KEGG   Streptomyces koyangensis: D0C37_31540
Entry
D0C37_31540       CDS       T06436                                 
Name
(GenBank) SDR family NAD(P)-dependent oxidoreductase
  KO
K16393  candicidin polyketide synthase FscB
Organism
sky  Streptomyces koyangensis
Pathway
sky01052  Type I polyketide structures
Brite
KEGG Orthology (KO) [BR:sky00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    D0C37_31540
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins [BR:sky01008]
    D0C37_31540
Polyketide biosynthesis proteins [BR:sky01008]
 Polyketide synthase (PKS)
  Modular type I PKS
   cis-AT PKS
    Candicidin PKS
     D0C37_31540
SSDB
Motif
Pfam: ketoacyl-synt Acyl_transf_1 KR Ketoacyl-synt_C PKS_DH_N KAsynt_C_assoc PP-binding PS-DH adh_short SpnB_Rossmann Thiolase_N CurL-like_PKS_C Epimerase ADH_zinc_N_2 RhiE-like_linker ADH_zinc_N PKS_DE ADH_N NmrA GDP_Man_Dehyd Polysacc_synt_2 Docking 3Beta_HSD RmlD_sub_bind
Other DBs
NCBI-ProteinID: AXQ58697
UniProt: A0A385DLX8
LinkDB
Position
7045838..7062436
AA seq 5532 aa
MSNEDRLRAYLKRAVTDLQEARQQLSDAENRDREPVAVVAMACRYPGGVRTPEDLWELAR
DGVDAISAFPANRGWDLDHLFHPDPAHHGTTYTREGGFLHDAGEFDPAFFGISPREALAM
DPQQRLLLETSWEALERAGILPDTLAGSTTGVFVGTGHGDYDGASRGRQEEVAGHLLTGN
TVAVASGRLSYTYGFEGPAVTVDTACSSSLVALHLAVRSLRQGECSLALAGGATVMSTPK
MFTEFSRQQGLAADGRCKPFAAGADGTAWSEGVGLVLLERLSDAERNGHEILAVIRGSAI
NQDGASNGLTAPNGPSQQRLIRQALIDAGLTSGEVDVVEAHGTGTALGDPIEAQALLNTY
GQDRGDAHPLLLGSLKSNTGHTQAASGVAGVIKMVQAMRHGTLPKSLHVDAPTPHADWAA
GGVELLTESTTWPETGRPRRAAVSSFGVSGTNAHLILEQAPEDQAPRTEDPGTEPAGTTG
DGTWRSWMVSGKSRAAVGEQAARLAASVRASGASVLDVAHALVSSRVAMDRRAVVVGSDR
MELLAGLDALAAGEPSPRLVEGSVGEGSGKVAFVFPGQGSQWVGMAVELLGSSPVFAGRV
AECAAVLEPFTGWSLLDVLNGVDGAASLERVDVVQPVLWAVMVSLAEVWRAQGVEPGAVI
GHSQGEIAAAVVAGGLSLEDGARVVALRSRALRALSGLGGMVSVARGVEEVRGLLAGWEG
RIGVAAVNGPSSVVVSGDAGALDEFVAVCEESGVRARRVAVDYASHSAHVERIEEELAEL
LAPVAPRSCDVPFYSTLSGGVIDTAGLDAAYWYGNLRGAVEFEAGTRALLADGFRVFVEV
SAHPVVATGVQETIEDAGVRAGVVGTLRRDEGGLERFALSLGEAWALGADVDWETHYAGT
RPRHVDLPTYPFRRDWYWLTPAESAAAAATGDPADGDFWSAVESGDLTRLSSVLEVTGDD
VEAFGTLLPALASWRRRRTLRSTLDTWRHRVTWTMLTGADDAAPAGRWPALVPAGHADDP
WVHAVLGALTARGLRVERHDLTGDEDAAALAALLDGAEDIAGVLSLLALDERPHPDHPAV
PRGLATVKELLHALSGTEAPVWALTRGAVAVDSRDRLTSPVQAETWGFGRAVALELPDAW
GGLADLPAEPDARSLARLATLLGGPEDQIAVRSSGAYARRLAPMPLPEPDRATGADADLA
VREADDDGIGGWGDHDTVLITGGTGALGAHVARSLAASGARHLVLTSRRGPGSPGAAELV
AELEELGAGVTVAECDVADRDQLAGLLDSLPAGLPLTGVVHAAGVLDDGVLDALTLDRFE
AVLRPKTLGIAHLHELTRDHDVTLFVLFSSIVGVLGNAGQANYAAANAYLDAVAEQRRAE
GLPVTSVAWGPWADAGMATADVLTDRMSHDGLAPMDPDTAVAALRAAVTEGAPHATVLDV
DWRAYASAMTAARPSPLIGDLPEVRRALEATAATAPDTHALRDRLRGLAPAEQDRLLTDL
VRAEVATALRHSSPEAVDVSRAFKDLGFDSLTAVEVRNRITAATDVKLPTTLLFDHPNTT
AVVAHLRTLLLGDERPAAAPVVVPAGVTDEPMAVVAMACRFPGGVTTPEELWNLMAAEVD
AVSTPPEDRGWDLDALYDPDPERHGTTYSREGGFIQDVAGFDPAFFGISPREALAMDPQQ
RLLLETSWETFERAGIDPGTLRNSATGVFVGSITTDYQVRLGGAAAQEQLAGHLMTGNAS
SIASGRLSYTYGFEGPAVTMDTGCSSSMVALHLALQSLRTGECTMALAGGVTVMSTPEPY
VEFSRQRGLAADGRCKAFAEGADGMGFAEGVGLVLLERLSDARRNGHPVLAVVRGSALNQ
