Streptomyces laculatispora: P8A22_28810
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Entry
P8A22_28810 CDS
T09657
Symbol
murF
Name
(GenBank) UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
slai
Streptomyces laculatispora
Pathway
slai00300
Lysine biosynthesis
slai00550
Peptidoglycan biosynthesis
slai01100
Metabolic pathways
slai01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
slai00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
P8A22_28810 (murF)
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
P8A22_28810 (murF)
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
P8A22_28810 (murF)
Enzymes [BR:
slai01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
P8A22_28810 (murF)
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Mur_ligase
PGM1_C_vert_fung
Motif
Other DBs
NCBI-ProteinID:
WLQ43572
LinkDB
All DBs
Position
6493246..6494652
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AA seq
468 aa
AA seq
DB search
MIALSLAEIAEIVGGQSYDIPDQAVTVSGPVVIDSREVKQGSLFVAFAGERVDGHDYAQR
AVEAGAAVVLAVRPVGVPAIVVDDVVAALGALARAVVGRLGTTVVALTGSAGKTSTKDLI
AQLLERKGPTVYPAGNLNNEIGLPLTALRATDETRHLVLEMGARYIGDICYLTGLVPPRI
GLVLNVGTAHIGEFGGREQIAQAKGEMVESLPADGLAVLNADDPLVRAMTSRTKARVLLF
GEAADADVRGENVRLTDDGRPAFRLHTPTGCSDVTMRLYGEHHVSNALAAAAVAHELGLS
ADEIAEALSEAGTLSRWRMEVTERPDGVTFVNDAYNANPESMRAALRALAAMGKGRRTWA
VLGQMAELGDASLTEHDAVGRLAVRLNVSKLVAVGGREASWLQLGAYNEGSWGEESVHVS
DAQAAVDLLRSELRPGDVVLVKASRSVGLEQVAMALLDNATEGEVAGR
NT seq
1407 nt
NT seq
+upstream
nt +downstream
nt
gtgatcgccctttccctcgccgagatcgccgaaatcgtcggcgggcagtcgtacgacata
ccggatcaggcagtaaccgtcagcgggccagtcgtcatcgactcccgggaggtgaagcaa
ggcagcctcttcgtcgccttcgccggcgaacgggtcgacggccacgactacgcgcagcgc
gcggtcgaggcgggcgcggcagtcgtcctggccgtccgccccgtcggcgttcccgcgatc
gtcgtggacgacgtggtggcggcgctcggcgcgctcgcccgcgccgtcgtcgggcgcctc
ggcaccaccgtggtcgccctcaccgggtccgccggcaagacctccaccaaggacctgatc
gcccagctcctggagcgcaagggccccaccgtctacccggcgggcaacctcaacaacgag
atcggactgccgctcaccgcgctgcgcgccaccgatgagacccggcacctggtcctcgaa
atgggtgcccgctacatcggcgacatctgttacctcaccggcctcgtcccgccccggatc
ggcctcgtcctgaacgtcggcaccgcccacatcggcgagttcggcggtcgcgagcagatc
gcacaggccaagggcgagatggtcgagtcgctgcccgcggacggcctcgccgtactcaac
gccgacgacccgctcgtccgcgccatgacctcccgcaccaaggcccgcgtcctgctcttc
ggtgaagccgcggatgcggacgtacggggagagaacgtgcggctcaccgacgacggccgc
cccgcgttccgcctccacacacccaccgggtgcagcgatgtgaccatgcgcctgtacggt
gagcaccacgtgtcgaacgcgctcgccgcggccgccgtcgcccatgagttgggcctgtcc
gcagacgagatcgccgaggcgctctccgaggcgggcaccctctcccgctggcgcatggag
gtcaccgagcgtccggacggcgtgacgttcgtcaatgacgcctacaacgccaaccccgaa
tccatgagagccgcgctgcgcgcgctggccgccatggggaaggggcgtcgtacgtgggca
gtgctcggccagatggccgagctcggcgacgcctcgctcaccgagcacgacgcggtcgga
cggctcgccgtccggctcaacgtcagcaagctcgtcgcggtcgggggcagagaagcctcc
tggctgcaactgggcgcatacaacgagggttcgtggggtgaggagtcggtgcatgtgtcc
gacgcacaggctgccgtcgacctgttgcgcagtgaactgcgcccgggagacgtcgtgctg
gtgaaggcgtcccggtcggtcggcctggagcaggttgccatggcactgctggataacgcg
accgagggcgaggtcgccggccgatga
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