Streptomyces luomodiensis: PS467_12185
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Entry
PS467_12185 CDS
T10277
Name
(GenBank) UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
sluo Streptomyces luomodiensis
Pathway
sluo00300
Lysine biosynthesis
sluo00550
Peptidoglycan biosynthesis
sluo01100
Metabolic pathways
sluo01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
sluo00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
PS467_12185
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
PS467_12185
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
PS467_12185
Enzymes [BR:
sluo01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
PS467_12185
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Gene cluster
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Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Mur_ligase
DUF2126
Motif
Other DBs
NCBI-ProteinID:
WNE96038
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Position
complement(2833872..2835302)
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AA seq
476 aa
AA seq
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MIALSLTEIAGLVGGQPHDIPDPDLKVTGPVVIDSREVRPGSLFAALPGERVDGHDFARG
AVEAGATAVLAARPVGTADAPVPAIVVPDVIAAMGALARAVVERLGVTVVALTGSAGKTS
TKDLIAQLLQRRGPTVWTPGSLNNEIGLPLTAMSADEATQHLVLEMGARGKGHIRYLTDL
TPPRIGLVLNVGTAHIGEFGGREQIAEAKGELVEALPAAEDGGVAVLNADDPLVRAMASR
TKARTVLFGEAEDADVRAGNVRLADGGRPAFTLHTPTGCSDVTMRLYGEHHVSNALAAAA
VAHELGMSVDEIAVALSEAGQLSRWRMEVTERSDGVTVVNDAYNANPESMRAALRALVAM
GAATPGRRTWAVLGPMAELGEESLAEHDAVGRLAVRLNVSKLVAVGGREAGWLNMGAKNE
GSWGEESVHVSDVRAAVDLLRSELRPGDVVLVKASRSVGLERVAQALLEGKGEGVR
NT seq
1431 nt
NT seq
+upstream
nt +downstream
nt
gtgatcgcactgtccctcaccgagatcgccggcctagtcggtggacagccgcacgacata
ccggacccggacctgaaggtcacgggccctgtcgtgatcgactcccgcgaggtgcggccc
ggcagcctcttcgccgcgctccccggggagcgcgtggacggccacgacttcgcgcggggc
gcggtcgaggccggcgccacggcggttctggccgcccgtcccgtcggcaccgcagacgct
cccgtaccggcgatcgtcgtgcccgatgtcatcgccgccatgggggcgctcgcgcgcgcc
gtcgtggagcggctgggcgtcaccgtggtcgcgctcaccggctccgcgggcaagaccagc
accaaggacctcatcgcccagctgctccagcgccgcggcccgaccgtatggacgccgggc
tcgctgaacaacgagatcggtctgccgctcaccgcgatgagcgccgacgaggccacccag
cacctggtgctggagatgggtgcccgcggtaagggccacatccggtatctgacggacctc
accccgccccgtatcggactcgtgctcaacgtcggcaccgcccatatcggggagttcggc
ggccgggagcagatcgccgaggccaagggcgaactggtggaggcgctgccggcggccgag
gacggcggggtggcggtgctcaacgccgacgaccccttggtgcgcgccatggcgtcgcgc
accaaggcccgtaccgtcctgttcggcgaggccgaggacgccgatgtgcgtgccgggaat
gtccggctcgccgacggcggccggcccgccttcacgcttcacacccctaccgggtgcagc
gacgtgaccatgcgcctgtacggtgagcaccacgtgtcgaacgcgctcgccgcggccgcc
gtcgcccatgagttgggcatgtccgtcgacgagatcgccgtggcgctctccgaggcgggg
cagctctcccgctggcggatggaggtcaccgagcgctcggacggcgtgacggtcgtcaac
gacgcctacaacgcgaaccccgagtccatgcgagctgcgctgcgcgcgctggtcgccatg
ggcgctgctacaccggggcgtcgcacgtgggcggtgctcggcccgatggccgagctgggc
gaggagtcactggccgagcacgacgcggtcgggcggctggccgtccggctcaacgtcagc
aagctcgtggcggtcggcggccgggaggccggctggctgaacatgggcgccaagaacgag
ggttcgtggggtgaggagtcggtgcacgtgtccgacgtgcgggcagcggtcgatctgctg
cgcagcgagctgcgaccgggggacgtcgtgttggtgaaggcttccaggtcggtggggctg
gagcgggtcgcgcaggcgctgctcgagggcaagggtgagggcgtccgctga
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