Sitophilus oryzae (rice weevil): 115877801 Help Entry 115877801         CDS       T07985                                  Name (RefSeq) ryanodine receptor isoform X1   KO K04962   ryanodine receptor 2 Organism soy  Sitophilus oryzae (rice weevil) Brite KEGG Orthology (KO) [BR:soy00001]  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:soy04040]     115877801    04990 Domain-containing proteins not elsewhere classified [BR:soy04990]     115877801 Ion channels [BR:soy04040]  Voltage-gated cation channels   Ryanodine receptor    115877801 Domain-containing proteins not elsewhere classified [BR:soy04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    115877801 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR SPRY Ins145_P3_rec MIR RR_TM4-6 RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  115877801 NCBI-ProteinID:  XP_030749975 UniProt:  A0A6J2XGA9 LinkDB All DBs Position Unknown AA seq 5122 aa AA seqDB search MVAEAEGGSEQDDVSFLRTEDMVCLSCTATGERVCLAAEGFGNRHCFLENIADKNIPPDL SQCVFVIEQALSVRALQELVTAAGNETDSDNLGKGTGSGHRTLLYGNAILLRHQNSDMYL ACLSTSSSNDKLAFDVGLQEHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERY LHTTKENELSIVNASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGGDECLTIPST WSTEETHNIVIYEGGSVMSQARSLWRLELARTKWAGGFINWSHPMRIRHITTGRYLAVKE NNELYLVSREEATTASTAFCLRHEKDDQKVVLEDKDLEVIGSAIIKYGDSTVIVQHSESG LWLSYKAYETKKKGVGKVEEKQAVLHEEGKMDDGLDFSRSQEEESRTARVIRKCSSLFTQ FINGLESLQVNRRHSMFFQVVNLNEMVMCLEDLINYFAQPEDDMEHEEKQNRLRALRNRQ DLFQEEGILNLILEAIDKINVITSQGFLATLAGDQSWEMISGYLYQLLAAIIKGNHTNCA QFANSNRLNWLFSRLGSQASSEGTGMLDVLHCVLIDSPEALNMMRDEHIKVIISLLEKHG RDPKVLDVLCSLCVGNGVAVRSSQNNICDYLLPGKNLLLQTQLVDHVASVRPNIFVGRVE GSAIYQKWYFEVTVDHLEQTTHMMPHLRIGWANTTGYVPYPGGGEKWGGNGVGDDLYSFG FDGAFLWTGGRSTQVVGGVVEPYIKKNDVIGCALDLTVPQISFTFNGHLVTGSFRNFNLD GMFFPSISCSSKLSCRFLLGGDHGKLKFSPPEDFSPLVESLLPQQILNLDPCFYFGNMNK NVIAGPFYIEDDTAFVPNPVDTSMVSLPSYIESIKDKLAENIHEMWAMNKIEAGWSWGDY RDDLRHIHPCLVPFDKLPPAEKKYDSQLAVQTLKTIIALGYYITMDKPPSRIKTVRLPHE PFMQANGYKPAPLDLSAINLSPKLEELVDQLAENTHNLWAKERIQQAWTYGLNEDPEMLR SPHLVPYSKVDDAIKKANRDTASETVRTLLVYGYIIDPPTGEQQETLLAEASRLRQQAFR TYRAEKNYAVSSGKWYFEFEILTAGPMRVGWAKADCAPGCMLGSDENTWAFDGYNEEKVY SNSAESFGKQWQVGDVVGVFLDLIDHTISFSLNGELLMDALGGETTFADVQGDNFVPAFT LGVGQKARLCFGQDVNQLKYFTMCGLQEGYEPFCVNMNRAVTYWYTKDQPIFENTDDMPD TKIDVTRILAGSDSPPCLKISHNTFETMEKANWEFLRLSLPVICHSEFITEEEKMRRWNE IKIRQHRLKAEVEQQMTPAHIENIMKSGFSMSDIKGLHRNYSEDAVESDEVLKQQQQQQH LSRSPTHGKAMPARPPRKGSLSRNANVNGFDENYLAMNGTRGVHRSTSELDMHRYHDAAP QIVVDKAEDKKKRGRSPFRFFSKKRGDTSSAERVKNKKGRTPEPHSVRIGAGMTPTARSV GLSNTMLSRSPTVKPLPGESLQVPSIPERQQKQLSVPQTSDIEAVGNEIYDAECLKLINE YFYGVRIFPGQDPTHTYIGWVTTQYHFFSKEFNQNHVLKSSVVIADEYNRIIECIDRQSC YMVRADELYNQVTQDASGKGASQGMFIGCFLDAATGIITFTCDGKPTSHRFKMEPETKLF PAIFVEATSKEIMQIELGRTSTSLPLSAAVLQNSAKHVIPQFPPRLKVQCLKPHQWARVP