DGASNGLTAPNGPSQQRVIRQALANAGLAPGEVDVVEAHGTGTPLGDPIEAQAILATYGQ
DRDPARPLLLGSLKSNIGHTQAAAGVAGMMKMILAMRQGTLPKSLHITRPTSVVDWSSGA
VRLVTESTPWPETGRPRRAGVSSFGISGTNGHLILEQAPAPEPAEDEPADPFTEPATADS
DTVRSWMVSGKSRAAVGEQAARLAASVRASDASVLDVAHALVSSRVAMDRRAVVVGRDGE
ELLAGLDALAAGEPSPRLVEGSVGDGSGKAAFVFPGQGSQWVGMAVELLGSSSVFAGRVA
ECAAALEPFTGWSLLDVLNGVEGAASLERVDVVQPVLWAVMVSLAEVWRAQGVEPGAVIG
HSQGEIAAAVVAGGLSLEDGARVVALRSRALRALSGLGGMVSVARGVEEVRGLLAGWEGR
IGVAAVNGPSSVVVSGDAEALDEFVAACDESGVRARRVAVDYASHSVHVERIEGELAGLL
APVAPRSCDVPFYSTLSGGVIDTAGLDAGYWYRNLRGAVEFEAGTRALLADGFRVFVEVS
AHPVVVTGVQETIEDAGVRAGVVGTLRRDEGGLERFALSLGEAWALGAEVDWETHYAGTR
PRHVDLPTYAFQRQHYWPRFAELGGDVSSAGLDSPDHPLLGASVELAGGDGLVATARWSL
RTHPWLADHAVSGTVIVPGTALVESVIRAGDVLGCGRIEELTLQAPVVLQERGEAQVQIG
VGEPDASGRRPVTVHTRTTGPDGATEELWTLRAQGTLTPPGAPAVDRPEDFTAWPPPGAT
AVAAEGFYDLLAGRGYEFGPVFQGVRATWSRGEDLYAEVVLPEQVRGDAGRFGIHPALLD
AALHAAHLAPGSAERTVVPFTWTGVCLHAAGATALRVRVSPAGQDAISVQLTDPTGAPVA
AIDALAVREIAPDTLDPSARAARDWLFLLDWTPVTAPAAEPAATSWAVLGAPAAAVTAPD
GSGTTLPAFATPGEMAKHTEATGHRPGAVLLFAGAVATDSTAAPDAGQDCPDAVLGEVLA
TVQSWLADETTEGIPLVVVTRGAVPTGPADPAHDLPGAAVWGLVRSAQSQHPGRLVLVDL
DVHDDSWLALPAALAAGEPQLALRQGAAYAPRLVRPRTSDALTVPEGTGNWRLDIPEKGS
VDRLELVADPGTAEEPAAGEVVIEVRAAGLNFRDVLNTLGMYPGPAVLLGAEAAGVVTAV
GEGVTGFAPGDRVMGLVSGGFAPRAVADARMLAPVPDGWTWAQAASVPVAFLTAYYGLRD
LARLDAGESVLVHAAAGGVGMAAAQLARHWGAEVYGTASDHKRTLLRADGWDYARLASSR
TLAFEDRFRATSGGRGVDVVLNSLAGDYIDASLRLLAPGGRLVDMGKTDVRDPAQVVRDH
PAVALYQAYELREAGEDRIQEMFRDLSELFASGALRPLPTVTWDVRHAREAFRHMAQAKH
YGKIVLTLPRAWDPEGTVLVTGGAGVLGGILARHLVTRHGMRHLVLTGRRGPDTPGAGEL
AAELRELGAEVTLAACDAADADALAAVLAAVPAEHPLTAVVHAAGVLDDGVLESLTPDRL
RTVLAPKADAARHLHRLTRDLDLADLVLFSAGAGVFGNAGQANYAAANTYLDALAHRRRT
DGLPTTSLSWGLWADTSALTGQLDDTDLARVRRSGVLPLSAADGMALFDAALAEQRPHLV
PVRLETGQLRASGDEVPPLLRSLYRGPVRRTADAGAAAGTDSLRARLAGRSAEDRLSTLR
DLVGAHAAAVLGHDDTEPFHAGRAFRDLGFDSLTAVELRNRLSAATGLRLPATLVFDHPT
VAALAAHLDGDLSDGTPAALPAAPTPAPAVPGDDDPFAIVGMACRLPGDIHSPEDLWRLL
ADGADAVAPFPDDRGWDLARLYDSVPEGQGSSRTREGGFLRDAADFDADFFGISPREALA
MDPQQRLLLETAWETFERAGIDPRSARGSRTGVFAGLSSSDYLKRVTHVPDEIAGYVNNG
NANSIVSGRVSYTLGLEGPAVTVDTACSSSLVALHMALQALRRGECTMALAGGVTVMSSP
EIIVDFSRQRGLAADGRCKPFAEAADGTGFSEGVGLILVERLSDARRNGHQVLALIRGSA
VNQDGASNGLSAPNGPAQQRVIRQALADAGVGAAEVDAVEAHGTGTRLGDPIEAQALLAT
YGRDRDGGQPLLLGSVKSNLGHTQAAAGVAGVMKMVLALRHRLLPESLHIDAPTPHVDWA
DSGVRLLTEATAWPEPPAPRPRRAAVSSFGISGTNAHVILEEAPAPAAGPDGGEPEPAGA
DATETGPAPLPWVLSARSEAALRGQAKALLAHLDAHPGTDPADIAHTLVTRRAQLEKRAV
VVGGATGDFRAGLAALAEGSPAAHVVTGGRGAGRDRRTVLVFPGQGSQWAGMGAELLDAS
PAFADRVAACEEALAPYVDWSLTAVLRQEEGAPTLDRVDVVQPVTWAVMVALAEVWRTHG
LRPAAVLGHSQGEIAAAAVAGVLSLADAARIVAVRSRAIARELSGHGGMVAVTASHDEVT
ALLADLPGVCVAAVNGPSSVVVSGETGGLDTLLAACEERGVRARRVPVDYASHSAHVDRL
AESLPAALDGIEPRDGDIPFFSTVTADWQPGTGLGAAYWHRNLRGTVRLEESLRALVEQG
HDVFVECGPHPVLTVGIEDTVAALGADAVALGTLRRDDGGPARLLTALAAAHVEGVPVDW
RPAVSHGAPVDLPAYAFQRRRYWLEAGTPQGDPAGLDTAVRLADGGAVLSGSLSLATQPW
LDAHRTHGAAAVPTTALLDWAVRAGDETGLPVVAALDEHSPLVVPEEGSVEIQLTVAAAG
TGSRPFAVHSRLHAADAPEPDTPWTRNATGALTDRPTTTPQASGAWPPADAVAGDPAPAR
ALAEDRGLDLAAPFDTVRSLWRAGTDVLAEVTLPDTAHADAARFRLHPALLQTPLALAAT
