Streptococcus pyogenes MGAS6180 (serotype M28): M28_Spy0023
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Entry
M28_Spy0023 CDS
T00263
Symbol
purL
Name
(GenBank) phosphoribosylformylglycinamidine synthase
KO
K01952
phosphoribosylformylglycinamidine synthase [EC:
6.3.5.3
]
Organism
spb
Streptococcus pyogenes MGAS6180 (serotype M28)
Pathway
spb00230
Purine metabolism
spb01100
Metabolic pathways
spb01110
Biosynthesis of secondary metabolites
Module
spb_M00048
De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:
spb00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
M28_Spy0023 (purL)
Enzymes [BR:
spb01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor
6.3.5.3 phosphoribosylformylglycinamidine synthase
M28_Spy0023 (purL)
BRITE hierarchy
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Ortholog
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Gene cluster
GFIT
Motif
Pfam:
GATase_5
AIRS_C
FGAR-AT_linker
GATase_3
FGAR-AT_PurM_N-like
DJ-1_PfpI
GATase
Svf1_C
Motif
Other DBs
NCBI-ProteinID:
AAX71137
LinkDB
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Position
36501..40274
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AA seq
1257 aa
AA seq
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MSSYFPVAPLSDLVSYMNKRIFVEKKADFGIKSASLVKELTHNLQLTSLKALRIVQVYDV
FNLAEDLLARAEKHIFSEQVTDCLLTETEITAELDKVAFFAIESLPGQFDQRAVSSQEAL
LLFGSDSQVKVNTAQLYLVNKDIAEAELEAVKNYLLNPVDSRFKDITLPLEEQAFSVSDK
TIPNLDFFETYKADDFTAYKVEQGLAMEVDDLLFIQDYFKSIGRVPTETELKVLDTYWSD
HCRHTTFETELKNIDFSASKFQKQLQTTYDKYIAMRDELGRSEKPQTLMDMATIFGRYER
ANGRLDDMEVSDEINACSVEIEVDVDGVKEPWLLMFKNETHNHPTEIEPFGGAATCIGGA
IRDPLSGRSYVYQAMRISGAGDITTPIAETRAGKLPQQVISKTAAHGYSSYGNQIGLATT
YVREYFHPGFVAKRMELGAVVGAAPKENVVREKPEAGDVVILLGGKTGRDGVGGATGSSK
VQTVESVETAGAEVQKGNAIEERKIQRLFRAGNVTRLIKKSNDFGAGGVCVAIGELADGL
EIDLDKVPLKYQGLNGTEIAISESQERMSVVVRPSDVDAFIAACNKENIDAVVVATVTEK
PNLVMTWNDETIVDLERRFLDTNGVRVVVDAKVVDKDLTVPEARITSAETLEADTLKVLS
DLNHASQKGLQTIFDSSVGRSTVNHPIGGRYQITPTESSVQKLPVQHGVTTTASVMAQGY
NAYIAEWSPYHGAAYAVIEATARLVATGADWSRARFSYQEYFERMDKQAERFGQPVSALL
GSIEAQIQLGLPSIGGKDSMSGTFEDLTVPPTLVAFGVTTADSRKILSPEFKAAGENIYY
IPGQAISEDIDFDLIKANFSQFEAIQTQHKITAASAVKYGGVLESFALMTFGNRIGASVE
IAELDSSLTAQLGGFVFTSAEEIADAVKIGQTQADFTVTVNGNDLAGASLLAAFEGKLEE
VYPTEFEQTDVLEEVPAVVSDTVIKAKETIEKPVVYIPVFPGTNSEYDSAKAFEQVGASV
NLVPFVTLNEVAIAESVDTMVANIAKANIIFFAGGFSAADEPDGSAKFIVNILLNEKVRA
AIDSFIEKGGLIIGICNGFQALVKSGLLPYGNFEEAGETSPTLFYNDANQHVAKMVETRI
ANTNSPWLAGVEVGDIHAIPVSHGEGKFVVSASEFAELRDNGQIWSQYVDFDGQPSMDSK
YNPNGSVNAIEGITSKNGQIIGKMGHSERWEDGLFQNIPGNKDQTLFASAVKYFTGK
NT seq
3774 nt
NT seq
+upstream
nt +downstream
nt
atgtcctcctattttccagtcgctcccttgtcggacttggtatcttatatgaataaacgt
atttttgttgagaaaaaggctgactttggtattaaatcggctagccttgtgaaagagttg
acgcataatctacaactgacttctttgaaggctttgcgtattgtgcaggtctatgatgtc
ttcaatttggctgaggatttgctggcgcgtgctgagaagcatattttctctgagcaggtg
acagactgtcttttgacggaaactgaaatcactgcggagcttgataaggttgccttcttt
gccattgagtcgcttcctggtcaatttgaccaacgtgctgttagttcgcaagaagctttg
ctattatttggaagtgacagtcaggttaaggtcaatacagcccagctttacttggtcaat
aaggatattgcagaagcagagcttgaagccgttaagaactatcttttgaaccctgttgat
tcgcgtttcaaggacattactttgccgcttgaagagcaggctttctctgtgtctgataag
acgatccctaatcttgatttcttcgagacttataaggctgacgattttacggcttataag
gtagagcagggcttggctatggaggtcgatgatcttctcttcatccaagattatttcaaa