NHNLQVHALKLSDIRGWSMLCEDPISMLALHIPEEDRCIDILELIEMDKLLSFHAHTLTL YSALCYQSNYKAAHVLCKHVDQKQLLYAIKSEYMSGPLRQGFYDLLISLHLEATATTMEV CKNEYVIPLGQELKDLYEDSEMGHSLRRLQIESVVPQMKTSEISDNIENIKSLYSPYFPL DVVRDYVMTALAESVEINQVHNRDPIGGSNENLFLPLLKLVDRLLLVGMLSDDHVEKLLI MICPETWDPTFEKDGKDEHRKGLLSMKMAEGAKLQMCYLLHHLCDIQLRHRVESIIAFSH DFVGELQTDQLRRYIEIKQSDLPSAMAAKKTKEFRCPPREQMNAILCKFKEQAFKNLEEE DKDNCPLGDDLCERMNGFHDQLMSHVSLQALAAPQDEENSDDKIKAGPLNKLYNFINAVK ELEEEPKPEPEPEKKTPEEVFRKVLISTIVRWAEEAQIENSKLVQEMFSLLVRQYDAVGE LIRALEKTYIINIKTKSDVAEMWVGLSQIRALLPVQMSQEEEELMRERLWKLVNNHTFFQ HPDLIRVLRIHENVMAVMINTLGRRSQAQSDASAQPQNPDGETTGKEKDTSHEMVVACCR FLCYFCRTGRQNQKAMFEHFDFLLDNSNILLSRPSLRGSTPLDVSYSSLMENTELALALR EHYLEKIAIYLSRCGLQSNTELVEKGYPDLGWDPVEGERYLDFLRFCVWVNGESVEENAN LVIRLLIRRPECLGPALRGEGEGLLKAIVDANKMSDRITDRRKMMEDAPEGTVNLAQFSH PLPENDDDEDYIDTGAAILNFYCTLVDLLGRCAPDAAVIALGKNESLRARAILRSLVPLE DLQGVLSLKFTLHNPAQGEERPKSDMPSGLTPPHKQSIVLFLERVYGIETQELFFKLLEE AFLPDLRCATMLDRHDGSESDMALSMNRYIGNSILPLLIQHSKFYSEAENYASLLDATLH TVYRLSKNRMLTKGQREAVSDFLVALTSQLQPSMLLKLLRKLTVDVSNLSEYTTVALRLL TLHYDRCAKYYGSSSGQGIYGAASDEEKRLTMMLFSNIFDSLSKMDYEPELFGKALPCLT AIGCALPPDYSLSKNYDDEWYSNKTVKTGPDGPYNPQPINTSTVQLSNDLNNIVQQFSEH YHDAWASRKLENGWRYGEQYSGWEGNKSHPRLKPYSMLTDYERERYKEPVRESLKALLAL GWSVEHTEVDLPSSNRGSQFMRGESATPFDYDPHPVDMTNLTLSREMQNMAERLAENAHD IWARKKKEELNTCGGGIHPQLVPYDLLTDKEKKKDRERSQEFLKYLQYQGLKLHRPNRGG QQETELSTAGPSVELRFAYSLLEKLIQYLDKATINMKLLKPSQTFSRRNSYTKSSRDIKF FSKVVLPLMEKYFSTHRNYFIAVATATNNTGAASLKEKEMVAALFCKLANLLRSRLAAFG ADVRITVRCLQVLVKGIDAKSLVKNCPEFIRTSMLTFFNNTADDLGHTIINLQEGKYSHL RGTHLKTSTSLFYVNSVLLPVLTSLFDHLANCEYGSDLLLDEIQVASYKILQGLFHLGTD ATLHRDRKYLKTEMEKYKPTLGSCLGAFSSTFPVAFLEPHLNKNNQFSLLNRIADHSLEA QDIIVKMEAFMPTLETILSEVDHFVESDKTYSDAPHIIDVIMPMLCSYLPFWWSQGPDNV SPTGGSYVSMVTGEHMNQLLKNVLKLIKKNIGNENAPWMTRIAAYTQQIIINSSEELLKD PFLPLAERVKKRTEAMFHKEESLRGFIKSSSDDTSQIETQIQEEWHLLVRDIYSFYPLLI KYVDLQRNHWLRHNVEEAEHLYNHVADIFNIWSNSQYFLREEQNFISANEIDNMVLIMPT ATRRTVVPDGSQPSVGKKKKKHRDKKRDKDKEIQASLMVACLKRLLPVGLNLFAGREQEL VQHCKDRFLKKMPEYEIIDFAKIQLTLPDKIDPADEMSWQHYLYSKLGKKSVTVNTVDSN GKNQLEETVDRIVAMSKVLYGLHMIDHPQQQQKGVYRSIVSTQRKRAVLSCFRQASLHSL PRHRAINIFIRTYRDFWLQDENVGQEVMIEDLTQSFEDSELKKKDEEEEEGKPDPLTQLV TTFCRGAMTERSGALQEDPLYMSYAEIIAKSCGEEEEEGEEGGEEGGEGEEGGSSIHEQE MEKQKLLFNQARLANRGVAEMVLLHISACKGVPSDMVMKTLELGISILRGGNFDIQMGML NHLKDKKDVGFFTSIAGLMNSCSVLDLDAFERNTKAEGLGVGSEGAAGEKNMHDAEFTCA LFRFIQLTCEGHNLEWQNYLRTQAGNTTTVNVVICTVDYLLRLQESIMDFYWHYSSKELI DPAGKANFFKAIGVASQVFNTLTEVIQGPCTLNQQALAHSRLWDAVGGFLFLFSHMQDKL SKHSSQVDLLKELLNLQKDMITMMLSMLEGNVVNGTIGKQMVDTLVESASNVELILKYFD MFLKLKDLTSSASFQEIDVNSDGWVYPKDFKEKMEQQKSYTPEEIEFLLACCETNHDGKI DYEGFIDRFHEPAKEIGFNLAVLLTNLSEHMPNEPRLARFLETAGSVLNYFEPFLGRIEI LGSSKRIERVYFEIKESNIEQWEKPQIKESKRAFFYSIVTEGGDKEKLEAFINFCEDAIF EMQHASGLMAVEDSGGSGQIRATTYSYMADEDEQKGKDPVRRTYQNFKEAIYYGFSALSP