| Entry |
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| Symbol |
LRP6
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| Name |
(RefSeq) low-density lipoprotein receptor-related protein 6
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| KO |
| K03068 | low density lipoprotein receptor-related protein 5/6 |
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| Organism |
shr Sarcophilus harrisii (Tasmanian devil)
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| Pathway |
| shr04928 | Parathyroid hormone synthesis, secretion and action |
| shr05022 | Pathways of neurodegeneration - multiple diseases |
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| Brite |
KEGG Orthology (KO) [BR:shr00001]
09130 Environmental Information Processing
09132 Signal transduction
04310 Wnt signaling pathway
100930633 (LRP6)
04150 mTOR signaling pathway
100930633 (LRP6)
09150 Organismal Systems
09152 Endocrine system
04928 Parathyroid hormone synthesis, secretion and action
100930633 (LRP6)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100930633 (LRP6)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
100930633 (LRP6)
05226 Gastric cancer
100930633 (LRP6)
05224 Breast cancer
100930633 (LRP6)
09164 Neurodegenerative disease
05010 Alzheimer disease
100930633 (LRP6)
05022 Pathways of neurodegeneration - multiple diseases
100930633 (LRP6)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:shr04131]
100930633 (LRP6)
Membrane trafficking [BR:shr04131]
Endocytosis
Clathrin-mediated endocytosis
Low-density lipoprotein receptor (LDLR) family proteins
100930633 (LRP6)
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| Position |
5:complement(103213265..103342636)
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| AA seq |
1613 aa
MGAVLRSLLACSFCVLLRGAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVF
DHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIE
VSNLDGTLRKVLFWQELDQPRAIALDPANGFMYWTDWGEVPKIERAGMDGSNRFIIINTD
IYWPNGLTLDYEEEKLYWADAKLNFIHKSNLDGTNRQAVVRGSLPHPFALTLFEDTLYWT
DWNTHSILACNKYTGEGLREVHSDIFSPMDIHAFNQQRQPNATNPCGIDNGGCSHLCLMS
PIKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPLEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWT
DTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSD
RVVLVNTSLGWPNGLALDYDEEKIYWGDAKTDKIEVMNADGTGRRVLVEDKIPHIFGFTL
LGDYVYWTDWQRRSIERVHKRSAEREIIIDQLPDLMGLKATNVHRIIGSNPCANENGGCS
HLCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTG
VKEASALDFDVTDNRIYWTDISLKTISRAFMNGSSLEHVVEFGLDYPEGMAVDWLGKNLY
WADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDG
SERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQ
YQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQAGWNECASSNGHC
SHLCLAVPVGGFVCGCPAHYSLNTDNRTCSAPTTFLLFSQKNAINRMVIDEQQSPDIILP
IHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGLTVVVSSVPNQNVDMQPYDLS
IDIYSRYIYWTCEATNVINVTRLDGRPVGVVLKGEQDRPRAIMVNPEKGYMYFTNLQERS
PKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLE
DSNILQPVGLTVFENWLYWIDRQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLL
EYRQHPCSQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGE
IDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGVLRCNGDANCQDKSDEK
NCEVLCLIDQFRCTNGQCIGKHKKCDNNVDCSDKSDELDCYPTEEPTPQATNTVGSVIGV
ILTIFLFGAMYFICQRVFCPRMKGDGETMTNDYVVHGPASVPLGYVPHPSSLSGSLPGMS
RGKSMISSLSIMGGSSGPPYDRAHVTGASSSSSSSTKGTYFPGILNPPPSPATERSHYTM
EFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTDVCDSDYAPSRRITTVAAAKGYTSDL
NYDSEPVPPPPTPRSQYLSAEENYESCPPSPYTERSYSHHLYPPPPSPCTDSS |
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| NT seq |
4842 nt +upstreamnt +downstreamnt
atgggggccgtcctgaggagcctcttggcctgcagcttttgcgtcctcctgagaggggct
cccttgttgctttatgcaaatagacgggatttacgactggtggatgctaccaatggtaaa
gagaatgctacaattgtggttggaggtttggaggatgcagctgcagtggacttcgttttt
gaccatggcttgatatactggagtgatgtaagtgaagaagccattaaacgaacagaattt
aacaaaaccgagagtgtacaaaatgtggttgtttccggattattatcccccgatgggctg
gcctgtgattggttgggagaaaaattatactggacagattctgaaactaatcggattgaa
gtttccaatttagatggaactttaagaaaagttttgttttggcaagagttggatcagcca
agagctattgcattagatcctgcaaatgggttcatgtattggactgactggggagaagtt
ccaaagatagaacgtgctggaatggatggatcaaatcgtttcattataataaacacagat
atttactggccaaatggattaaccttggattatgaggaagaaaaactttattgggcagat
gcaaaacttaattttatccacaaatcaaatctggatggaactaatcgacaggcagtggtt
