Streptomyces parvulus: Spa2297_32540 Help Entry Spa2297_32540     CDS       T04685                                  Name (GenBank) hypothetical protein   KO K15670   rifamycin polyketide synthase modules 1, 2 and 3 [EC:6.2.1.74] Organism spav  Streptomyces parvulus Pathway spav01051   Biosynthesis of ansamycins spav01052   Type I polyketide structures Brite KEGG Orthology (KO) [BR:spav00001]  09100 Metabolism   09109 Metabolism of terpenoids and polyketides    01052 Type I polyketide structures     Spa2297_32540    01051 Biosynthesis of ansamycins     Spa2297_32540  09180 Brite Hierarchies   09181 Protein families: metabolism    01008 Polyketide biosynthesis proteins [BR:spav01008]     Spa2297_32540 Enzymes [BR:spav01000]  6. Ligases   6.2  Forming carbon-sulfur bonds    6.2.1  Acid-thiol ligases     6.2.1.74  3-amino-5-hydroxybenzoate---[acyl-carrier protein] ligase      Spa2297_32540 Polyketide biosynthesis proteins [BR:spav01008]  Polyketide synthase (PKS)   Modular type I PKS    cis-AT PKS     Rifamycin PKS      Spa2297_32540 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  ketoacyl-synt Acyl_transf_1 Ketoacyl-synt_C KR AMP-binding PP-binding KAsynt_C_assoc CurL-like_PKS_C adh_short RhiE-like_linker Thiolase_N PKS_DH_N AMP-binding_C SpnB_Rossmann PKS_DE Epimerase ACP_syn_III PS-DH 3Beta_HSD GDP_Man_Dehyd NmrA Motif Other DBs NCBI-ProteinID:  ANJ11853 UniProt:  A0A191VAF2 LinkDB All DBs Position pSPA1:85554..102038 Genome browser AA seq 5494 aa AA seqDB search MRTDLIKPLPVALLENAARLPDKVAFADDKRAVTYGDLEARTRRLAGHLAHLGVGHGDRV AICLGNTVATVESYLAVVRAGGIGVPLNPASAPAELEYLLADSGALVVITDATRARHFRG GPGKDTGPVLLVTGRTAADLAEEAGVHAYEALACSEPPLPARDDLALDEVAWMFYTSGTT GRPKGVLSTQRNCLWSVASSYVPIPGLSDRDRVLWPLPLFHSLSHIACVLSVTVTGATAR LVDGASADDVMRILKEDRSTFLAGVPTTYHHLVSAARDGGFDAPDLRIGLVGGAVTGPGL RRDFEETFGVPLVDAYGSTETCGAITMNPPDGPRVDGSCGLPVPGVDVRIVDPVTGTDAP TDVEGEVWVSGPNVMVGYHNAPEATAEAIRDGWFRTGDLARRDERGYFAIRGRIKELVIR GGENIHPEEVEAVLRTVDGVVDAAVAGAPHDTLGEVPVAYVVAGDSGFDAAELIARCRER LSAYKVPERVREVAGIPRTASGKTKRLVLAEQPGRLRYAADGHHDALTRVEWLPASESSG TRPAETRPAETRPAETRPAETRPGGVRWAVAGPVAGLLDTLDAAGVEVRHYEDLAALADA VTAGDPVPDVTVVVPPPATPAARHTDAFAAARERARRLGRDLETWTAWPQASAGRLVLLT RGAVAATITDPAQNLAEAALWGVVRSLQETRPGSLTVVDIPDGADGSGPEASLGTLSAVL ATGEPQVAVRAGDLLVPRLTPLPVTDPPRQDSPRPGFTAPGNSGGPADSGGSGRSGTVLV TGADTEHGAALAHRLATVHGATSLLLVGAPGSRADTPGDALAFAGTSVLRITADAAHREP LRAALADLTELGQPVIAVVDAAGDPDLTLCLDLLTAGDDLRTWVAAVPGAAGLPGVAGAS DAAASVAVDGSLCEALVRARRLRGLPGSFLTWSGPTADAAAGTDMGRLRQDMLAAFDFAL TDGSPAPLAVPPPGVAADGEQIPAILRALAPAPTTAGRGEPDAALKASLRAELSGMDDRA QLTFLEDLVRTLAAEAMHLAGPASVPADRAFRDLGFTSMAVVALRNRLTERTGLRLPTTV AFDHPTPADLAVFLRSEILGVPQSAPVTGLALTANTDDPADPVVIVGMACRLPGGVSSPE QLWRLVADGVDAISDFPEDRGWDLKHLYAPDQPERPGTSSTNQGGFLTGAGLFDAGFFGI SPREALAMDPQQRLLLEASWEAFESAGMDPLALKGADVGVFSGLFGQGYGTGSVPPELEG FASTGTASSVASGRVSYVFGFEGPAVSVDTACSSSLVAMHLAAQALRQGECTTALAGGVA VMATPDNFVEFSRQGALSADGRCKAFAEGADGTGWAEGVGVVVLERLSVARERGHKVLAV LRGSAVNQDGASNGLTAPNGPSQQRVIRRALASAGLSSSDVDAVEAHGTGTALGDPIEAQ ALLATYGQGRDPERPLWLGSLKSNVGHTQAAAGVAGVIKMVQALRHGVLPATLHVDAPTT