SNIKHKIIEMQQMTIPELFVGFFKLLFYSFYYSGFGFVVVIKYLLGILMSLMRGPVVEEP MIEIKEEEKVSPLRMLPQLPPAEDPNTQIQAFGVDVTKEEGGQYKMAAHESPTGSQPSSG EGEGETTPEDGEQTEAETPEQPLSLSDLLGGEQAKLAAQEKVEAQAAQQAAMQAIESENK AKSTTEVSAMQQINFSAYTHRAVSFLARNFYNLKYVALVLAFCINFMLLFYKVSTLGGDS DGSGSGSGKGSDIIEGSVEGSGSGGSEEEDDPPELVMVDEDFYYMAHVMRLAAALHSLVS LAMLIAYYHLKVPLAIFKREKEIARRLEFEGLYIAEQPEDDDLKSHWDKLVISAKSFPVN YWDKFVKKKVRQKYSETYDFDSISNLLGMEKTSFQQQDSDEGHKTIIWYILNIDWRYQVW KSGVTITDNSFLYSLWYFTFSILGNFNNFFFAAHLLDVAVGFKTLRTILQSVTHNGKQLV LTVMLLTIIVYIYTVIAFNFFRKFYVQEEDEEVDRKCHDMLTCFVFHLYKGVRAGGGIGD EIEPPDGDDYEVYRIMFDITFFFFVIVILLAIIQGLIIDAFGELRDQLEKVIEDMDSNCF ICGLDKGYLDKVPHGFDTHVQQEHNLANYMFFLMHLINKPDTEYTGQETYVWNMYQQRCW DFFPMGDCFRKQYEDEIGGGGG NT seq 15369 nt NT seq  +upstreamnt  +downstreamnt atggtggctgaagctgaagggggctcggagcaggacgatgtttcgttcttgcggacggaa gacatggtgtgtttatcctgtacagccacaggagaacgcgtatgtcttgccgcagaaggg tttggtaatcggcattgctttttagaaaatatcgcagacaagaatattcctccagacctg tcgcaatgcgtgttcgttatagaacaggctctatcagtgcgagctttgcaggaattggtc accgcagcaggaaacgagaccgattcggacaacttaggtaaaggtactggatctggacat agaacattgctttacggcaatgctattctgctcagacatcaaaacagcgatatgtacttg gcatgcttatcgactagttccagtaatgataagctggctttcgatgtgggtttgcaagaa cacagtcaaggagaggcttgctggtggacggtacatccagctagcaaacagagatctgaa ggtgaaaaagtacgtgtgggtgacgacctgatcttagtctcagttgctacagaaagatat ttgcacacaaccaaggaaaatgaactctccatcgtcaacgctagttttcacgtcacccat tggtcggtacaaccctacggtaccggtatatcccgtatgaagtacgtcggttatgtattc ggaggtgacgtactaagattcttccacggaggtgatgagtgccttaccataccatcaaca tggagcacagaagaaactcacaatattgttatttatgaaggaggtagtgttatgtcccaa gctagatcattgtggaggttagagctggctagaacgaaatgggcgggtggcttcataaac tggagtcatccaatgagaatccggcacatcactactggtcgatatctagctgtaaaagag aataacgaactttatctcgttagcagagaagaagctaccacagcatctacagctttttgc ttgagacatgaaaaagacgaccaaaaagtagttctagaagacaaagatttagaagtaatt ggttcggccatcataaaatacggtgattccactgtaatcgtccaacattcggaatcggga ctttggttgtcctataaggcctacgaaacgaagaaaaaaggagtgggtaaagtcgaagaa aaacaagccgtactccacgaagaaggcaaaatggacgacggcctagacttcagcagaagc caagaggaagaatcgcgaacagctagagtcatccgcaaatgcagctcactattcacgcaa ttcatcaacggcttggaaagcctgcaagtcaacaggcggcactccatgttcttccaagtc gtcaacctcaacgaaatggtcatgtgcttggaagatctaatcaattactttgctcaaccc gaggatgatatggaacacgaagaaaagcagaacagactcagagctttgaggaaccgtcaa gacctcttccaagaggaaggaatcttgaatttgatcttggaagcgattgataagatcaac gtaatcacttcgcaaggattcttagctactctggcaggtgatcagagctgggagatgatt tccggatacttatatcaacttctggcagcaataatcaaagggaaccacacgaattgtgct cagtttgctaattctaatcgattaaattggttattttctcgattaggatctcaagcttct agcgaaggtacaggaatgttagatgtacttcactgcgtccttattgattctcctgaagct ctaaacatgatgagagatgaacacattaaagtaattatttccctactcgaaaaacacggt agagatcctaaagttctggatgtcctctgttctctttgtgttggtaacggagtagccgta agaagttcacagaataatatttgcgattacctccttcctggaaagaatcttttactacaa