Streptomyces laculatispora: P8A22_11445 Help Entry P8A22_11445       CDS       T09657                                  Name (GenBank) type I polyketide synthase   KO K19203   pimaricinolide synthase PimS1 Organism slai  Streptomyces laculatispora Pathway slai01052   Type I polyketide structures Brite KEGG Orthology (KO) [BR:slai00001]  09100 Metabolism   09109 Metabolism of terpenoids and polyketides    01052 Type I polyketide structures     P8A22_11445  09180 Brite Hierarchies   09181 Protein families: metabolism    01008 Polyketide biosynthesis proteins [BR:slai01008]     P8A22_11445 Polyketide biosynthesis proteins [BR:slai01008]  Polyketide synthase (PKS)   Modular type I PKS    cis-AT PKS     Pimaricinolide synthase      P8A22_11445 BRITE hierarchy Motif Pfam:  ketoacyl-synt Acyl_transf_1 KR Ketoacyl-synt_C PKS_DH_N PS-DH PP-binding KAsynt_C_assoc adh_short Thiolase_N Epimerase Polysacc_synt_2 TraD Motif Other DBs NCBI-ProteinID:  WLQ40546 LinkDB All DBs Position complement(2724848..2741176) Genome browser AA seq 5442 aa AA seqDB search MTESENFVSGTDGVPDGGTVQRSALVRELESLPTSEQTRVLLDLVRESTEAVLRQTRPDT TQTVDPARAFRELGLDSVALVALHARLTAATGLPLPPTVAFDHPSPAALAAHLRTEALGL PDLPDPVVAPGIATDDPIAVVGIGCRYPGDVSSPEDLWRLVADGTHIRDEFPTDRGWDLD RLFDDDPATPGTTYARHGGFLSGAAEFDADFFSISPREALAMDPQQRLVLETVWEAVERA GIDARTLRSSRTGVFVAAEPQEYAMRLHEAPDGLDGYLLSGNAPSVVSGRVAYTLGLEGP ALTVDTACSGSLVGLHLAVQSLRRGECTLALAGGVAVMGSPGVFTAFSRQRGLAADGTVK AFAAAADGTAFAEGAGVFVLERLSDARANNHPVLAVLRGTAINQDGASNGLTAPSGRAQR QVIRQALADAGLTAGEVDAVEAHGTGTTLGDPIEAQALIATYGQERTDGPVWLGSVKSNI GHTQAAAGSAGLIKMIMAMRHGVLPATLHVDAPSPNVDWSAGEVRLLTEPVPWAPGERPR RAAVSSFGVSGTNAHIVVEEPPAETARSAAAEGDGTAAADGRPLPATLSARTEAALRDQA RRLLAHVENTPDARPLDLAHSLATTRSALPHRAVVLAGDRAGLLDGLRAVAEGRDAPGVF TSVTGGGTAFLFTGQGSQRLAMGRRLYEAHPAYAKALDNAIGYLDLQLDRSLWDVLFADE DTPEAALLDGTMYAQAALFAVEVALFRLLESWGVHPDYVAGHSIGELTAAHVAGVLSLDD AATLVAARGRLMQALPEGGAMIAVEAAEETVEPLLAHCRDTVGIAAVNGPRSVVLSGDEE TVTAVAARLEADGHRTKRLRVSHAFHSPLMAPMLDDFRQIARILSYAAPKLPVVSALTGR LATAGELTDPEYWVRHICAPVRFHDAVASLTDRGVATFLELGPDPVLCAMGRTGADPAAV FTPLLRRGHDEPHQLLSALAVAHTRGTRVDWHAFFAGAGAHRVELPTYAFQRERFWLSAP GAAQDATALGQVAAGHPLLGAVVGLADTGGAVLTGRVSLRSHPWLADHVIDGHVLLPGTA FVDLAVRAGEQTGCERLDELVMAAPLILPGTGGVALQIVVDAPDAAGRRPVAFYSRDEDA PADAPWTRHATGRLAPRDPSGRQTADFASGTWPPPGAEPLDITGLYADLATQGYGYGPAF HGLQAVWRAGEGEVFAEVRLPATAGDPASAYGLHPALLDAVLHATDFAAAPHADSQDGRI LLPFAWTGVTLHAAGATTLRVRVTATGTDEVALELADATGAPVASVDSFLVRPLTAGGLA ATAHPDALHHVRWTPLPVPATTPSNPDTDAVHTCPAPTGADIAADVRTVLATTLTAVRDW LADERSATRRLTVLTRGAVAAAPGEQAALAQAPVWGLVRSAQAEHPGRFLLLDTDGSLGT DELLRLTADSDEPEIALRDGRLHAPRLTRTTQAPDPDATPWRTDGTVLITGGTGGVGATL ARHLVTVHGVRGLLLTGRRGADAPGAQELRSELTALGAEVTITACDAADRDALAGVLAAV PERLPLSAVVHAAGVLDDALVDSLDDTRLDTVLRPKADGAWNLHELTRDSDLSAFVLFSS TATLLDGAGQGNYAAANVFLDALATHRAALGLPATSLAWGLWTGTGGMGGALDEAALRRI ERLGLQPLSVAENLALLDRAITTGAHPAVVPVRLNLRTLNARADEAPALLRALVRPPRRA VGGGGVSVEQSLARSLGGLTRPERGEALLDLVRTQVAAVLGHDGPERVVTTRAFNEMGFD