QVDWSAGAVELLTEAREWPRGDRPRRAGVSSFGVSGTNAHLILEEAPAEEDASLAPSSGG VVPLVLSARSAGSLAGQAERLAAVAGSAGVPLESVAGSLVTRRALLGERAVVVADSGEEA VAGLRALARGESAPGVVSGSSGAPGRVVWVFPGQGSQWAGMGRELLEASPVFAERITECA AALEPFIDWSLIDVLRGDADPGLMERVDVLQPASFAVMVGLAAVWQSAGVKPDAVLGHSQ GEIAAAAVSGALSLEDAARVVALRSQAIAGQLAGRGGMASVALSEDEAVGRLERWAGRVE VAAVNGPSSVVIAGDAEALDEALEALAADGIRVRRVAVDYASHTRHVEDIRDTLAETLAG VTAQAPSIPFYSTVTGEWIETAGVLDGGYWYRNLRSQVGFGPAVAVLLKQGHGVFVEVSA HPVLVQPITETVYAADGDTDAMVTGSLRREDGGLRRLLTSMAEVFVRGVPVDWSGILPEG ATSARLELPTYAFDHQHYWLQATDAPTDATALGLAAADHPLLGAVVGLPNSGGLVATSRW SLRAQPWLAEYLLSDTVVVPNAALVELAVRLGDLASVPFLDVLTVDTPVVLPQGGDRSIQ VVVGECDGERRPVEVYSRAADAPLDAEWTRHAHGVLAPAAGHETPAVPERGGEAAEVRLG DAVGQDADRYGLHPALLDAAVRTVVPDGTVPSVWSGVALLASGATELRVRGGEALGGAVP LLLTDPTGRPVMSVEGVRATPFSAERLGIGAALPYDSLFRVDWVQVPLPAVDRVLGLVAV GGGRDVADLGATGGAAPDFLVYDSRPESASGDPRAAVGATLAVLRAWLAEPALAETRLAV VTGDCDTLEAAAVWGLVRSAQSEHPDRIVLLDLGGDFASVPPAAILSGEPQLRMRGRLAH VPRLVRSRGGASPEAGTAVPRLDPEGTVLITGGAGTLGALTARHLVTVHGVRHLLLVGRR GRAEGLREELTALGACVTVAACDVADRRQVEELLRTVPVAHPLTAVVHTAGVLDDGVLTE QTPDRVDTVLRPKLDAALHLHELTRDMDLAAFVLFSSAAGVLGNPGQANYAAANACLDAL ARQRHRLGLPAVSIAWGYWSTVSAMTEHLDAADLRRNRRIGMAGLTAAEGMALLNAALGS AADADGTLLAAKFDLTALRAAATDGPVPAPLRALAPAPRPVAGSAAPAPGRGGVAERLAG LSGTEQHEFLTDLVRRHAAEVLGHASADAIRADRPFKDAGFDSLTAVELRNRLVAATGLT LSPAVIFDYPKPAVLARHLRGRLLGTAEPGADELAVRGAADGSAGSDTGDEPIAIVAMAC RFPAGVHSPEDLWRVVADGVDVVTEFPDDRGWDTDRLFDPDPDHAGTTYVRHGAFLDDAA GFDAAFFGISPNEALAMDPQQRLLLETSWEAFERAAIDPTTLAGQDVGVFVGVNSHDYSV LMHQASGVEGFRLTGSSGSVTSGRVAYHLGTEGPAITVDTACSSSLVALHLAAQALNRGE CTMALAGGVMVMGTVETFVEFSRQRGLAPDGRCKAFADGADGTGWSEGAGLLLVERLSDA RRNGHQVLAVVRGTAVNQDGASNGLTAPNGPAQQRVIRRALAHAGLRADDVDAVEAHGTG TTLGDPIEAEALLATYGQGRPAERPLWLGSVKSNIGHTQAAAGVAGVIKMVMAMRHGVLP RTLHVDRPSTHVDWSAGSVELLTEAREWPREGRPRRTGVSSFGIGGTNAHVILEEAPGLP EPTPADREPAGPEAAASSSGPVPVPVLVPVSGRTSAGLRGQADRLARFLAERPGTPLAET AHALATTRAQLDHRAVVLATDPEQLGADLVALAADRATPAAVTGAPATGRLAVLFTGQGS QWAGMGRELAEAFPVFRDAFDSACAAVDIHLSGHADRPLREVVLGVADAPGSALLDRTLY TQGALFALETALYRLFESWGVRPDLVAGHSVGEITAAHVSGVLGLQDAAELVAARGRLMQ ALPEGGAMVAVKATEADLAPLLDRASGEVCVAAVNGPDALVLSGAEDAVLAVAGELARRG HKTHRLTVSHAFHSALMEPMLDEFRTVAERLPFRRGTLRVVSTVTGELATDEQLTDPGYW VGQARAAVRFGDALTTLGEQGATTFLELGPGGVLTALALAAPGIPEQGCLATLRKDGAEP ADVLTALAHLHVRGVPLDWAAVLGRTTPATETGTELPTYAFQHRRYWVDTANGSATGNGT GGAGIATADGSGSIGGADIADPRVESDQRAVAPDAGVDGAFAARLAGLSAQEQHRTVTDL VKESVAVVLGHGDPDAFDWNAQQSFRSLGFDSLGGVKLRNRLRDFTGVELPATLVFDYPT PEVLVDHLRAELLGEQAQSPGATTATGLTAATDEPIAIVAMSTRLPGGVDSPEALWELVS EGQDAITGFPVDRDWDLDGLYHPDPDHPGTSYTRSGGFLHEAAQFDAALFGISPREALAM DPQQRLLLETSWEALERAGIDPLSTRGSDIGVFTGIVHHDYVTRLREVPADVQGYLMTGT ASSVASGRVSYVFGFEGPAVTVDTACSSSLVAMHLAAQALRQGECSMALAGGATVMASPD AFMEFSRQRGLSADGRCKAFAEGADGTGWAEGVGVVVLERLSVARERGHKVLAVLKGSAV NQDGASNGLTAPNGPSQQRVIRRALASAGLSASDVDVVEAHGTGTALGDPIEAQALLAAY GKERDAERPLWLGSLKSNIGHAQAAAGVAGVIKMVQALRHGVLPATLHADTPTTQVDWSA GAVQLLTEAREWPREERRPRRAGVSSFGASGTNAHVILEEAPAEDEGPVRAPSSGGVVPL VLSARSAGSLAGQAGRLASFVERNDGVDLVDVAGALVGGRAVLGERAVVVADTDGGALTG LRALVRGEGAPGVVSGSSGTPGRVVWVFPGQGSQWAGMGRELLDASPVFAERITECAAAL