actcaactagtcgatcacgtagcaagtgttagaccaaacatcttcgtaggccgagtggag ggtagcgctatttaccagaagtggtacttcgaagtgacggtggatcatctggagcaaacc actcacatgatgccgcatttgaggatcggctgggctaatactactggttacgttccttat ccaggtggtggggagaaatggggtggcaatggagtgggggatgacttgtattcgtttggt ttcgacggtgccttcttgtggactggcggtagatcgactcaagtggttggtggtgtggtc gagccttacataaaaaagaatgacgtaattggttgtgccttggatcttactgttccacaa atttcatttacatttaacggacatttggtaactggtagctttagaaattttaatttggac ggcatgttcttcccttccattagctgttcttccaagctcagttgtcgctttttgcttggc ggagatcacggaaaactaaaattttcccctcctgaagatttttcaccgttggttgaaagc cttctgcctcaacaaatcctcaacctagacccttgtttctacttcggaaatatgaacaag aacgtgatagcagggccgttttacatcgaagatgacactgcttttgtacccaatcccgtc gatacctccatggtctccttgcctagttatatagaatctatcaaagataagttagctgag aacatccacgaaatgtgggcgatgaacaagatcgaagctggatggtcgtggggtgattat agagatgatttgaggcatatacatccgtgtttggtgcctttcgataaactaccacccgca gagaagaagtacgattcacagttggcagtacaaactttaaaaaccatcattgctctgggt tattacatcacaatggataagccaccgtccagaattaagacggttagactcccccacgag cctttcatgcaagccaacggttacaagcctgcacctctcgacctcagcgctatcaaccta tcgcctaaattggaggaactagtcgaccagctagcggagaatacccacaacctttgggcc aaagaacgaattcaacaggcatggacctatgggttgaacgaggacccagagatgttgcgt agtcctcatctagtgccttatagcaaagtagatgacgctatcaagaaagctaatagggat acagcttccgaaacagtacgcacgttgttggtatatggatatatcatagatccaccaacc ggtgaacaacaagaaactttactggctgaagcaagtagattgagacaacaagcctttaga acttacagagccgaaaaaaattacgctgtcagttccggaaagtggtacttcgagttcgaa attttgacagccggacccatgagagtgggctgggctaaagccgactgtgctcctggttgt atgctgggttcagacgagaatacttgggcttttgacggctataacgaagaaaaagtttat tctaactctgccgaatctttcggaaaacagtggcaagtgggagatgttgtcggtgtattt ctcgatctaatcgatcatacgataagtttctcactgaatggtgaactactcatggacgct ttgggtggtgaaacgacgtttgctgacgtccaaggtgataattttgttcccgccttcaca ctgggtgttggtcagaaagcgcggctatgttttggccaggatgtgaatcaacttaaatat ttcacaatgtgcggcctacaagagggatacgaacctttttgcgtaaacatgaaccgtgca gtaacttactggtacactaaagaccaacccatattcgaaaacaccgacgacatgccggac acaaaaattgacgtaaccaggattctagctggctctgacagtccgccatgtttaaaaatc agccacaacactttcgagaccatggaaaaagcaaactgggaatttttgaggctcagttta cctgtaatctgccactcagagttcataactgaggaggaaaaaatgagacgttggaatgaa atcaagattaggcaacacaggcttaaggctgaggtggagcagcagatgacgccagctcac atagagaatatcatgaagagcggattttcaatgagtgatattaaagggcttcataggaac tactccgaagacgctgttgaatctgacgaagtcctcaaacagcaacagcaacaacaacat ttatccagatctccaactcatggaaaggcaatgccggctcgtccaccaaggaaaggatcc ctttccagaaatgccaacgtcaatggatttgacgaaaattatttggctatgaacggtact agaggtgttcacagatccaccagtgagttggatatgcacaggtatcacgatgcggcacca cagattgtagtggacaaggctgaagataagaaaaagagaggaagatcacctttcagattt ttctccaaaaaacgtggtgacacttcaagcgcggaacgcgtcaaaaacaagaaaggtcgt actcctgagccccactctgtcagaattggtgcaggaatgacaccaacagctagatctgta ggtctgtccaacaccatgttgtcaagaagtcctactgtcaaacctttaccgggtgaatca ttgcaagtaccttccatcccagaacgtcaacaaaaacagttatctgttccccaaacatca