SLAAVELRNRLGSATGLPLTATLVFDYPSPAALADHLASRLGGDAEQRAGRPVPAAATVS DDDPVAIVSMACRYPGGVSSPEELWQLVEEGRDVVSAFPTDRGWAADIHDPEPGAPGKSL TDQGGFLHEAADFDAEFFGISPREAQAMDPQQRLLLEIAWETVERAGIDPHALRGSDTGV FAGVMYHDWGLRLGPLPEHVAGYHGNGSLASVVSGRVAYTLGVEGPAVTVDTACSSSLVA LHWAAQALRRGDCALALAGGVTVMSTPDTFVDMSRQRGLAADGRCKSFGSGADGTGWGEG VGMLLLERLSDAERNGHRVLGIVRGSAVNSDGASNGLTAPNGPAQQRVIRRALSVAGLTP ADVDAVEGHGTGTVLGDPIEAQALLETYGQERPADGSPLLLGSIKSNMGHTQAAAGVAGI IKMVQAMRHGTLPATLHADEPSPQVDWDSGAVALLTGPTAWPAHGRPRRAGVSSFGISGT NAHVIIEEPPAATPQDAPEPAGTTSGPAAWPLSARTPDALSAQAARLLSHLATVPDDALA ATGHALATTRAALDHRAVALGADRTELIASLEALASGAGPVRDTVSEGKVAFLFTGQGAQ RLGMGRELYEAFPVFAEAFDAVLVELDARLGCSLREVVWGEDADVLNGTMFAQAGLFAVE TALFRLVESWGVRADFLVGHSVGEIAAAHVSGVLSLADAAELVVARGRLMQGLPAGGSMV AVEATEAEVLPLLNGEVGIAAVNGPRSVVVSGTEAAVRGLVAMFEERGRRTSVLRVSHAF HSPMMEPMLAEFGAVVAGLEFGAASIPVVSGVSGDVAEGWGSAAYWVRHVREAVRFADAV RFLEDRGVSSYIEIGPDAVLSGMGQNCVQDADGAAFVPSLRRNRPEVRELLAAVARAHAR GVTVDWDTFFGLRGIGQGPDLPTYAFQHQRYWLDLATAPGDLDAVGLEAVSHPLLSAAVA TPDDGGVVLTGRLATGTQPWLADHGVLGSVLLPGTGFVELAIRAGDHVGCGRIEELLLEA PLTLPARSGVALRVVVGAPDPSGACSVSIHSRGSTDPDAPWTRHAHGTLTREAPAPAFDL TQWPPAGAAPVDVESAYERLRERGYAYGPAFQGLRAAWRRGDDVFAEVALDGPARVEAPA YGLHPALLDAAMHADLLTDPAADAATLLPFSWNGVTLHAAGTPSLRVHIQRIRGDEVSAI MVADESGAPVATVESLVSRPVSPEQIAAASGAPSASLHRIGWQRTEPATATAGATPAYTV LHCPASPGGMDVPDAVRALTHHVLGEIRDRLADPDAGDRTLVVVTRRAVPVRPGEDVDPV QAPVWGLVRAAQAENPGRFQLVDVEAESEATDAALSAAVASAEPESALREREVWVPRLGP VIAPEPTRPAPWDTGGTVLITGGTSGLGALVARHLVTEHGIRHLLLAGRRGMDAPGAQAL AAELTGLGAQVQIAACDVADRDGLAALLAGIGTEHPLRAVVHAAAVADGGLVAGLTPERF DAVLRPKAEGAWHLHELTRDTDLTAFVMFSSAGGLVLAAGQADYAAANVFLDALATHRVA AGLPATSLAFGMWEVSTGLGGDLTEADLDRMRRLGLPALPADLGLALFDAALVAGDAVVV PLTIDTAALAARGDELPALLRGRVRTPARRTVRATATGSALERRLAGATPDERARILLDT VRTQVAAVLGQPSPEAVGPDTAFRDQGFDSLAAVELRNLLVGSTGLRLPATLVFDYPNSR AVAGHLDTLLTGTTTTAPTAAPLAAVDDDPIAVVAISCRFPGGVRSPEDLWDLVAAGTDA IGDFPADRGWDADALYDPEPGLPGRTYVREGGFLYDAAEFDPEFFGIMPREALAMDPQQR LLLQSAWEAFERAGIDPETLRGSQTGVYAGVMYHEYGSRVTDVPDDLAGYLGNGSAGSIA SGRVAYALGLEGPAVTVDTACSSSLVSLHMACQALRTGEIDLALAGGVTVMPTPEIFVDF SRQRGLAADGRSKAFAGAADGTSWAEGVGLLLVERLSDARRNGHPVLAVVRGSAINQDGA SNGLTAPNGPSQQRVIRKALSAAGLTPAEVDAVEGHGTGTRLGDPIEAQALLATYGQDRP ADRPLWLGSVKSNIGHAQAAAGVSGVIKMVMALRNGLLPRTLHVDEPSPQVDWAAGGVRL LTEPVTWAAQDRPRRAGVSSFGLSGTNAHVIIEEAPQIEEAPQIGEALLDDAAPAEPLTV VPLALSARSATALTAQAGRLLAHVEAHPDESLVDVGRSLATTRAVLDLRAVVMSADRDAA VRALSDLAAGRESADVVTRAGSSVEGLTAFLFTGQGAQRLGMGRELYGTFPVFAEAFDAV LVELDARLGRSLREVVWGEDAALLNGTMFAQAGLFAVETALFRLVESWGVRADVVAGHSI GEITAAHVAGVLPLTDAAELVAARGRLMQALPAGGVMVAVAAPEADVLPLLTDEVGLAAV NGPSSVVISGAREATLAVAEHFAALGRRTKRLSVSHAFHSPLMEPMLDAFRKVAEKLTYT APTLRVVSHVTGTEATAEQLTSPEYWVRHVREAVRFADGIAHLCGQGVTRFVELGPDAVL TALTEATAHHTPDTLTVPALRKGRPEVATLLAAVARLHVAGPVVRWADVLDGRGGRTVEL PTYAFDRTTYWLDAPAPLGGDVTGLGQRAAAHPLLSAVVASPEAGGVVLTGRLSVRTHPW LADHDVLGTVLLPGTGYIELAIRAGEEVGCEVVEELTIEALMPLPPHGGLAVQVVVDAPD AGGRCSLAVYSRADDAPAGAPWSKHASGVLAPGSGQAPPAGTFAPDPADWPPTGATEVDI SGVYDYLTGQGYGYGPMFRGLRGIWSRGGETFAEVSLPEDSLDVGKDFRLHPSILDAALS