Serratia liquefaciens: M495_02775
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Entry
M495_02775 CDS
T02740
Symbol
thrA
Name
(GenBank) bifunctional aspartokinase I/homoserine dehydrogenase I
KO
K12524
bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:
2.7.2.4
1.1.1.3
]
Organism
slq
Serratia liquefaciens
Pathway
slq00260
Glycine, serine and threonine metabolism
slq00261
Monobactam biosynthesis
slq00270
Cysteine and methionine metabolism
slq00300
Lysine biosynthesis
slq01100
Metabolic pathways
slq01110
Biosynthesis of secondary metabolites
slq01120
Microbial metabolism in diverse environments
slq01230
Biosynthesis of amino acids
Module
slq_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
slq_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
slq_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
slq00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
M495_02775 (thrA)
00270 Cysteine and methionine metabolism
M495_02775 (thrA)
00300 Lysine biosynthesis
M495_02775 (thrA)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
M495_02775 (thrA)
Enzymes [BR:
slq01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
M495_02775 (thrA)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
M495_02775 (thrA)
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Motif
Pfam:
Homoserine_dh
AA_kinase
ACT_9
NAD_binding_3
ACT_7
ACT
DUF8747
Motif
Other DBs
NCBI-ProteinID:
AGQ29395
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All DBs
Position
590166..592619
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AA seq
817 aa
AA seq
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MLKFGGTSVANAERFLRVADIMESNARQGQVATVLSAPAKITNHLVAMIEKTVAGQDILP
NMSDAERIFADLLSGLAQALPGFEYDRLKTFVDQEFAQLKQVLHGVALLGQCPDSVNAAI
ICRGEKLSIAIMEGVFRAKGFPVTVINPVEKLLAQGHYLESTVDIAESTLRIAASAIPAD
HIVLMAGFTAGNDKGELVALGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRTVPD
ARLLKSMSYQEAMELSYFGASVLHPRTIAPIAQFQIPCLIKNTANPQAPGTLIGGENLDS
DTPVKGITNLNNMAMINVSGPGMKGMVGMAARVFAVMSRAGISVVLITQSSSEYSISFCV
PQSELQRARRALEDEFYLELKDGLLEPLDVMEQLAIISVVGDGMRTLRGISASFFSALAR
ANINIVAIAQGSSERSISVVVSNDSATTGVRVCHQMLFNTDQVIEVFVIGVGGVGGALIE
QIYRQQPWLKQKHIDLRVCGIANSRAMLTNIHGIQLESWRDELAGAQEPFNLGRLIRLVK
EYHLLNPVIVDCTSSQAVADQYADFLADGFHVVTPNKKANTSSMNYYQQLRTAAAGSRRK
FLYDTNVGAGLPVIENLQNLLNAGDELTRFSGILSGSLSFIFGKLDEGMSLSAATLEAKA
KGYTEPDPRDDLSGMDVARKLLILAREAGYKLELEDIEVESALPPSFDASGDVETFMARL
PELDKEYARNVANAAEQGKVLRYVGVIENGRCQVRIDAVDGNDPLYKVKNGENALAFYSR
YYQPLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV
NT seq
2454 nt
NT seq
+upstream
nt +downstream
nt
gtgctgaaatttggcggaacctcggtagcgaatgcagaacgttttctgcgcgttgccgac
atcatggaaagtaatgcacgtcagggacaggtggccacggtcttgtccgctccggctaaa
atcactaaccacctggtggcgatgattgaaaaaacggtagcggggcaagacattctgcca
aatatgagcgatgcagagcgcatcttcgccgacctgctgagcgggctggcgcaggcgttg
cccggctttgagtacgatcgcctcaagacgtttgtcgatcaggagttcgcccagctcaag
caggtgctgcatggcgttgcgttgcttggacagtgcccggacagcgtgaatgcggccatc
atctgccgcggcgagaagctctccatcgccatcatggaaggggtgtttcgtgccaaaggt
ttcccggtcacggtgattaatccggttgaaaagctgctggcacaggggcattacctggag
tccacggtagatatcgcagaatccacattgcgtatcgccgcatcggccatcccggcggat
cacattgtgctgatggccggtttcaccgccggcaacgacaagggcgaattggtggcgctg
ggccgtaatggttccgactactctgccgcggtgctggctgcctgtttgcgcgccgactgt
tgcgagatctggaccgatgttgacggtgtttatacctgtgacccacgcaccgtgccggat
gccaggctgttgaaatcgatgtcgtaccaggaagccatggagctttcctatttcggtgcc
agcgttctccacccccgtaccattgctcccatcgcccagttccaaatcccctgcctgatc
aaaaacaccgctaatccacaggcgccaggcacgctgattggcggcgaaaatctggattcc
gatacgccggtgaagggcatcaccaacctgaacaatatggcgatgatcaacgtctccggt
ccggggatgaaaggcatggtcggcatggcggcgcgggtatttgccgtaatgtcgcgcgcc
ggcatctctgtggtgctgatcacccagtcgtcctccgaatacagcatcagtttctgcgtg
ccgcagagcgaactgcaacgtgcgcgtcgtgcgctggaagacgagttctatcttgaattg
aaagacggcctgctggagccgctggacgtaatggaacagttggcgatcatctcggtggtc
ggcgacggcatgcgtaccctgcgcggcatttcggccagcttcttttctgcgctggctcgc
gccaatatcaacattgtcgctattgctcagggctcttctgaacgctccatctcggtggtg
gtcagcaatgattccgcgaccaccggggtgcgcgtttgccatcagatgttgttcaacacc
gatcaggtgattgaagtgtttgtcatcggcgttggtggcgtgggcggcgcgttgatcgag
cagatttaccgtcagcaaccttggctgaaacaaaagcatatcgatctgcgggtgtgcggc
attgccaattcgcgcgccatgttgaccaacattcacggcattcagcttgaaagctggcgt
gatgagctggccggcgcgcaagagccgttcaacctggggcgtttgattcgtttggtgaag
gagtaccacctgctgaacccggtgattgtcgactgcacctctagccaggccgttgccgat
caatacgcggacttcctggcggatggattccacgtggtgacgccgaataaaaaggccaac
acctcgtcgatgaactactaccaacagttgcgcaccgccgcggccggttcgcgccgcaag
tttctgtatgacaccaacgtcggcgcgggcttgccggtgatcgaaaacctgcaaaacctg
cttaacgccggtgatgagctgacgcgtttctccggcatcctgtccggttcgctgtcgttt
attttcggcaaactggacgagggcatgtcgctgtcggcggcgacccttgaggccaaggcc
aaaggatataccgagccggatccacgtgacgacctttccggtatggacgtggcccgcaag
ctgctgatcctggcccgtgaagcggggtacaaactggaactggaagatattgaggtcgag
tcggcgctgccgccttcctttgacgcctccggggatgtggaaacctttatggcgcgcctg
ccggaactggataaagagtatgctcgcaatgtggccaacgccgctgagcagggcaaggtg
ctgcgctacgtcggcgtcattgaaaatggccgctgtcaggttcgcatagatgcggtagat
ggcaacgatccgttgtataaagtgaagaacggcgagaacgccttggctttctacagccgt
tactatcagccgttgccgttggtactgcgtggctacggtgccggtaacgatgtgactgca
gcaggggtcttcgccgatctgttgcgcacactgtcatggaagttgggagtttaa
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