Streptomyces nodosus: CP978_03055 Help Entry CP978_03055       CDS       T06839                                  Name (GenBank) type I polyketide synthase   KO K16386   polyene macrolide polyketide synthase Organism snq  Streptomyces nodosus Pathway snq01052   Type I polyketide structures Brite KEGG Orthology (KO) [BR:snq00001]  09100 Metabolism   09109 Metabolism of terpenoids and polyketides    01052 Type I polyketide structures     CP978_03055  09180 Brite Hierarchies   09181 Protein families: metabolism    01008 Polyketide biosynthesis proteins [BR:snq01008]     CP978_03055 Polyketide biosynthesis proteins [BR:snq01008]  Polyketide synthase (PKS)   Modular type I PKS    cis-AT PKS     Polyene macrolide PKS      CP978_03055 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  ketoacyl-synt Acyl_transf_1 KR Ketoacyl-synt_C PKS_DH_N PS-DH KAsynt_C_assoc PP-binding SpnB_Rossmann adh_short CurL-like_PKS_C Thiolase_N Epimerase ADH_zinc_N_2 RhiE-like_linker ADH_zinc_N SDR ADH_N NmrA ACP_syn_III Docking AlaDh_PNT_C Motif Other DBs NCBI-ProteinID:  QEV37651 UniProt:  A0A5P2VYE1 LinkDB All DBs Position complement(643747..660666) Genome browser AA seq 5639 aa AA seqDB search MNAPAENVVAALRAAVKETERLRRRNRTIVAAAREPIAVVGMGCRFPGGVDSPQALWEMV AGGTDVISEFPDDRGWDLEALRTSGIDDRDTSVSQRGGFLDSIADFDPGFFGISPREAVT MDPQQRLLLETAWEAIERARIDATRLRGTRTGTFIGTNGQDYAYLLVRSLDDATGDVGTG IAASAVSGRLSYTFGLEGPAITVDTACSSSLVALHLAVQSLRNGECTLALAGGVNVMSTP GSLVEFSRQGGLAGDGRCKAFSDSADGTGWSEGAAVLALERLSDAQRNGHPVLAVIRGSA VNQDGASNGFTAPNGPSQQRVIRQALSNAGLNPADVDVVEAHGTGTPLGDPIEAQSILAT YGQDREQPLLLGSIKSNMGHTQAASGVAGIMKMIMAMRNEVLPKTLHVDRPSTHVDWTAG KVELLTENRPWPTAPDRPRRSGVSSFGVSGTNAHVIVEQAPQTPAHQPEEAPADPSDEAP AAPRTAGVLPWVLSARSAAALREQAAALLAHLDAPGAPGALDTGYSLATTRASLEHRLAV VTGADGTAGREALTSWLAGDPAPDAHEGRPVGRTRSAFLFSGQGAQRLGMGRELHARFPV FAEALDQVLDLLDEELDASLGDIIWGEEEAPLNETGFTQPALFAVEVALYRLVESWGVTP DFVAGHSIGEIAAAHVAGVFSLEDACRLVAARAGLMQALPSGGAMVAVEATEDEVLPLLT EGVAVAAVNGPTSVVVSGEEKATLAVAEQLAAKGRRTSRLRVSHAFHSPLMDPMLDDFRA VAETLSYDEPQLPVVSNLTGTLAADGQLTSPEYWVRHVREAVRFADGVRALAEAGADVLL ELGPDGVLAALAQQSATALTVPFLRKDRPEEHSAVTALARLHTAGVTVDWAAFHDGTGAR TGELPTYAFQHERYWPKATATAVDATGLGLASADHPLLGAAMSVAGSDELLLTGTLSLAT HPWLADHSVDGMVVFPGTGFLELAVRAADQAGCDRVQELTVATPLVLPATGAVQMQISVG AAGEDGSRELRFFTRPGEDFDAEWTQHATGRIASGEHVLGFDTTVWPPRDSEAVDIEELF DRFASDGLEYGPVFRGLRAAWRQDDTVYAEVELPDSVEDAGAFGLHPALLHAALHGTAFL SDDSGLLPFAWEGVSLHADGASTLRVRIASCGEDTVEIAAVDPAGQPVLSVESLTLRAAD SGAGAASRREEANSLFRVDWTPRTVAAPAAPATWAVLGEDPFGLTAALAGDSEAVAGVHA PAATLEELAARSGAVPDMVAVTVRGDADGGPEAARELTREVLALVQGWLAEPAFASSRLV VVTRDAVADGERGAVDLAAAPVWGLVRSAQSENPGRLLLADVDDTADSLARLPLLAGLFD AEEPQAVVREGTVRVGRLARLESGDSSARALDPEGTVLVTGGTGGLASALARHLVAEHDI RHLLLTSRRGPDAPGAADLVQALAELGAEARVAACDVADREALAALLASVPAEHPLTAVV HTAGVLDDGIFPSLTPDRLDSVMRPKVDAAWHLHDLTRDLDLAAFVLYSSTAGVMGSPGQ ANYAAGNTFLDALAAHRQSLGLPATSLAWGAWEQGVGMTGQLSGQDARRISDAGGMPLLS VERGLALYDAAMLADEPLVVPLGLGGGGPLPAGAGVPAILRGLVRTGGRRARAATAAVAR AGLAERLAVLPEEQRRPFVVDLVRAEAAAVLGHGSADAVDSRREFRGLGFDSLTAIELRN RLGKATGLTLPATLVFDYPTPEQLADHLLDELLGADAIEVFAASQSAADVHDDPVVIVGM