Silurus meridionalis (southern catfish): 124389836 Help Entry 124389836         CDS       T08004                                  Name (RefSeq) ryanodine receptor 3-like   KO K04963   ryanodine receptor 3 Organism smeo  Silurus meridionalis (southern catfish) Pathway smeo04020   Calcium signaling pathway smeo04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:smeo00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     124389836    04020 Calcium signaling pathway     124389836  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:smeo04040]     124389836 Ion channels [BR:smeo04040]  Voltage-gated cation channels   Ryanodine receptor    124389836 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  124389836 NCBI-ProteinID:  XP_046711318 LinkDB All DBs Position 8:complement(6908891..7371638) Genome browser AA seq 4869 aa AA seqDB search MVEGADAEDEIQFLRTDDEVVLQCVAGIQKENRKFCLSAEGFGNRLCYLELTSEAKYVPP DLCICNFVLEQSLSVRALQEMLATTGENNEAAHGGGHRTLLYGHAILLRHSFSRMYLACL KTSRSLTDKLSFDVGLQESLTGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYLH LSISNGNIQVDASFMQTLWNVHPTCSGSTVKEGYLLGGHVMRLFHGHDDVLTIPGLDQSE EQQRIVNYDTGKVGAKARSLWRVEPLRISWCGSHIRWGQPFRLHHLTTGHYLALTEDKGL VLQDREKSDTTSTTFCFRSSKEKLESSPKKDVEGMGVPEIKYGDSLCFIMHMATGLWLSY QAPDVKSTRLGPLTRRACLHAEGHMDDGFTLQRCQHEESRAARIIRNTTQLFSHFIRDLD SLAGKNRTSVTLPIDEVFQTLNDLITYFQLPDAKLEHEEKQIKLRSLKNRQNLFKQEGML TLVSNCIDRLSVYSSTAHVGECLGKEAGTAWKDILNLLYELLAALIRGNRNNCTQFSQNL DWLVSMLERLESSSGILEVLHCILIESPEALNVIQRGHIKSIISLLYKHGRNYKILDVLC SLCVCNGVAVRANQNLICDNLLPKRDLLLQTRLVNNVQSMRPNIFLGVRDGSAQYKKWYF ELIIDQVEHFVTSEPSHLRVGWASSKGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLWSG RIPRRVASVNQHILTSDDVISCCLDLEAPSISFRTNGLPVQGMFESFNKDGHFFPVVSFS AGVKVRFLLGGRHGEFKFLPPSGYAPCYEALLPKERVRVEPVKEYKRDVDGVRDLLGTAQ FLSQASFIPTPVDTSHIVMPPHLEKVRDRLAGNIHELWAMNKIELGWSYGKIRDDNKQQH PCLVDFSKLPETERNYNLQMSTETLKTLLALGCHVVQVSVDAEEELKKIKLPKNYMMSNG YKPMPLELSEVKLSPAQELLVDKLAENGHNVWAKDRVKQGWTYGIQQDLKSRRNPRLVPY ALLDERTKKSNRDSLREAIRTLIGYGYNIEPPDQEAGHVVERLSIDKIRFFRLERTYAVK TGKWYFEFEVVTGGDMRVGWARPGVRPDLELGTDDQAFVFDGYKGHRLNQGSYLFGRCWH AGDVVGCMINMEDKSMIFTLNGEILITNKGSELCFADFDIKDGFIPVCSLGLSQVGRMNL GKDASSFKYYTMCGLQEGFEPFAVNMNREVTMWFSKRLPTFVTVPKDQSHIAVTRIDSTI DSPPCLKVTHKTFGTQNSNTDMVFCRLSMPVEFYSTYKSVPATEINGVHEEEPLKLKYRY PVKSMKHVDDGGRTAYSNITTYYHSVRVFAGQDPKCVWVGWVTPDYHYYSNLFNLSKNRS VTITLGDERGRVHESVRRSNCYMVWGGDAISSSHSSNRSNVDLEIGCLIDLATGLVAFTV NGKELPISYQVEPNTKLFPAVFVHPTSPNLFQFELTKIKNAMPLSSAIFKSEHKNPVPQC PPRLDIQTIKSVLWSRMPNTFLKVDTARVSERHGWQVQCLEPLQMLAVHIPEENRCVDIM ELSEQEDLQTFHYHTLKLYCALSALGNTRIAHALCSHLDQSQLLYIIDNQYLSGMLRQGF YDVLISIHLETAKAAQLMMNNEFIIPITAETCSIRLFLNTTKRHQSPGVGLSTSLKPRLS