TEEATAPVLPAAWRDVTVHATGATRLRVRLTPGDDATWSVEARDAAGDLVLTGTAETRPA
GPDRLPATAGPDAPHRVAWLPWTDNTSSAGPEPHGPWAVIGAPGRLNAALERSGATVQLH
PDLAALTTALDHGEAAPPALVVAFHGHDSGEDPTRAAHTSATHALELSTAWLREPRLADA
RLLLVTEGAVATGPDDTVPGLADATAWGLLRTAQTEHPGRFLLADLDPAPGGTGEDSAAD
ALIAAAAAAGRTGEHQFAVRAGTVTVPRLVPAGHPEGAPAPAATVPWGEGTGVGTVLITG
GTGTLGSLVARHLVTRHGVRNLLLTSRRGPDAPGAAALREELAALGAEAQIVACDVADRE
QLAGALDAVPAEHPLTAVVHAAGVLDDGTLDGLTPDRVAHVLRPKADAAWHLHELTRDTK
LTAFVMFSSYAGVAGGPGQANYAAANAFLDALAQHRRASGLPAHSLAWGLWEDRSDLTGA
LDTTGLARLERSGLRPLTTGQGLALLDASTALDTAHLVPVRLDTRTLRADEVPPLLRALA
RPAGRRAAGSGPDAATGAPADLRDRLAGLSGPQQRALLHRTVLGHLAAVLGHASAASLDA
DRGFLDLGMSSLTAVELRNRLNADTGLSLPTTLIFDHPDPAALVRHLQAELGTGTGEPDQ
PVFAELAALEAAVGGAALDDQDRARLAQRLKALRWKLDATSQDADEPDDDSDLDTTTDDE
MFDLIDNELGLA
NT seq 16599 nt   +upstreamnt  +downstreamnt
atgtcgaacgaggacaggctccgcgcatatctcaagcgggccgtcaccgatctccaggag
gcccggcagcagctcagcgacgccgagaaccgcgaccgcgagcccgtcgccgtcgtcgcc
atggcctgccgctaccccggcggcgtgcgcacccccgaggacctgtgggaactggcccgc
gacggagtggacgccatctccgcgttccccgcgaaccgtggctgggacctcgaccacctg
ttccacccggaccccgcccaccacggcaccacctacacgcgtgaaggcggattcctccac
gacgccggtgagttcgacccggcgttcttcgggatctcgccgcgcgaggccctggccatg
gacccgcagcagcggctcctgctggagacctcctgggaggcgctggagcgcgccggcatc
ctgcccgacaccctcgcgggcagcaccaccggtgtcttcgtcggcaccgggcacggcgac
tacgacggcgcctcgcgcggccgccaggaagaggtcgccgggcacctgctcaccggcaac
acggtcgccgtcgcctccggccgcctgtcgtacacgtacggcttcgaaggccccgccgtg
acggtggacaccgcctgctcctcctccctcgtcgccctgcacctggccgtccgttcgctg
cggcagggcgaatgctcgctggccctggccggcggcgccacggtcatgtcgacgccgaag
atgttcaccgagttctcccgccagcagggcctggcggccgacgggcgctgcaagcccttc
gccgccggcgccgacggcaccgcctggtccgagggcgtcggcctggtcctgctggagcgg
ctctccgacgcggagcgcaacggccacgagatcctcgccgtcatccggggttccgccatc
aaccaggacggcgcgtccaacggcctgaccgcccccaacggcccctcccagcagcggctg
atccgccaggccctcatcgacgccggcctcacctcgggcgaggtcgacgtggtcgaggcg
cacggcaccggcaccgccctcggcgaccccatcgaggcgcaggccctcctcaacacctac
gggcaggaccgcggcgacgcgcacccgctgctgctcggctcgctgaagtccaacaccggc
cacacccaggccgcttccggcgtcgccggggtcatcaagatggtgcaggccatgcgccac
ggcaccctgcccaagagcctccacgtcgacgcgcccaccccgcacgccgactgggcggcc
gggggcgtggaactgctcaccgagtccaccacctggcccgagacggggcgtccgcgccgc
gccgccgtctcctccttcggcgtcagcggcaccaacgcccacctcatcctggaacaggcc
cccgaggaccaggccccccgcacggaggaccccggtaccgagcccgccgggacgaccggc
gacgggacgtggcggtcgtggatggtgtcgggcaagtcgcgtgcggcggtgggggagcag
gcggcgcgtctggcggcgtcggtgcgtgcgtccggggcctcggtgctggacgtggcgcat
gcgctggtgtcgtcgcgggtggcgatggaccggcgtgcggtggtcgtggggtccgaccgt
atggagctgctcgcggggctggacgcgctcgccgccggggagccttccccgcgtctggtg
gaaggctcggtcggtgagggctccggcaaggtcgccttcgtgttcccgggtcagggttcg
cagtgggtgggtatggcggtggagttgttgggttcgtcgccggtgttcgcgggtcgggtg
gcggagtgtgcggcggtgttggagccgttcaccgggtggtcgttgctggatgtgctgaac
ggtgtggatggtgccgcgtcgttggagcgggtggatgtggtgcagccggtgttgtgggcg
gtgatggtgtcgttggcggaggtgtggcgggctcagggtgtggagccgggtgcggtgatc
ggtcattcgcagggcgagatcgcggctgcggtggtggcgggcgggttgtcgttggaggac
ggggcgcgggtggtggcgctgcggtcgcgtgcgttgcgtgcgttgtcgggtctgggcggc