GCRFPGGVGSPEDLWDLLASGSDAITGFPADREWESSRLVAGEAGGVSAQGGFLSDIAGF DADFFGISPREALAMDPQQRILLEVTWEAIERAGVDPTALRGSRTGVFMGVNGQDYSSLV MGSRDDVAGHATAGLAVSVVSGRLSYALGLEGPALSVDTACSSSLVSLHLAAQALRSGEC SMALVGGVTVMTTPANFAGFSRMGGLAQDGRCKAFSDSADGTGWSEGAAVLVVERLSDAR RAGHRVLAVVRGSAVNQDGASNGLTAPNGPSQQRVIRQALANAGLRPGDVDAVEAHGTGT PLGDPIEAQALLATYGSDRDPQQPLLLGSVKSNIGHTQAAAGVAGLVKMVMAMRNGVLPR TLHITEPSTHVDWSLGAVQVLTEETAWPETGRVRRAGVSSFGISGTNAHVILEGAPDEPV PAPVADRPVPGAVAWPVSAKSEGALDDQAERLRESADALPALDTAYTLATGRADFEHRAV LLAADGTLTEVARGVAEPHRSAFLFSGQGAQRLGMGRELHARFPVFAEAFDSVTALLESE LDTSVREVMWGTDEGALNATAFTQPALFAVEVALYRLVESWGVTPDFVAGHSVGEIAAAH VAGVFSLEDACRLVAARAGLMQALPSGGAMVAVEATEDEVLPLLTEGVAVAAVNGPTSVV VSGEEQATLAVAEQLAAQGRRTSRLRVSHAFHSPLMDPMLEDFRAVAETLSYHEPRIPVV SNLTGEVAAAGVHTHPDYWVRHVREAVRFADGVRGLADRGVTALLEIGPDGVLSALAAAS LTDTDTVVVPALRKDRDETVSVLSGVARLYVAGVDVDWSAPLSGAGARIADVPTYAFQHE RYWPKAAPAALDATGLGLASADHPLLGAAMSVAGSDELLLTGSLSAATHPWLADHVVGGM IFFPGTGFLELAVRAADQAGCDRVEELMIAAPLVLPATGAVQVQISVGAADEEGSRELRF FTRPGEDFDAEWTQHATGRIGSGEQVIDFDATVWPPRDAEAIDIDGMFERYAADGLEYGP VFRGLRAVWRQDDTVYAEVALPESVEDADAFGLHPALFDAALHSTVFLSAEGDTRSLLPF AWEGVSLHADGASTLRVRIASCGEDTVQIAAVDPGGQPVVSVESLTLRAAGPGDAAEPRR DDSNSLLRVDWTARTLGAPAAPATWAVLGEDPFGLTAALAGDSEAVAGVHAPAATIEELA ARSGAVPDMVAVTVRGDADAGPDDAHELAHEVLALVQGWLAEPAFASSRLVVVTRNAVAD GERGAVDLAAAPVWGLVRSAQSENPGRLLLADVDDTADSLARLPLLAGLFDAEEPQAVVR EGTVRVGRLARLESGTSLVPPAGTPWRLGCRAKGSLDGLALLPYPEAVTPLTGREVRIGI RAAGLNFRDVLNALGMYPGEAGLFGSEGAGVVSEVGPDVTGLAPGDRVMGMVFGGFGPLG VADERLLTRVPDDWSWETASSVPLVFLTAYHALKDLAGLRPGEKILIHAGAGGVGMAAIQ IAHHLGAEVFATASEGKWDVLRSLGVADDHIASSRTLDFETAFTEVAGDKGLDVVLNALA GEFVDASMRLLGTGGRFLEMGKTDIRDSDAASDGITYRFFDLGMVDPDHIQQMLLDLVDL FERDVLSPLPVRAWDVRRSREAFRFMSMAKHIGKIVLTMPRAMDPEGTVLVTGGTGGLAS ALARHLVAEHGIKHLLLTSRRGPDAPGAADLVQALAELGAEARVAACDVADRDALAGLLA SVPAERPLTAVVHTAGVLDDGILASLTPDRLDTVMRPKVDAAWHLHDLTRDLDLAAFVLY SSTSGVFGSPGQANYAAGNTFLDALAAHRQSLGLPATSLAWNAWEQGSGMTSGLSDEDMR RINDNSGMPLLSVERGLALYDAATLADEPLVVPLGLGGGGSLPPGMSVPAILRGLVRTGG RRAKAGAAAVARAGLAERLAVLPEEQRLPFVVDLVRAEAATVLGHGSADAVDARREFRGL GFDSLTAIELRNRLGKASGLTLTATLVFDYPTPQQLAEHLLDELLGADAAEAFAAPQTAA AASDDDPVVIVGMGCRFPGGVGSPEELWDLVASGTDAITGFPADREWESSTIGGEPGDLS GQGGFLSDIADFDADFFGIAPREALAMDPQQRILLEVTWEAVERAGLDPTALRGSRTGVF MGVSGQDYSGLVMRSRDDIASHATTGLAVSVVSGRLSYTLGLEGPALSVDTACSSSLVSL HLAAQALRSGECTMALAGGVTVMTTPANFTGFSKMGGLAHDGRCKAFSDSADGTGWSEGA AVLVLERLSDARRAGHRVLAVVRGSAVNQDGASNGLTAPNGPSQQRVIRQALANAGLRPG DVDAVEAHGTGTPLGDPIEAQALIATYGSDRDPQQPLLLGSVKSNIGHTQSAAGAAGLVK MVMAMHQGTLPRTLHVTEPSTHVDWSLGAVRLLTEETAWPETGRVRRAGVSSFGISGTNA HVILEGAPEPTADDRSAEDTVTPAVTPWVVSARSEQALDAQLERLRAHAAAHPELSGADI GLSLVTSRPSFEHRAVLLAGPDGITEAARAEAGTARTPAFLFSGQGAQRLGMGRELHARF PVFAEVFDSVTALLESELGTSVREVMWGTDEAALNSTAFTQPALFAVEVALYRLVESWGV TPDFVAGHSVGEIAAAHVAGVFSLEDACRLVAARARLMDALPRGGAMAAVEATEDEVLPL LDDGVAVAAVNGPTSVVVSGPEDGVDQLVALLESDGRRTTRLRVSHAFHSSLMDPMLEDF RAVAETLSYHEPRIPVVSNLTGEVASAGTHTHPDYWVRHVREAVRFADGVRALADRGVTA FLEIGPDGVLSALAAASLPDTGTVVVPALRKDRDETVSVLTALARLHTAGLDTDWSAHFA GTGARTVELPTYAFQGTRFWPDTTAAPGDAGGLGLDAGGHPLLTAATSVAGSDETLLSGR LSAAAQPWLTGRTENGTTILPTAVLAELALHAAEACDRTTVENLTVGAPLALTGNRPQRL