gacatcgaagcagtaggcaacgaaatatatgatgcagaatgtctgaaattgatcaacgaa tatttctatggagttaggatttttcctggtcaggacccaactcacacttacatcggttgg gttactacccagtaccactttttcagcaaagaattcaaccaaaaccacgtattgaaatca tccgtagttattgctgatgaatacaaccgaatcattgaatgcattgacagacaatcctgc tacatggtcagggccgacgaactatacaaccaagtgacccaagatgcttcaggcaaaggt gcctcgcaaggcatgtttattgggtgtttcctggacgctgccactggcatcatcacattc acatgtgacggtaaacctacctcgcacagattcaagatggagccagagactaagctattt cctgcaatcttcgtggaagccaccagcaaagaaatcatgcaaattgagctgggtaggaca tctaccagtcttcctctatcagcagcagtgttgcaaaatagcgctaagcatgttatacca caatttccacctaggttgaaggttcagtgcttgaagcctcatcagtgggctagggttcct aatcacaatcttcaagtccacgccttaaaactctccgacatacgaggatggtcgatgtta tgtgaagaccccatttccatgcttgccctccatatcccagaagaagatcgctgtatcgac atcttggaattgatagaaatggataaattactgagcttccatgcccatactcttacactg tactcagccctgtgctaccagagcaactataaagcagctcacgtgttatgcaagcacgtt gatcaaaaacaactgctttacgccatcaagtctgagtatatgagcggtcctttaagacaa ggattctacgatttgttgatatcactgcatttggaagcaacagcaactactatggaggtt tgtaagaacgagtatgttatacctttaggtcaagaattaaaagacttgtatgaagactca gaaatgggacacagtttaagacgattgcaaatagagtctgtagtaccacaaatgaaaact tcggaaataagcgacaatatcgaaaatatcaagagtttgtattcaccctattttccgctg gatgtggttcgtgactatgtgatgaccgccttagctgagtcggttgaaatcaaccaagta cacaatagggatcctataggcggttcaaacgaaaacctatttttacctctactcaaatta gtagaccgtctgctcctagtaggaatgctgagcgacgaccacgtggaaaaactcctgata atgatctgccccgaaacgtgggaccccaccttcgaaaaagacggcaaggacgagcaccgc aaaggcctactctcgatgaaaatggccgagggggccaaactccaaatgtgctacctcctc caccacctgtgcgacatccagctgcgccacagagtcgaatcgatcatcgctttcagccac gacttcgtcggagaacttcaaaccgaccagttgcgcagatacatcgagatcaagcagtcg gatttgccctcggctatggccgctaagaagacgaaggagttccggtgtccgccaagggag cagatgaacgccatcttgtgtaagtttaaggaacaagcttttaaaaacttggaggaagag gataaagacaactgcccccttggtgatgatctctgtgaacgaatgaacggatttcacgat cagctgatgtctcacgtgtcgttacaagcgctagctgcaccacaggatgaggaaaattcc gacgacaaaattaaagctggtccattaaataagctttacaacttcattaatgctgtgaag gagttggaagaagaacctaaaccagagccagaaccagaaaaaaaaacaccggaagaagta ttccgtaaagtactcatcagtaccatagtcaggtgggcagaagaagcccaaatagaaaac tcgaaactagtccaggaaatgttcagtttactagtcagacagtacgacgctgttggagaa ctaattcgtgcattagaaaaaacctacatcatcaatatcaaaaccaaatcagacgtagcc gaaatgtgggtgggtctgagccagatcagagcacttttacctgtccaaatgtctcaagaa gaagaagaacttatgagggaacggctttggaagctcgtgaacaaccacacgttcttccag catcctgatttgatcagagttctaagaattcacgagaatgtgatggccgttatgatcaac actctcggtagaagatcacaggctcagtctgatgccagtgcgcagccgcagaaccctgat ggcgagactactggcaaagaaaaagatacctcacacgaaatggtggtagcttgttgcagg tttttgtgttacttttgtagaactggtcgtcaaaaccaaaaggccatgttcgagcatttc gactttttattggacaacagtaatatcctcctttcccgaccaagtcttagaggttctaca cctctggacgtttcctattcgtctctaatggagaacactgagctagcactggctcttagg gaacactatttagaaaaaatcgcgatatatttgtcacgttgtggtctacagtcgaatact gagcttgtagaaaagggttatccagatttaggatgggatccagttgaaggggagcgttac