atggtgtcggtggcgcggggtgtggaggaggttcgtggtctgctggcgggctgggagggg
cggattggtgtggcggcggtgaacgggccgtcgtcggtggtggtgtcgggtgatgcgggt
gcgttggacgagttcgtggccgtgtgtgaggagtcgggtgtgcgggcgcgtcgggtggcg
gtggactacgcgtcgcactccgcccatgtggagcgcatcgaggaggagctggccgagctc
ctggctccggtggcgccgcgttcgtgtgatgtgccgttctattcgacgttgtccggtggg
gtgatcgacacggctggtctggacgcggcgtactggtacgggaacctgcggggggcggtg
gagttcgaggcggggacgcgtgcgttgctggctgacgggttccgggtgttcgtggaggtg
agtgcgcatccggtggtggcgaccggggtgcaggagacgattgaggacgcgggtgtgcgg
gctggtgtcgtcggcacgctgcggcgtgacgagggtggtctggagcggttcgcgctgtcg
ctgggcgaggcgtgggcgctgggcgcggatgtcgactgggagacgcactacgcgggcacc
cggcctcgccacgtcgacctccccacctaccccttccgccgtgactggtactggctgacg
ccggcggagtcggctgcggcggcggccaccggcgaccccgccgacggcgacttctggtcg
gccgtggagagcggcgatctcacccggctctcctccgtgctggaggtgaccggcgacgac
gtggaggcgttcggcacgctgctgcccgcgctggcgtcctggcgccgtcgccgtaccctg
cgctccaccctcgacacctggcgccaccgcgtcacctggaccatgctcaccggcgccgac
gacgccgcccccgcaggccgctggcccgcgctcgtccccgccggccacgccgacgacccc
tgggtgcacgccgtgctgggcgccctcaccgctcgcggcctgcgtgtcgagcgccacgac
ctcaccggcgacgaggacgccgccgcgctcgcagccctgctcgacggcgccgaagacatc
gcgggcgtcctctcgctcctcgccctcgacgagcgcccccaccccgaccaccccgccgta
ccgcgcggcctcgccaccgtcaaggagctgctgcacgcgctgtccggcaccgaagccccg
gtgtgggcgctgacccgcggcgccgtcgccgtcgacagccgcgaccggctgacctcgccg
gtccaggccgagacctggggcttcggacgcgccgtcgccctggaactccccgacgcctgg
ggcggcctcgccgacctgcccgccgaacccgacgcccgcagcctcgcccgcctggccacg
ctcctcggcggccccgaggaccagatcgccgtgcgctcctccggcgcgtacgcccgtcgg
ctggcccccatgccgctgcccgagccggaccgggccaccggcgcggacgcggacctcgcc
gtgcgggaggccgacgacgacgggatcgggggctggggcgaccacgacaccgtcctgatc
accggcggtaccggtgcgctcggcgcccacgtggcacgctcgctcgccgcctccggcgcc
cgccacctggtactcaccagccgacgcggacccggcagtcccggtgccgccgaactcgtc
gcggaactggaggagctgggtgccggagtcaccgtcgccgagtgcgacgtggccgaccgc
gaccagctcgccggtctgctggactccctccccgccggcctccccctcaccggcgtcgtg
cacgccgccggtgtcctggacgacggtgtcctcgacgccctcaccctggaccgcttcgaa
gccgtcctgcgccccaagaccctcggcatcgcccacctgcacgaactgacccgcgaccac
gacgtcaccctgttcgtcctcttctcctcgatcgtcggtgtcctcggcaacgccggacag
gccaactacgccgccgccaacgcctatctggacgccgtcgccgagcagcggcgggccgag
gggctgcccgtcacctccgtggcctggggtccgtgggccgacgcgggcatggccaccgcc
gacgtgctcaccgaccggatgagccacgacggcctcgccccgatggaccccgacaccgcc
gtcgccgcgctgcgcgccgccgtcaccgagggcgccccgcacgccaccgtcctcgacgtg
gactggcgggcctacgcctccgccatgaccgcggcccggcccagcccgctcatcggggac
ctccccgaggtccgccgtgccctggaggcgaccgccgccaccgcgcccgacacccacgcc
ctgcgcgacaggctgcgcggcctcgcgcccgccgaacaggaccggctcctcaccgacctg
gtccgcgccgaggtcgccaccgcgctgcgccactcctcaccggaggccgtggacgtcagc
cgtgccttcaaggacctgggcttcgactcgctgaccgccgtggaggtccgtaaccggatc
accgccgccaccgacgtcaagctgcccaccaccctcctcttcgaccaccccaacaccacg
gcggtcgtcgcccacctgcgtaccctgctcctcggcgacgagcgccccgccgccgcgccc
gtggtcgtcccggcgggcgtcaccgacgagcccatggcggtcgtcgccatggcctgccgc
ttccccggtggcgtcaccacgcccgaggaactgtggaacctcatggccgccgaggtggac
gccgtctccaccccgcccgaggaccgcggctgggacctcgacgccctgtacgacccggac
cccgaacgccacggcaccacctacagccgtgagggcggcttcatccaggacgtcgccgga
ttcgacccggcgttcttcgggatctcgccgcgcgaggccctggccatggacccgcagcag