EPFIDWSLIDVLRGDADPGLMERVDVLQPASFAVMVGLAAVWQSVGVKPGAVLGHSQGEI AAACVSGALSLEDAARVVALRSQAIAGQLAGRGGMASVALSESEAVGRLERWADRVEVAA VNGPSSVVIAGDAEALDEALEALAADGIRVRRVAVDYASHTRHVEDIRDTLADTLAEVTA KAPSIPFYSTVTGEWIANEGVLDGGYWYRNLRGQVGFGPAVAALLKQGHGVFVEVSAHPV LVQPITETVYAADGDTDAMVTGSLRREDGGLRRLLTSMAELFVRGVPVDWSGILPDGATS ARVELPTYAFDRQHYWLQEAEATGEAADVAEGADSDFWQAVEQADLNALTELLETATAEE RDALGSVVPVLAEWRGKRRERSSAERLRYHVTWQPLERDAAGVPGGQWLVVVPAERPDDT AIDALLEELTGQGLGMVLLEVDDADRTRERLVERLTGVLAGRDVSGVLSLLALDERTAGG PQDPLAVTASTLALVQALADSLVTQPLWCLTRGAVNMGINDTLTSPAQAALWGLGRAAAL ERLDRWGGLVDLPARTDARAAQYLLGVLNGVGGEDQLAVRRSGVYSRRLVRKPAPDATAG DGRWQPRGTVLVTGGAEGLGRHVAVRLAQAGADRLVVTTTARAPGTAVPDLTAELAGLGL DTAVASCADTDREAITRLLAGTEHPLTAVVHAADITRTSSIDDTGAAELAEVFAAKVDTA VWLDERFEDTPLDAFVVFSSIAGVWGGGGQGPSGAANAVLDALVEWRRARGLRATAIACG ALDEIGVGMDEAALAQLRRRGVLPVDPKLAVTAMVQAVQAGEKFVTVADMDWGAFVPAFT SVRPSPLLADLPEAKAVLQAAQRDSENTDAAASLADSLRAVTDTDQNRILLRLVRSHASV VLGHGGAEGIGPRQAFQEVGFDSLAAVNLRNSLGAATGLRLPATLVFDYPTPEALVGYLR AELLQDTEDAEDAVDEREDDLRQVLASVPFARFKEAGVLDALLSLADNAAGDEQDEHGES ADGSAAGEPQAGTEELIDAMDVAGLVQRALGKTS NT seq 16485 nt NT seq  +upstreamnt  +downstreamnt gtgcgcaccgacctcatcaagcccctgcccgtcgcactcctggagaacgcggcccgtctc cccgacaaggtcgccttcgcggacgacaagcgagcggtcacctacggggacctggaggca cggacgcgccggctggccggacacctggcccacctgggcgtcggacacggcgaccgggtg gccatctgcctcggcaacaccgtggccaccgtggagagttacttggccgtcgtgcgcgcg ggaggcatcggcgtaccgctcaaccccgcctccgcgccggccgagctggagtacctgctc gccgacagcggcgccctcgtggtcatcaccgatgccacccgggcgcggcacttccggggc gggcccggcaaggacacggggcccgtcctcctcgtcacggggcgcacggcggctgacctg gccgaggaggccggtgtccacgcctacgaggcgctggcctgctccgagccgcccctgccc gccagggacgacctcgccctggacgaagtggcgtggatgttctacacgtccggaacgacg ggccggcccaagggcgtgctgtcgacacagcgcaactgcctgtggtccgtggcctcgtcc tacgtaccgatccccggcctctcggaccgggaccgggtgctgtggccgctgccgctcttc cacagcctctcgcacatcgcgtgcgtgctgtccgtcaccgtcaccggcgccaccgcccgg ctcgtggacggcgcctccgccgacgacgtcatgcggatcctgaaggaggaccgctcgacc ttcctcgccggcgtccccaccacctaccaccacctcgtctccgccgcccgcgacggcggc ttcgacgcgccggacctgcgcatcggcctggtcgggggcgccgtcaccggccccggactg cgccgggacttcgaggagaccttcggggtgccgctggtcgacgcctacggcagcaccgag acctgcggggccatcaccatgaacccgcccgacggcccccgcgtcgacggctcgtgcggc ctgcccgtgcccggcgtcgacgtccgcatcgtcgaccctgtcaccggcaccgacgccccc acggacgtcgagggcgaggtctgggtcagcgggcccaacgtcatggtcggctaccacaac gcccccgaggcgaccgccgaggcgattcgcgacggctggttccgtaccggagacctggcc cggcgcgacgagcgcggctacttcgccatccgcggccggatcaaggaactcgtcatccgg ggcggggagaacatccatcccgaggaggtcgaggcggtcctgcggaccgtcgacggcgtc gtggacgcggccgtcgccggcgcaccgcacgacacgctcggcgaagtacccgtcgcctac gtcgtcgcgggcgactccggcttcgatgccgccgagctgatcgcccgctgccgcgagcgg ctgtccgcctacaaggtgccggaacgcgtccgcgaggtcgccggcatcccccgtaccgcg tcgggcaagaccaagcgtctcgtgctggccgagcagccgggcaggctgcggtacgcggcg gacggtcaccacgacgcgctgacgcgggtcgagtggctcccggcatcggagtcctccggc acccgcccggccgagacccgcccggccgagacccgcccggccgagacccgcccggccgag acccgcccgggcggcgttcgctgggccgtggccggtcccgtggccgggctcctcgacacc ctggacgcggccggcgtcgaggtccgtcactacgaggacctggcggccttggccgacgcg