QVLVGVPDETGRRTLTVHTRADGDDAPWVERATAMLTDAPAAATPDTVWPPADATPVDEL PEPTGPSVLRAAWRRGGDVFAEVEITEQSPAEQAFALHPALLDTAVRAAVLLEGDGGGSG DDTLDAVAWDGLVLHAAHPVLLRVRLTATGDDTWALEATDPQGGPVLSVASVTLGATVAA PVTGAPATDDAALLALDWVAPAPAPRSGDSGPWTVLGDALPGLDTALAAVDNVLVTRADS LAELLDSGAPLPSLMLLPVEGGPTAGHDLPAAVRAATTRVLDLLRRWTSDPRTADSRLAI VTRGAVAAGREDVTDLAAAAVWGLVRSAQSENPGCFLLLDLDPADAAEATDAAVLASLPA LFDAGETQAAVRGGALTVARLTRTEATPAPAADQVRAWDRDGTVLITGGTGGLGAVLARH LVTGHGIKHLLLAGRRGPDAPGATALSKELSALGAEVTVRACDVSDRSAVDALLAGLPAE HPLTAVVHTAGVLDDATIGTLTAEQLDTVLRPKADAAWHLHQATRALPLAGFVLYSSVAG VTGGPGQGNYAAANTFLDALAAHRAAQGLPALSLAWGPWGQGAGMTGTLSDADLERMERS GMPPLTERQGLALFDAANGHDEALAVAIRVSRSAAAPDAGEVPAVLRSLVRARRRAAATA GADGLTRRLAGLGAEQRHETLVGLVRQETAGVLGHSGADAVPADRDFSRLGFDSLMAVEL RTRLSAATGVRLPSTLVFDHPTPAAVARHLADSLTGQDRSGTAASPLAALDRLEAELSAD GVDEAVRRGVEGRLRRLLAAWDGTGSDGNGPAVEERIEAASAEEIFAFIDNELGRSSDS NT seq 16920 nt NT seq  +upstreamnt  +downstreamnt atgaacgcccccgctgagaacgtagttgcggcactgcgcgccgcggtcaaggagaccgag cggctgcgacgccgcaaccggacgatcgtggccgcggcccgggagccgatcgccgtggtc ggcatgggctgccgcttccccggcggcgtcgactccccgcaggccctgtgggagatggtc gccggcggcaccgatgtgatctccgagttcccggacgaccggggctgggacctggaggcg ctgcgcaccagcggcatcgacgaccgggacacctccgtcagccagcggggcggattcctg gactccatcgccgacttcgaccccggcttcttcgggatctcgccgcgcgaggccgtcacc atggacccgcagcagcggctgctcctggagacggcctgggaggcgatcgagcgcgcccgc atcgacgccacccggctgcgcggcacccgcaccggcacgttcatcggcaccaacgggcag gactacgcctatctgctggtgcggtccctggacgacgccaccggggacgtcggcaccggc atcgccgccagtgccgtctccggccggctgtcgtacaccttcggcctggaggggccggcg atcaccgtcgacaccgcctgctcctcctcgctggtggcgctgcacctcgccgtgcagtcg ctgcgcaacggcgagtgcaccctggcgctggccggcggcgtcaatgtgatgtcgacgccg ggctccctggtcgagttcagccggcagggcggtctcgccggggacggtcgctgcaaggcg ttctccgactccgcggacggtaccggctggtccgagggcgcggccgtgctcgccctggag cgcctctccgacgcccagcgcaacggccaccccgtgctcgccgtcatccgcggctccgcc gtcaaccaggacggtgcctccaacggcttcaccgcccccaacggcccctcccagcagcgc gtcatccggcaggccctctccaacgcgggcctgaacccggccgatgtcgacgtggtcgag gcgcacggcaccggcactccgctcggcgaccccatcgaggcccagagcatcctcgccacc tacggccaggaccgtgaacagcccctgctgctcggctcgatcaagtcgaacatgggccac acccaggccgcgtccggtgtcgccgggatcatgaagatgatcatggcgatgcgcaacgag gtgctgccgaagaccctgcacgtcgaccggccctccacccatgtcgactggacggcgggc aaggtcgagctgctcaccgagaaccgcccctggcccaccgcgcccgaccgcccccgccgc tccggcgtctcctccttcggcgtcagcggcaccaacgcccatgtcatcgtcgagcaggcg cctcagactcccgcccatcagccggaagaggcgccggccgacccgtcggacgaggcaccg gccgcgccccgcaccgccggtgtcctgccctgggtgctctcggcgcgctccgccgccgcc ctgcgcgagcaggccgccgccctcctcgcccatctggacgcccccggtgcccccggcgcg ctggacaccgggtactcgctggccaccacccgcgcgtccctggagcacagactcgccgtc gtcaccggcgcggacggcaccgccggccgtgaggcgctcacctcctggctggcgggggac cccgccccggacgcccacgagggccggcccgtcggccgcacccgcagcgccttcctgttc tccgggcagggcgcccagcgcctcggcatgggccgtgaactgcacgcccgcttcccggtg ttcgccgaagccctggaccaggtcctggatctgctcgacgaggaactcgacgcgagcctc ggcgacatcatctggggcgaggaggaagccccgctgaacgagacgggcttcacccagccc gccctgttcgcggtcgaggtcgccctctaccgcctggtggagtcctggggcgtcaccccc gacttcgtcgccggccactccatcggtgagatcgcggcggcgcatgtggcgggggtgttc tcgctggaggacgcctgccgtctggtggccgcacgtgccgggctgatgcaggcgctgccg