ttagattttctaaggttctgcgtttgggttaacggagaaagcgtggaggaaaatgctaac ttagttataaggctgttgattagacggcccgaatgcttaggtccagccctgagaggtgaa ggggaaggtttattgaaagctattgtcgatgcaaacaagatgtcagacagaattactgac agaagaaagatgatggaagacgcgccagaaggaactgttaatctcgcccaattctcccac ccactccctgaaaacgacgatgatgaagactacatagacaccggagcagccatccttaac ttctactgtactttagtagaccttctaggtcgttgtgctcccgacgctgcagtcatcgcc ttgggtaaaaacgaatcgttaagagcaagagccatcttgaggtctttggtgccgctagaa gacctccaaggcgtgcttagtctcaagttcacactacacaaccctgctcaaggagaggaa agacctaaatctgatatgccttcaggtctaacaccgcctcacaagcaatctatagttctg ttcttagaacgagtttacggtatagagacacaagaattgttctttaagctactggaagaa gcatttttacctgacttgagatgtgccacaatgctggataggcatgatggcagtgagtca gacatggccctaagcatgaacagatatataggcaattccatactgcctctcctgattcaa cacagtaaattctacagcgaagcagaaaactacgcttctcttctcgatgccactcttcac acggtataccgtctgtcaaagaaccgcatgctgaccaaaggtcaaagagaagcagtatca gacttcctggtcgctctaaccagtcagctacaaccatcaatgctgttgaaactgttaagg aaattaacagtagatgtctcgaatttatctgaatacactacggtagctttgagacttcta accttacattacgacagatgtgcgaagtattatggttcaagttcaggtcagggtatttat ggagcagccagtgatgaggaaaaaaggcttactatgatgttgttttcgaatatattcgac tctctttctaagatggattatgagccagaactttttggaaaggctttaccatgccttacc gccattggttgtgccttaccacctgattattcactgtccaaaaactacgatgacgaatgg tactcgaacaaaactgtcaaaaccggtcctgatggtccttataacccgcaacccatcaat acatcgactgtacagctcagcaacgatcttaacaatatagttcagcaattttctgaacac taccacgatgcttgggcatcgagaaagctcgaaaacggttggagatacggagaacagtat tctggctgggaaggtaacaagtctcatccgaggctcaaaccgtactctatgctcacggat tatgaaagagagcgatataaggagccggtaagagagtcgttgaaagctttgttagcgtta ggctggtcagtagagcatactgaagtggatcttccttcttcgaacagagggtctcagttt atgagaggagagagtgcgacgccgtttgattatgatccacatccggtggatatgacgaat ttaactttgtcaagggagatgcagaatatggctgaacgattggccgagaatgctcatgat atttgggctaggaagaagaaggaggaacttaacacttgtggaggtggaattcaccctcag ttagtaccatacgatcttctaacagacaaagaaaagaaaaaagacagagaacgttcacaa gaattcctcaagtacttgcagtatcaaggtttaaaacttcacagaccaaatcgcggaggt caacaagaaacagaattatccacagcaggtccctctgttgaactccgttttgcttacagt ctactcgaaaagctcatccaatacctggataaagccaccatcaacatgaagttgctcaaa ccctcacagaccttcagcagaagaaactcgtacactaaatcatcaagagatatcaaattt ttctccaaagttgtactaccgttgatggagaaatatttttcaactcatagaaactacttc atcgctgttgccacagctacaaacaacaccggagctgccagtttgaaggagaaagaaatg gtagcagcgttgttctgtaaattggctaatttgctcagatccaggttggccgcttttgga gctgacgtcagaattacagtgaggtgcttacaagtgttggtcaaaggcattgatgccaag tctcttgttaaaaattgtcctgagttcatcagaacatcgatgttgacgttcttcaataat actgctgacgatttggggcatacgatcataaatttgcaagagggaaaatacagtcaccta agaggaacgcacttaaaaacatccacatcactgttttacgtgaattcagtgttgttgcct gttcttacttcactgtttgatcacttggctaattgtgaatatggaagcgacttattattg gacgaaattcaggtagcttcctataaaattctccaaggcctcttccatcttggcacagac gctacactccatcgtgacaggaagtacctaaaaacagaaatggaaaaatacaaacctact cttggttcctgcttgggagcgttcagttccacctttcctgtagcctttttggagccacat