ATDFMDGRRPQDVGGTQLPFAWSGVTLHAAGSSRLRVRITAVESHRSQGSDAVRLELTDP AGTPVATIDSLVVRPVTAAKVNAAAAAGGGEHEAVFQLVTQQLPLGAAVAAATDRWAVLG AGPDGTPAGPGTAYRDLPALGAALTDGAPVPDVVVLPVPPATDHDDIPAAVRSMTGQLLA TLQSWLADERYAHSRLMVVTRNALPIEESDAAAVDLVHAPAWGLLRSAQEEYPGRFVLVD SDGTATARESLPAVAASGEPEAILRGAEVRVPRLARVAAAAPTKPLPWDAEGTVLITGGT SGLGAVVARHLVEQHGVRHLLLAGRRGQDAPGATELRDALHGLGARVTLAACDTSDRAAV DGLLTAIPAAHPLTAVVHAAAVMDNALLAALTPAQVDTVMRPKVDAAWNLHEATRGLDLK AFILFSSCAGLVVGVGQGNYAAANRFLDALSAHRRAAGLPGTALAFGLWETKTGLGGGVT HADLRRMRTMGMPALPTAEGLALLDEALELDRPVLVPIRVERDHHATGEPPHLLKDVLGA PERPAARKEVRAPAVAPVAAPATQQTLEQRLSGMKAAERKRTVLDVVREQVAGVSHSVPA TIDVSKGFTELGLDSLAAIDLRNRLQKATGLRLPATLMFDYPSPMVLADFLLDELPPGID ENTPDASAGSAPAQNGPGTAETDAAIRQTLADIPIAALRESGLLDALLRLAPRPAVPATE SRTSAQPGEAAQAGEAIRTMDIDDLVRAALASTDPTRNPSEG NT seq 16329 nt NT seq  +upstreamnt  +downstreamnt atgactgagtcggaaaacttcgtctctggcaccgacggtgtgccggacgggggcacggtg cagcggtccgcactcgtgcgtgagctggaatccctccccacctcggagcagacccgggtg ctgctcgacctggtgcgggagagcaccgaggccgtactgcggcagacccggccggacacc acgcagaccgtggacccggcccgcgccttccgcgaactggggctcgactccgtggcgctg gtggccctgcacgcccggctgaccgcggccaccggcctcccgctgccccctaccgtcgcc ttcgaccacccctcaccggccgcgctcgcggcacatctgcgcaccgaggccctgggcctg cccgatctgcccgacccggtcgtcgcacccggcatcgccaccgacgacccgatcgccgtc gtcggcatcggctgccgctaccccggcgacgtgtcgtcccccgaggacctgtggcggctg gtcgccgacggcacccacatccgcgacgagttccccaccgaccggggctgggacctcgac cggctcttcgacgacgaccccgcgacccccggcaccacctacgcccggcacggcggattc ctgtccggtgcggccgagttcgacgcggacttcttctccatcagcccccgtgaagccctc gcgatggacccgcagcagcgcctcgtgctggagaccgtgtgggaggccgtggagcgggcc gggatcgacgcgcggaccctgcgctcaagccggaccggcgtcttcgtcgccgccgagccg caggagtacgcgatgcgcctgcacgaggcgccggacggcctggacggatacctgctcagc ggcaacgcccccagcgtggtctccggccgggtcgcgtacacgctcggtctggagggcccc gcgctgaccgtcgacaccgcctgctcgggttcgctggtcggcctccacctcgccgtccag tccctgcggcgcggcgagtgcaccctcgcgctggcgggcggggtcgccgtcatgggcagc cccggcgtgttcaccgcgttcagccgacagcgcggactcgcggccgacggcacggtcaag gcgttcgccgccgccgcggacggtacggcgttcgccgagggcgccggtgtgttcgtcctg gaacgcctctccgacgcacgggccaacaaccacccggtcctcgccgtcctgcgcggtacg gccatcaaccaggacggcgcgtccaacggcctgaccgcgccgagcggccgcgcccagcgc caggtcatccgccaggcactcgcggacgccggactcaccgccggtgaggtcgacgccgtc gaggcgcacggcaccggcacgacgctcggcgaccccatcgaggcccaggcactgatcgcc acctacgggcaggagcgcaccgacgggccggtctggctcggttcggtgaagtcgaacatc gggcacacccaggcggcggcgggctcggccggcctgatcaagatgatcatggcgatgcgt catggtgtgctgcccgcgacgctgcacgtggacgccccctcacccaacgtcgactggtcg gcgggggaggtccggctgctgaccgaacccgtgccgtgggcgcccggcgagcgcccccgc cgggccgccgtctcctccttcggcgtcagcggcaccaacgcccacatcgtcgtcgaggag cccccggccgagaccgcgcggagcgccgccgccgagggcgacggcaccgccgccgccgac ggacgccccctgcccgcgacgctctccgcccgcaccgaggccgccctgcgcgaccaggcc cgacgcctgctggcccacgtcgagaacacccccgacgcccgcccgctcgacctcgcccac tcgctggcgaccacccgctccgccctgccccaccgcgccgtggtgctcgccggcgaccgc gcgggcctcctcgacggactgcgcgccgtggcggagggccgcgacgcccccggcgtgttc acctcggtcaccggcggcggcaccgcgttcctcttcaccggccagggcagccagcgcctc