tcaatcgggcgtgtgccaactgagactgagttgaaagttttggatacgtattggtcagac
cactgtcgtcacacaacctttgaaactgaattgaagaacattgatttttcagcttctaaa
ttccaaaaacaattgcagacaacttatgacaaatatatcgccatgcgtgatgagcttggt
cgttctgaaaagccacaaacacttatggatatggcgactatttttggtcgttatgagcgt
gccaacggtcgtctggacgatatggaagtctcagatgaaatcaatgcctgctcagttgag
attgaagtagatgttgatggtgtgaaagagccttggctcctcatgtttaagaatgagaca
cacaatcacccaacagaaattgagccattcggtggagcggcgacttgtatcggtggtgct
attcgtgacccattgtcaggacgttcatacgtttatcaggctatgcgtatttcaggcgca
ggcgatatcacgactccgattgcggaaacacgtgctggtaaattgccacaacaggttatt
tctaagactgcggcgcacggctattcttcatatggtaaccaaattggacttgcgacaact
tatgtgcgtgagtacttccaccctggcttcgtagccaaacgtatggagcttggagctgtg
gttggtgctgcacctaaggaaaatgtggttcgtgaaaaaccagaagcaggtgatgtggta
atcttgcttggtggtaaaacagggcgtgacggtgtcggcggtgcgacaggttcatctaag
gttcaaacggttgaatctgtggaaacagcaggagcagaggtacaaaaagggaatgccatc
gaagagcgtaagattcaacgtcttttccgtgctggcaatgtcactcgtctgatcaagaaa
tcaaatgacttcggtgcaggtggtgtctgtgttgccatcggtgaattggctgacggtctt
gaaatcgatttggacaaggtgcctcttaaataccaaggtcttaatggtactgaaattgca
atctcagaatctcaagagcgtatgtcagtcgttgttcgtccaagtgatgtggatgccttc
atcgcagcctgcaacaaggaaaatatcgatgcagtcgtagttgcgactgtgactgaaaaa
ccaaatcttgtcatgacttggaatgatgaaacaattgttgatttggaacgccgtttcctt
gataccaatggtgtccgtgtcgttgttgatgctaaagtcgttgacaaggacttgacagtt
ccagaagcacgcataacatcagcagagacacttgaagcagatacgcttaaggtcttgtct
gacctcaaccatgctagtcaaaaaggtctccaaaccatctttgactcatctgttggtcgt
tcaaccgttaaccacccaatcggtggtcgttaccaaatcacaccgacagaaagttctgtt
caaaaattgccagttcaacatggtgtgacaacaactgcatctgttatggctcaaggttac
aatgcttatattgcagagtggtcaccttatcacggtgctgcctatgctgttattgaagcg
acagctcgcttggtagcaacaggtgctgactggtctcgtgcacgtttctcttaccaagag
tatttcgagcgtatggataaacaggcagagcgttttggtcagccagtatcagctcttctt
ggttctattgaggctcagattcaacttggcttgccatcaatcggtggtaaggactctatg
tctggtactttcgaagacttgacagtaccaccaaccttggtagctttcggtgtgacaaca
gcggacagccgcaagattctctctcctgagtttaaagcggctggtgagaatatctactac
attccaggtcaagctatttcagaagatattgattttgaccttatcaaggctaacttcagt
cagtttgaagctattcaaactcaacataagattacagctgcctcagccgttaaatacggt
ggtgtcctagaaagttttgctctcatgacttttggtaaccgtatcggtgcttctgttgaa
attgcagagcttgacagcagcttgacagctcaactcggaggttttgtctttacatcagct
gaggaaattgctgacgcggtgaaaattggtcaaactcaggcagactttacagtcactgtc
aatggaaatgaccttgctggcgctagccttctagcagccttcgaaggcaaattggaagag
gtttacccaacagaatttgaacagacagatgttcttgaagaagttcctgctgtggtatca
gatactgttatcaaggctaaggaaacaattgaaaaaccagtggtttacattccagtcttc
cctggtaccaactcagagtacgattcagctaaggcctttgaacaggttggagctagtgtc
aacttggtaccatttgtaaccttgaatgaggttgctattgctgagtcagttgacactatg
gttgctaatattgctaaggcaaatatcatcttctttgctggaggtttctcagcagcggat
gaaccagatgggtctgctaagtttatcgtcaatatcttgcttaacgagaaggtccgcgca
gctattgacagcttcatcgaaaaaggtggccttatcatcggtatctgtaatggtttccaa
gcccttgttaaatcaggtcttcttccatacggaaacttcgaggaagctggtgagacaagt
ccaactctcttctataacgatgctaatcagcatgttgccaagatggttgagactcgtatc
gcaaataccaactcaccttggttggcaggagttgaggtcggcgatattcatgccattcca
gtttcacatggtgaaggtaaatttgttgtcagcgcttctgaatttgcagagctaagagac
aatggtcaaatctggagccaatatgtggactttgacggacaaccatctatggattctaaa
tacaatccaaacggctctgtcaatgccatcgaagggattaccagcaagaatggtcaaatc
atcggtaagatgggacactcagaacgctgggaagacggactcttccaaaatattcctggt
aacaaagaccaaaccctctttgcaagtgctgtaaaatactttacagggaagtaa
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