FASPCFVTPKRDQYLYSPEIPLDVLREKAISMLTEAVQGGGDHIRDPVGGSVEYQFVPIL GLISTLLTMGVLTSQDVHKILLLIEPRIFGEQKADKTSEATKKEGMTEAEEKAVEAGKEE ATDTKQPIKGLLEKKLPESVKLQMCKLLRYFCDCELKHRIEAIVSFSDSFVSKLQYNQKF RYSELMLALNMSAAVTAKKTKEFRSPPQEQINILLTFSMGKDCPCPEDIQEELYDFHSEL RLHCGIPIEEEKEDQDISIKGRLMSLVNKIKGQPHKAEEKPTKKEQAIPSNLRELISQTM VSWAQESHIQDPELVRAMFGLLRRQYDSIGELLFAMRKTYTISAASVHDTIHLLASLGQI RSLLSVRMGKEEEQLMIDGLSDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGGKSQE IAFPKMVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPSMRGSTPLDVAASS VMDNNSLALALEEPDLSKVVMYLAGCGLQSCPMLLAKGYPDIGWNPIEGERYLSFLRFTV FVNGESVEENSSVVVKLLIRRPECFGPALRGEGGNGLLAAMKEAIKISETPALDLSSTTQ GLVSDTSTDDEEEEEVVHMGNAIMSFYSALIDLLGRCAPEMHLINKGKGEALRIRAILRS LVPTEDLVGIISIPLRMPVVNKDGSVTEPDMSACFCPDHKAPMVLFLDRVYGIEDQTFLL HLLEVGFMPDLRSAASLDTEALRTTETALAMNRYIGSAILPLLTCCAPHFAGTEHHIALI DSMLHTIYQLSKGSSLTKAQRDAIEECLLAVCKYLRPSMLQQLLRCLVFDVPLLSEYCKM PLKLLTYHYEQNWKYYCLPSGWGNYGMASDEELLLTKKIFWGIFDSLSQKEYGQELFKMA MPCLSAIAGALPPDYVDSSLSTTQEKPVFADAQGNFDPRPINTANISLPEKLEYITHKYA EHSHDKWSAEKVILGWKYGESIDEKAKTHPMLRSYKLLSEKEKDVYRFPVKESLKSMLAM GWNIDRTKEGEAMFQQRENEKMCKASQVNDSSGFHPNLVDMSNVLLSRELQAMVEVLAEN YHNIWAKNKKSDLEVKGGMHSLLVPYDTLTAKEKARNREKAQDLFRFLQINGYAITRGLK DMEQNSSSMEKRFAYKFLKKLLKYVDCAQEYISHLEVMASSGKNDRSPNEQEIKFFAKVL LPLIDQYFKNHSLYFLSSPSKTLSSSGYASNKEKEMVTSLFCKLATLVRHRISLFGSDSA TIVSCLHILAHTLDTRTVMKSGSKLVKAALKTFFENAADDLEKTLENLKLGKFTHSRSQI KGVSQNINYTTVALLPILTALFEHITEHHFGVDLLLDVVQMSCYRILNSLYSLGTGKNIY VERHLPALGECLATLAGAMPVAFLEPHLNTHNPFSVFNTKTSCEQAILGMPDTVEQMCPE VPHLDCLMKDINDMSESGARYTEMPHVIEVVLPMLCNYLSYWWKRGTENQAKGTETACST TVTSEHLSLILGNILKILNSNLGIDEASWMKRIAVYAQPIISKARADLLKTHFLPTLEKL KKKTVKVVAEEELLKADNKGDTQEAELLILDEFAMLCRDLYAFYPMLIRYVDNNRSRWLK EPDADSNELFRMVAEIFILWCKSHNFKREEQNFVVQNEINNLSFLTGDSKTNMSKAGGQD QERKHKKRRGEVYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKTRYGLKDTDEEVK EHLRQNMHLQVKTEDPAVRWQLNLYKDVIVKNEGPPDPELTIDRLQTISAAVFHLEQVEQ PLRSKKCVWQKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLTGYQRIWIETETYSFEE KLVQDLARTHKEEEEEEVDKIHPDPLHELILHFSHNALTERSSLEDDLLYIAYTDMMAKS CAEDENEDEEGKEKTFEEKEMEKQKILYQQARLHDRGAAEMVLQVISASRGRLGPMVTFT LKLGISVLNGGNILVQQKMLDYLKEKQDVGFFKSLSGLMQSCSVLDLNAFERQNKAEGLG MVTEEGSINVRERGAKVLQNDEFTKDLFRFLQLLCEGHNNDFQNFLRTQTGNTTTVNIII STVDYLLRLQESISDFYWYYSGKDIMDEAGQLNFSKALAVAKQIFNSLTEYIQGPCIGNQ QSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIKLLKELMDLQKDMIVMMLSLLEGNVVN GTIGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTTSDNFKEHDSDSKGIISKREFQKSM ENQKQYSQSEIEFLLSCVEADENDMFNYVEFVKRFHEPAKDIGFNVAVLLTNLSEHMPYD SRLATFLNLAESVLNYFEPFLGRIEIMGGAKRIERVYFEISESSRTQWEKPQVKESKRQF IFDVVNEGGESEKMELFVNFCEDTIFEMQLASVISETDAVERGEDEDELQNVTKDMVLVE