Streptomyces avermitilis: SAVERM_2918
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Entry
SAVERM_2918 CDS
T00126
Symbol
thrA
Name
(GenBank) putative homoserine dehydrogenase
KO
K00003
homoserine dehydrogenase [EC:
1.1.1.3
]
Organism
sma
Streptomyces avermitilis
Pathway
sma00260
Glycine, serine and threonine metabolism
sma00270
Cysteine and methionine metabolism
sma00300
Lysine biosynthesis
sma01100
Metabolic pathways
sma01110
Biosynthesis of secondary metabolites
sma01120
Microbial metabolism in diverse environments
sma01230
Biosynthesis of amino acids
Module
sma_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
sma00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
SAVERM_2918 (thrA)
00270 Cysteine and methionine metabolism
SAVERM_2918 (thrA)
00300 Lysine biosynthesis
SAVERM_2918 (thrA)
Enzymes [BR:
sma01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
SAVERM_2918 (thrA)
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Gene cluster
GFIT
Motif
Pfam:
Homoserine_dh
NAD_binding_3
ACT
ACT_AHAS_ss
ACT_4
Sacchrp_dh_NADP
ACT_6
Semialdhyde_dh
DUF1611_N
TTHA0829-like_ACT
DUF4684
DUF7217
ACT_9
Usp
Motif
Other DBs
NCBI-ProteinID:
BAC70629
UniProt:
Q82J64
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Position
complement(3651141..3652430)
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AA seq
429 aa
AA seq
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MRTRPLKVALLGCGVVGSEVARIMTTHADDLAARIGAPVELAGVAVRRPSKVREGIDPAL
VTTDATALVKRGDIDVVVEVIGGIEPARALITTAFEHGASVVSANKALLAQDGAALHAVA
EEHGRDLYYEAAVAGAIPLIRPLRESLAGDKVNRVLGIVNGTTNFILDKMDSTGAGYQEA
LDEATALGYAEADPTADVEGFDAAAKAAILAGIAFHTRVRLDDVYREGMAEVTAADFASA
KNMGCTIKLLAICERAADGGSVTARVHPAMIPLTHPLASVRGAYNAVFVESDASGQLMFY
GPGAGGSPTASAVLGDLVAVCRNKLSGTTGPGESAYAALPVSPMGEVVTRYHISLDVADK
PGVLAQVATVFAEHGVSIDTVRQQGKDGEASLVVVTHRASDASLSGTVEALRSLDTVRGV
ASIMRVEGE
NT seq
1290 nt
NT seq
+upstream
nt +downstream
nt
atgcgtacgcgtccgctgaaggtggcgctgctgggctgtggggttgtcggctcagaggtg
gcgcgcatcatgacgacgcacgccgacgatctcgccgccaggatcggggccccggtggaa
ctcgcgggcgtggccgtccgccggccctccaaggtgcgtgagggcatcgaccccgcactg
gtcaccaccgacgccaccgccctcgtcaaacggggcgacatcgacgtcgtcgtcgaggtc
atcggcggtatcgagcccgcccgtgccctgatcaccacggccttcgagcacggcgcgtcc
gtcgtctccgccaacaaggcgctcctcgcccaggacggcgccgccctgcacgccgtcgcc
gaggagcacggccgcgacctctactacgaggccgccgtcgccggtgccatcccgctgatc
cggccgctgcgcgagtccctcgccggcgacaaggtcaaccgtgtgctcggcatcgtcaac
ggcaccaccaacttcatcctcgacaagatggactcgacgggcgccggctaccaggaagcc
ctcgacgaggccaccgcgctcgggtacgccgaggccgacccgaccgccgacgtcgagggg
ttcgacgccgccgccaaggccgccatcctcgccggaatcgccttccacacgcgcgtgcgt
ctcgacgacgtctaccgcgagggcatggccgaggtcaccgccgccgacttcgcctcggcg
aagaacatgggctgcaccatcaagctgctcgccatctgtgagcgggccgcggacgggggt
tccgtcaccgcgcgcgtgcaccccgcgatgattccgctcacccacccgctcgcctccgtg
cgcggcgcgtacaacgccgtcttcgtcgagtcggacgcgtccgggcagctcatgttctac
gggccgggtgcgggcggctcgccgaccgcctccgccgtgctcggcgacctggtcgccgtg
tgtcgcaacaagctcagcggcacgaccgggcccggcgagtccgcgtacgccgccctgccc
gtgtcgcccatgggcgaggtcgtcacgcgctaccacatcagccttgacgtggccgacaaa
ccgggtgttctcgcccaggttgccaccgtcttcgccgagcacggggtgtcgatcgatacc
gtgcgtcagcagggcaaggacggcgaggcctccctcgtcgtcgtcacccaccgtgcgtcc
gacgcgtccctgagcgggaccgtcgaggcactgcgcagcctcgacaccgtgcggggtgtc
gccagcatcatgcgggttgaaggagagtaa
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