agtggtggtgccatggtcgccgtggaggcgaccgaggacgaggtgctgccgctgctgacc gagggcgtggctgtcgccgcggtcaacggcccgacgtctgtggtcgtttcgggtgaggag aaggccactctcgcggtcgccgagcagttggcggcgaaggggcgtcgtaccagccgtctg cgggtgagccatgccttccactcgccgctgatggaccccatgctcgacgacttccgcgcg gtcgccgagacactctcctacgacgagccacagctcccggtcgtctccaacctgaccggt accctcgccgccgacgggcagttgaccagcccggagtactgggtgcgtcatgtccgcgag gccgtccggttcgccgacggcgtccgcgcgctcgccgaggccggcgccgacgtcctgctc gaactcggccccgacggtgtgctcgccgccctggcccagcagtccgccaccgccctcacc gtcccgttcctgcgcaaggaccgccccgaggagcacagcgccgtcaccgcgctggcccgg ctgcacacggccggtgtcacggtcgactgggccgcgttccacgacggcaccggtgcccgc accggcgaactgcccacctacgccttccagcacgagcgttactggcccaaggcgaccgcg accgctgtcgacgccaccggtctcggcctcgcctccgccgaccatccgctgctgggcgcc gcgatgtcggtggccggttccgacgaactcctgctcaccggcaccctgtcgctcgccacc cacccctggctcgccgaccacagcgtcgacggcatggtcgtcttccccggtaccgggttc ctggagctggcggtgcgcgccgccgaccaggccggctgcgaccgggtccaggaactgacc gtcgccaccccgctcgtgctgcccgccacgggcgccgtgcagatgcagatctccgtcggc gccgccggcgaggacggctcccgtgagctgcgcttcttcacccggcccggtgaggacttc gacgccgagtggacccagcacgccaccggccgcatcgcctccggcgagcacgtcctcggc ttcgacaccacggtgtggccgccgcgcgactccgaggccgtcgacatcgaggaactgttc gaccgcttcgcctccgacggtctggagtacggcccggtcttccgcggactgcgcgccgcc tggcgccaggacgacacggtctacgccgaggtcgaactgcccgactccgtcgaggacgcc ggtgccttcggtctgcacccggccctgctgcacgccgccctgcacggcaccgccttcctg tccgacgacagtggactgctgccgttcgcctgggagggcgtgtccctgcacgcggacggg gcgagcaccctgcgggtgcggatcgcctcctgcggcgaggacacggtggagatcgcggcg gtcgacccggcgggtcagccggtcctctccgtggagtcgctgacgctgcgcgccgcggac tcgggagccggcgccgcgtcgcgccgtgaggaggccaactcgctgttccgcgtcgactgg acgcctcgtacggtggcggcgccggctgcgcccgccacctgggcggtgctgggcgaggac ccgttcggcctgacggccgcgctggccggtgactccgaggcggtggcgggagtgcatgct ccggccgcgacgctcgaggagctggccgcccggtccggggcggtgcccgacatggtcgcc gtgacggtgcgcggtgacgccgatgggggacccgaagccgctcgcgagctgacgcgtgag gtgctggccctggtgcaggggtggctggccgagcccgccttcgcctcctcccggcttgtg gtggtcacccgggatgcggtcgccgacggtgagcgtggtgcggtcgatctggccgccgct cctgtgtggggtctggtgcgttccgcccagtccgagaacccgggccggctgctgctggcg gatgtcgacgacaccgccgactcgctcgcccgactgccgctgcttgcggggctgttcgac gcggaggagccgcaggccgtcgtccgtgagggcacggtccgggtcggccggctcgcccgg ctggagtccggtgactcttccgcccgcgccctggaccccgaggggaccgtcctggtcacc ggtggcaccggcggcctcgcctccgcgctggcccgccacttggtcgccgagcacgacatc aggcatctgctgctgaccagccgtcgtgggcccgacgccccgggtgccgccgacctcgtc caggcgctggccgaactgggtgccgaggccagggtcgccgcatgtgatgtcgccgaccgt gaagctctggccgcgctgttggcctccgttccggcggagcacccgctgaccgcggtggtg cacacggcgggtgtcctggacgacggcatcttcccctcgctcaccccggaccgtctcgac tcggtcatgcggccgaaggtcgatgccgcctggcatctgcacgacctcacccgcgacctc gacctggccgccttcgtcctgtactcctcgacggccggtgtcatgggcagccccggtcag gccaactacgcggcgggcaacaccttcctggacgcgcttgccgcgcaccgtcagtccctc ggtctgcccgccacctccctcgcctggggagcctgggaacaaggcgtcggcatgaccggc cagttgagcggtcaggacgcacgccgcatcagcgacgccggtgggatgccgctgctgtcc gtcgagcggggccttgccctgtacgacgccgccatgctcgccgacgagccgctggtggtg ccgctcggtctgggcggcggtggcccgttgcccgccggtgccggcgtccccgcgatcctg cgcggactggtccgcaccggtggacgccgcgcccgggcggccaccgccgcggtcgcccgc