gccatgggacgccggctgtacgaggcccacccggcctacgccaaggccctcgacaacgcc atcggctacctcgacctccagctcgaccgctccctgtgggacgtcctgttcgccgacgag gacacccccgaagcggcgctgctggacggcaccatgtacgcgcaggcggccctcttcgcc gtcgaggtcgccctgttcaggctcctggagtcctggggcgtccaccccgactacgtggcc gggcactccatcggcgagctgaccgccgcccacgtcgccggtgtcctctcgctcgacgac gccgccaccctcgtcgcggcacgcggccggctgatgcaggcactgcccgagggcggcgcc atgatcgccgtggaggccgccgaggagacggtggagccgctcctcgcgcactgccgcgac acggtgggcatcgccgccgtcaacggcccccgctccgtcgtcctgtccggggacgaggag acggtcaccgccgtagccgcccggctggaggccgacgggcaccgcaccaagcggctccgg gtcagccacgcgttccactcgccgctcatggcgcccatgctcgacgacttccggcagatc gcccggatcctcagctacgccgcacccaagctccccgtcgtctccgccctcaccggccgg ctcgccaccgccggggaactcaccgaccccgagtactgggtacggcacatctgcgcgccc gtacgcttccacgacgccgtcgcctccctcacggaccggggcgtcgccaccttcctcgaa ctgggacccgacccggtgctctgcgccatgggccgcaccggcgccgacccggcagcggtg ttcaccccgctcctgcggcgcggacacgacgagccgcaccagctgctcagcgccctggcc gtcgcccacacgcggggcacccgcgtcgactggcacgccttcttcgccggcgccggcgcc caccgcgtcgaactgcccacctacgccttccagcgcgaacggttctggctcagcgccccc ggcgccgcccaggacgcgaccgcgctcggccaggtcgccgccgggcaccccctgctgggc gcggtggtgggcctcgcggacaccggaggcgccgtcctcaccgggcgggtctcgctgcgc tcgcacccctggctcgccgaccacgtgatcgacggccatgtcctgctgcccggcaccgcg ttcgtcgacctcgcggtccgggccggcgagcagaccggctgcgaacgcctcgacgaactg gtcatggcggccccgctgatcctgcccggcacgggcggcgtcgccctccagatcgtcgtc gacgcccccgatgccgccggccggcgccccgtcgccttctactcgcgcgacgaggacgcc cccgccgacgccccctggacccggcacgccaccggccgcctggccccccgggacccgtcc ggtcggcagaccgcggacttcgcctcgggtacctggccgccacccggcgccgaacccctc gacatcaccggcctctacgcggacctggccacgcagggctacggatacggccccgccttc cacggcctgcaagcggtctggagggccggcgagggcgaggtgttcgccgaggtacggctg cccgcgacggccggcgacccggcctccgcctacgggctccaccccgcactgctcgacgcg gtcctgcacgccaccgacttcgccgcggcgccccacgccgacagccaggacggccgcatc ctgctgcccttcgcctggaccggcgtcaccctccacgcggcgggcgccaccacgctgcgg gtacgcgtcaccgccaccggcaccgacgaggtcgccctcgaactggccgacgccaccggc gccccggtggcctccgtcgactccttcctggtccgccccctcaccgccggcggactggcc gccacggcgcaccccgacgcgctccaccacgtccggtggaccccgctgccggtccccgcc accaccccgtcgaacccggacaccgacgccgtccacacctgccccgcccccaccggagcc gacatcgccgccgatgtccgcaccgtcctggccaccacactcacggccgtacgggactgg ctcgccgacgaacgctccgccacccggcggctgaccgtactcacccggggcgcggtcgcc gccgcccccggcgaacaggccgcactcgcccaggcacccgtctggggactggtgcgctcg gcccaggccgagcatcccggccgcttcctcctcctcgacaccgacggctccctcggcacc gacgaactgctgcgcctcaccgccgactccgacgaacccgaaatcgccctgcgcgacggc cggttgcacgccccccggctgacccgcaccacccaggcaccggaccccgacgccaccccc tggcgcaccgacggcaccgtactgatcaccggcgggaccggcggcgtcggcgccacgctc gcccggcacctggtcaccgtgcacggcgtacgcggactgctgctcaccggccgccggggc gcggacgcccccggcgcccaggagctgcggtccgagctgaccgcactcggcgccgaggtc acgatcaccgcctgcgacgccgccgaccgcgacgcactggccggggtcctggccgccgta ccggagcggctgccgctgagcgcggtggtgcacgcggccggggtgctcgacgacgcactg gtcgactccctcgacgacacccgcctggacaccgtcctgcggcccaaggccgacggagcc tggaacctccacgagctcacccgtgacagcgacctgtcggcgttcgtcctgttctcctcc accgccaccctcctggacggtgcgggacagggcaactacgccgccgccaacgtcttcctc