EENVLESSSAFTMAFAAMKKNLSSLGRLLTLKNLGKQYKKLRKMSLREIIAGFFYFFWMI FTGLLCFLYNLVWCFFLILWSTLFGGGLVEGAKNIKVTDILGNMPDPTQFGIHGDVLETE KLEVSEALLVAEIDQLAQGDKTEMDLISELLSIQSKKEGGKHGAEPGLGDVSEVVGVDSP SLVSAVRQKKAQEAASKKPAENESNADSEKADTEDVEKNNQGKAKELLIEPPFEEQKKTL KRRCGQKKEQPEAIMASFFAGLDIYQTKILNYLARNFYNLRFLALFVAFAINFILLFYKV TDEESEEVDSWRSEEDEGGIEHFILQESSGYMAPTLCFLSVLHTIISFLCVVGYYYLKVP LVVFKREKEIARKLEFDGLYITEQPSDDDIKGQWDRLVINTPSFPFNYWDKFVKRKVINK YGDLYGAERIAELLGLDKSALDFNPTEETIPKEASLVSWLSSLDTKYHIWKMGVVFTDNS FLYLVWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVV YLYTVVAFNFFRKFYNKSENEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDP YELYRILFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYF DTTPHGFETHTLQEHNLANYLFFLMYLVNKDETEHTGQESYVWKMYQERCWDFFPAGDCF RKQYEDQLG NT seq 14610 nt NT seq  +upstreamnt  +downstreamnt atggttgaaggcgcagatgcggaagatgagatccagtttctacgcacggatgatgaggtg gtgttgcagtgcgttgccggcattcagaaggagaatcgcaagttctgtctgtctgctgag ggatttggcaatcggctatgttacttggaactcacctcagaggccaagtatgtccctcca gacctgtgcatctgtaactttgtgttggaacagtcactgtcagtccgggcactgcaagag atgctggccacaaccggggaaaataatgaagcagcccatggaggtggacacagaacactt ctgtatggacacgctatcctcctacgacactctttcagtaggatgtatctggcatgttta aagacatccaggtctctgacagataagttgtcttttgatgttggacttcaggagagtttg acaggtgaagcttgctggtggacaatccatcctgcttctaagcagagatcagaaggggaa aaagttcgtattggtgatgacctcattcttgtcagtgtatcatctgaacgctatctacac ctgtctatctccaatggcaacattcaggtggatgcatcttttatgcagactctgtggaat gtccaccccacctgttcaggcagcactgtgaaggaaggatatctccttggtggtcatgtg atgcgtttgttccatggacatgatgatgttttgacgatcccaggcttggaccagagcgag gaacagcaaagaatagtcaactatgatacagggaaagtaggggccaaggccagatctctt tggagagtggagcctctacggatcagttggtgtggcagtcatatccgctggggtcagcca ttccgcctgcaccacctaactacaggtcattatctggctctgactgaagacaaaggcctt gtgctgcaggatcgggaaaaatcagacacaacctccaccaccttctgcttccgatcttcc aaggagaagctggagtcgagtccaaaaaaagatgttgagggtatgggggtgcctgagatt aagtatggagactcactctgtttcatcatgcacatggccactggcctgtggctctcatat caggcaccagatgtgaaatcaacacgactggggcctctcacgagacgggcctgtcttcat gcagaaggacacatggatgatggcttcacacttcaacgctgtcagcatgaagaatcacgt gctgcacgcatcattcgcaacaccacacaactcttcagccattttatcagggacctggac agtcttgctggcaagaatcgtacatctgttactcttcccattgatgaggttttccagacc cttaatgatctcattacatattttcaactccctgatgccaaacttgagcatgaagagaag cagatcaagctgcgttcactcaagaaccgccagaacctcttcaaacaggagggaatgctg acactggtgtcaaactgcattgatcgtttgagtgtctacagcagtacagcacatgttggg gaatgtttgggaaaggaagctggcacagcttggaaggacattctcaacttactctatgag cttctagctgctctgattcgaggaaatagaaataactgcacacagttctctcaaaacctg gactggctggtcagcatgctggaaagactggagtcatcctcaggcattctggaggtcctt cactgcatcctaattgaaagcccggaggcacttaatgtcattcagagaggacatatcaaa tctatcatctcgctgctatacaaacatggacgcaactacaagatcctagatgtcctgtgc