Sarcophilus harrisii (Tasmanian devil): 100934924
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Entry
100934924 CDS
T02286
Symbol
SRD5A2
Name
(RefSeq) 3-oxo-5-alpha-steroid 4-dehydrogenase 2
KO
K12344
3-oxo-5-alpha-steroid 4-dehydrogenase 2 [EC:
1.3.1.22
]
Organism
shr
Sarcophilus harrisii (Tasmanian devil)
Pathway
shr00140
Steroid hormone biosynthesis
shr01100
Metabolic pathways
shr05215
Prostate cancer
Module
shr_M00976
C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:
shr00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
100934924 (SRD5A2)
09160 Human Diseases
09162 Cancer: specific types
05215 Prostate cancer
100934924 (SRD5A2)
Enzymes [BR:
shr01000
]
1. Oxidoreductases
1.3 Acting on the CH-CH group of donors
1.3.1 With NAD+ or NADP+ as acceptor
1.3.1.22 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
100934924 (SRD5A2)
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Motif
Pfam:
Steroid_dh
DUF1295
PEMT
Motif
Other DBs
NCBI-GeneID:
100934924
NCBI-ProteinID:
XP_003757875
Ensembl:
ENSSHAG00000000495
UniProt:
A0A7N4NWS3
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Position
2:complement(197269023..197348252)
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AA seq
392 aa
AA seq
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MRKKPVESNFISKVMYAIVKCSPLKWCIMPYREILRVNISHPGLPTNSTGTYEETWQKYE
RLGVVAVAETDGLEPRGLQKLLGMDPLSSLASHSFCSAEPAAWRVEGADTGKCLCPHKGT
FGGCAPHTRSGGERRTVVILMTCQLSPVLAGSAVMIGFGLLSMLSSGPSNYGKQANSLLP
LATRLPARVAWFLQELPSFLVPAGLIAWQPQPHFGLPGTLLLGLFCGHYFHRTFIYSLLT
RGSPFPLKLLFPGLIFCTVNGFLQGHYLIYCAEYPDEWFTDVRFTSGIFLFFLGMTINIH
SDYLLRHLRKPGETSYKIPQGGLFTYISGANYFGEIVEWIGYAMATWSLPGLAFAFFSLC
FLGKRAREHHRFYLKKFQDYPKSRKAIIPFIF
NT seq
1179 nt
NT seq
+upstream
nt +downstream
nt
atgagaaagaagccagtggagagtaacttcattagcaaagtcatgtatgccatcgtgaag
tgcagcccactgaaatggtgcattatgccttatagggagatcctcagagttaacatttca
cacccagggctacctaccaactccacaggaacctatgaagagacttggcagaagtatgaa
aggctaggagtagtggcggtggccgaaactgatggattggagcctcggggcttacaaaaa
ttactaggaatggatccactttcttctctcgcctcccacagtttctgctcagctgagcca
gcagcctggagagtggaaggggcggacacggggaagtgtctctgtccccataaaggaacc
tttgggggctgcgctcctcacacccggagtggtggtgagaggcgcactgtcgtgatactc
atgacatgccaattgagcccggtgctggctggcagcgctgtgatgatcggcttcgggttg
cttagtatgctgtcttccggaccctcaaactatggcaaacaggccaacagccttttgccc
ttggccacccggttgccagcccgcgtagcctggttcctccaggaactcccctctttcttg
gtgcccgctgggctgattgcctggcagccccaaccacatttcggcttgccggggacctta
ctgcttggcctcttctgcggacactacttccacagaacattcatttacagccttctcacc
agaggaagtccttttccactcaaactactttttccaggccttattttctgtaccgtgaat
ggcttccttcaaggacactatttaatttactgtgctgaataccctgatgaatggttcact
gatgtccggtttacttcaggtatctttttatttttcttgggaatgacaatcaatattcac
agtgattatttactacgccacctcagaaagcctggagaaacctcctataagattccacaa
ggaggactgttcacttacatatctggagccaactactttggtgaaatagtggaatggatt
ggctatgccatggcaacctggtcattaccaggtttggcctttgcctttttctcactatgt
tttcttggaaaacgagctcgtgagcatcacaggttctatctcaagaagtttcaggactac
cctaagtctcggaaagccatcattcctttcatattttaa
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