Streptomyces leeuwenhoekii: sle_31470
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Entry
sle_31470 CDS
T04414
Symbol
sle_31470
Name
(GenBank) Porphyrin biosynthesis protein hemD
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
sle
Streptomyces leeuwenhoekii
Pathway
sle00860
Porphyrin metabolism
sle01100
Metabolic pathways
sle01110
Biosynthesis of secondary metabolites
sle01120
Microbial metabolism in diverse environments
sle01240
Biosynthesis of cofactors
Module
sle_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
sle_M00924
Cobalamin biosynthesis, anaerobic, uroporphyrinogen III => sirohydrochlorin => cobyrinate a,c-diamide
sle_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
sle00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
sle_31470 (sle_31470)
Enzymes [BR:
sle01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
sle_31470 (sle_31470)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
sle_31470 (sle_31470)
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GFIT
Motif
Pfam:
HEM4
TP_methylase
BiPBP_C
Motif
Other DBs
NCBI-ProteinID:
CQR62608
UniProt:
A0A0F7VVW9
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Position
chromosome:complement(3749522..3751252)
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AA seq
576 aa
AA seq
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MSPTTLPAGPEHGHVTFLGAGPGDPGLLTLRAVEALANADVLVAEHEVLDVVREHARQGV
AEVHTDADPSAEPAGSSSGPHPGTGTPQLTVVDGTSTTAGVPAVRDAAHLVMEAARGGRR
VVRAVSGDPGLDADAAEEMLACAAAGVPFEVVPGIATAVGVPAYAGVPLRDAEGADVRFV
DARTASDRCWTEVGASDGTVVVSTTLDSVAVAAGELVAAGRKPDTPLTVTVAGTTTRQRT
WTATLGTIAQTLKQAKVLPSPEGGRPVIAVVGERGAAARREKLSWFESKPLFGWKVLVPR
TKEQAASLSDQLRSYGAVPHEVPTIAVEPPRTPQQMERAVKGLVTGRYEWIAFTSVNAVK
AVREKFEEYGLDARAFAGIKVAAVGEQTAKALVAFGVKPDLVPSGEQSAAGLLEDWPPYD
PVFDPIDRVFLPRADIATETLVAGLIELGWEVDDVTAYRTVRASPPPAETREAIKGGGFD
AVLFTSSSTVRNLVGIAGKPHNVTVIACIGPATAKTAEEHGLRVDVMAPEPSVHKLAEAL
ADFGMKRRLAAIEAGDPVTRPSERRPGARRRRSTTT
NT seq
1731 nt
NT seq
+upstream
nt +downstream
nt
ttgagccccaccacccttcccgccggtccggaacacgggcacgtcaccttcctgggtgcc
ggacccggagatccgggactgctgaccctgcgcgctgtggaggcgctggcgaacgcggac
gtcctcgtcgccgagcacgaggtgctcgacgtcgtccgcgagcacgccaggcagggcgtc
gccgaagtgcacacggacgccgatccttcggcggaaccggccggctcttcctccggaccg
catccgggcacaggcacgcctcagctgacggtagttgacggcacgtcaaccaccgcggga
gttcccgctgtgcgggatgccgcacatcttgtcatggaggccgcacggggcggcaggcgg
gtcgtccgtgcggtgtccggggaccccggactcgacgcggacgccgccgaggagatgctg
gcctgcgccgccgccggggtgcctttcgaggtcgtcccgggcatcgcgacggccgtcggc
gtgccggcgtacgccggtgtgccgctgcgcgacgccgagggcgccgacgtgcggttcgtg
gacgcccgtaccgcctccgaccgctgctggacggaggtgggcgcctccgacggcacggtc
gtggtctccacgacgctcgactcggtcgccgtggcggccggtgagctggtggcggcgggc
cgcaagccggacaccccgctgaccgtgaccgtcgccggtacgaccacccggcagcggacc
tggaccgccacgctcggcaccatcgcgcagacgctgaagcaggccaaggtgctgccgtcg
ccggagggcggccgcccggtgatagccgtggtcggtgagcgtggtgccgccgcccggcgc
gagaagctgtcgtggttcgagtccaagccgctgttcggctggaaggtgctcgtgccgcgc
acgaaggagcaggcggcctcgctctccgaccagttgcggtcctacggggccgtgccgcac
gaggtgccgacgatcgccgtcgagccgccgcgcaccccgcagcagatggagcgcgcggtc
aagggcctggtgaccggccggtacgagtggatcgcgttcacctcggtcaacgcggtcaag
gccgtacgggagaagttcgaggagtacgggctggacgcccgtgccttcgcgggcatcaag
gtcgccgcggtcggtgagcagaccgcgaaggcgctggtcgccttcggtgtgaagccggat
ctggtgccgagcggggagcagtccgcggccggtctgctggaggactggccgccgtacgac
ccggtgttcgacccgatcgacagggtcttcctgccgcgcgccgacatcgccaccgagacg
ctcgtcgccgggctgatcgagctgggctgggaggtcgacgacgtcaccgcctaccggacg
gtgcgcgcctcgccgccgcccgccgagacgcgggaggcgatcaagggcggtggtttcgac
gcggtgctgttcacgtcgtcgtccaccgtgcggaacctcgtcggcatcgcgggcaagccg
cacaacgtgacggtgatcgcctgcatcggcccggccaccgccaagacggcggaggagcac
ggactgcgcgtcgacgtcatggcacccgagccgtccgtgcacaagctggccgaggcgctg
gccgacttcggcatgaagcggcggctggcggccatcgaggccggcgacccggtgacgcgg
ccgagcgagcggcggccgggcgcgcgcaggcggcggtcgacgacgacatga
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