tcactttgtgtttgtaatggagtagctgtaagagccaatcagaacctcatctgtgataac ctgctcccaaaacgagatctgttactccagacacggttggtcaacaatgtccaaagtatg agacctaacatctttctgggtgtgagggacggttcagctcagtacaaaaagtggtacttt gagttgataatagaccaggtggagcactttgtaaccagcgaaccttctcacctgcgggtt gggtgggcttcctctaaaggttatgccccctacccaggaggtggagaggggtggggagga aacggggttggagatgacctctactcttatggctttgatggacttcacttgtggtcaggt cgaatcccacggagagtagcttcagtaaaccagcacatacttacatccgatgatgtgatc agttgctgtttggatcttgaagccccgagcatttcttttagaaccaatgggctgcctgtt caaggcatgtttgagagtttcaacaaagatggtcacttcttccctgttgtcagcttctcc gctggagtcaaggtgcgctttcttttaggtggtcgtcatggtgaatttaagttcctgcct ccttcaggctatgcaccctgctatgaggcactgcttcctaaagaaagggtgcgtgtcgaa ccagtgaaggaatacaaaagggacgtggatggagtgagagacttgctgggcactgcacaa tttctctcccaggcttcttttatacccacaccagtggacacctctcatattgtcatgcct cctcacctcgagaaagtacgtgacaggttggctgggaacatccatgaactctgggccatg aacaagattgaactgggctggtcttatggcaagataagagatgataataaacagcagcac ccctgtctggtggatttctcgaagctgcctgaaacagagaggaattacaacctacagatg tcaacagagacgttaaagactcttttggctctgggttgccatgtggttcaggtcagtgtc gatgctgaggaggagctgaaaaaaattaaactcccaaaaaactacatgatgtctaatggc tacaagcccatgcctttggagctatcagaagtaaaactgagccctgcgcaagagcttctt gttgataagttagccgagaatggacacaatgtttgggccaaagatcgtgtcaaacaaggc tggacctatggcatacagcaggatttgaaaagcaggcgcaatcctcgccttgtgccatat gcattgcttgacgaacgcaccaagaagtctaaccgagacagtctgcgtgaagccatccgt acactaattggatatggctataacatcgagcctcctgaccaggaggctggccatgtggtg gagagattaagcatcgacaaaattcgctttttccgtttggagaggacttatgcagtaaaa acagggaaatggtattttgagtttgaggtggttactggtggagatatgagggttggctgg gctcggccaggtgtgcggcctgacctggaactgggaacagatgatcaggccttcgtcttt gatggttataaaggtcatcgtctcaatcagggcagttatttgtttggtcgttgctggcat gctggagatgtggtcggctgcatgattaacatggaggacaagtctatgatctttacgctt aatggagaaatcctcatcacaaacaagggctctgagctttgctttgctgactttgatatt aaggatggatttattccagtgtgtagtctgggcctttcccaagttggacgtatgaacctg ggcaaggatgccagttccttcaaatattacaccatgtgtggactgcaagagggatttgaa ccatttgctgtgaacatgaaccgagaggtcaccatgtggtttagcaagcgccttcctact tttgtcactgttcccaaagatcagagtcatattgcggtcacgaggatcgatagcactatt gacagccccccatgtctaaaagtgactcacaagacatttgggacacagaacagcaacact gacatggtgttctgtcgtctgagcatgccggttgagttctactctacctacaagagtgtc cctgccactgaaataaatggggtacatgaagaggagccactcaaactcaaatacaggtat cctgtgaaatctatgaaacatgtggatgatggagggcgaactgcctacagtaatataaca acttactaccattcagtacgggtgtttgctggtcaggatcctaaatgtgtgtgggtaggc tgggtcacacctgattaccattactacagcaacctcttcaatctcagcaagaaccgatcc gttacaattacactaggagacgagcgaggtcgtgtccatgaaagtgttagaaggagtaac tgctacatggtgtggggaggtgatgccataagttccagccattcctccaacagaagtaat gtggatttggagattgggtgcctcattgatttggctacaggcttagttgcatttactgtc aatggcaaagagcttccaatctcatatcaggtggagccaaataccaaactattccctgct