gtcaccgccggcgaccccgtcccggacgtgacggtcgtcgtaccgccgcccgcgacccct gccgcgcggcacaccgacgcgttcgccgccgcgcgggagcgggcccggcgactgggccgg gacctggagacgtggaccgcgtggccgcaggcgtcggccggccggctggtcctcctcacc cgcggcgccgtagcggcgaccatcaccgacccggctcagaacctggccgaggcggcgctc tggggcgtcgtgcgctccctgcaggagacgcggccggggtcgctgacggtggtggacata cccgacggagcggacgggtccggcccggaggcgtccctcggcacgctgtcggccgtgctc gccactggagagccgcaggtcgcggtgcgtgcaggggatctgctcgtgccccggctgacc ccgctgcccgtcaccgacccgccgcggcaggactccccgcgaccgggcttcaccgccccc gggaactcaggcggccccgcggactcaggcggctccggccgctccggaacggtgctggtc accggcgcggacaccgagcacggcgcggcgctcgcacaccgcctcgccacggtccatggc gcgacgtccctcctcctcgtcggagcccccggcagccgagccgacaccccgggcgacgcc ctggccttcgccggcaccagcgtgctgcggatcaccgcggacgccgcacaccgcgagccg ctgcgcgccgccctggccgacctgaccgaactcgggcagccggtcatcgcggtcgtcgac gcggccggagaccccgacctgaccctgtgcctcgacctcctgaccgcgggggacgacctc cggacctgggtcgcggcggtgcccggtgcggcggggttgccaggcgtcgccggagcctcg gacgcggccgcgtccgtggccgtagacggcagcctctgcgaagcactggtgcgcgcgcgc cgactgcggggcctgcccggatcgttcctcacctggagcggacctacggccgacgcggcc gccggcaccgacatggggcggctgcggcaagacatgctcgccgcgttcgacttcgccctg accgacggctccccggctccgctggccgtcccgccgccgggcgtcgccgcggatggtgag cagatacccgccatcctgcgtgccctcgccccggccccgacgaccgccggacggggcgag ccggacgcggccctcaaggcatccctgcgcgccgaactgtccgggatggacgaccgcgcg caactgacgttcctggaagacctcgttcgcaccctcgcagccgaggcgatgcacctcgca ggccccgcctccgtacccgccgaccgcgccttccgcgatctgggcttcacctcgatggcc gtcgtcgcgctgcgcaaccggctgaccgagcgcaccgggctgcgcctgcccacgacggtc gccttcgaccatccaaccccggcggacctcgccgtcttcctgcggtccgagatcctcggc gtcccgcagtcggcgccggtcaccggactggccctgaccgcgaacaccgacgacccggcc gacccggtcgtcatcgtcggcatggcctgccggctgcccggcggggtgtcctcgcccgaa cagctctggaggctggtggcggacggtgtcgacgccatctccgacttccccgaggaccgg ggctgggacctgaagcacctttacgcacccgaccagcccgagcgtcctggaacctccagc accaatcagggtggcttcctgaccggggcgggtctgttcgacgcgggcttcttcggcatc tcgccgcgtgaggcgctggcgatggacccgcagcagcggctgctcctggaggcttcctgg gaggcgttcgagagcgccgggatggacccgctcgcgctcaagggcgccgacgtcggcgtc ttctccgggctgttcggccagggctacggaacgggttccgtcccaccggaactggaaggc ttcgcgagcaccggtacggcgtcgagtgtcgcgtcgggccgggtgtcgtacgtcttcggc ttcgagggccccgcggtgtcggtggacacggcgtgctcgtcgtcgctggtggcgatgcat ctggccgcgcaggcgctgcgccagggcgagtgcaccacggccctcgccggcggcgtggcg gtgatggcgacccccgacaacttcgtcgagttctcccggcagggcgccctctccgcggac gggcgttgcaaggcgttcgcggagggtgcggacggcacgggctgggccgagggtgtgggg gtcgtggtcctggagcgcctgtcggtggcacgggagcgcggtcacaaggtgctggccgtg cttcggggcagtgcggtgaaccaggacggtgcgtccaatggtctgacggcgccgaacggt ccctcgcagcagcgggtgatccggcgggcgctggccagtgccgggctctcgtcgagcgat gtggatgccgtcgaggctcatgggacgggcacggcgctgggcgatccgatcgaggcgcag gcgctgctggcgacctacgggcaggggcgcgatccggaacggcccttgtggctcggttcg ttgaagtcgaacgtcgggcatacgcaggcggccgcgggtgtggccggtgtgatcaagatg gtgcaggcgctgcggcacggtgtgctgccggcgacactgcatgtggatgcgcccacgacg caggtggactggtcggcgggtgcggtggagctgctgacggaggcgcgggagtggccgcgc ggggaccgtccgcgtcgcgcgggcgtctcgtccttcggggtgagcgggacgaacgcgcac ctgattctggaggaggcgcctgccgaggaggacgcctccctggctccctcttccggtggt gtggtgccgctggttctgtcggcgcggagtgcgggttcccttgccggacaggcggagcgg