cggctcctcctggagacctcctgggagaccttcgaacgtgccggcatcgacccgggaacc
ctgcgcaacagcgccaccggggtcttcgtcggcagcatcaccacggactatcaggtccgc
ctgggcggcgccgcggcccaggaacagctcgccggccacctcatgaccggcaacgcctcc
agcatcgcctccggccgcctgtcgtacacgtacggcttcgaaggccccgccgtcaccatg
gacaccggctgctcctcgtccatggtcgccctccacctggccctgcagtcgctgcgcacc
ggcgagtgcacgatggccctggccggcggtgtcaccgtcatgtccacgcccgagccctac
gtcgagttctcccggcagcgcggcctggcggccgacgggcggtgcaaggccttcgccgag
ggcgccgacggcatgggcttcgccgagggcgtcggcctggtcctgctggagcggctctcc
gacgcgcgccgcaacggtcacccggtcctcgccgtggtccgcggctccgccctgaaccag
gacggcgcgtccaacggcctgaccgcccccaacggcccctcccagcagcgcgtcatccgc
caggccctcgccaacgcgggcctcgccccgggcgaggtcgacgtggtcgaggcgcacggc
accggcaccccgctcggcgaccccatcgaggcgcaggccatcctcgccacctacggccag
gaccgtgaccccgcccggccgctgctgctcggttcgctcaagtccaacatcggccacacc
caggccgccgccggcgtcgccggcatgatgaagatgatcctggcgatgcggcagggcacc
ctgcccaagagcctccacatcacccggccgacctccgtcgtggactggtcgagcggcgcc
gtccgcctcgtcaccgagtccaccccctggcccgagaccggccgtccgcgccgcgccggc
gtctcctcgttcggcatcagcggcaccaacggccacctcatcctggaacaggcccccgcc
cccgaacccgccgaggacgagccggcggacccgttcaccgagcccgcgacggcggactcc
gacaccgtccggtcgtggatggtgtcgggcaagtcgcgtgcggcggtgggggagcaggcg
gcgcgtctggcggcgtccgtgcgtgcctccgacgcctcggtgctggacgtggcacatgcg
ctggtctcctcgcgtgtggcgatggaccggcgtgcggtggtcgtgggccgggacggtgag
gaactgctcgccgggctggacgcgctcgccgccggggagccttccccgcgtctggtggaa
ggctcggtcggtgacggctccggcaaggccgccttcgtgttcccggggcagggttcgcag
tgggtgggtatggcagtggagttgttgggttcgtcgtcggtgttcgcggggcgggtggcg
gagtgtgcggcggcgttggagccgttcacggggtggtcgttgctggatgtgctgaatggt
gtggagggtgctgcgtcgttggagcgggtggatgtggtgcagccggtgttgtgggcggtg
atggtgtcgttggcggaggtgtggcgggctcagggtgtggagccgggtgcggtgatcggt
cattcgcagggggagatcgcggctgcggtggtggcgggcgggttgtcgttggaggacggg
gcgcgggtggtggcgttgcggtcgcgtgcgttgcgtgcgttgtcgggtctgggcgggatg
gtgtcggtggcgcggggtgtggaggaggttcgtggtctgctggcgggctgggaggggcgg
attggtgtggcggcggtgaacgggccgtcgtcggtggtggtgtcgggtgatgcggaggcg
ttggacgagttcgtggccgcgtgtgacgagtcgggggtgcgggcgcgtcgggtggcggtg
gactatgcgtcgcactccgtgcatgtggagcggatcgagggggagcttgccgggcttctg
gcgccggtggcgccgcgttcgtgtgacgtgccgttctactcgacgctgtccggcggagtg
atcgacaccgctggtctggatgccgggtactggtatcggaacctgcggggggcggtggag
ttcgaggcggggacgcgtgcgttgctggctgacgggttccgggtgttcgtcgaggtgagt
gcgcatccggtggtggtgaccggggtgcaggagacgattgaggacgcgggtgtgcgggcc
ggtgtcgtcggcacgctgcggcgtgacgagggtggtctggagcggttcgcgctgtcgctg
ggcgaggcgtgggcgctgggtgccgaggtggactgggagacgcactacgcgggcacccgg
ccccgccacgtcgacctccccacgtatgccttccagcggcagcactactggccgcgtttc
gccgagctgggcggtgacgtcagctcggccggcctcgactcgcccgaccaccccctgctc
ggcgcctccgtcgaactcgcgggcggcgacggcctggtggccacagcgcggtggtcgctg
cggacccacccctggctcgcggaccacgcggtgtccggcaccgtgatcgtccccggaacc
gcgctcgtggagtccgtgatccgggccggagacgtactcggctgcggccggatcgaggaa
ctgaccctccaggcccccgtggtcctccaggaacggggcgaggcgcaggtccagatcggc
gtcggtgagcccgacgcctccggccgccgtcccgtcaccgtccacacccgcaccaccggc
cccgacggcgccaccgaggagctgtggacgctccgcgcccagggcaccctcaccccgccc
ggcgccccggccgtcgaccggcccgaggatttcaccgcctggccgcccccgggcgccacc
