KEGG   PATHWAY: spen00908
Entry
spen00908                   Pathway                                
Name
Zeatin biosynthesis - Solanum pennellii
Description
Zeatin is a member of the cytokinin family, a class of phytohormones involved in various processes of growth and development in plants. Most abundant cytokinins are adenine-type, where the N6 position of adenine is substituted with an isoprenoid, such as in zeatin, or an aromatic side chain, such as in kinetin. Zeatin can be synthesized in two different pathways: the tRNA pathway and the AMP pathway. In the tRNA pathway zeatin is a recycled product of isopentenylated tRNAs. In the AMP pathway zeatin is synthesized from an isopentenyl donor, dimethylallyl diphosphate (DMAPP), and AMP, ADP, or ATP by isopentenyltransferases. After synthesis cytokinins can be glucosylated.
Class
Metabolism; Metabolism of terpenoids and polyketides
Pathway map
spen00908  Zeatin biosynthesis
spen00908

Other DBs
GO: 0009691
Organism
Solanum pennellii [GN:spen]
Gene
107003683  adenylate isopentenyltransferase 7, mitochondrial-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
114073888  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
114074767  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
114074769  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
107027702  adenylate isopentenyltransferase 7, mitochondrial-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
107003647  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
107003648  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
107003649  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
107003650  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
107003681  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
107003716  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
107003973  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
107003974  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
107003978  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
107003981  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
107020035  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
107003992  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
107017324  adenylate isopentenyltransferase-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
107029782  adenylate isopentenyltransferase 3, chloroplastic [KO:K10760] [EC:2.5.1.27 2.5.1.112]
107013666  adenylate isopentenyltransferase 5, chloroplastic [KO:K10760] [EC:2.5.1.27 2.5.1.112]
107027700  adenylate isopentenyltransferase 5, chloroplastic-like [KO:K10760] [EC:2.5.1.27 2.5.1.112]
107009621  cytokinin hydroxylase-like [KO:K10717]
107010496  cytokinin hydroxylase-like [KO:K10717]
107016377  cytokinin dehydrogenase 1 [KO:K00279] [EC:1.5.99.12]
107016001  cytokinin dehydrogenase 5 [KO:K00279] [EC:1.5.99.12]
107028037  cytokinin dehydrogenase 7-like [KO:K00279] [EC:1.5.99.12]
107006947  cytokinin dehydrogenase 3-like [KO:K00279] [EC:1.5.99.12]
107002172  cytokinin dehydrogenase 1-like [KO:K00279] [EC:1.5.99.12]
107006755  cytokinin dehydrogenase 3-like [KO:K00279] [EC:1.5.99.12]
107026651  cytokinin dehydrogenase 7-like [KO:K00279] [EC:1.5.99.12]
107015845  cytokinin dehydrogenase 6 [KO:K00279] [EC:1.5.99.12]
107021835  UDP-glycosyltransferase 73C4-like [KO:K13496] [EC:2.4.1.-]
107031915  UDP-glycosyltransferase 73C4-like [KO:K13496] [EC:2.4.1.-]
107030780  UDP-glycosyltransferase 73C4-like [KO:K13496] [EC:2.4.1.-]
107031980  UDP-glycosyltransferase 73C4 [KO:K13496] [EC:2.4.1.-]
107005281  UDP-glycosyltransferase 73C4-like [KO:K13496] [EC:2.4.1.-]
107032135  UDP-glycosyltransferase 73C3-like [KO:K13496] [EC:2.4.1.-]
107022697  UDP-glycosyltransferase 73C3-like [KO:K13496] [EC:2.4.1.-]
107005183  tRNA dimethylallyltransferase 9 isoform X1 [KO:K00791] [EC:2.5.1.75]
107003267  tRNA dimethylallyltransferase 2 [KO:K00791] [EC:2.5.1.75]
107016343  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107005128  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107019877  zeatin O-xylosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107019891  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107032581  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107004845  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107007339  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107002005  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107017809  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107017424  zeatin O-xylosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107002435  zeatin O-xylosyltransferase-like isoform X1 [KO:K13495] [EC:2.4.1.215]
107023551  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107026077  zeatin O-xylosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107032401  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107005717  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107016226  zeatin O-xylosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107021268  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107020926  zeatin O-xylosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107001795  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107025427  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107005883  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
107032138  zeatin O-glucosyltransferase-like [KO:K13495] [EC:2.4.1.215]
Compound
C00002  ATP
C00008  ADP
C00015  UDP
C00019  S-Adenosyl-L-methionine
C00020  AMP
C00029  UDP-glucose
C00033  Acetate
C00147  Adenine
C00170  5'-Methylthioadenosine
C00190  UDP-D-xylose
C00235  Dimethylallyl diphosphate
C00371  Zeatin
C00979  O-Acetyl-L-serine
C01513  Lupinate
C01804  Discadenine
C02029  Dihydrozeatin
C03300  O-beta-D-Xylosylzeatin
C03423  O-beta-D-Glucosylzeatin
C04083  N6-(Delta2-Isopentenyl)-adenine
C04432  tRNA containing 6-isopentenyladenosine
C04713  N6-(delta2-Isopentenyl)-adenosine 5'-monophosphate
C07330  3-Methyl-2-butenal
C15545  cis-Zeatin
C15546  O-beta-D-Glucopyranosyl-cis-zeatin
C16424  Isopentenyladenosine-5'-triphosphate
C16426  Isopentenyladenosine-5'-diphosphate
C16427  Isopentenyl adenosine
C16428  trans-Zeatin riboside triphosphate
C16429  trans-Zeatin riboside diphosphate
C16430  trans-Zeatin riboside monophosphate
C16431  trans-Zeatin riboside
C16441  cis-Zeatin riboside monophosphate
C16443  trans-Zeatin-7-beta-D-glucoside
C16445  Dihydrozeatin riboside monophosphate
C16447  Dihydrozeatin riboside
C16448  Dihydrozeatin-O-glucoside
C16449  cis-Zeatin riboside
C16467  cis-Prenyl-tRNA
C17324  tRNA adenine
Reference
  Authors
Kasahara H, Takei K, Ueda N, Hishiyama S, Yamaya T, Kamiya Y, Yamaguchi S, Sakakibara H.