cttgcggctgtggccggttccgcgggtgtgccgttggagtcggtggccggttcactggtg acgcgtcgagctctgctgggtgagcgcgcggtggtcgtggccgactccggtgaggaggct gtggccgggctgcgggcgcttgcgcggggtgagagtgcgcctggtgtggtgtcaggcagt tctggggcgccgggccgggtggtgtgggtgttcccgggtcagggctcgcagtgggcgggc atgggccgggaactcctcgaagcctccccggtgttcgccgagcggatcaccgagtgcgcg gcggccctggagcccttcatcgactggtcgttgatcgacgtactgcgcggagatgcggac cccggcctgatggagcgggtcgacgtcctccagccggcgagcttcgcggtgatggtgggt ctggcggccgtctggcaatcagcgggcgtcaaacccgatgcggtgctggggcactcgcag ggtgagatcgctgcggccgcggtcagtggtgctctgtcgttggaggatgcggctcgcgtc gtggcgctgcgcagtcaggccatcgccgggcagctcgccgggcggggtggcatggcctcg gtcgcgctgagcgaggacgaggcggtcgggcggctggaacgctgggcgggccgcgtggag gtggccgccgtcaacgggccctcgtccgtggtgatcgccggtgacgccgaagccctggac gaagcactggaggccctggccgccgacgggatcagggtgcggcgggtcgcggtggactac gcctcgcacacccggcacgtcgaggacatccgcgacacgctcgccgagaccctcgctggc gtcacggcccaggcgccgtcgatcccgttctactcgaccgtgacgggggagtggatcgag accgccggtgtcctggacggcggttactggtaccgcaacctccgcagtcaggtcggcttc ggccccgcggtcgccgtcctcctgaagcagggccacggcgtcttcgtcgaggtcagcgcg cacccggtgctggtgcagccgatcaccgagaccgtctacgccgccgacggcgacaccgac gctatggtcaccggttcgctgcgccgcgaggacggcggcctgcgccgtctgctcacgtcg atggccgaagtcttcgtgcgcggcgtcccggtcgactggtccggcatcctgcccgagggg gccacgtcggcccgcctcgagctgcccacgtacgccttcgaccaccagcactactggctc caggccacggacgcccccaccgatgccaccgccctcgggctggccgctgccgatcacccg ctgctcggtgcggtcgtcggcttgccgaactcgggtgggctcgtggccacgtcccggtgg tcgctcagggcgcagccctggctggccgagtacctgctgtccgacacggtcgtggtgccg aacgccgctctggtcgaactggccgtccggctcggtgacctggcgtccgtccccttcctc gacgtactgaccgtcgacacacccgtagtcctgccgcagggcggcgaccgcagcatccag gtcgtcgtgggcgagtgtgacggggaacggcggccggtggaggtctactcccgtgccgcc gacgccccgctggacgcggagtggacccggcacgcgcacggcgttctggcgccggccgcc ggtcacgagacacctgccgtaccggagcggggcggcgaggccgccgaagtgcgcctgggc gatgccgtcgggcaggacgccgaccgctacgggctgcacccggcactgctcgacgccgcc gtccgtacggtcgtcccggacggcacggtcccctccgtgtggtccggtgtcgccctgctc gcttcgggtgccaccgaactgcgtgtgcgtgggggagaggcgttgggcggggccgtaccc ctgctgctgaccgatcccacggggcgacccgtgatgtcggtcgagggcgttcgcgcgacg ccgttctccgccgaacggctgggaatcggggcggcgttgccgtacgactcgctgttccgg gtcgactgggtccaggtgccgttgcccgccgtggaccgtgttctggggctcgtcgcggtc ggtggcggtcgtgacgtcgccgatttgggcgcgacgggcggggccgctcccgacttcctg gtgtacgactcccgccccgagtccgcttcgggcgacccgcgggcggcggtcggcgccact ctcgccgtcctgcgggcctggcttgcggagcccgccctggcggagacccggctggccgtg gtcacgggcgactgcgacacgctcgaagcggccgcggtgtggggtctggtgcggtcggcc cagtcggagcatccggaccgtatcgtcctcctggacctcggaggcgacttcgcgtcggtg ccgccggccgcgatcctgagcggtgagccgcaactgaggatgcgcggccgtctcgcgcac gtcccccgcctcgtgcggtcgcgcggcggggcgtcgcccgaggccggaaccgcggtcccg cggctcgaccccgagggcaccgtcctgatcaccggtggtgccgggacgctcggcgcgctg acggctcggcacctggtcacggtgcacggcgtccgccacctgctcctggtcggccggcgc ggccgtgccgaggggctgcgagaggagctgaccgcgctcggcgcgtgcgtcaccgtcgcc gcctgcgacgtggcggaccggcgccaggtcgaggaactgctgcgcacggtaccggtcgcg catccgctgacggccgtcgtgcacaccgccggggtcctcgacgacggggtgctcaccgag cagaccccggaccgcgtcgacaccgtactgcggcccaagctcgacgcggcgctccacctg cacgagctgacccgggacatggacctggccgcgttcgtgctgttctcctcggcggcgggc