gccgtcgccgccgaaggcttctacgaccttctcgcgggccgtggctacgagttcgggccc
gtcttccagggcgtccgcgccacctggagccgcggcgaggacctgtacgccgaggtcgtc
ctgcccgaacaggtccgcggcgacgccggacggttcggcatccaccccgcgctcctcgac
gccgccctgcacgccgcccacctcgcacccggcagcgccgagcgcacggtggtcccgttc
acctggaccggagtctgcctgcacgccgccggagcgaccgcgctgcgcgtccgcgtctcc
ccggcagggcaggacgccatctccgtccagctcaccgacccgacaggcgccccggtcgcc
gccatcgacgccctggccgtacgcgagatcgcaccggacaccctcgatccgtccgcccgc
gccgcccgcgactggctgttcctcctcgactggacaccggtcaccgcgcccgccgccgag
ccggccgccaccagctgggccgtcctcggcgccccggccgccgcggtcaccgcacccgac
ggcagcgggaccacgctgcccgccttcgccacccccggcgaaatggccaagcacaccgag
gccaccggtcaccggccgggcgccgtcctgctgttcgccggggccgtcgccacggactcg
accgccgcgcccgacgccggacaggactgcccggacgccgtcctcggcgaggtcctcgcc
accgtccagagctggctcgccgacgagaccaccgagggcatcccgctggtcgtcgtcacc
cgcggcgccgtccccaccggccccgccgaccccgcccacgacctgcccggcgccgccgtc
tggggcctggtgcgctccgcccagtcccagcacccgggccgcctcgtcctggtggacctc
gacgtccacgacgactcctggctcgccctgccggccgcgctcgccgccggtgagccgcaa
ctcgccctccgccagggcgccgcgtacgcgccgcgcctggtccggccccgtacctccgac
gccctcaccgtgcccgaggggaccgggaactggcgcctcgacatccccgagaaggggtcc
gtcgaccggctggagctcgtcgccgaccccgggacggccgaggagcccgccgccggcgag
gtggtgatcgaggtgcgggccgccggactgaacttccgcgacgtcctcaacaccctcggc
atgtaccccggccccgccgtgctcctcggcgccgaggcggccggtgtggtcaccgccgtg
ggcgagggagtcaccggcttcgccccgggcgaccgcgtcatggggctggtctccggcggc
ttcgccccccgcgccgtcgccgacgcccgcatgctcgcccccgtgcccgacggctggacc
tgggcgcaggccgcctccgtccccgtcgccttcctcaccgcctactacggactgcgcgac
ctcgcccgcctcgacgccggcgagtccgtcctcgtccacgccgccgccggcggtgtcggc
atggccgccgcccagctcgcccgccactggggcgccgaggtctacggcaccgcgagcgac
cacaagcgcactctgctgcgcgccgacggctgggactacgcccgcctcgcctcctcccgc
accctcgccttcgaggaccgcttccgcgccaccagcggcggccgtggcgtcgatgtcgtc
ctcaactccctggccggcgactacatcgatgcctccctgcggctgctcgcccccggcgga
cgcctcgtcgacatgggcaagaccgacgtccgcgatcccgcgcaggtcgtccgcgaccac
cctgccgtcgccctctaccaggcgtacgaactgcgtgaggccggtgaggaccgcatccag
gagatgttccgcgacctgtcggaactcttcgcctccggcgccctgcgccccctgcccacc
gtcacctgggacgtccggcacgcccgcgaagccttccgccacatggcccaggccaagcac
tacggcaagatcgtgctcaccctgccgcgcgcctgggaccccgagggcaccgtcctcgtc
accgggggcgccggtgtcctcggcggcatcctcgcccgccacctcgtcacccgccacggc
atgcgccacctcgtcctcaccggccgccggggacccgacacccccggcgccggggaactc
gccgccgagctgcgggaactgggtgccgaggtcaccctcgccgcctgcgacgcggccgac
gccgacgccctcgccgcggtactcgccgccgtccccgccgagcacccgctgaccgccgtc
gtccacgccgcgggcgtcctcgacgacggcgtcctcgaatccctcacccccgaccggctg
cgcaccgtcctcgccccgaaggccgacgccgcccgccacctgcaccgcctcacccgcgac
ctcgacctcgcggacctggtgctgttctccgcgggcgccggcgtcttcggcaacgccgga
caggccaactacgccgccgccaacacctacctcgacgccctcgcccaccggcgccgcacc
gacggcctgcccaccacctccctctcctggggcctgtgggccgacaccagcgccctgacc
ggacagctcgacgacaccgacctggcccgggtgcgccgctccggcgtcctgccgctctcc
gccgccgacggcatggccctcttcgacgccgccctcgccgagcagcgcccccacctggtg
cccgtccgcctggagaccgggcagctgcgcgcctccggcgacgaggtcccgcccctgctg
cgctccctgtaccgcggcccggtccggcgcaccgccgacgccggggccgcggccggcacc
gacagcctgcgggcgcgcctggccggccgctccgccgaggaccggctcagcaccctgcgc
gacctggtcggtgcccacgcggccgccgtcctcggccacgacgacaccgagccgttccat
