Serratia marcescens SM39: SM39_0002
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Entry
SM39_0002 CDS
T03592
Symbol
thrA
Name
(GenBank) fused aspartokinase I and homoserine dehydrogenase I
KO
K12524
bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:
2.7.2.4
1.1.1.3
]
Organism
smar
Serratia marcescens SM39
Pathway
smar00260
Glycine, serine and threonine metabolism
smar00261
Monobactam biosynthesis
smar00270
Cysteine and methionine metabolism
smar00300
Lysine biosynthesis
smar01100
Metabolic pathways
smar01110
Biosynthesis of secondary metabolites
smar01120
Microbial metabolism in diverse environments
smar01230
Biosynthesis of amino acids
Module
smar_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
smar_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
smar_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
smar00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
SM39_0002 (thrA)
00270 Cysteine and methionine metabolism
SM39_0002 (thrA)
00300 Lysine biosynthesis
SM39_0002 (thrA)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
SM39_0002 (thrA)
Enzymes [BR:
smar01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
SM39_0002 (thrA)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
SM39_0002 (thrA)
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Motif
Pfam:
Homoserine_dh
AA_kinase
ACT_9
NAD_binding_3
ACT_7
ACT
Motif
Other DBs
NCBI-ProteinID:
BAO32073
UniProt:
A0AAT9ES55
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All DBs
Position
357..2816
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AA seq
819 aa
AA seq
DB search
MRVLKFGGTSVANAERFLRVADIMESNARQGQVATVLSAPAKITNHLVAMIDKTVAGQDI
LPNISDAERIFADLLSGLAQALPGFEYDRLKSVVDQEFAQLKQVLHGVSLLGQCPDSVNA
AIICRGEKLSIAIMEGVFRAKGYPVTVINPVEKLLAQGHYLESTVDIAESTLRIAAAAIP
ADHIVLMAGFTAGNDKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRTV
PDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNTSNPQAPGTLIGKDST
DDAMPVKGITNLNNMAMINVSGPGMKGMVGMAARVFAVMSRAGISVVLITQSSSEYSISF
CVPQGELLRARRALEEEFYLELKDGVLDPLDVMERLAIISVVGDGMRTLRGISARFFSAL
ARANINIVAIAQGSSERSISVVVSNESATTGVRVSHQMLFNTDQVIEVFVIGVGGVGGAL
IEQIYRQQPWLKQKHIDLRVCGIANSRVMLTNVHGIALDSWRDELAGAQEPFNLGRLIRL
VKEYHLLNPVIVDCTSSQAVADQYVDFLADGFHVVTPNKKANTSSMNYYQQLRAAAAGSH
RKFLYDTNVGAGLPVIENLQNLLNAGDELVRFSGILSGSLSFIFGKLDEGLSLSAATLQA
RANGYTEPDPRDDLSGMDVARKLLILAREAGYKLELSDIEVESVLPPSFDASGDVDQFLA
RLPELDKEFARNVANAAEQGKVLRYVGLIDEGRCKVRIEAVDGNDPLYKVKNGENALAFY
SRYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV
NT seq
2460 nt
NT seq
+upstream
nt +downstream
nt
atgcgagtgctgaaatttggcggaacctcggtggcgaatgcagaacgttttctgcgcgtt
gccgacatcatggagagtaatgcgcgtcagggacaggtagccacggtcttgtccgccccc
gcaaagatcaccaaccatctggtggcgatgatcgacaaaacggtggcgggccaggacatt
ctgccgaatatcagcgacgccgagcggatctttgccgatctgctgagcggcctggcgcag
gcgctgccgggctttgaatacgatcgcttgaaaagcgtggtcgatcaggagttcgcgcag
ctcaaacaggtgctgcacggcgtttcgctgctggggcagtgcccggatagcgtaaacgcg
gcgatcatctgccgcggcgaaaagctctccatcgccatcatggaaggggtgttccgcgcc
aagggctacccggtcacggtgatcaacccggtggagaaactgctggcacagggccactac
ctggagtccaccgtggacatcgccgagtccacgctgcgcatcgccgcggcggcgatcccg
gctgaccacatcgtgctgatggctggtttcaccgccggtaacgacaagggcgagctggtg
gtgctgggccgtaacggctccgactattccgccgccgtgctggccgcctgcctgcgcgcc
gactgctgcgagatctggaccgacgtcgacggcgtgtatacctgcgatccgcgcaccgta
ccggacgccaggctgctgaagtcgatgtcgtatcaggaggcgatggaactctcttatttc
ggcgccaaagtgctgcaccctcgtaccatcacgccgattgcccaattccaaatcccttgc
ctgattaaaaacacctccaacccgcaggcccccggcacgctgatcggcaaagacagcacc
gatgacgcgatgccggtgaaaggcatcaccaacctgaacaacatggcgatgatcaacgtc
tccggcccgggcatgaaaggcatggtcggcatggccgcgcgagtgttcgccgtgatgtcg
cgcgccggaatttcggtggtgctgatcacccaatcctcttccgaatacagcatcagcttc
tgcgtgccgcagggcgaactgctgcgcgcgcgccgcgcgctggaggaggagttctatctg
gagttgaaagacggcgtgctggatccgctggacgtgatggaacgcctggcgatcatctcg
gtagtcggcgacggcatgcgcaccctgcgcggcatctccgcgcgcttcttctccgcgctg
gcgcgcgccaacatcaatatcgtcgccatcgcccagggctcttccgagcgttcaatctcg
gtggtggtcagcaatgaatccgccaccaccggcgtgcgcgtcagtcaccagatgctgttc
aacaccgatcaggtgatcgaagtgttcgtcatcggcgtcggcggcgtcggcggagcgctg
atcgaacagatttaccgccagcagccgtggctgaagcaaaagcatatcgacctgcgggtg
tgcggcatcgccaactcgcgcgtgatgctgaccaacgtgcacggtatcgcgctggacagc
tggcgcgacgaactggccggcgcgcaggagccgttcaatctcggccgcctgatccggctg
gtgaaggagtatcacctgctgaacccggtgatcgtcgactgcacttccagccaggcggtg
gccgatcagtatgtggatttcctggcggacggtttccacgtggtgacgccgaacaaaaag
gccaacacctcgtcgatgaactattatcagcaactgcgcgcggccgccgccggttcgcac
cgcaagttcctctacgacaccaacgtcggtgccggtttgccggtgattgagaacctgcaa
aacctgctgaacgccggcgatgagctggtacgcttctccggcatcctgtccggctcgctg
tcctttatcttcggcaagctggatgaagggctgtcgctgtcggcggcgaccctgcaggcc
cgggccaacggctacaccgagccggatccgcgcgacgatctgtccggtatggacgtggcg
cgcaagctgctgatcctggcgcgcgaggccggttacaagctggagctgagcgatatcgag
gtcgagtcggtgctgccgccgtccttcgacgcgtcgggcgacgtggatcagttcctggcg
cgcctgccggagctggataaagagttcgcgcgcaacgtggccaacgccgccgagcaaggc
aaggtgctgcgctatgtcggcctgatcgacgaaggccgctgcaaggtgcgcatcgaggcg
gtggacggcaacgatccgttgtataaagtgaagaacggcgagaacgcgctggccttctac
agccgctactatcagccgctgccgctggtgctgcgcggctacggcgccggtaacgatgtg
accgcagcgggcgtgttcgccgatctgctgcgcacactgtcatggaagttgggagtttaa
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