KEGG   Sarcophilus harrisii (Tasmanian devil): 100934049
Entry
100934049         CDS       T02286                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
shr  Sarcophilus harrisii (Tasmanian devil)
Pathway
shr00562  Inositol phosphate metabolism
shr01100  Metabolic pathways
shr04015  Rap1 signaling pathway
shr04020  Calcium signaling pathway
shr04022  cGMP-PKG signaling pathway
shr04062  Chemokine signaling pathway
shr04070  Phosphatidylinositol signaling system
shr04071  Sphingolipid signaling pathway
shr04072  Phospholipase D signaling pathway
shr04081  Hormone signaling
shr04082  Neuroactive ligand signaling
shr04261  Adrenergic signaling in cardiomyocytes
shr04270  Vascular smooth muscle contraction
shr04310  Wnt signaling pathway
shr04371  Apelin signaling pathway
shr04540  Gap junction
shr04611  Platelet activation
shr04613  Neutrophil extracellular trap formation
shr04621  NOD-like receptor signaling pathway
shr04713  Circadian entrainment
shr04720  Long-term potentiation
shr04723  Retrograde endocannabinoid signaling
shr04724  Glutamatergic synapse
shr04725  Cholinergic synapse
shr04726  Serotonergic synapse
shr04728  Dopaminergic synapse
shr04730  Long-term depression
shr04742  Taste transduction
shr04750  Inflammatory mediator regulation of TRP channels
shr04911  Insulin secretion
shr04912  GnRH signaling pathway
shr04915  Estrogen signaling pathway
shr04916  Melanogenesis
shr04918  Thyroid hormone synthesis
shr04919  Thyroid hormone signaling pathway
shr04921  Oxytocin signaling pathway
shr04922  Glucagon signaling pathway
shr04924  Renin secretion
shr04925  Aldosterone synthesis and secretion
shr04926  Relaxin signaling pathway
shr04927  Cortisol synthesis and secretion
shr04928  Parathyroid hormone synthesis, secretion and action
shr04929  GnRH secretion
shr04933  AGE-RAGE signaling pathway in diabetic complications
shr04934  Cushing syndrome
shr04935  Growth hormone synthesis, secretion and action
shr04961  Endocrine and other factor-regulated calcium reabsorption
shr04970  Salivary secretion
shr04971  Gastric acid secretion
shr04972  Pancreatic secretion
shr04973  Carbohydrate digestion and absorption
shr05010  Alzheimer disease
shr05016  Huntington disease
shr05017  Spinocerebellar ataxia
shr05022  Pathways of neurodegeneration - multiple diseases
shr05142  Chagas disease
shr05143  African trypanosomiasis
shr05146  Amoebiasis
shr05163  Human cytomegalovirus infection
shr05200  Pathways in cancer
shr05415  Diabetic cardiomyopathy
shr05417  Lipid and atherosclerosis
Module
shr_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:shr00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100934049 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    100934049 (PLCB4)
   04310 Wnt signaling pathway
    100934049 (PLCB4)
   04371 Apelin signaling pathway
    100934049 (PLCB4)
   04020 Calcium signaling pathway
    100934049 (PLCB4)
   04070 Phosphatidylinositol signaling system
    100934049 (PLCB4)
   04072 Phospholipase D signaling pathway
    100934049 (PLCB4)
   04071 Sphingolipid signaling pathway
    100934049 (PLCB4)
   04022 cGMP-PKG signaling pathway
    100934049 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    100934049 (PLCB4)
   04081 Hormone signaling
    100934049 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    100934049 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100934049 (PLCB4)
   04613 Neutrophil extracellular trap formation
    100934049 (PLCB4)
   04621 NOD-like receptor signaling pathway
    100934049 (PLCB4)
   04062 Chemokine signaling pathway
    100934049 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    100934049 (PLCB4)
   04922 Glucagon signaling pathway
    100934049 (PLCB4)
   04929 GnRH secretion
    100934049 (PLCB4)
   04912 GnRH signaling pathway
    100934049 (PLCB4)
   04915 Estrogen signaling pathway
    100934049 (PLCB4)
   04921 Oxytocin signaling pathway