gtgtttgtgcatcccaccagtccaaatctgttccagtttgaactgacaaagatcaagaat gctatgcccctttcatcagcaatttttaagagtgaacacaagaacccagtccctcaatgt cctcctcgtctggatatccagaccataaagtcagttttgtggagccggatgcccaacacc ttcctgaaggtggacacagctcgagtgagtgagagacatggctggcaggtacaatgcctg gagcctctgcagatgcttgcagtacacattccagaggaaaaccggtgtgttgacatcatg gaactctctgagcaagaagacctgcagacttttcattatcacaccttaaaactttactgc gctctttctgctcttggtaacacccgtatagcccatgctctctgcagccaccttgaccag tcacagctcctttacattattgacaaccaatacctgtctggcatgctgcgccaaggcttc tatgacgtactaataagtatccatctagagacagcaaaagctgcacagcttatgatgaac aatgagtttatcatcccaatcacagcagagacctgcagcatccgtctctttctaaatacc accaaacggcaccaatcaccaggtgtaggactcagtacatctctaaaacccagacttagc tttgcttcaccatgcttcgtcactccaaaacgtgaccagtatctctatagtccggaaatt cctcttgatgttctgagggagaaggcaattagcatgctaacagaggctgttcagggtgga ggagaccacattcgagatcctgtagggggcagcgtggagtaccagtttgtgccaattctc ggactgattagcactctgctaactatgggtgtgctaacgagccaggatgttcataagatc ttgctgctcattgaacctcgtatttttggggagcagaaagcagataaaacaagtgaagct acaaaaaaagagggaatgacagaagcagaagaaaaggcagttgaggctggaaaggaagaa gccactgatactaagcagccaataaagggattgttggagaaaaaattgccggagtcagtc aagctgcagatgtgcaaacttcttcggtacttctgtgactgtgaactgaagcaccgtatt gaggcgattgtgtcgttctctgatagctttgtgtcaaagctgcagtataaccagaagttc cgttacagtgagttaatgcttgctctcaacatgtctgctgctgttactgccaagaagact aaagagttccgttcaccaccacaggaacagatcaacatattgttaactttcagtatgggc aaggactgtccatgccctgaggacattcaggaggaactatacgacttccacagtgaactt cgtctacactgcggtatcccaatagaagaggagaaagaggatcaggacatatccattaaa ggccgcttaatgtctctagttaacaagatcaaagggcagccacacaaagcagaagagaag ccaaccaagaaagagcaagcaataccttcaaacctgagggagttgatctctcagaccatg gttagctgggctcaggagagccacatccaagacccagagctggtacgtgccatgtttggc ctactgaggaggcaatatgacagcattggtgaactgctttttgctatgcgcaaaacctac acaatcagtgctgcatctgtacatgacaccatccacctgctggcctcactgggtcagatc cgctcactgctcagcgtccgtatgggcaaagaggaagagcagctcatgattgatggcctc agtgacataatgaacaataaagttttctaccagcacccgaacctgatgagagtactaggc atgcatgaaactgttatggaggtgatggtgaatgtactgggtggaggcaagtcccaggaa attgcttttcccaaaatggttgctagttgctgccgcttcctttgctatttttgtcgaatc agtcggcagaaccaaaaggccatgtttgatcatctgagttacctgctagaaaacagcagt gtgggcttggcttctccatcaatgagaggttccactcctctagatgtagctgcttcgtct gtaatggacaacaacagccttgctcttgctcttgaggagcctgacctcagcaaggtggta atgtatctggctggctgtggactgcagagttgtcccatgctccttgccaaaggttatcca gatataggttggaacccaattgagggagagcgctacctctcctttcttcgcttcacagtc tttgtcaatggtgaaagtgtagaagagaactctagtgttgtggtaaagttgctgattcgt aggcctgagtgttttggacctgcgttgcgtggagaaggtggtaatggactgctagctgct atgaaggaagccattaaaatatcagaaacaccagcacttgatctgtctagcaccacgcag ggtctggtttctgacacgtctacagatgatgaggaggaggaagaggtggttcacatgggc aatgccatcatgtccttctactcagccctcatcgatctgctgggacgctgtgcacctgaa