Streptomyces phaeoluteigriseus: NFX46_33490
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Entry
NFX46_33490 CDS
T08568
Symbol
leuA
Name
(GenBank) 2-isopropylmalate synthase
KO
K01649
2-isopropylmalate synthase [EC:
2.3.3.13
]
Organism
sphw
Streptomyces phaeoluteigriseus
Pathway
sphw00290
Valine, leucine and isoleucine biosynthesis
sphw00620
Pyruvate metabolism
sphw01100
Metabolic pathways
sphw01110
Biosynthesis of secondary metabolites
sphw01210
2-Oxocarboxylic acid metabolism
sphw01230
Biosynthesis of amino acids
Module
sphw_M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:
sphw00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00620 Pyruvate metabolism
NFX46_33490 (leuA)
09105 Amino acid metabolism
00290 Valine, leucine and isoleucine biosynthesis
NFX46_33490 (leuA)
Enzymes [BR:
sphw01000
]
2. Transferases
2.3 Acyltransferases
2.3.3 Acyl groups converted into alkyl groups on transfer
2.3.3.13 2-isopropylmalate synthase
NFX46_33490 (leuA)
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Gene cluster
GFIT
Motif
Pfam:
HMGL-like
IPMS_D2
LeuA_dimer
Motif
Other DBs
NCBI-ProteinID:
USQ88230
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Position
complement(7548960..7550681)
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AA seq
573 aa
AA seq
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MANRQQPSSMPIHKYGQYEQVDIPDRTWPDRRITVAPRWLSTDLRDGNQALIDPMSPERK
RRMFDQLVKMGYKEIEVGFPASGQTDFDFVRSIIEEEGAIPDDVTISVLTQAREDLIERT
VESLKGARRATVHLYNATAPVFRRVVFRGSKDDIKQIAVDGTRLVMEYAEKLLGPETEFG
YQYSPEIFTDTELDFALEVCEAVMDVYQPGPGREIILNLPATVERSTPSTHADRFEWMSR
NVSRREHVCISVHPHNDRGTAVAAAELALMAGADRVEGCLFGQGERTGNVDLVTLGMNLF
SQGVDPQIDFSDIDEIRRTWEYCNQMEVHPRHPYVGDLVYTSFSGSHQDAIKKGFDAMEA
DAAAKGVTVDDIEWAVPYLPIDPKDVGRSYEAVIRVNSQSGKGGIAYVLKNDHKLDLPRR
MQIEFSRIIQAKTDAEGGEVTGGDIWATFQDEYLPNPENPWGRIQVRNGQSTTDTDGVDT
LTVDAVVDGEETVLSGSGNGPISAFFNALESIGIDVRLLDYQEHTMSEGASAQAASYIEC
AIGDKVLWGIGIDANTTRASLKAVVSAVNRATR
NT seq
1722 nt
NT seq
+upstream
nt +downstream
nt
atggcgaaccgccagcagcccagttccatgccgatccacaagtacgggcagtacgagcag
gtcgacatccccgaccgcacctggcccgaccggcggatcaccgtcgccccccgctggctc
tccaccgacctgcgtgacggcaaccaggccctgatcgacccgatgtcgcccgagcgcaag
cgccggatgttcgaccaactggtcaagatgggctacaaggagatcgaggtcggcttcccg
gcctccggtcagaccgacttcgacttcgtgcgctcgatcatcgaggaagagggcgcgatc
ccggacgacgtcacgatctccgtgctgacccaggcccgcgaggacctgatcgagcggacc
gtggagtccctgaagggcgccaggcgcgccaccgtccacctgtacaacgcgaccgcgccg
gtcttccgccgggtcgtgttccgcggttccaaggacgacatcaagcagatcgccgtggac
ggcacccgcctggtcatggagtacgcggagaaactgctgggcccggagaccgagttcggc
taccagtactcgccggagatcttcaccgacaccgagctggacttcgcgctggaggtctgc
gaggcggtgatggacgtctaccagcccggccccggccgcgagatcatcctgaacctgccg
gccaccgtcgagcgctccacgccctccacccacgccgaccgcttcgagtggatgagccgc
aacgtctcgcgccgcgagcacgtctgcatctcggtccacccgcacaacgaccgcggtacg
gccgtcgccgccgccgagctggcgctgatggccggcgccgaccgcgtcgagggctgcctg
ttcggccagggcgagcgcaccggcaacgtcgacctggtcaccctgggcatgaacctgttc
tcgcagggcgtcgacccgcagatcgacttctccgacatcgacgagatccgtcgcacgtgg
gagtactgcaaccagatggaggtccacccgcgccacccgtacgtgggcgacctggtctac
acgtccttctccggctcccaccaggacgccatcaagaagggcttcgacgcgatggaggcc
gacgcggccgccaagggcgtcaccgtggacgacatcgagtgggcggtcccgtacctgccg
atcgacccgaaggacgtcggccgctcctacgaggcggtcatccgggtcaactcgcagtcc
ggcaagggcggtatcgcgtacgtcctgaagaacgaccacaagctggacctgccgcgccgg
atgcagatcgagttctcgcggatcatccaggcgaagacggacgccgagggcggcgaggtc
accggcggcgacatctgggcgaccttccaggacgagtacctgcccaaccccgagaacccg
tggggccgcatccaggtccgcaacggccagtcgaccaccgacaccgacggcgtggacacc
ctcaccgtggacgcggtcgtcgacggcgaggagaccgtcctgtccggctcgggcaacggt
ccgatctcggccttcttcaacgccctggaatccatcggcatcgacgtacgcctgctggac
taccaggagcacacgatgagcgagggagcctccgcgcaggccgcctcgtacatcgagtgc
gcgatcggcgacaaggtcctgtggggcatcggcatcgacgccaacacgacgcgggcctcg
ctgaaggcggtcgtgtccgccgtcaaccgcgctacgcgctga
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