gtcctcggcaatccgggacaggccaactacgccgccgccaacgcctgcctggacgcgctg gcgcggcagcggcaccggctcggcctgccggccgtctccatcgcctggggctactggtcg acggtcagtgccatgaccgagcacctggacgccgccgacctgcggcgcaaccggcgcatc ggcatggccggtctcaccgccgccgagggcatggcgcttctaaacgccgccctgggctcc gccgcggacgcggacggcacgctgctggcggcgaagttcgacctgaccgccctgcgcgcc gcggcgaccgacggccctgtacccgcgccgctgcgcgcactggcgccggcgccccgcccg gtggccgggtccgccgcccccgcccccggcaggggtggcgtggcggagcgtctcgccggg ctgagcggcaccgagcagcacgagttcctgaccgacctggtgcgacggcacgcagccgag gtcctcggtcacgcctccgccgacgcgatccgcgccgaccggccgttcaaggacgccggc ttcgactcgctgaccgccgtggagctgcgcaaccggctcgtcgccgcgactggcctcacc ctctccccggcggtgatcttcgactacccgaagcccgccgtgctcgcccgacatctgcgc ggcaggctcctcggcaccgcggaaccgggtgcggacgaactcgccgtgcgcggggcggcg gacggctcggccggttcggacaccggtgacgagccgatcgcgatcgtggccatggcctgc cgtttcccggccggcgtccacagccccgaggacctctggcgcgtggtggccgacggcgtc gacgtcgtcaccgagttccccgacgaccgcggctgggacaccgaccggctcttcgacccg gaccccgaccacgccggcacgacgtacgtgcgacacggcgccttcctcgacgacgccgcc gggttcgacgccgccttcttcggcatctcgcccaacgaggcgctggcgatggacccccag cagcggctgctgctggagacgtcctgggaggccttcgagcgggccgcgatcgacccgacg accctcgccgggcaggacgtcggcgtgttcgtcggcgtcaacagccacgactacagcgtc ctcatgcaccaggcgagcggagtcgagggcttccgcctcaccggctcctccggcagcgtc acctccggccgggtcgcctaccacctgggtaccgagggtcccgccatcaccgtcgacacg gcctgctcctcctccctggtggcgctgcacctggccgcgcaggccctcaaccggggcgag tgcaccatggcgctggccggtggcgtgatggtgatgggcaccgtcgagaccttcgtcgag ttctcccggcagcgcggtctggcacccgacgggcggtgcaaggcgttcgcggacggtgcg gacggcaccggctggtcggagggcgccgggctgctcctggtcgagcggctgtcggacgcg cgccgcaacggccaccaggtcctggccgtcgtccgggggaccgcggtgaaccaggacggc gcgtcgaacggcctgaccgcgcccaacggccccgcccagcagcgcgtcatccgcagggct ctggcccacgccggactgcgggccgacgacgtggacgccgtcgaagcgcacggcacgggc acgacgctcggcgacccgatcgaggcggaggcactgctggcgacgtacggccagggccgg cccgccgaacggccgctgtggctcggctcggtgaagtcgaacatcggccacactcaggcc gccgcgggcgtcgccggcgtgatcaagatggtgatggcgatgcggcacggcgtgctgccc cgcaccctgcacgtggaccgtccgtcgacccacgtcgactggtcggcgggatcggtggag ctgctgaccgaggcgcgggagtggccgcgcgagggccgcccgcgccggaccggtgtgtcc tccttcggcatcggcggcaccaacgcgcacgtcatcctcgaagaggcccccggcctcccg gagcccacccccgcggaccgcgagccggccggacccgaagcggcggcgtcgtcctccggg cccgtacccgtgcccgtgctcgtacccgtgtccgggcggacgtcggcagggctgcgcggg caggccgaccggctcgcgcgcttcctcgccgagcggcccggcacaccgctcgcggagacc gcgcacgcgctcgccaccacgcgcgcccaactcgaccaccgcgccgtcgtcctggccacc gacccggagcagctcggcgccgacctcgtcgccctcgcagcggacagggccacccccgcg gcggtcaccggcgcccccgccacgggcagactggccgtcctcttcaccggacagggcagc cagtgggccggcatgggccgcgaactcgccgaggccttcccggtcttcagggacgccttc gacagcgcgtgcgccgccgtcgacatccacctgagcggacacgcggaccgtccgctgcgc gaggtcgtcctcggcgtggccgacgcccccggcagcgcactgctcgaccgcaccctgtac acccagggcgccctgttcgccctggagaccgcgctgtaccggctcttcgagtcctgggga gtacgcccggacctcgtcgccggacactccgtcggagagatcaccgccgcccacgtctcc ggcgtcctcggtcttcaggacgccgccgaactcgtggccgcacggggccggctgatgcag gccctgcccgagggcggcgcgatggtcgccgtcaaggccacggaggccgacctcgcaccc ctgctcgaccgggcctcgggcgaggtctgcgtcgccgcggtgaacggccccgacgcgctg gtgctctccggcgcggaggacgccgtgctcgccgtcgccggggaactcgcgcggcgcggc cacaagacgcaccggctgaccgtcagtcacgccttccactccgcgctgatggaacccatg