atgcatcttatcaataaaggcaaaggagaggctctgagaatccgtgccatcttgcgctcc ttggtgcccactgaagaccttgttggcatcatcagcatcccactcaggatgcctgtggtt aataaagatggcagtgtgactgagccagacatgtcagcctgtttctgcccagaccacaag gctcccatggttctgtttctggacagagtctatggaatagaagaccaaaccttcctctta catcttctggaagttggcttcatgcctgacctaagatcagcggcctctctagacacagaa gcattaaggaccacagaaacagcactggccatgaatcgttatattggatctgcaatattg cctttgctgacttgctgtgcccctcattttgccggtacagaacaccacattgcactcatt gactccatgcttcacaccatctaccagctgagcaagggctcctcactcactaaagcccag agagatgctattgaggagtgcctgctggctgtatgcaagtacttgcggccctctatgctt cagcaactgttgcgttgcttggtgtttgacgtgcccttgctatctgaatattgtaagatg cctctgaagctgttgacctatcattatgaacagaactggaagtactactgcctgccctct ggttggggcaactatggcatggcatctgatgaggaattacttcttaccaagaagatcttc tggggcatttttgattcactttctcaaaaagagtatgggcaggagctgtttaagatggca atgccatgtctgagtgctatagctggagctttgcctccagattatgttgattcttctctt agcaccactcaggagaagccagtctttgctgatgcacagggcaactttgacccaagacct atcaacacggcaaacatctctctgccagagaaactggaatacatcactcacaaatacgct gaacattcccatgacaaatggtctgctgagaaggttattctgggctggaaatatggtgag agcattgatgagaaagcaaaaactcaccccatgctgagatcctacaagttactctcagag aaggaaaaggatgtttatcgcttcccagtaaaggaatctttgaagagtatgctagccatg ggctggaacattgacaggaccaaagagggagaagccatgttccagcaaagggagaatgag aagatgtgcaaagcatctcaggtaaatgattccagtggcttccacccaaatctagtggac atgagcaatgtattgctttctcgagaacttcaggctatggtagaggttttggctgaaaac taccacaacatttgggctaaaaataagaagagtgatctagaagtgaaaggtggaatgcat tcgttgttggtgccatatgatacacttacggccaaagagaaagccaggaaccgtgagaaa gcccaggacctgttccgcttcctgcagataaatggctatgctattaccaggggtttgaaa gacatggagcagaactcatcctcgatggagaaaaggtttgcctataaattcctgaaaaag ctactgaaatatgttgactgtgcacaggaatacatttctcacttggaggttatggctagc agtggaaaaaatgacaggtcacctaatgagcaagaaatcaagttcttcgccaaggttctt ctgccactgatagatcagtacttcaagaaccactctctttacttcctctcctcccccagt aaaactctcagcagcagtgggtatgcatcaaacaaagagaaagaaatggttaccagtctt ttctgtaagctggctacccttgttagacacaggatttctctctttggaagtgactctgcc actatagttagctgtctgcatatcctggcccacactcttgacacaagaacggtgatgaag tctggctctaagttggtgaaggctgctttaaagacattctttgagaatgcagcagatgac ctggagaaaaccctggagaacttgaagctggggaagtttacacactcacgcagccagata aagggtgtttcccagaacatcaactacactacagttgccctgttgccaatcctcactgcc ctgtttgagcacatcactgagcatcatttcggagtggaccttctgttggatgttgtccag atgtcatgctatcggatcctaaacagtctctactcattgggaactggcaagaacatctat gttgaaagacaccttccagctctaggtgagtgtttggccaccttagcgggagccatgccc gtggcatttttggagcctcacctcaatacacacaacccattctctgtcttcaacactaaa acatcatgtgaacaagccatattaggcatgcctgatactgtagaacagatgtgccctgaa gtaccccatctggactgtctgatgaaagacataaatgacatgtctgaatcaggagctcgc tacactgaaatgccccatgtcattgaggtagtgctgcccatgctgtgtaactacttatcc tactggtggaagagagggacagagaaccaggccaagggcacagaaactgcatgtagcacc