gacgccctggccacccaccgcgccgccctcggcctccccgcgacctcgctcgcctggggg ctgtggaccggcaccggcggcatgggcggcgccctcgacgaggccgcgctgcggcgcatc gagcgcctcggcctccagcccctgtccgtcgcggagaacctcgccctcctggaccgcgcg atcaccaccggggcgcacccggccgtcgtacccgtgcggctgaacctgcgcacgctcaac gcccgcgccgacgaggccccggccctcctgcgggccctggtccgtccgccgcgccgcgcc gtggggggcggcggggtgagcgtcgaacagtccctcgcgcgcagcctgggcggcctgacc cgcccggagcgcggcgaggccctcctcgatctggtccgtacccaggtggccgccgtcctc ggccacgacggacccgaacgcgtcgtcaccacaagggcgttcaacgagatgggcttcgac tccctcgcggccgtcgaactccgcaaccggctcggctccgccaccggactgccgctgacg gccacgctcgtcttcgactacccctcgcccgccgccctcgccgaccacctggcctcccgg ctcggcggcgacgcggaacagcgggccggacggcccgttccggccgccgccaccgtctcc gacgacgaccccgtcgccatcgtctccatggcctgccgctaccccggcggcgtgtcctcg cccgaggagctgtggcagctcgtcgaggagggacgcgacgtcgtctcggcgttccccacc gaccgcggctgggctgccgacatccacgacccggagcccggcgcgccgggcaagagcctc accgaccagggcggattcctccacgaggccgccgacttcgacgccgagttcttcggcatc agcccccgcgaggcccaggccatggacccccagcagcggctgctgctggagatcgcctgg gagaccgtcgagcgcgcgggcatcgacccgcacgccctgcgcggcagcgacaccggtgtg ttcgccggtgtgatgtaccacgactgggggctgcggctcggcccgctgcccgagcacgtg gcggggtaccacggcaacggcagcctcgccagcgtggtgtccggccgggtcgcctacacg ctcggcgtcgaaggccccgccgtcaccgtcgacaccgcctgctcgtcctccctggtcgcc ctgcactgggcggcccaggccctgcgccggggagactgcgcgctcgccctcgcgggcggc gtcaccgtcatgtccacccccgacaccttcgtcgacatgagccggcagcgcggcctggcc gccgacggacggtgcaagtcgttcggcagcggcgccgacggcaccggctggggcgagggc gtcggcatgctcctgctggagcggctctccgacgccgaacgcaacggccaccgcgtgctc ggcatcgtccggggctccgccgtcaactccgacggtgcctccaacggcctcacggcgccg aacggcccggcccaacagcgcgtcatccgccgtgcgttgagcgtcgccggcctcaccccc gccgacgtcgacgccgtcgagggccatggcaccggaaccgtcctgggcgacccgatcgag gcccaggcactgctggagacctacggccaggagcgccccgcggacggcagcccgctgctg ctcggctccatcaagtccaacatgggccacacccaggcggccgccggggtggcgggcatc atcaagatggtccaggcgatgcgccacggcaccctgcccgcgaccctgcacgccgacgag ccgtcaccccaggtggactgggactccggcgccgtcgccctgctgaccggccccaccgcc tggcccgcgcacggccgcccgcgccgcgcgggggtgtcgtcgttcggtatcagcggcacc aacgcccacgtgatcatcgaggagccgcccgccgccacgccgcaggacgcgcccgagccg gccgggaccacgtccggcccggccgcctggccgctgtcggcgaggaccccggacgcgctg agcgcccaggcggcgcgcctgctcagccacctcgcgaccgtccccgacgacgcgctcgcc gcgacgggccacgccctcgcgacgacccgcgccgccctggaccaccgcgccgtcgcactc ggagccgaccgtacggaactcatcgcgtccctggaggcgttggcctccggcgcggggccg gtgcgggacaccgtcagcgagggcaaggtcgcgttcctgttcacggggcagggtgcgcag cggctggggatgggccgggagctgtatgaggcgttcccggtgttcgctgaggcgttcgat gctgtgctggttgagctggatgcgcggctgggctgctcgttgcgtgaggtggtgtggggt gaggacgccgatgtcctgaacgggacgatgtttgcgcaggccgggttgttcgcggtggag acggcgttgttccggttggtggagtcgtggggggtgcgtgcggacttcctggtgggccac tcggtgggtgagatcgctgccgcgcacgtctcgggtgtgctgtcgctggcggacgcggcc gagctggtggtggcgcgtggccggttgatgcaggggttgcctgccggtgggtcgatggtg gcggtggaggcgacggaggccgaggtgcttccgctgctgaacggtgaggtggggatcgcg gcggtcaacgggccgcgttccgtggtcgtttcgggtacggaggcagcggtacgcgggctg gtcgcgatgttcgaggagcgcggccgcaggacgagtgtgttgcgggtgtcgcatgcgttc cattcgccgatgatggagccgatgctggcggagttcggtgcggtggtggccgggctggag