gccggactggccgagcggctggccgtcctgcccgaggagcagcgtcggccgttcgtcgtg gacctggtgcgtgcggaggccgccgcggtcctcgggcacggttccgccgacgccgtggac tcccgtcgtgagttccgtggtctcggcttcgactcgctcaccgcgatcgagctgcgcaac cggctcggcaaggcgaccggtctcaccctccccgccacgctcgtcttcgactacccgacg cccgagcagctcgccgaccatctcctggacgaactcctcggcgccgacgccatcgaggtc ttcgccgcctctcagagcgctgccgatgtgcacgacgatcccgtggtcatcgtcgggatg ggctgccgcttcccgggtggcgtcggatcgcccgaggacctgtgggacctcctggcgtcc ggttccgacgccatcaccggcttccccgccgatcgcgagtgggaatcgtcgaggctcgtc gccggtgaggccggcggcgtgtccgcgcagggcgggttcctgagcgacatcgccggcttc gacgcggacttcttcgggatctcgccgcgcgaggccctggccatggacccgcagcagcgc atcctgctcgaggtcacctgggaggccatcgagcgcgccggggtcgacccgaccgccctg cgcggcagccgcaccggtgtcttcatgggcgtcaacggccaggactactccagcctggtc atggggtcccgtgacgacgtcgcgggccacgccaccgccggtctggccgtcagtgtggtc tccggccgactctcctacgcgctcggcctggagggtcccgccctctcggtcgacacggcc tgttcctcctccctggtgtcgctgcatctcgccgcgcaggcgctgcggtcgggggagtgc agcatggctctggtgggtggtgtcaccgtgatgaccacccccgccaacttcgccgggttc tcccggatgggcggtctcgcccaggacggacgctgcaaggcgttctccgactccgccgac ggcaccggctggtccgagggcgcggccgtgctcgtggtggagcgcctctccgacgcccgc cgcgccggacaccgggtgctcgccgtggtgcgtggctccgcggtgaaccaggacggtgcc tccaacggcctgaccgcccccaacggcccctcccagcagcgggtcatccggcaggcactg gccaacgccggtctgcgtcccggcgatgtcgacgccgtcgaggcgcatggcaccggcact ccgctcggtgacccgatcgaggcccaggccctgctggccacctatggctccgaccgtgac ccgcagcagccgctgctgctcggctcggtgaagtccaacatcggccacacccaggccgcc gccggtgtcgccgggctcgtcaagatggtcatggcgatgcgcaacggcgtgctgccgcgc accctgcacatcaccgagccgtccacgcatgtcgactggtccctgggcgccgtacaggtg ctcaccgaggagaccgcctggccggagacgggccgggtccgcagggccggtgtgtcctcc ttcggcatcagcggcaccaacgcccatgtcatcctcgagggcgcccccgacgagccggtg cccgcgcctgtcgccgaccggcccgtgcccggcgccgtcgcctggcccgtctcggcgaag tccgagggcgcgctcgacgaccaggcggagcggctgcgggagtccgccgacgcgctgccc gcgctcgacaccgcctacaccctggccaccggccgagccgacttcgagcaccgggcggtc ctgctcgcagccgacggcaccctcaccgaggtcgcccggggcgtcgccgaaccgcaccgc agtgccttcctgttctccggtcagggcgcccagcgcctcggcatggggcgtgaactgcac gcccgtttcccggtgttcgccgaggccttcgactccgtcaccgccctgctggagagcgaa ctcgacacctccgtccgtgaggtgatgtggggcaccgacgaaggcgccctgaacgccacc gcgttcacccagcccgccctgttcgcggtcgaggtcgccctctaccgtctggtggagtcc tggggagtgacccccgacttcgtggccggtcactcggtcggtgagatcgcggcggcgcat gtggcgggggtgttctcgctggaggacgcctgccggctggtggccgcgcgtgcggggctg atgcaggcgttgccgagtggtggtgccatggtcgcggtggaggcgaccgaggacgaggtg ctgccgctgctgaccgagggcgtggctgtggccgcggtcaacggcccgacgtctgtggtc gtttcgggtgaggagcaggccaccctggcggtcgccgagcagcttgccgcgcagggccgc cgcaccagccgtctgcgggtgagtcatgccttccactcgcccttgatggacccgatgctg gaggacttccgggcggtcgcggagacgctctcgtaccacgagccgcggatcccggtcgtg tccaacctgaccggtgaggtcgccgctgcgggcgtacacacccaccccgactactgggtg cgtcatgtccgtgaggccgtgcggttcgccgacggtgtccgcgggctggccgaccggggc gtgaccgccttgctggagatcggccccgacggagtgctctccgcgctcgccgccgcctcc ctgaccgacaccgacaccgtcgtcgtgccggcgctgcgcaaggaccgcgacgagaccgtg tccgtcctcagcggtgtcgcccggctgtacgtcgccggggtcgacgtcgactggtcggcc ccgctgtccggcgccggcgcccgcatcgccgacgtgcccacctacgccttccagcacgag cgttactggcccaaggcggcccccgccgccctggacgccaccggcctcggtctggcctcg gccgaccacccgctgctcggtgccgccatgtcggtggcgggctccgacgaactcctgctg