaaagtacgagccatatatatgcaactcagcaaaactatggtttgtaagcag
aaggccctggaattgttacctcaagtggaagaagtggtgaacttaatgaacgaagatgaa
aagacagttgtgcagcttcaggagaagagacagaaggaactgtggaacctcttgaagata
gcttgtagcaaagttcgaggtccagtgagtgggagtccagatagcatgaatgcatcgcgt
cttagtaatccttctcagttgttgtctcaacctcctgcagctccctacagcttacctgag
tcaatcaagaaaagtgaagaattggtaatggaaacacagaccctctgtacccagttacaa
aatgcaatggaggataccatgaaaaagcaggatcagagttttatgaccctggattggacc
tggttacattctgaagatggggagcagaatggtgtggagcagtcacagatctga

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