ttcggtgccgcgtcgattccggtggtgtcgggtgtgtcgggtgatgtggctgagggctgg ggttcggccgcgtattgggtgcggcatgtgcgggaggcggtgcggttcgcggacgcggtc cggttcctggaggaccgtggcgtcagctcgtacatcgagatcggccccgacgccgtgctc agcggcatgggccagaactgtgtccaggacgcggacggggccgcgttcgtcccgtcgctg cgacggaaccggcccgaggtccgcgaactcctggccgccgtcgcccgtgcccacgcgcgc ggcgtcaccgtcgactgggacaccttcttcggtctgcgcggcatcggacagggcccggac ctgcccacctacgccttccagcaccagcgctactggctcgacctggccaccgcccccggc gatctggacgcggtcggcctcgaagccgtcagccaccccctgctcagcgccgccgtggcg acaccggacgacggcggtgtcgtcctcacgggacggctcgccaccggcacccagccatgg ctcgcggaccacggtgtgctgggcagcgtgctgctgccgggcaccggattcgtcgagctg gcgatccgggcgggcgaccacgtcggctgcggccggatcgaggaactcctcctcgaagca ccgctgacactgccggcccggtcaggcgtcgccctgcgcgtcgtcgtcggcgcaccggac ccctccggtgcctgctcggtcagcatccactcacgcggctccaccgaccccgacgccccg tggaccaggcacgcccacggcaccctgacccgcgaagcacccgcccccgccttcgacctg acccagtggccgccggccggcgccgccccggtcgacgtcgagtccgcctacgagcggctg cgcgagcgcggctacgcctacggccccgccttccagggcctgcgtgcggcctggcgacgc ggcgacgacgtgttcgccgaggtcgccctcgacggtcccgcccgcgtcgaggcaccggcc tacggactgcaccccgcgctcctcgacgcggcgatgcacgccgatctgctgacggatccg gccgccgacgcggcgaccctgctgcccttctcctggaacggcgtcaccctgcacgccgcc ggaaccccctcgctgcgcgtccacatccagcggatacgcggcgacgaggtgtccgccatc atggtcgccgacgagagcggtgcgccggtggcgaccgtggagtcactcgtctcccgcccg gtctcgccggagcagatcgcggcggcctcgggcgcgccgtccgcctccctccaccggatc ggctggcagcgcacggagccggccaccgcgacggcaggcgccacccccgcgtacaccgtc ctgcactgcccggcgtcgcccgggggcatggacgtcccggacgccgtgcgcgccctcacc caccacgtgctcggtgagatacgcgaccggctcgccgatcccgatgcgggtgaccgcacc ctcgtcgtggtcacccggcgcgccgtgcccgtacggcccggcgaggacgtggacccggtg caggcccccgtatggggcctggtgcgtgccgcgcaggccgagaacccgggccggttccaa ctggtcgacgtcgaggccgagtccgaggcgaccgacgcggccctctccgccgccgtcgcc tccgcggaacccgaatccgccctgcgcgagcgtgaggtgtgggtgcctaggctgggcccc gtcatcgcgcccgagcccacccggcccgccccgtgggacaccgggggcacggtgctgatc accggaggcaccagcggcctcggcgcactcgtcgcgcgtcacctcgtcaccgagcacgga atacggcatctcctcctggccggccggcgcggcatggacgcgcccggtgcgcaggcactc gccgccgaactcaccggcctcggcgcccaggtccagatcgccgcgtgcgacgtggccgac cgcgacgggctggccgccctgctcgccgggatcggcaccgaacacccgctgcgcgccgtc gtgcacgcggcggcggtcgccgacggcgggctggtcgccggcctcacgcccgagcggttc gacgccgtcctgcgccccaaggccgagggcgcctggcacctgcacgaactgacccgggac accgacctcaccgcgttcgtcatgttctcctcggcaggcggcctcgttctcgccgccggc caggccgactacgcggcggccaacgtcttcctggacgcgctcgccacccaccgtgtggcg gccggactgcccgcgacctccctcgcgttcggcatgtgggaggtcagcaccggcctcggc ggcgacctcaccgaagccgatctggaccggatgcgccggctcggcctgcccgccctcccc gccgacctgggcctggcgctcttcgacgccgccctcgtcgccggggacgccgtcgtcgtc cccctcaccatcgacacggcggcgctcgccgcccgcggcgacgaactgcccgcactgctg cgcggccgggtccgtacccccgcgcgccgcaccgtccgggcgaccgccaccggctccgcg ctggaacgccgcctggccggtgcgacccccgacgagcgggcccgcatcctgctcgacacg gtccgcacccaggtcgccgccgtcctcggccagccgtcgcccgaggcggtcggacccgac acggccttccgcgaccaggggttcgactccctcgccgccgtggaactgcgcaacctgctg gtcggctccacggggctgcgactgcccgcgacgctggtcttcgactaccccaactcccgt gccgtggccggtcatctcgacaccctgctcaccggcacgaccaccaccgctcccaccgcc