    100934049 (PLCB4)
   04926 Relaxin signaling pathway
    100934049 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    100934049 (PLCB4)
   04918 Thyroid hormone synthesis
    100934049 (PLCB4)
   04919 Thyroid hormone signaling pathway
    100934049 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    100934049 (PLCB4)
   04916 Melanogenesis
    100934049 (PLCB4)
   04924 Renin secretion
    100934049 (PLCB4)
   04925 Aldosterone synthesis and secretion
    100934049 (PLCB4)
   04927 Cortisol synthesis and secretion
    100934049 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100934049 (PLCB4)
   04270 Vascular smooth muscle contraction
    100934049 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    100934049 (PLCB4)
   04971 Gastric acid secretion
    100934049 (PLCB4)
   04972 Pancreatic secretion
    100934049 (PLCB4)
   04973 Carbohydrate digestion and absorption
    100934049 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100934049 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    100934049 (PLCB4)
   04725 Cholinergic synapse
    100934049 (PLCB4)
   04728 Dopaminergic synapse
    100934049 (PLCB4)
   04726 Serotonergic synapse
    100934049 (PLCB4)
   04720 Long-term potentiation
    100934049 (PLCB4)
   04730 Long-term depression
    100934049 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    100934049 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    100934049 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    100934049 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    100934049 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100934049 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    100934049 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100934049 (PLCB4)
   05142 Chagas disease
    100934049 (PLCB4)
   05143 African trypanosomiasis
    100934049 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100934049 (PLCB4)
   05016 Huntington disease
    100934049 (PLCB4)
   05017 Spinocerebellar ataxia
    100934049 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    100934049 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100934049 (PLCB4)
   05415 Diabetic cardiomyopathy
    100934049 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    100934049 (PLCB4)
   04934 Cushing syndrome
    100934049 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:shr04131]
    100934049 (PLCB4)
Enzymes [BR:shr01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100934049 (PLCB4)
Membrane trafficking [BR:shr04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    100934049 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    100934049 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_6 EF-hand_7
Other DBs
NCBI-GeneID: 100934049
NCBI-ProteinID: XP_031806973
Ensembl: ENSSHAG00000012910
UniProt: A0A7N4P5V6
LinkDB
Position
2:complement(162758023..163185206)
AA seq 1205 aa
MAKPYEFNWQKPVSPFLQEGAIFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVL
ECSLINSIRFGSVPKDPKILAALEAFGKSESDLEGRIVCVCSGTDLVNISFTYMVAENPE
IAKQWVEGLRAIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFRKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDTKRAMQIIETYEPDDELKTKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQILLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESAAPVNILEDDNEEEIECVDQEEEAHPEFKFGSELSDDFSQKEAVANSVKKAAED
LEHENNKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFNVAEERNIH
YNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSL
NYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVIS
GQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAV
LRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTVFCNIVLKTYVPDGFG
DIVDALSDPKKFLSVMEKRADQMRAMGIETSDIADVPNDTSKNDKKGKANNAKANVTPQS
SSELRPATTSGLGAGVEGKKGIELIPQVRIEDLKQMKAYLKHLKKQQKEINSLKKKHAKE
HSTMQKLHCTQVDKIVAQFDKEKLSHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDH
KSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCDLLKKLLINAHEQQTQQLKLSH
DRECKEMRANQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQ
SKEMDQLKKVQLEHLEVLEKQNEQLLKSCHAVSQTQGKGDAADGEIGSRDGPKTSNSGVK
LHNPN
NT seq 3618 nt   +upstreamnt  +downstreamnt
atggccaaaccatatgaatttaactggcagaagccggtttccccatttttacaggaggga
gccatttttgacagatatgaagaggaatcctttgtatttgaacctaactgcctcttcaaa
gtggatgaatttggtttctttttgacctggaaaagtgaaggaaaggaaggacaggtatta
gagtgctccctcatcaacagcattcgttttggatctgtaccaaaggatcccaaaatccta
gcagctcttgaggcttttggaaaatcagagagtgatttggagggaaggatagtctgtgtc
tgcagtggcactgacctggtgaatatcagcttcacttatatggtggcagaaaatccagaa
attgccaagcaatgggtagaagggttaagagccatcatacataattttagagctaacaac
gttagtccaatgacatgcctgaagaaacactggatgaaattggcatttatgacaaacaca
aatggtaaaattccagttaggagtattactagaacgtttgcatcaggtaaaacagaaaag
gtgatttttcaagcccttaaggagttaggccttcccagcggaaagaatgatgaaattgag
cctgcagcatttacttatgaaaagttttatgaactaacacaaaaaatttgtcctcgaact
gacattgaggacctctttaggaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagaccctcgactgaatgaaattttattc
ccattctatgatacaaaaagggcaatgcagataattgagacttatgagcctgatgatgag
ttgaagacaaaaggactcatatccagtgatgggttttgcagatatctgatgtctgatgaa
aatgcgccagtcttccttgaccgcctggaactttaccaagaaatggatcatcctttggcc
cactactttatcagttcttcccataacacatatctcacaggacgtcaatttggcgggaaa
tcttcggtggaaatgtacagacaaatcctcttagctggatgcagatgtgttgagctagat
tgctgggatgggaaaggtgaagatcaagaaccaataataactcatggaaaagcaatgtgt
acagatattctttttaaggatgtgattcaagccatcaaggaaacagcttttgtcacatca
gaatatcctgtcattctgtcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaagtattgtgaagatctatttggagatctcctgttgaaacaagcacttgaatcacat
ccacttgaaccaggaagacctttaccgtcccctaatgaccttaaaagaaaaattctgata
aaaaacaaacgactgaaacctgaggtggaaaaaaaacagcttgaagcattaaaaagtatg
atggaagctggagaatcagcagccccagtaaatatcttagaagatgacaatgaagaagaa
atagaatgtgttgaccaagaggaggaagctcacccagaattcaaatttggaagtgaactc
tctgatgatttcagtcaaaaggaagctgttgcaaatagtgtaaagaaggctgcagaagac
cttgaacatgaaaacaataaaaagggattagttactgtggaagatgaacaggcatggatg
gcatcatacaaatatgtgggcgctacaaccaatattcacccatatttatccacaatgatc
aactatgcccagcctgtaaagtttcagggcttcaatgtagcagaagaacggaatattcat
tacaacatgtcttcttttaatgaatcagttggacttggttacttgaaaacgcatgcaatt
gaatttgtgaattataataaacgacaaatgagtcggatttaccccaagggaggtcgagtg
gattccagtaattacatgcctcagattttctggaatgctggctgccagatggtgtcactg
aactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgaatataatgga
tcatgtgggtatcttctcaaaccagatttcatgagacggccagatcgaacatttgatcct
ttctctgaaacacctgtagatggtgttattgcagctacttgttcagtgcaggttatatca
ggacagttcttatctgataagaaaattggtacgtatgtagaagtggatatgtacggtttg
cccacagacactatacggaaggagtttcgaacgcgtatggttatgaacaatggtctcaat
cctgtttacaatgaagaatcattcgtattccgaaaggttattctccctgatctggctgtc
ttgagaatagctgtgtatgatgacaacaacaagctgattggtcaaagaatcctccctctt
gatggcctccaggcaggctacagacacatttctcttcgaaatgaagggaataaaccatta
tcactgccaactgttttctgcaacattgtgcttaaaacatatgtgccggatggttttgga
gacattgtggacgctttgtcagacccaaaaaaatttctttctgtaatggaaaagagagca
gatcaaatgagagcaatgggtattgaaactagtgatatagctgatgtgccaaatgacact
tccaagaatgacaagaaaggaaaagccaataatgctaaagccaatgtgactcctcagagc
agctctgaactcagaccagctaccacctccggcttgggagcaggagtggaagggaaaaaa
ggtattgaacttattcctcaagtgaggatagaagacttaaaacaaatgaaggcttattta
aaacacttaaagaaacaacaaaaagagataaattctttaaagaagaaacatgcaaaggaa
cacagcaccatgcagaagttacactgtacacaagttgacaaaattgtggctcagtttgac
aaggagaaattatctcatgagaaaatcttagaaaaagcaatgaagaagaagggaggaagt
aattgtcttgaaatgaagaaagaaactgaaattaaaattcagacattaacatcagatcat
aaatctaaggtaaaagagattgtagcccagcatacgaaagaatggtcagaaatgatcaat
acccacagcgctgaggagcaagaaattcgggatttacacctcagccagcagtgtgatctc
ttgaaaaaactgttgatcaatgctcatgagcaacaaactcagcagctaaagctttcccat
gacagagaatgcaaggaaatgcgcgccaatcaggccaagatttccatggaaaacagcaaa
gccatcagccaagacaaatcaatcaaaaataaagcagaaagagagaggagagtcagggaa
ctaaacagcagtaacactaaaaagtttctggaagaaagaaagagacttgcaatgaaacag
tcaaaagaaatggatcagttgaaaaaagttcaacttgaacatctagaagtcctggaaaaa
caaaatgagcagcttttgaaatcctgtcatgcagtgtctcaaacacaaggcaaaggagat
gcagcagatggtgaaattggaagcagagatggaccgaagaccagcaacagtggtgtaaaa
ctccataatccaaactga

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