ttgaacaaaaacaatcaattttctttactgaaccgtatagcagaccattcacttgaagct caagatattatagtgaaaatggaggcttttatgcctactttggaaacaattttgtctgaa gtagatcattttgtggagagcgacaagacttattctgatgctcctcatattattgatgtt attatgcctatgttgtgttcttatctgccgttttggtggtcacagggtccagataatgtc agtcctactggaggatcctacgtctctatggttaccggagaacatatgaatcagctcctg aagaatgtgttaaagctcatcaagaagaacatcggtaacgagaacgctccatggatgacg aggatagcagcgtatactcaacaaatcatcatcaatagcagcgaagaattgttgaaagat ccgttcttacctctggctgaaagagttaagaaacgaaccgaagcaatgttccataaagaa gagagtttaagagggtttattaagagtagttcggatgatacatcacagattgaaactcag atccaggaagaatggcatcttttagtgcgggacatctactcgttctaccctcttctaata aaatacgtggatcttcaaagaaaccattggctaaggcacaatgtagaagaagctgaacac ctttacaaccacgtcgcagatatcttcaacatctggtctaactctcagtacttcttgaga gaagaacaaaactttatatctgcaaacgaaattgataatatggtgttgattatgcccact gctacaagaagaactgttgtacctgatggttcacaaccttcagtgggaaagaaaaaaaag aagcatcgcgacaaaaagcgagacaaggacaaagaaattcaagcctccttgatggtagcc tgcctcaaacgtctccttcctgtcggtttgaacttgttcgcaggcagagaacaagaatta gtccaacattgcaaggacaggttcttgaaaaagatgccggaatacgaaattatcgatttt gccaaaattcaactaacactgcccgacaaaattgacccggcagatgagatgtcgtggcaa cattacttgtatagtaaacttggcaagaagagtgtcactgtcaatacggtggacagtaat ggcaagaaccaactagaggagactgtggatagaatagttgctatgagtaaagtcttgtac ggattacatatgatcgaccatccccagcagcagcagaagggcgtttataggtcgatagtt tccacgcaaaggaaaagggcggttctgtcttgtttccgccaagcttctttgcacagtttg ccaaggcatcgggctatcaacatttttatccgaacataccgagacttctggcttcaagac gagaatgtcggacaggaagtgatgatcgaagatcttactcaaagttttgaggactctgaa ctgaagaaaaaggacgaggaagaagaagagggaaaaccagatcctcttacacagcttgtc actacgttctgtagaggagccatgacagaaagatccggagcgttacaagaagatcccctc tatatgagttatgcggaaattatcgctaaatcttgcggtgaggaagaggaagaaggagaa gaggggggcgaagaagggggtgaaggtgaagaaggaggttcctccatccatgaacaagaa atggaaaaacagaaattactcttcaaccaagccagactggcaaacagaggcgtagcagaa atggtactgttacatatatcagcctgcaaaggcgtaccatcggatatggtgatgaaaacc ttagaactgggtatctccattctgagaggcggtaacttcgacatacaaatgggcatgctg aaccacctgaaagacaagaaagacgtagggttcttcactagtattgctggtttaatgaat agttgtagtgtattggatctggacgcttttgaaagaaacaccaaggcagaaggtctggga gttggttctgaaggtgcggctggcgagaagaatatgcatgacgctgaattcacttgtgcc ttgtttagatttatccagcttacttgtgaaggtcacaatttagaatggcagaactatttg cgtacccaagccggtaacaccaccacagtgaacgtagtcatttgcacggtagattaccta ctgagactgcaagaatccatcatggacttctactggcattactctagcaaggaactcatc gacccagctggtaaagcgaatttcttcaaagccattggcgtagctagtcaggttttcaac acgctcactgaagtcattcagggtccttgtactctgaatcagcaggctctggcacattcc aggttatgggatgcagttggtggtttcctgtttctgttctctcacatgcaggataagtta tccaaacactcgagtcaggtggatttgctgaaggaacttcttaacttgcaaaaggacatg attaccatgatgctttcaatgcttgaaggtaatgtcgtgaacggcaccatcggtaaacaa atggtggacaccttggtggaaagtgcctccaacgtagaattaatcctgaaatacttcgac atgttcctgaagctaaaagatctaacatcgtcggccagtttccaagaaatcgatgtcaac agcgacggctgggtctatcccaaagacttcaaagaaaaaatggaacagcaaaaaagctat