gccggccgcgccttccgcgacctcggcttcgactcgctgaccgccgtcgaactgcgcaac
cgcctcagcgccgccaccggtctgcggctgcccgccaccctcgtcttcgaccacccgacc
gtcgccgccctcgccgcccacctcgacggcgatctctccgacggcaccccggccgcgctt
cccgcagcccccacgccggcacccgccgtgccgggcgacgacgaccccttcgccatcgtc
ggcatggcctgccgcctccccggcgacatccactcgcccgaggacctgtggcggctgctg
gccgacggcgccgacgccgtcgcgcccttccccgacgaccgcggctgggacctcgcccgc
ctctacgactccgtccccgagggccagggcagctcccgcacccgcgagggcggcttcctc
cgcgacgccgccgacttcgacgccgacttcttcggcatctcccctcgtgaggcgctggcc
atggacccgcagcagcgcctgctcctggagacggcctgggagaccttcgaacgcgccggc
atcgacccccgctcggcccgcggcagccgcaccggcgtcttcgccggcctctcctccagc
gactacctcaagcgcgtcacccacgtccccgacgagatcgccggatacgtcaacaacggc
aacgccaacagcatcgtctccggccgcgtctcctacaccctcggcctggagggcccggcc
gtcaccgtcgacaccgcctgctcctcctccctcgtcgcgctgcacatggcgctccaggcg
ctgcggcgcggcgagtgcaccatggccctggccggcggcgtcaccgtcatgtcctcgccc
gagatcatcgtggacttctcccggcagcgcggcctcgccgccgacggccgctgcaagccc
ttcgccgaggccgccgacggcaccggcttctccgagggcgtcggcctgatcctcgtcgag
cgactctccgacgcccgccgcaacggccaccaggtcctcgccctgatccggggttccgcc
gtcaaccaggacggcgccagcaacggcctcagcgcccccaacggccccgcccagcagcgg
gtgatccgccaggcccttgccgacgcgggagtcggcgccgccgaggtcgacgccgtcgag
gcgcacggcacggggacccgcctcggcgacccgatcgaggcccaggcgctcctcgcgacg
tacggccgcgaccgggacggcggccagccgctgctcctcggctccgtcaagtccaacctc
ggccacacccaggccgcggccggtgtcgccggtgtgatgaagatggtgctggccctgcgt
caccgcctgctccccgagagcctgcacatcgacgcgccgaccccgcacgtcgactgggcg
gactccggcgtgcgcctgctgaccgaggccaccgcgtggcccgagccccccgccccccgc
ccgcgccgcgccgccgtctcctccttcggcatcagcggcaccaacgcccacgtcatcctg
gaggaggcccccgcccccgctgccggcccggacggcggcgagccggagcccgccggcgcc
gacgcgacggagaccggccccgcgcccctgccatgggtgctctccgcccgcagcgaggcc
gccctgcgcggccaggcgaaggccctcctcgcccacctcgacgcccaccccgggaccgac
cccgccgacatcgcccacaccctggtcacgcgccgggcccagctggagaagcgggccgtc
gtcgtcggaggcgccaccggcgacttccgcgccggcctcgccgccctcgccgagggcagc
cccgccgcccacgtggtgaccgggggccggggagccgggcgcgaccgccggaccgtcctc
gtcttccccggacagggctcccagtgggccggcatgggcgccgaactcctcgacgccagc
ccggccttcgccgaccgcgtcgccgcctgcgaggaggcgctcgccccgtacgtcgactgg
tccctgaccgccgtcctgcgccaggaggagggcgcccccaccctcgaccgcgtcgacgtc
gtccagcccgtcacctgggccgtgatggtcgccctcgccgaggtgtggcgtacccacggc
ctgcgtccggccgccgtcctcggccactcccagggcgagatcgccgcggcggccgtcgcc
ggagtgctctccctcgccgacgccgcccggatcgtcgcggtccgcagccgggccatcgcc
cgcgaactctccggacacggcggcatggtggccgtcaccgcctcgcacgacgaggtgacc
gccctcctcgccgacctgcccggcgtctgcgtcgccgccgtcaacggcccctcctcggtg
gtggtctccggcgagaccggcggcctcgacacgctcctcgccgcctgcgaggaacggggc
gtccgcgcccgccgcgtccccgtcgactacgcctcccactcggcccacgtcgaccggctc
gccgagagcctgcccgccgccctcgacggcatcgaaccccgcgacggcgacatccccttc
ttctccaccgtcaccgcggactggcagcccggcaccggactcggcgccgcctactggcac
cgcaacctgcgcggcaccgtccgcctggaggagtccttgcgggccctcgtcgaacagggc
cacgacgtcttcgtggagtgcggcccgcatccggtgctcaccgtcggcatcgaggacacc
gtcgccgccctcggggccgacgcggtggccctcggtacgctgcgccgcgacgacggcggc
cctgcccgtctcctgaccgccctcgccgccgcccacgtcgaaggcgtccccgtcgactgg
cgtcccgccgtgtcccacggcgcccccgtcgacctgccggcctacgccttccagcgccgg