actgtcacttctgagcacctgagtctaatcctgggcaacatcttaaagatcctgaatagt aatctaggcattgatgaggcctcctggatgaagaggattgcagtgtacgctcaacctatc atcagcaaggcgagggcagatcttttaaagacacacttcctgccaactctggagaaatta aagaagaagactgtgaaggttgtggcagaggaggagcttctcaaagctgacaacaaaggc gatacccaggaggcagagctactgattctggatgagtttgcaatgctttgcagggatttg tatgcattctatcccatgcttattcgctatgtggacaacaacaggtcacgatggctgaaa gagcctgatgctgactctaatgagcttttcaggatggtagcagaaattttcattctttgg tgcaagtcacacaattttaagcgagaggaacaaaactttgttgtgcagaatgaaatcaat aatctctcctttctcactggggacagcaagacaaatatgtcaaaggcaggaggacaggat caggagagaaaacacaagaagagacgtggtgaggtttactccatccagacctcactgatc gtggcagcgctgaaaaaaatgttacctattggtctgaacatgtgcacgcctggagaccaa gagctcatctcactggctaagactcgctatggactgaaagatacagatgaagaggtaaag gagcatttgaggcagaacatgcacttgcaagtgaagacagaggaccctgctgtgagatgg cagcttaatttgtataaagatgtgattgtgaagaatgagggcccacccgatccagagctc acaattgatcgtctacagactatctcagctgcagtgtttcaccttgagcaggtggagcag ccactaaggtccaagaagtgtgtgtggcaaaaactcctgtccaaacagcgtaagcgtgct gtagtggcctgtttccgtatggcaccgttatacaacttgcccaggcatcgctctattaac ctgttcctcacgggctaccagagaatatggatagagacagagacatactcatttgaggag aagctagtgcaggatttggcaaggacacataaggaagaagaggaagaggaggtagataaa atacatcctgaccctcttcatgaacttattctgcactttagtcataatgctttgacagaa agaagttccctagaggatgatttactatatatagcatacacagacatgatggcaaagagt tgtgctgaagatgagaacgaggatgaagaaggaaaagagaaaacctttgaggaaaaggaa atggaaaagcagaaaatattgtatcagcaggccaggttacatgaccgaggggctgctgag atggttttgcaggtgatcagtgccagcagaggtcgactgggtcccatggttactttcact cttaagcttggtatctctgttctaaatggtggcaacattttagttcagcagaaaatgctg gactatctgaaggagaagcaagatgttggcttcttcaagagtttgtcaggacttatgcag tcatgcagtgtattggacctgaatgcatttgaaaggcaaaacaaagctgaaggattgggt atggtgactgaggagggttcaatcaacgtgagggagcggggtgccaaggttcttcagaat gatgagttcactaaagatctgtttaggttcttgcagcttctctgtgaaggtcataacaat gacttccagaactttttgaggacccagactggaaatacaactacagttaatataataata agcacagtagactatcttcttagacttcaggagtccatcagcgatttctactggtattac tctgggaaagatataatggatgaagctggtcaactaaatttctctaaagcattagctgtg gccaagcagatttttaattccctcactgaatatatacagggtccatgtataggaaaccaa caaagcttggcccacagcagattatgggatgcagttgttggctttttgcatgtttttgct aacatgcagatgaagctctcacaggactccagccaaattaagttgctgaaagaacttatg gatctacaaaaggacatgatagtcatgatgctttcccttttagaaggtaatgttgtaaat ggcaccattggcaaacagatggttgacaccttggttgagtcctccagcaatgtggagatg atcctcaaatttttcgacatgttcctaaagctgaaggacctcaccacatctgacaatttt aaagagcatgactctgattctaaaggaatcatctccaaaagagagtttcagaaatcaatg gaaaatcagaagcagtactctcagtctgaaattgagttcctactttcttgtgttgaggca gatgaaaatgacatgtttaactatgtggaatttgtgaaacgcttccatgagcctgccaag gacattggtttcaatgtcgcagtactgcttacaaatctgtcagaacacatgccctatgac