gccccgctcgcggccgtcgacgacgacccgatcgcggtggtggccatcagctgccgcttc cccggcggcgtccgctcacccgaggacctgtgggacctcgtcgcggccggcaccgacgcc atcggcgacttccccgcagaccgtggctgggacgccgacgccctctacgaccccgaaccg ggactccccggccgcacctacgtgcgtgaaggcggattcctctacgacgcggccgagttc gacccggagttcttcggcatcatgccgcgcgaggccctcgcgatggacccgcagcaacgg ctgctgctccagtccgcgtgggaggccttcgagcgcgccggaatcgacccggagacactg cgcggcagccagaccggtgtgtacgccggtgtgatgtaccacgagtacggcagccgggtc accgacgtccccgacgacctggccggctacctcggcaacggcagcgcgggcagcatcgcc tccggccgcgtcgcctacgcgctgggcctcgaagggcccgccgtcaccgtcgacaccgcc tgctcctcctccctggtcagtctccacatggcctgccaggcgctgcgcaccggcgagatc gacctcgccctggcgggcggtgtcaccgtcatgccgaccccggagatcttcgtcgacttc agccggcagcgcggtctcgccgccgacggacgctccaaggcgttcgccggcgccgccgac ggcacgagctgggccgagggcgtcggactcctgctggtggagcgcctctccgacgcccgc cgcaacgggcaccccgtcctcgcggtggtccggggcagcgccatcaaccaggacggcgcc tccaacggcctgaccgcccccaacggcccctcccagcagcgcgtcatccgcaaggccctg tcggccgccggactcaccccggccgaggtggacgcggtggagggacacggcaccggtacc cgtctcggcgacccgatcgaggcacaggccctgctcgccacgtacggccaggaccgcccc gccgaccgcccgctgtggctcggctcggtcaagtcgaacatcgggcacgcccaggccgcc gccggcgtcagcggagtcatcaagatggtgatggccctgcgcaacgggctgctgccccgg accctgcacgtcgacgagccgtcacctcaggtggactgggcggccggcggcgtacgactg ctgaccgagccggtcacctgggcagcacaggaccggccccggcgggcgggggtctcctcg ttcgggctcagcggcaccaacgcccacgtcatcatcgaggaagcaccccagatcgaggaa gcaccccagatcggggaagcactcctggacgacgccgcgcccgccgaaccgctgaccgtc gtaccgcttgcgctgtccgcgcgcagtgccacggccctcaccgcgcaggcggggcgcctc ctggcccatgtggaggcgcacccggacgagtcgctggtggacgtcggccgctcgttggcc acgacgcgggccgtgctggatctccgtgcggtggtgatgtccgcggaccgtgacgcggcg gtgcgcgcgctgtccgatctggcggcgggccgggagagcgcggacgtggtcacgcgggcc ggctcctccgtcgagggtctgacggccttcctcttcacggggcagggcgcgcagcggctg gggatgggccgggagctgtacggcacgttccccgtgttcgcggaggcgttcgacgctgtg ctggtcgagctggacgcgcggctggggcgatcgctgcgtgaggtggtgtggggtgaggac gccgctctgctgaacgggacgatgttcgcgcaggccgggttgttcgccgtcgagacggct ctgttccggctggtggagtcgtggggcgtccgggccgatgtggtggcggggcattcgatc ggtgagatcaccgcggcgcacgtcgccggcgtgctgccgctgacggacgcggccgaactg gtcgcggcacgcggccggttgatgcaggcgctgccggccggtggggtgatggtggcggtg gccgcgccggaggcggacgtgctgccgctgctgacggacgaggtgggactggcggccgtg aacggtccgtcgtccgtggtgatctcgggggcgcgggaggcgacgctcgcggtggcggag cacttcgccgcgctgggacggcgcaccaagcggctgagcgtgtcgcacgccttccactcg ccgctcatggagcccatgctcgacgcgttccggaaggtcgccgagaaactcacctacacc gcccccacgctgcgcgtcgtgtcccatgtgaccgggaccgaagcgaccgccgaacagctc acctcgcccgagtactgggtccgccatgtgcgcgaggccgtccggttcgccgacggcatc gcccacctctgcggccagggcgtcacccgcttcgtggaactcgggcccgacgcggtgctc accgcactcaccgaggccaccgcacaccacacccccgacaccctcaccgtgcccgccctg cgcaagggccgccccgaggtcgccaccctgctcgccgccgttgcccggctgcacgtcgcc ggccccgtcgtccgctgggccgacgtcctcgacggccgcggcggccgcacggtcgaactg cccacgtacgccttcgaccggaccacgtactggctggacgcccccgcccccctcggcggc gatgtgaccggcctcggccagagggccgccgcgcacccgctgctcagcgccgtggtcgcc tccccggaggccggcggcgtggtgctcaccggccgcctctccgtgcgcacccacccctgg