accggctccctgtcggccgccacccatccctggctggccgaccatgtcgtcggcggcatg atcttcttccccggtaccgggttcctggagctggcggtgcgcgccgcggaccaggccggc tgtgaccgggtcgaggaactgatgatcgccgcgccgctggtgctgcccgctacgggcgcg gtccaggtgcagatctccgtgggcgccgccgacgaggagggctctcgcgagctgcgtttc ttcacccggcccggtgaggacttcgacgccgaatggacccagcacgccaccggccgcatc ggctcgggtgagcaggtcatcgatttcgacgccacggtgtggccgccgcgcgacgccgag gcgatcgacatcgacggcatgttcgagcgctatgccgcggacggtctggagtacggcccg gtcttccgtggactgcgtgccgtctggcgtcaggacgacacggtctacgccgaggtcgcg ctgcccgagtcggtcgaggacgccgacgccttcggtctgcacccggcgctcttcgacgcc gccctgcactccacggtcttcctgtccgccgagggcgacacccgcagtctgctgccgttc gcctgggagggcgtgtccctgcacgcggacggggcgagcaccctgcgggtgcggatcgcc tcctgcggcgaggacacggtccagatcgccgcggtcgacccgggcggtcagcccgtggtc tccgtggagtcgctgacgctgcgtgccgcgggcccgggcgacgctgccgagccgcgccgt gacgactccaactccctgctccgggtcgactggaccgcccgtacgctcggggcgcctgcc gcccctgccacctgggcggtgctgggcgaggacccgttcggcctgacggccgcgctggcc ggtgactccgaggcggtggcgggagtgcatgctccggccgcgacgatcgaggagctggcc gcccggtcgggggccgtgcccgacatggtcgccgtgacggtgcggggcgacgccgacgcg ggacccgacgacgctcatgagctggcccacgaggtgctggccctggtgcaggggtggctg gccgagcccgccttcgcctcctcccggcttgtggtggtcacccggaacgcggttgccgac ggtgagcgtggtgcggtcgatctggcggccgctcctgtgtggggtctggtgcgttccgcc cagtccgagaacccgggccggctgctgctggcggatgtcgacgacaccgccgactcgctc gcccgactgccgctgcttgcggggctgttcgacgcggaggagccgcaggccgtcgtccgt gagggcacggtccgggtcggccggctcgcccggctggagtccggcacctccctcgttccg ccggccgggacgccgtggcggttgggctgccgcgccaagggcagcctcgacggtctcgcc ctgctgccgtacccggaggcggtgacaccgctcaccggccgcgaggtgcgcatcggtatc cgtgccgcgggcctcaacttccgcgatgtcctcaacgcgctcggcatgtatcccggtgag gcgggcctgttcggctccgagggcgcgggcgtagtcagcgaggtcggcccggatgtcacc gggctcgcccccggcgaccgggtcatgggcatggtgttcggcggtttcggcccgctgggc gtcgccgacgagcgtctgctgacccgggttcccgacgactggtcctgggagaccgcgtcg tccgtgccgctggtgttcctcaccgcttaccacgcgctgaaggacctcgccgggctgcgg ccgggggagaagatactgatccacgccggcgccggtggtgtcggcatggcggccatccag atcgcccaccatctcggtgcggaggtcttcgcgacggccagcgagggcaagtgggacgta ctgcgctccctcggggtcgccgacgaccacatcgcctcctcgcgcaccctcgactttgag acggcgttcaccgaggtcgcgggggacaagggcctcgatgtcgtcctgaacgcgctggcc ggggagttcgtcgacgcgtcgatgcggctgctcggcacgggcggccggttcctggagatg ggcaagaccgacatccgggactccgacgccgcgtcggacggcatcacctaccggttcttc gacctgggcatggtcgaccccgaccacatccagcagatgctgctcgacctggtcgacctc ttcgagcgggacgtactgtccccgctgccggtccgtgcctgggacgtccgccgatcccgt gaggccttccgcttcatgagcatggccaagcacatcggcaagatcgtgctgaccatgccc cgggccatggaccccgagggcaccgtcctggtcaccggcggtaccggtggcctcgcctcc gcgctggcccgccacttggtcgccgagcacggcatcaagcacctgctgctgaccagccgc cgcggacccgatgcccccggcgccgccgacctcgtccaggcactggccgaactgggtgcc gaggccagggtcgccgcgtgtgatgtcgccgaccgtgatgccctggccgggctgctcgcc tccgttccggccgagcgcccgctgaccgcggtggtgcacacggcgggtgtcctggacgac ggcatcctcgcctccctcacccccgatcgcctcgacaccgtcatgcggccgaaggtcgat gccgcctggcatctgcacgacctcacccgcgatctcgacctggccgccttcgtcctctac tcctcgacctccggcgtcttcggcagcccgggtcaggccaactacgcggcgggcaacacc ttcctggacgccctcgccgcgcaccgtcagtcgctcggcctgcccgccacctccctcgcc tggaacgcctgggagcagggcagcggcatgacgagcggactgagcgacgaggacatgcgc cgcatcaacgacaacagcggcatgccgctgctgtccgtcgagcggggccttgccctgtac