cggtactggctggaggccggcacgccccagggcgacccggccggcctcgacaccgccgtc
cgcctggccgacggcggagccgtcctcagcggctccctgtccctcgccacccagccctgg
ctggacgcccaccggacccacggcgccgccgccgtccccaccaccgccctgctggactgg
gcggtccgggccggcgacgagacgggcctgcccgtcgtcgccgcactcgacgagcacagc
ccgctcgtcgtgccggaggaggggagcgtggagatccagctcaccgtcgccgcggccggc
accggctcccgcccgttcgccgtccactcaaggctccacgccgccgacgcgccagagccc
gacaccccctggacgcggaacgcgaccggcgccctcaccgaccggcccaccaccacccca
caggcttccggcgcctggccaccggccgacgccgtcgcgggcgacccggccccggcgcgt
gccctcgccgaggaccgcggcctcgacctcgccgcgcccttcgacacggtgcgctccctg
tggcgcgccggcaccgacgtcctcgcggaggtcacgcttcccgacaccgcgcacgccgac
gcggcgcgcttccgcctccacccggcgctcctccagaccccgctcgccctggccgcgacc
accgaggaggccaccgcacccgtcctgcccgccgcctggcgggacgtcaccgtgcacgcc
accggcgccaccaggctccgcgtccgcctcaccccgggagacgacgccacctggagcgtc
gaagcccgcgacgccgcaggtgacctcgtcctcaccggcaccgccgagacccgcccggcc
ggccccgaccggctccccgccaccgccggccccgacgccccgcaccgggtcgcctggctc
ccgtggaccgacaacacctcctccgccggcccggaaccacacggtccgtgggccgtcatc
ggtgcccccggacggctcaacgccgccctcgaacgcagcggcgccaccgttcagctccac
cccgacctggccgccctcaccaccgccctcgaccacggcgaggccgcacctcccgccctg
gtcgtcgccttccacggccacgacagcggcgaggacccgacgagggccgcgcacacctcc
gcgacccatgccctggagctgtccaccgcctggctccgggagccgcgcctcgccgacgcc
cggctcctcctggtcaccgagggcgccgtcgccaccggcccggacgacaccgtccccggc
ctcgccgacgccaccgcctggggcctgctgcgcaccgcccagaccgagcaccccggacgc
ttcctcctggccgacctcgaccccgcccccggcggtaccggcgaggacagcgccgccgac
gccctgatcgccgccgccgcggcggccgggcgcaccggggagcatcagttcgccgtacgg
gccggcaccgtcaccgtgccgcgcctcgtccccgccggacacccggagggcgcccccgcg
cccgccgccaccgttccgtggggcgaggggaccggagtcggcaccgtgctgatcacgggc
ggaaccggcaccctcggctccctcgtcgcccgtcacctcgtcacccgccacggcgtacgc
aacctgctgctcaccagccgtcgcgggcccgacgcccccggcgcggcggccctgcgcgag
gaactcgccgcgctcggcgccgaggcccagatcgtcgcctgcgacgtcgccgaccgcgag
caactggccggcgccctcgacgccgtaccggccgaacaccccctgaccgccgtcgtccac
gcggccggagtcctggacgacggcacactggacggcctcacccccgaccgcgtcgcccac
gtcctgcgccccaaggccgacgccgcctggcacctccacgaactcacccgcgacaccaaa
ctcaccgcgttcgtgatgttttcctcctacgcgggcgtcgccggtggccccggtcaggcc
aactacgccgccgccaacgccttcctcgacgccctcgcgcagcaccgccgggcgagcggc
ctccccgcgcactccctggcctggggactgtgggaggaccgcagcgacctgaccggcgcc
ctcgacaccaccggcctggcccgcctggaacgctccggcctccggcctctcaccaccggt
caggggctcgccctcctcgacgcgagcaccgccctggacaccgcccacctcgtccccgta
cgactcgacacccgcaccctgcgcgccgacgaggtgcctccgctgctgcgagccctggcc
cgcccggccgggcgacgcgccgccggctccgggcccgacgcggccaccggcgctccggcg
gacctccgcgaccggctggccggcctcagcggcccccagcagcgggcgctgctgcaccgt
acggtcctcggtcacctcgccgccgtcctcggccacgcctccgcggcgtccctcgacgcg
gaccgcggcttcctcgacctcgggatgtcctcgctgaccgcggtcgaactccgcaatcgg
ctcaacgccgacaccggactctccctgcccaccaccctgatcttcgaccacccggacccg
gccgccctcgtacgccacctccaggcggaactcggcacaggtaccggcgaaccggaccag
cccgtcttcgcggaactggccgccctggaggccgccgtcggcggcgccgccctcgacgac
caggaccgcgcccgcctggcgcagcgactcaaggccctccggtggaagctcgacgccacc
tcccaggacgccgacgagcccgacgacgactccgacctcgacaccaccacggacgacgag
atgttcgacctcatcgacaacgaactcgggctcgcctga

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