ctcgacgagttccgcacggtcgcggagcgcctgcccttccgccgggggaccctgcgcgtc gtctccaccgtcaccggtgaactcgccacggacgaacagctcaccgaccccggttactgg gtcggccaggcgcgcgccgcggtgcggttcggcgacgccctcaccacgctcggcgaacag ggcgccacgaccttcctcgagctgggccccggcggcgtcctcaccgcactcgccctcgcc gcgcccggcatcccggagcaagggtgcctcgccaccctgcgcaaggacggtgccgaaccc gccgacgtcctgaccgcactcgcccacctgcacgtgcgcggcgtacccctggactgggcg gccgtcctcggacgtacgacgcctgccaccgagaccggcaccgagctgcccacctacgcg ttccagcaccgccgttactgggtcgacacggccaacggctccgccaccggcaacggcacc ggcggtgccggcatcgccaccgccgacggctccggcagcatcggcggtgccgacatcgcc gacccgcgcgtcgagagtgatcagcgtgccgtggcgccggacgcgggcgtggacggggcg ttcgccgcacggctggccggcctctccgcgcaggaacagcaccgcacggtgacggacctg gtgaaggagagcgtcgccgtcgtcctcggccacggcgacccggacgccttcgactggaac gcccagcagtccttcaggagcctcggcttcgattccctcggcggggtcaagctccgcaac cggctccgcgacttcaccggggtcgaactgcccgccacgctcgtcttcgactaccccacc cccgaggtgctggtcgaccacctgcgggccgaactgctcggcgagcaggcgcagtcgccc ggtgcgaccaccgccaccggcctgacggcggccacggacgagccgatcgcgatcgtcgcc atgagcactcggctgccgggcggcgtggacagccccgaagccctgtgggaactcgtgtcg gaaggccaggacgccatcaccggcttccccgtcgaccgcgactgggacctcgacggcctg taccaccccgaccccgaccaccccggcacgagctacacccgctccggcggattcctccac gaggccgcgcagttcgacgccgcgctcttcgggatctcgccgcgtgaggcgctcgccatg gacccgcagcagcggctgctcctggagacctcgtgggaggcgctggaacgcgcgggcatc gacccgctctccacccggggcagcgacatcggagtcttcaccggcatcgtccaccacgac tacgtcacccggctccgcgaggtgcccgcggacgtgcagggctatctcatgaccggtacg gcgtcgagtgtggcgtcgggccgggtgtcgtacgtcttcggcttcgagggcccggcggtc accgtcgacacggcgtgctcgtcgtccctggtggcgatgcacctggccgcgcaggcgctg cgccagggcgagtgctcgatggcgctcgccggcggcgccaccgtcatggccagtccggac gccttcatggagttctcccggcaacggggcctgtccgcggacgggcgttgcaaggcgttc gcggagggtgcggacggcacgggctgggccgagggtgtcggggtcgtggtcctggagcgc ctgtcggtggcacgggaacggggtcacaaggttctcgcggtgctgaagggcagcgcggtc aatcaggacggtgcgtccaatggtctgacggcgccgaacggtccctcgcagcagcgggtg atccggcgggcgctggccagtgccgggctctcggcgtccgacgtggacgtcgtcgaggcg cacgggacgggcacggcgctgggcgatccgatcgaggcgcaggccctgctggcggcctac ggcaaggagcgcgatgccgaacggccgctgtggctcggttcgttgaagtcgaacatcggt cacgctcaggcggccgcgggtgtggccggtgtgatcaagatggtgcaggcgctgcggcac ggtgtgctgccggcgacactgcatgcggatacgcccacgacgcaggtggactggtcggcg ggtgcggtgcagctgctgaccgaggcgcgggagtggccgcgtgaggagcggcgtccgcgc cgtgcgggcgtgtcctcgttcggagccagcggcacgaacgcccacgtaatcctggaggag gcgcctgccgaggacgagggcccggttcgggctccgtcgtccggtggtgtggtgccgctg gtcctttcggcgcggagtgctggatcgctggccggacaggccgggcgcctcgcgtccttc gtcgagcggaacgacggggtcgacctggtcgacgtcgccggcgcgttggtcggcgggcgt gcggtgctgggtgagcgtgcggtggtggtggccgataccgacggcggggcgctcaccggt ctgcgggcgctggtgcggggtgagggtgcccctggtgtggtgtccggcagctcggggacg ccaggccgggtggtgtgggtgttcccgggtcagggctcgcagtgggccggcatgggccgg gaactcctcgatgcctccccggtgttcgccgagcggatcaccgagtgcgcggcggccctg gagcccttcatcgactggtcgttgatcgacgtgctgcgtggtgatgccgacccgggtctg atggagcgggtcgacgtcctccagccggcgagtttcgcggtaatggtgggtctcgcggcc gtctggcagtcggtgggcgtcaaacccggtgcggtgctggggcattcgcagggtgagatc gcagccgcgtgtgtgtcgggtgccctgtcgttggaagacgcggctcgggtcgtggcgttg cgcagtcaggccatcgccgggcagcttgccgggcggggcggtatggcctcggtcgcgttg