  Title
Distinct isoprenoid origins of cis- and trans-zeatin biosyntheses in Arabidopsis.
  Journal
J Biol Chem 279:14049-54 (2004)
DOI:10.1074/jbc.M314195200
Reference
  Authors
Takei K, Sakakibara H, Sugiyama T.
  Title
Identification of genes encoding adenylate isopentenyltransferase, a cytokinin biosynthesis enzyme, in Arabidopsis thaliana.
  Journal
J Biol Chem 276:26405-10 (2001)
DOI:10.1074/jbc.M102130200
Reference
  Authors
Kakimoto T.
  Title
Identification of plant cytokinin biosynthetic enzymes as dimethylallyl diphosphate:ATP/ADP isopentenyltransferases.
  Journal
Plant Cell Physiol 42:677-85 (2001)
DOI:10.1093/pcp/pce112
Reference
  Authors
Takei K, Yamaya T, Sakakibara H.
  Title
Arabidopsis CYP735A1 and CYP735A2 encode cytokinin hydroxylases that catalyze the biosynthesis of trans-Zeatin.
  Journal
J Biol Chem 279:41866-72 (2004)
DOI:10.1074/jbc.M406337200
Reference
  Authors
Hou B, Lim EK, Higgins GS, Bowles DJ.
  Title
N-glucosylation of cytokinins by glycosyltransferases of Arabidopsis thaliana.
  Journal
J Biol Chem 279:47822-32 (2004)
DOI:10.1074/jbc.M409569200
Reference
PMID:9874810
  Authors
Martin RC, Mok MC, Mok DW
  Title
Isolation of a cytokinin gene, ZOG1, encoding zeatin O-glucosyltransferase from Phaseolus lunatus.
  Journal
Proc Natl Acad Sci U S A 96:284-9 (1999)
DOI:10.1073/pnas.96.1.284
Reference
  Authors
Martin RC, Mok MC, Mok DW
  Title
A gene encoding the cytokinin enzyme zeatin O-xylosyltransferase of Phaseolus vulgaris.
  Journal
Plant Physiol 120:553-8 (1999)
DOI:10.1104/pp.120.2.553
Reference
  Authors
Veach YK, Martin RC, Mok DW, Malbeck J, Vankova R, Mok MC
  Title
O-glucosylation of cis-zeatin in maize. Characterization of genes, enzymes, and endogenous cytokinins.
  Journal
Plant Physiol 131:1374-80 (2003)
DOI:10.1104/pp.017210
Reference
  Authors
Werner T, Motyka V, Laucou V, Smets R, Van Onckelen H, Schmulling T
  Title
Cytokinin-deficient transgenic Arabidopsis plants show multiple developmental alterations indicating opposite functions of cytokinins in the regulation of shoot and root meristem activity.
  Journal
Plant Cell 15:2532-50 (2003)
DOI:10.1105/tpc.014928
Reference
  Authors
Miyawaki K, Tarkowski P, Matsumoto-Kitano M, Kato T, Sato S, Tarkowska D, Tabata S, Sandberg G, Kakimoto T
  Title
Roles of Arabidopsis ATP/ADP isopentenyltransferases and tRNA isopentenyltransferases in cytokinin biosynthesis.
  Journal
Proc Natl Acad Sci U S A 103:16598-603 (2006)
DOI:10.1073/pnas.0603522103
Related
pathway
spen00900  Terpenoid backbone biosynthesis
KO pathway
ko00908   
LinkDB

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