acaccggaagagattgagttccttttagcttgttgtgagaccaaccacgacggaaaaatc gactacgaaggttttatagatcgtttccacgaacccgctaaagaaatcggtttcaacttg gccgtgttgctcacaaatctgtcagaacacatgcctaacgagcctaggctggctagattc ttagaaactgcaggctctgtattgaattattttgagcccttcttaggtcgcattgaaatc ttaggtagcagcaaacgaatcgagagagtatatttcgagatcaaagaatcgaacatcgag cagtgggagaagcctcaaatcaaggaatccaagcgggccttcttctactccattgtgacg gaaggtggtgacaaggagaagcttgaggcctttatcaatttctgcgaggacgccatcttt gagatgcaacacgccagcggattgatggccgttgaagattcgggtggcagtggccaaatt cgtgcgacgacttatagttatatggctgacgaagatgaacaaaaggggaaagatccagtg agacgaacttaccaaaacttcaaagaagcaatctactatggtttctcagcactgagtcca tcgaacatcaaacacaaaatcatcgaaatgcaacagatgacgataccagaactattcgtg ggcttctttaaattactcttctactccttctactattccggtttcggattcgtggtcgtt ataaaatatctcctgggcatactgatgtccttgatgagaggtccggtagtcgaagaaccg atgatcgaaataaaggaggaggaaaaagtgagtccgctgagaatgctgcctcagttaccg ccggcagaagaccctaacactcagattcaggcgtttggtgtggacgtaacaaaagaagaa ggcgggcagtacaaaatggcagctcacgagtctccaactggaagtcagccgtcttctgga gaaggtgaaggtgaaacaactcctgaagatggagaacaaacggaagctgaaacgcccgaa caaccgttgtcgctgtccgatctcttaggtggagaacaagccaagttagccgcccaagaa aaagtggaagctcaggcggctcaacaggccgctatgcaagccatcgagtctgagaacaag gctaaatcaactaccgaagtatcggcgatgcaacagatcaatttcagcgcctacacccac agagccgtctcgtttttggccaggaacttctacaatttgaaatatgtcgccttggtattg gctttctgcatcaatttcatgttattgttctacaaggtatctacgctaggtggcgattct gacggtagcggaagcggtagtggcaaaggctccgacataatcgaaggttcggtcgagggt agtggctcaggaggatcagaagaagaagacgacccgcctgaattggtaatggtggacgaa gatttctactacatggcgcacgtgatgagactggcggccgctttacattctctggtatct ctagccatgctgatagcgtactaccacttaaaagtacctctggccatctttaaaagggaa aaggaaatcgcgaggagattggaatttgaaggattgtatatagcggaacaacctgaggat gatgacttgaagtctcattgggataaacttgttatttcggcaaaatcgtttccggtgaac tattgggacaaatttgtcaagaaaaaggtgcgtcagaagtacagtgagacctacgacttc gactccatcagcaacttactagggatggaaaaaacgtctttccaacaacaggactctgat gagggacacaaaactatcatttggtatatactgaacatcgattggagataccaagtctgg aaatccggagttaccatcaccgacaactccttcctctattccctgtggtacttcacgttc tccatcctgggtaacttcaacaacttcttcttcgccgctcatctcctagatgtcgctgtc ggtttcaaaacgttgcgcaccatcttgcagtcggtcactcacaacggaaaacagctggtg ctcaccgtgatgctgctcaccatcatcgtgtacatttacacggtcatagcgttcaacttc ttcaggaagttctacgtgcaggaggaggacgaggaagttgacaggaaatgtcacgacatg ttgacgtgtttcgtgttccatctttacaaaggtgtgagagctggtggtggtataggtgac gaaattgaacctccagatggtgatgactatgaggtctaccgaataatgttcgacatcaca ttcttcttcttcgtcattgtcatcctgttggccatcatccaaggtttgatcatcgacgct tttggtgaactccgtgaccagttggagaaggttatagaagacatggactcaaattgtttc atttgtggattggataagggatatttggataaggtgccgcacgggttcgatacccacgtc caacaggaacataacctcgctaattacatgttcttcctcatgcacttgatcaacaaaccg gacacagaatacactggtcaagaaacatacgtatggaacatgtaccagcaaagatgctgg gacttcttcccaatgggtgactgtttccgcaaacagtacgaagatgaaataggaggtggt ggaggctag

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