agcgagagcgaggcggtcgggcggctggaacgctgggcggaccgggtcgaggtagccgcc gtcaacgggccgtcctccgtagtgatcgccggtgacgccgaagcgctggacgaggccctg gaggcgctggccgccgacgggatccgggtacggcgggtcgcggtggactacgcctcccac acccggcatgtcgaggacatccgcgacacgctcgccgacaccctcgccgaagtcacggcc aaggccccgtcgatcccgttctactcgaccgtcacgggggagtggatcgcgaacgaaggc gtcctggacggcggttactggtaccgcaacctccgcggccaggtcggcttcggccccgcg gtagccgccctcctgaagcagggccacggcgtcttcgtcgaggtcagcgcgcaccccgtg ctggtccagccgatcaccgagaccgtctacgccgccgacggcgacaccgacgctatggtc accggttcgctgcgccgcgaggacggcggcctgcgccgtctgctcacgtcgatggccgaa ctcttcgtgcgcggcgtgccggtcgactggtccggcatcctgcccgacggggccacctcg gcccgcgtcgagctgcccacgtacgccttcgaccgccagcactactggctccaggaagcg gaggcgaccggcgaggccgccgatgtcgcggaaggtgccgactccgacttctggcaggcg gtggagcaggccgacctgaacgccctcaccgaactgctggagacggcgacggccgaggaa cgcgacgcgctgggcagtgtcgtgcccgtcctcgccgagtggcgcgggaagcgccgtgag cggtccagcgctgagaggctgcgctaccacgtcacctggcagccgctggaacgcgatgcc gccggtgtgccgggcgggcagtggctggtggtcgtaccggccgagcgaccggacgacacc gccatcgacgcgctcctggaggagttgaccggtcagggactcggcatggtcctgctggag gtggacgacgccgaccggacgcgggagcgcctcgtcgagcggctgaccggcgtgctggcc ggacgggacgtgtccggagtgctgtccctgctcgccctggacgagcggaccgccgggggc ccgcaggacccgctcgccgtcaccgcctcgacgctcgcactggtccaggccctggccgac agcctcgtcacccagcccctgtggtgcctgaccaggggcgcggtgaacatgggcatcaac gacacgctcacctcgccggcccaggcggccctgtggggtctggggcgtgccgccgcgctg gaacgcctggaccggtggggcggtctggtcgacctgcccgccaggacggacgcgcgtgcc gcgcagtatctgctcggtgtgctgaacggcgtcggcggcgaggaccaactggcggtccgc cgctcgggcgtgtacagccgccgcctggtgcgcaagcccgcgccggacgcgacggccggt gacggccgctggcagccgcggggcaccgtcctggtgaccggcggcgccgaaggcctcggc cggcacgtcgccgtgcggctggcgcaagcgggcgccgaccggctcgtcgtcaccaccacc gcgcgggcgcccgggacggccgtaccggacctgaccgccgaactggccgggctgggcctc gacacggcggtggcgtcctgcgcggacacggaccgggaggcgatcacgcggctgctggcc gggaccgaacaccctctcaccgcggtcgtgcacgccgccgacatcacccggaccagctcc atcgacgacaccggcgccgcggaactcgccgaggtcttcgcggccaaggtggacaccgcc gtatggctggacgagcggttcgaggacaccccgctcgacgcgttcgtggtgttctcctcc atcgccggggtgtggggcggtggcgggcagggcccgtccggagcggccaacgccgtcctc gacgccctggtcgagtggcgtcgcgcccggggactgagggcgacggcgatcgcctgcggt gcgctcgacgagatcggcgtgggcatggacgaggccgccctcgcccagttgcggcggcgg ggtgtccttcccgtcgacccgaagctggcggtgaccgccatggtgcaggcggtgcaggcg ggcgagaagttcgtgaccgtggccgacatggactggggcgccttcgtcccggcgttcacc tcggtccggcccagcccgctcctggccgacctgcccgaggcgaaggcggtgctccaggcg gcgcagcgcgacagcgagaacaccgacgccgccgcttccctcgccgactcgctgcgggcc gtcacggacaccgaccagaaccgcatcctgctccgcctggtgcgcagccacgcctccgtc gtcctcggccacggcggcgccgagggcatcgggccgcggcaggcgttccaggaggtcggc ttcgactcgctggccgccgtgaacctgcgcaacagcctcggagcggcaaccggcctgcgg ctgcccgccacgctggtcttcgactaccccacgccggaggcactggtcggctacctgcgc gccgagctgctccaggacaccgaggacgccgaggatgcggtggacgagcgggaggacgac ctcaggcaggtgctggcctccgtaccgttcgcccgcttcaaggaggccggtgtcctcgac gcactcctgtcactcgccgacaacgccgccggcgacgagcaggacgagcacggcgagagc gctgacgggtcggctgccggggagccacaggccggcaccgaggaactgatcgacgcaatg gacgttgccggtctggtgcaacgggccttgggcaagacgagctga

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