Streptococcus pyogenes MGAS315 (serotype M3): SpyM3_0758
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Entry
SpyM3_0758 CDS
T00089
Symbol
folC.1
Name
(GenBank) dihydrofolate synthase
KO
K11754
dihydrofolate synthase / folylpolyglutamate synthase [EC:
6.3.2.12
6.3.2.17
]
Organism
spg
Streptococcus pyogenes MGAS315 (serotype M3)
Pathway
spg00790
Folate biosynthesis
spg01100
Metabolic pathways
spg01240
Biosynthesis of cofactors
Brite
KEGG Orthology (KO) [BR:
spg00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
SpyM3_0758 (folC.1)
Enzymes [BR:
spg01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.12 dihydrofolate synthase
SpyM3_0758 (folC.1)
6.3.2.17 tetrahydrofolate synthase
SpyM3_0758 (folC.1)
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Gene cluster
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Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Motif
Other DBs
NCBI-ProteinID:
AAM79365
UniProt:
A0A0H2UUB4
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Position
812527..813804
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AA seq
425 aa
AA seq
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MTYEETLEWIHDHLVFGIKPGLKRMLWVLGQLGNPQKNVKGVHIVGTNGKGSTVNHLQHI
FTTAGYEVGTFTSPYIMDFKERISINGRMISEKDLVIAANRIRPLTERLVQETDFGEVTE
FEVITLIMFLYFGDMHPVDIAIIEAGLGGLYDSTNVFQAMVVVCPSIGLDHQAILGETYA
DIAAQKAGVLEGGETLVFAVENPSAREVFLTKAEQVGASIWEWQEQFQMAENASGYRFTS
PLGVISDIHIAMPGHHQVSNAALAIMTCLTLKDRYPRLTSDHIREGLANSLWLGRTELLA
PNLMIDGAHNNESVAALVAVLKNNYNDKKLHILFGAIDTKPIADMLVALEQIGDLQVTSF
HYPNAYPLEKYPERFGRVADFKDFLALRKHAKADDFFVITGSLYFISEIRRYWKKHIEKS
VLLTH
NT seq
1278 nt
NT seq
+upstream
nt +downstream
nt
atgacttatgaagagactctagaatggattcatgatcacttagttttcggcatcaagcca
ggcttaaaacgtatgctttgggttcttggacagttaggaaatccccaaaaaaatgtcaag
ggagtgcatatcgttggaactaacggaaaaggttccacggtcaatcatttacaacacatt
tttacgacagctggttatgaagtggggacctttacctctccttatattatggatttcaaa
gaacgtattagcataaatggtcgaatgatttcagaaaaagatttggttattgctgctaat
cgtattcgtcctttgacagagcgtctagttcaagagactgattttggagaggtaactgaa
tttgaagtgattactttgatcatgttcctctattttggagacatgcatcctgtagatatt
gctattattgaagcaggccttggcggtctttatgattcgaccaatgtttttcaagcaatg
gttgtggtctgtccctcaattggtttagatcaccaagctattttgggcgagacttacgct
gatattgccgcccaaaaagctggtgttttagaagggggcgagacccttgtttttgccgtt
gaaaacccgtcagctcgagaggtttttttaacaaaagctgagcaggttggtgcttcaatc
tgggaatggcaagagcagtttcaaatggctgagaacgcatctggctatcgttttactagt
cctttaggagttatttcagatattcacatcgctatgccaggacaccaccaagtgtctaat
gcagctttagctattatgacttgcttaaccttgaaagaccgctatcctaggctaacttca
gatcatataagggaaggtctagcaaatagtttgtggctaggccgtaccgaattattagca
ccaaatctaatgattgatggggctcataacaatgaaagcgttgctgctttggtagccgtc
ttaaaaaataactacaatgataaaaagcttcatattttgtttggtgcgatcgacaccaag
cctattgcagatatgttggttgctcttgagcaaataggtgacttgcaggttactagcttt
cattaccctaacgcctatccattggaaaaatacccagaacgttttggtagggttgctgat
ttcaaagatttcttggccctgcgtaagcatgctaaagcagatgactttttcgtgattaca
gggtcactatattttatttcagaaattagacggtattggaaaaaacatattgaaaaaagc
gttcttttaacccattaa
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