gacgcggccaccctcgccgacgaaccgctggtggtgccgctgggcctcggcggtggcggc tcgctgccgcccggcatgagcgtccccgcgatcctgcgcggactggtccgcaccggcgga cgccgggccaaggccggcgccgccgcggtcgcccgcgccggactcgccgagcggctggcc gtcctgcccgaggagcagcgcctgccgttcgtggtcgacctggtacgggccgaggccgcc acggtgctcgggcacggttccgccgacgccgtcgacgcccgccgtgagttccgtggcctg ggcttcgactcgctcaccgcgatcgagctgcgcaaccggctcggcaaggcctcaggactc accctgaccgccaccctggtcttcgactacccgacgccccagcagctcgccgagcacctc ctggacgaactgctcggcgccgacgccgcggaggccttcgccgccccccagaccgccgcc gccgcgtccgacgacgaccccgtggtcatcgtcgggatgggctgccgcttcccgggcggc gtgggatcgcccgaggaactgtgggacctggtggcctccggcaccgacgccatcaccggc ttccccgccgaccgggagtgggagtcgtcgaccatcggcggcgagccgggcgacctgtcc gggcagggcggattcctcagcgacatcgctgacttcgacgccgacttcttcggcatcgca ccgcgcgaggccctcgccatggacccgcagcagcgcatcctgctcgaagtcacctgggag gccgtggagcgcgccggactggacccgaccgccctgcgcggcagccgtaccggtgtcttc atgggcgtcagcggccaggactactccggtctggtcatgcgctcccgcgacgacatcgcc agccacgccaccaccggcctcgccgtgagcgtggtctccggccgcctctcctacacgctc ggcctggagggccccgccctctcggtcgacaccgcctgctcctcctccctggtctcgctg cacctcgccgcgcaggcactgcgatcgggggagtgcaccatggcgctcgccggtggtgtc accgtgatgaccaccccggccaacttcaccgggttctccaagatgggcggtctcgcccac gacggacgctgcaaggcgttctccgactccgccgacggcaccggctggtccgagggcgcg gcggtactcgtcctggagcgcctctccgacgcccgccgcgccggacaccgggtgctcgcc gtggtgcgtggctccgcggtgaaccaggacggtgcctccaacggcctgaccgcccccaac ggcccctcccagcagcgggtcatccggcaggcactggccaacgccggtctgcgtcccggc gatgtcgacgccgtcgaggcacatggcaccggcaccccgctcggtgacccgatcgaggcc caggccctgatcgccacctacggctccgaccgtgacccgcagcagccgctgctgctcggc tcggtgaagtccaacatcggccacacccagtccgcggccggcgccgccggactcgtcaag atggtcatggcgatgcaccagggcacgctcccgcgcaccctgcacgtcaccgagccgtcc acgcacgtcgactggtccctgggcgccgtccggctgctcaccgaggagaccgcctggccg gagaccggccgggtccgcagggccggtgtgtcctccttcggcatcagcggcaccaacgcc catgtcatcctcgagggcgcccccgagcccaccgcggacgaccgctccgccgaggacacc gtgacgcccgccgtcaccccgtgggtcgtctcggcccgctccgagcaggcgctcgacgcc cagctggagcggctgcgcgcccatgccgccgcgcacccggagctgtccggcgccgacatc ggtctgtccctggtgacgagccggccctccttcgagcaccgggccgtcctgctggcgggc cccgacggcatcaccgaggccgcgcgcgccgaggccggcaccgcccgcacaccggcgttc ctgttctccggtcagggcgcccagcgcctcggcatgggccgtgaactgcacgcccgtttc ccggtgttcgccgaggtcttcgactccgtcaccgccctgctggagagcgaactcggcacc tccgtccgtgaggtgatgtggggcaccgacgaagccgccctgaactccaccgcgttcacc cagcccgccctcttcgcggtcgaggtcgccctctaccgcctggtggagtcctggggagtg acccccgacttcgtcgccggtcactcggtcggtgagatcgcggccgcgcatgtggcgggg gtgttctcgctggaggacgcctgccggctggtcgccgcccgcgcccggctcatggacgcg ctgccccggggcggcgccatggccgccgtcgaggccaccgaggacgaggtgctgccgctg ctcgacgacggggtcgccgtcgccgccgtcaacggccccacctccgtcgtcgtctccggc cccgaggacggcgtcgaccagctggtcgccctcctggagtcggacggccgccgcaccacc cggctgcgcgtcagccacgcgttccactcgtcgctgatggacccgatgctggaggacttc cgggcggtcgcggagacgctctcgtaccacgagccgcggatcccggtcgtgtccaatctg accggtgaggtcgcctccgcgggcacccacacccaccccgactactgggtgcgccacgtc cgtgaggcggtgcgcttcgccgacggtgtccgcgcgctcgccgaccggggtgtgaccgcc ttcctggagatcggccccgacggagtgctctccgcgctcgccgccgcctccctgcccgac accggcaccgtcgtcgtgccggcgctgcgcaaggaccgcgacgagaccgtgtccgtcctc