agaggttctcttccacatccctttgccttgacgttgtttgaagatacactgtactggact
gactggaacacacattccatcttggcctgcaataagtacactggggaggggttgcgtgaa
gtccattctgatatcttctctcccatggatatacatgcctttaaccagcagaggcagcca
aatgctacaaacccatgtggaattgataatggtggttgctcccacttgtgtctgatgtct
ccaatcaagcctttttatcaatgtgcctgcccaactggagtgaaactccttgagaatggg
aaaacctgcaaagatggagcaactgaattattgcttttagcccgaaggacagacttgagg
cgaatttccttagatacgccagactttacagatattgttttacagctagaagacatccgc
catgcaattgccatagactatgatcctttggaaggatatatctactggactgatgatgaa
gtgagggctatacgtcgctctttcatagatggatctggcagtcagtttgtggtgacagct
caaattgcacatcctgatgggattgcagtggattgggttgcaaggaatctttattggact
gacacaggcactgaccgcatagaggtgacgaggctcaatggaaccatgagaaagattttg
atttcagaggatttggaggaaccccgagctatagtactagatccaatggttgggtatatg
tattggactgattggggagaaatccctaaaatagagcgtgcagctttggatgggtctgac
cgagtagttttggtgaatacatctcttggttggccaaatggtttagctctggattatgat
gaagaaaaaatatactggggagatgccaaaacagacaagattgaggttatgaatgcagat
ggtactggaagaagagtattggtagaagacaagattcctcacatttttggatttaccttg
cttggagactatgtctattggactgactggcaaagacgtagcattgaacgggtgcataaa
cgaagtgctgaaagggaaatcatcatagatcagttacctgatcttatgggcctaaaagcc
acaaatgttcatcgaatcattggttccaacccatgtgctaatgaaaatgggggatgtagt
catctttgcctctatagacctcaaggactccgctgtgcctgccccattggctttgagctt
atcagtgacatgaagacttgcattgttccagaagctttcctcttgttttctcggagagcg
gacataaggcgcatttctttggaaacaaacaacaacaatgtggcaatcccacttactggt
gtgaaagaagcttctgctttagatttcgatgtaacagacaatcgtatttactggactgat
atttctctgaagactatcagcagagcatttatgaatggtagttcactggagcatgtggtg
gaatttggcttggattatccagaaggcatggctgtagactggctaggaaagaatttatac
tgggcagacactggaacaaatcgtattgaagtatcaaagttggatgggcagcatcgacaa
gttctggtatggaaggacctggatagccccagagctcttgcattagaccctgctgaaggg
tttatgtattggaccgaatggggtgggaaacccaagatagatagagctgcaatggatgga
agtgaacgtactacattagttccaaatgtaggacgggcaaatggattaactattgattat
gctaaaagaagactctattggacagacttggataccaacttaattgaatcttcaaatatg
ctaggtctgaaccgtgaagttatagcagatgacttgcctcatccttttggcttgactcag
tatcaagattacatttactggacagattggagccgacgtagcattgaacgtgccaacaaa
accagtggtcaaaaccgaaccatcatacagggtcatttggattatgtgatggacatccta
gtctttcactcctctcggcaggcaggatggaatgaatgtgcttctagcaatgggcactgt
tcccatctctgtttggctgtgccagttggtggttttgtttgtggatgtccagcccactac
tcattgaatactgacaacaggacttgtagtgctcctaccactttcctgctcttcagtcag
aagaatgccatcaaccgcatggtaatagatgaacaacagagtcctgatattatcctccct
atacacagcctacggaatgttcgagccattgactatgaccctttggacaaacaactttat
tggatcgactcacgtcaaaatatgattcgaaaggcacaagaagatggtagccagggtctt
actgtggttgtgagctcagttccaaatcagaatgtggacatgcagccctatgacctcagc
attgacatttatagccgttacatctattggacttgtgaggccactaatgttattaatgta
acaaggctggatgggagacctgttggagtggttctcaaaggagagcaagaccgacctcga
gccatcatggtaaacccagagaaagggtatatgtactttaccaatcttcaagaaagatct
cccaaaattgagagggctgctttggatggaacagaaagagaggtcctctttttcagtggc
ttaagtaaacctatagctttagctcttgacagccgcttgggcaaactgttttgggctgat
tcagacctccggcgaattgaaagtagtgatctctcaggtgccaatcgtatagttttagaa
gattccaatatcttgcagcctgtgggactgactgtttttgaaaattggctgtattggatt
gataggcagcagcaaatgattgaaaaaattgacatgactggtcgtgaggggaggaccaaa
gtccaggctcgaattgcccaactcagtgacattcatgctgtaaaggaactaaatcttctg
gaatatagacagcatccatgttctcaggataatggaggttgttcacatatttgtcttgtg
aaaggagatgggacaacaaggtgttcttgtccaatgcatctggtactacttcaggatgaa
ctgtcttgtggagagcctccaacgtgctcccctcagcagttcacatgtttcacgggagag
attgactgcatccctgtggcttggcgatgtgatggattcactgaatgtgaagaccacagt
gatgagttaaattgtcctgtctgctcagaatcccagtttcagtgtgctagtgggcagtgc
attgatggcgtccttcgatgcaatggagatgccaattgccaagacaagtcagatgagaag
aactgtgaagtgctttgtttaattgatcagttccgttgtaccaatggacaatgcattgga
aagcacaagaaatgtgataataatgtggactgcagtgacaagtcagatgagctagattgt
tatccaactgaggagccaaccccacaggccaccaatacagttggctcagtgattggagtg
atcctcactatttttttgtttggagccatgtacttcatctgtcagagggtgttctgtcca
cgaatgaagggagatggagagacaatgacaaacgactatgtagttcatggaccagcatct
gtgccccttggttatgtgcctcaccctagttctctttcaggttctctgccaggaatgtct
cgtggcaaatcaatgattagttccctcagtatcatgggtggaagcagtggaccaccttat
gacagagctcatgtcactggagcatcatctagtagttcttcaagtacaaaaggcacctat
ttccccgggattttgaaccctcctccatccccagctacagagcgttcacattatactatg
gaatttggttattcttcaaacagcccttctactcatagatcctacagctacagaccctac
agttaccgccactttgcgccacccaccactccatgcagcactgatgtctgtgacagcgac
tacgccccgagccggaggatcaccacagtggcagcagccaagggctacaccagtgactta
aactatgactctgagcctgtgcccccacctcccactccgcgaagccagtatctgtcagcc
gaagaaaactatgaaagctgccccccttccccctacacagagaggagctactctcaccac
ctctatccacctccaccatccccctgtacagactcctcctga |
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