ctcgccgaccacgacgtcctggggaccgtgctgctgcccggcaccggctacatcgaactg gccatccgcgccggtgaggaagtcggctgcgaggtggtggaggaactcaccatcgaggca ctgatgccgctcccgccccacggcggactcgccgtccaggtcgtcgtcgacgcacccgac gcgggcgggcgctgctcactcgccgtctactcccgcgccgacgacgccccggcgggcgca ccctggagcaagcacgccagcggtgtgctcgccccgggaagcggacaggccccgcccgcc ggcaccttcgcccccgacccggccgactggccgcccacgggtgcgaccgaggtcgacatc tccggtgtgtacgactacctcaccggccagggctacggctacggccccatgttccggggc ctgcgcggcatctggtcccggggcggggagaccttcgcggaggtgtccctgcccgaggac tccctggacgtcggcaaggacttccgcctccacccgtccatcctcgacgcggcgctcagc gcgaccgacttcatggacggccgccgcccccaggacgtcggcggcacccagctgccgttc gcctggtccggcgtcaccctgcacgccgccggctcctcccggctgcgggtccgcatcacc gccgtcgaatcccaccggtcacagggatcggacgcggtacgcctcgaactcaccgacccc gcgggcaccccggtcgccaccatcgactccctcgtggtccgccccgtcaccgcggccaag gtcaacgcggccgccgccgcgggcggcggtgagcacgaggccgtgttccagctggtcacc cagcaactgcccctcggcgcggccgtcgccgccgccacggaccgctgggcggtgctcggc gcaggccccgacggcacccccgccggacccggcaccgcctaccgggacctccccgccctc ggcgccgcgctgaccgacggcgcccccgtacccgatgtcgtcgtcctgcccgtaccgccc gccacggaccacgacgacatcccggcggccgtccgctccatgaccggacagcttctcgcc acgctgcagtcctggctcgcggacgagcggtacgcccactcccgcctcatggtggtcacc cgtaacgccctccccatcgaggagagcgacgccgccgccgtggacctcgtccacgcaccg gcatggggcctgctgcgctccgcccaggaggagtaccccggccggttcgtcctcgtcgac tccgacggcacggccacggcccgcgagtcgctgcccgccgtggccgcgtccggtgaaccc gaggcgatcctgcgcggcgccgaggtacgggtgccccgactggcccgggtggcagcggca gcgcccaccaagcccctgccctgggacgccgaggggaccgtactgatcaccggggggacc agcgggctcggcgccgtcgtcgcccgccacctggtggaacagcacggcgtacgccacctc ctgctcgccggacggcgcggtcaggacgcacccggcgccaccgaactccgcgacgcgctg cacggactcggcgcccgcgtcaccctcgcggcctgcgacacctccgaccgggcggccgtc gacggactgctgaccgcgataccggccgcgcacccgctgacggcggtggtccacgcggcc gcggtcatggacaacgcgctgctcgccgccctcacccccgcccaggtcgacacggtgatg cgccccaaggtggacgccgcctggaacctgcacgaggcgacccgcggcctggacctgaag gcgttcatcctcttctcctcctgcgccggactggtcgtcggcgtcggccagggcaactac gccgccgccaaccgcttcctggacgccctctccgcccaccgccgggccgccggactcccc ggtacggcgctggcgttcgggctctgggagaccaagacgggcctcgggggcggagtcacc cacgccgacctgcggcgcatgcgcaccatgggcatgccggccctgccgaccgccgagggc ctcgcccttctcgacgaagccctggaactcgaccggccggtgctcgtaccgatccgggtg gagcgcgatcaccacgccacgggcgaaccgccgcacctgctcaaggacgtgctcggcgcg ccggaacggcccgccgcccgcaaggaggttcgagcacccgccgtcgcaccggtagccgcc cccgccacccaacagaccctggaacagcggctgtccggcatgaaggcggccgaacgcaaa cgcaccgtgctggacgtcgtgcgcgagcaggtcgccggagtcagccacagcgtcccggcc accatcgacgtctccaagggcttcaccgagctcggcctcgactcgctcgccgcgatcgat ctccgcaaccggctccagaaggccaccggcctccggctcccggcgacactcatgttcgac taccccagcccgatggtgctggccgacttcctcctcgacgaactcccgccgggcatcgac gagaacacgccggacgcctccgccggatccgcacccgcacagaacgggccggggaccgcg gagaccgacgccgccatccggcagaccctcgcggacatcccgattgccgcgctccgggag tccggcctgctggacgcactgctgaggctcgccccccgacccgcggtacccgccaccgaa tcccgcacgagcgcccagccgggcgaggccgcacaggccggcgaagcgatcaggaccatg gacatcgacgacctggtgcgcgccgcgctcgcgtccaccgacccgacccggaacccgagc gagggctga

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