tctcggctggctaccttcctgaacctggcagagagtgtccttaattactttgagccattc cttggccgtattgagatcatgggtggtgctaagaggattgaaagggtctactttgaaatc agcgagtccagtagaacccagtgggagaaaccacaagttaaggaatctaaaagacaattt atctttgatgtagtcaatgagggtggagaatcagagaagatggagttgtttgtaaatttc tgtgaggacaccatttttgagatgcaactggcctcggtgatctcagagactgatgctgtt gaaagaggagaagatgaggatgagttgcagaatgtaaccaaggacatggttttggtagag gaggagaatgtactggaatcctcctcagcttttaccatggcatttgctgcgatgaagaag aatctctctagtcttggcagactgctcaccctgaagaacctggggaaacaatacaagaaa ctcaggaagatgagcctgagggaaataattgctgggttcttctactttttctggatgatc tttactggcctgctctgctttctctacaacctggtgtggtgcttcttccttatcctgtgg tcaacactgtttggtggtggcttggtggaaggtgccaagaatattaaggtgacagacatc cttggcaacatgccggaccccacacagtttggcatacatggtgatgtgctggagactgaa aaactagaggtcagtgaggctttactggttgctgaaatagaccagttggcacaaggagac aaaacagaaatggacctcatatcagaactgttaagtatacagtcaaagaaggagggaggg aagcatggagctgagcctggcctgggagatgtgtctgaagtggttggagtcgattcccca tccttagtttctgctgtaaggcagaaaaaagcccaggaagctgcaagtaagaagccagct gagaatgaatcaaatgcagactcagaaaaagcagatacagaggatgtggagaagaataac caaggcaaagctaaagagttactcatagaacccccatttgaggaacagaaaaagacactc aaaaggaggtgtggacagaagaaagaacaaccagaggccattatggccagcttttttgct ggcctagacatttatcaaaccaaaattctaaattacctagctcgaaacttttacaacctg cgattcctggctctgtttgtggcatttgccatcaacttcattctgcttttttataaggtg actgatgaagagtctgaggaggtggattcatggagaagtgaagaagatgaaggtggcatt gagcattttattctgcaggagagcagtggttacatggcacctacactttgctttctatct gttctgcacactattatctcatttctctgcgtggtgggatattactatctgaaggtgcct ttggtagtttttaagcgagagaaggaaattgccaggaaacttgaatttgatggcctttat ataactgaacaaccttctgatgatgacataaaaggacaatgggacagacttgttattaat acaccatcttttccttttaactactgggataagtttgtcaaacgtaaggtaataaataaa tatggggacttgtatggagcagagaggattgctgagttgcttggtttggacaaaagtgca ctggacttcaacccaactgaagaaactatccctaaagaggcttcacttgtgtcctggtta agttcgctggacacaaagtaccatatctggaaaatgggtgtggtatttacagacaattct ttcctgtatctagtatggtataccacaatgtctatcctaggccactacaacaatttcttc tttgctgctcacctgctcgacattgctatgggtttcaagactttgaggactatactgtct tcagtcactcacaacggcaaacagctggtgctgactgtaggtctactggctgtagttgtg tatctgtacactgtggtggcctttaacttcttccgcaaattctacaacaaaagtgaaaac gaggatgagccagatatgaagtgtgatgatatgatgacttgctatctgttccacatgtat gtgggtgtgcgtgctggtggaggaataggagatgagattgaggatccagcgggtgaccct tatgagctttaccgcatcctttttgatatcacctttttctttttcgtcattgtcatcctt ctagccattatccaaggtttgattattgatgccttcggagagcttcgagaccagcaggag caagtcaaagaggacatggagactaaatgcttcatctgtggaattgggaatgattacttt gacacaactccacatggatttgagacacacacattacaagagcacaatttggcaaactac ctgtttttcctaatgtatcttgtcaacaaggatgaaaccgagcatactggccaggagtca tatgtgtggaaaatgtatcaggagcgatgctgggatttctttccagccggagactgtttc aggaaacagtatgaggaccaactgggctaa

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