accgccctggcccggctgcacaccgcgggcctggacaccgactggagcgcccacttcgcc ggcaccggcgcccgcaccgtcgaactgcccacctacgccttccagggcacccgcttctgg cccgacaccaccgccgctcccggcgacgcgggcggactgggcctggacgccggagggcac ccgctgctcaccgccgccacatcggtcgccggctcggacgagacgctgctcagcgggcgc ctgtccgccgccgcacagccctggctcaccggccgcacggagaacggcaccaccatcctg cccaccgcggtcctcgccgaactcgcgctgcacgccgccgaggcctgcgaccgcaccacc gtcgagaacctcaccgtcggcgcacccctggcgctcaccgggaaccgcccccagcgcctc caggtactggtgggcgtccccgacgagaccggccggcgcaccctcaccgtgcacacccgc gccgacggcgacgacgccccctgggtcgagcgggccaccgccatgctcaccgacgcgccc gccgccgccacgcccgacaccgtatggccgcccgccgacgccaccccggtcgacgagctg cccgaacccaccggcccgtccgtgctgcgcgccgcctggcggcgcggcggggacgtcttc gccgaggtcgagatcaccgaacagagcccggccgagcaggcgttcgccctgcacccggcg ctcctggacaccgcggtccgcgccgccgtcctcctcgaaggagacgggggcggatccgga gacgacaccctcgacgccgtcgcctgggacgggctcgtcctgcacgccgcgcaccccgtc ctcctgcgggtacggctcaccgccaccggcgacgacacctgggcgctggaggcgaccgac ccacagggcggcccggtgctctcggtggcctcggtcaccctgggcgccaccgtcgccgca cccgtcaccggcgcccccgccacggacgacgccgcgctgctcgccctggactgggtcgcg cccgccccggccccgcgctccggcgacagcggcccctggacggtgctcggcgacgcgctg cccggcctggacaccgcgctcgccgcggtggacaacgtcctcgtcacccgcgcggactcg ctcgccgaactgctggacagcggggcacccctgccgtcgctgatgctgctgccggtcgag ggcggccccaccgcggggcacgacctgcccgccgcggtccgcgccgccaccacgagggtg ctggacctgctgcgccgctggacctccgacccccgcaccgcggactcccgcctcgcgatc gtcacccgtggcgccgtcgcggccggccgggaggacgtgaccgatctggcggccgcagcc gtctggggcctggtccgctccgcccagtccgagaacccggggtgcttcctgctcctcgac ctcgacccggccgacgcggccgaggcgaccgacgccgccgtcctggcctcgctgcccgcc ctgttcgacgcgggcgagacccaggccgccgtccgcggcggcgcgctcaccgtcgcccgc ctcacccgcaccgaggccacgcccgccccggccgccgaccaggtccgtgcctgggaccgc gacggcaccgtactgatcaccggcggcaccggaggcctcggcgccgtactcgcccgccac ctggtcaccggccacggcatcaagcacctgctgctggccggccgccgcggacccgacgca cccggggccaccgccctgagcaaggaactctccgcgctcggcgccgaggtcaccgtacgg gcctgcgacgtctccgaccggtccgccgtcgacgcgctgctcgccgggctgccggccgag cacccgctgaccgcggtcgtgcacacggcgggcgtcctcgacgacgccacgatcggcacc ctcaccgccgaacagctcgacaccgtgctgcggcccaaggcggacgccgcctggcatctg caccaggcgacccgggccctgccgctcgccggattcgtcctgtactcctccgtggccggc gtcaccggcggccccggacagggcaactacgctgccgccaacacgttcctcgacgcgctc gccgcgcaccgtgcggcccagggcctgcccgccctgtcgctcgcctggggaccgtggggc cagggcgccggcatgaccggcacgctcagcgacgccgacctcgagcgcatggaacgctcc gggatgccgccgctcaccgaacgacagggcctcgccctgttcgacgcggcgaacggccac gacgaggcgctggccgtggcgatccgggtctcccggtccgccgcggcccccgacgccggc gaggtgcccgcggtgctgcgctccctggtccgcgcccggcgtcgcgcggcggccacggcc ggcgccgacgggctcacccgccgactggccggcctcggcgccgagcagcggcacgaaacc ctcgtcggcctggtccgccaggagacggccggggtgctcggtcactccggggccgacgcg gtccccgccgaccgggacttcagccggctgggcttcgactcgctgatggcggtcgaactg cgcacccggctctccgcggccaccggtgtgcggctgccgtccacgctggtcttcgaccac ccgacgcccgccgccgtcgcccggcacctggccgactccctgacgggccaggaccgcagc ggcaccgccgcatccccgctggcggcgctcgaccggctggaggcggaactgtccgccgac ggcgtggacgaggccgtccgccgcggggtcgagggccggctgcggcggctgctggccgcc tgggacggcaccggctcggacgggaacggaccggccgtcgaggagcggatcgaggcggcg agcgccgaggagatcttcgccttcatcgacaacgaactcggccggtcgtcggattcctga

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