Streptomyces inhibens: KI385_40080
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Entry
KI385_40080 CDS
T08140
Symbol
leuA
Name
(GenBank) 2-isopropylmalate synthase
KO
K01649
2-isopropylmalate synthase [EC:
2.3.3.13
]
Organism
sine
Streptomyces inhibens
Pathway
sine00290
Valine, leucine and isoleucine biosynthesis
sine00620
Pyruvate metabolism
sine01100
Metabolic pathways
sine01110
Biosynthesis of secondary metabolites
sine01210
2-Oxocarboxylic acid metabolism
sine01230
Biosynthesis of amino acids
Module
sine_M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:
sine00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00620 Pyruvate metabolism
KI385_40080 (leuA)
09105 Amino acid metabolism
00290 Valine, leucine and isoleucine biosynthesis
KI385_40080 (leuA)
Enzymes [BR:
sine01000
]
2. Transferases
2.3 Acyltransferases
2.3.3 Acyl groups converted into alkyl groups on transfer
2.3.3.13 2-isopropylmalate synthase
KI385_40080 (leuA)
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Gene cluster
GFIT
Motif
Pfam:
HMGL-like
IPMS_D2
LeuA_dimer
TPR_14
Motif
Other DBs
NCBI-ProteinID:
UKY54404
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Position
8911828..8913669
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AA seq
613 aa
AA seq
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MPSPEPTVSAAPRGATLAFPTLRTPAGPVPPDAPAWNPQRGSAMPSHRYRPAHDRVEVPR
IERAWPAARMTRAPLWVPVDLRDGNQALAEPMDTPRKRRMFDLLVAMGFKEIEVAYPSAS
RTDFDFVRHLAESGAVPDDVTVVVFTPARRELIERTFAAIEGLPRTVVHLYTPTAPTWRE
VVLGRSRAEVCDLVRDAATYMAQLADARPGADIRFQFSPEVFNLTEPDLVLEICDRLTAL
WDASPDRPVTHNLPATVEIATPNVYADQIEYMHRHLARRDAVILSVHPHNDRGTGVACAE
LAVLAGAQRVEGCLFGNGERTGNVDLVTLALNLHTQGVDPMIDFSAIDTVRRTVEDCIRL
PVHPRHPYAGELVHTAFSGTHQDAISKGLAHHARRAAGLGVPASDAPWTVPYLPVDPADL
GCTYEAVIRVNSQSGKGGIAHLLQLHHGLDLPRDLRPDFSRTVQLATDDSGQEATPKDLW
ELFRRTYLAPGEDGPLRLVSWHTTEPAPGEHRVSCELDGGEGEAGRGRFEGSGNGPLAAF
ADALAATGHPVDIVTYAEHALTSGPDSAAIAYVRCRIGGATYWGAGQDTSVLTASVRAVL
SAVNRASLDRDSG
NT seq
1842 nt
NT seq
+upstream
nt +downstream
nt
atgcccagccccgaacccaccgtctccgccgccccgcgcggcgccacgctcgccttcccc
accctccgtacgcccgccggaccggtaccgcccgacgcaccggcgtggaatccgcagcgc
ggcagcgcgatgccctcgcatcggtaccggcccgcgcacgaccgcgtcgaagtaccgcgt
atcgaacgcgcctggcccgccgcccggatgacgcgggccccgctgtgggtgccggtcgat
ctgcgcgacggcaaccaggcgctggccgagccgatggacaccccccgtaagcgccggatg
ttcgatctgctcgtcgcgatgggcttcaaggagatcgaggtcgcctacccctcggcgagc
cgcaccgacttcgacttcgtccgtcatctggccgagagcggcgccgtgccggacgatgtg
acggtcgtggtcttcaccccggcccgccgcgagctgatcgagcggaccttcgccgccatc
gaggggctgccgcgtactgtcgtgcacctctacacacccaccgcacccacctggcgcgag
gtggtcctcggccggagccgggcggaggtgtgcgacctggtccgcgacgccgcgacgtat
atggcccaactggccgacgcccggcccggggccgacatccggttccaattctcgcccgag
gtcttcaatctcaccgagcccgatctcgtcctggagatctgcgaccggttgacggccctg
tgggacgcgtcgccggaccgcccggtgacccacaatctgccggccaccgtcgagatcgcc
acgcccaatgtgtacgccgaccagatcgagtacatgcaccgtcacctggcgcgccgggat
gcggtcatcctctccgtgcatccgcacaacgaccgtggcaccggggtggcctgtgcggaa
ctcgccgtgctggccggggcgcagcgtgtggagggctgtctgttcggcaacggggagcgc
accggcaatgtcgacctggtcaccctcgccctcaatctgcacacccagggcgtcgacccg
atgatcgacttctccgccatcgacaccgtccgccgcacggtggaggactgcatccggctc
cctgtccacccccgccacccctacgccggtgagctggtgcacaccgccttctccggcacc
caccaggacgccatcagcaaggggctcgcccaccatgcccggcgcgccgccggcctgggc
gtcccggcgtccgacgcgccctggacggtgccgtatctgccggtcgaccccgccgatctc
ggctgcacctacgaggcggtcatccgcgtcaacagccagtcgggcaagggcggtatcgcg
catctcctgcaactgcaccacggcctggacctgccgcgggacctgcgccccgacttctcc
cgcacggtgcagctcgccacggacgacagcgggcaggaggccacaccgaaggatctgtgg
gagctgttccggcgtacgtatctcgcccccggcgaggacggtccgctgcggctcgtctcc
tggcacaccaccgagcccgcgccgggcgagcaccgggtcagctgcgagctggacggtggc
gagggtgaggcgggccggggacgcttcgaaggctccggcaacgggccgctcgccgcgttc
gccgacgcgctggccgcgaccgggcaccccgtcgacatcgtcacctacgccgagcacgcc
ctcacctccggcccggacagcgccgccatcgcctacgtccggtgccgcatcggcggtgcc
acctactggggcgcgggccaggacacctccgtcctgacggcctcggtacgggccgtgctc
tcggccgtcaaccgcgcgagcctggaccgggacagcggctag
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