Sardina pilchardus (sardine): 134064251 Help Entry 134064251         CDS       T10667                                  Symbol ryr2b Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism spil  Sardina pilchardus (sardine) Pathway spil04020   Calcium signaling pathway spil04260   Cardiac muscle contraction spil04261   Adrenergic signaling in cardiomyocytes spil04371   Apelin signaling pathway Brite Ion channels [BR:spil04040]  Voltage-gated cation channels   Ryanodine receptor    134064251 (ryr2b) Domain-containing proteins not elsewhere classified [BR:spil04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    134064251 (ryr2b) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_6 EF-hand_1 Motif Other DBs NCBI-GeneID:  134064251 NCBI-ProteinID:  XP_062376093 LinkDB All DBs Position 18:12637684..12691217 Genome browser AA seq 4979 aa AA seqDB search MTEAGEVEDEIQFLRTNDELALRCSLSAQQRQQKFCLAAEGFGCRLCFLETTSNSKNVPV DLSVCVFVLAQCLSVRALQEMLAKQSHRQTGAVEMGSHRTLLYGQAVLLRHAYSGMYLCC LSTTYSSTDKLAFDVGLQEEIIGEACWWTVHPASKQRSEGEKVRVGDDLILVSVSSERYL HLSQSNCTSSGDEIGSLRVDAAFQQTLWSVASISSGSAVAQGYLKGGDTFRLLHGHTDDC LTVPPVEHGEEERRSVCFEGGSTSSEARSLWRLETMRVAWSGSHTHWGQSFRLRHVTTGM YLSLTQDKGLRLIEREKADAKATAFCFRSSKEKLDIVQRKDVDGMGTAEIKYGDSICFVQ HLDSGLWLTYQTGQGKRMAGAPRQAILHLEGHMDDGVTLSRSQSEESRAAQIIRSSVRLF SRFIRGLDDLGQRSNTLAPALPIATVRLSLQDLISYFQPPDDYQGQEERQNSMRALKNRQ NLFQEEGIIGYALDCIDRLHAYGNAGHFAEAAGREAGEEWESLLNSLYELLASLIRGNRN NCAQFSGSLEWLIGRLEKLDASSGILEVLHCVLEESPEALNFIKEGHIKSIISLLDKHGC NHKILDVLCSLCVCHGMAVRSNQHFICENLLPERDLLLQTRLCNQVTSVRPNLFLCMNED SAQCRKWYFELVVEKAEPFVTAEPTHLRVGWACTEGYHPSPTGGHGWGSNGVGDDLYSYG FDGLQLWSGGVGRSVSSPSQHLLREDDVVSCCLDLATLCMSFRVNGLPVQGMFENFSTDG LLFPVASFSAGVRICFLLGGRFGEFKFLPPPGFSPLSEALLPRVRCRVEPCLDFMRQRDS RQHDLLGPRVALKPPTFTPVPVDTSQVAFPPQLEQIREKLAENLHELWLISMVDQGWIYG PVKEENKKHHPDLVEFSKLPDQEKNMSLQAAQQTLRTLLALGVHIGLSDDRADEKVKYVR LSNKYELWNGYRPSPVDLSHVTLTAAQEAIVDRLAENDHNLWAKDRIRQGWSYGPQQDVK GKRSPHLVPFSLLDERRQRSGSEAVRDALSTVLAYGYTVEPLDQEQSTLSLAEKFRIFRV ERSYSVQRGKWYFEFEAVTTGEMKVGWAQFGCKPDLELGSDDQAFVFDGCKGRLWHQGSE QLGHAWQMGDIVGCMLDLDQCTMMFTLNGELLLNDHGSELAAKDFAVQDGFMPVCSVGVN QVGRLHFGQQDDPLRYFAVCGLQEGYQPFAHNMSRDVPLWMSWKQPHFTPVPPDHGHIQV TRLDGTVDRSPCLKVTQKSSGSKQGTSGTVTSDIGYYRLSLPIECAEVFSRPVEGAVPCS STAYHPKSKRVSEEGETDSDFEVLMKSARRHAVCDELNPHKDYGQEKPSRLKQRFMLKRP KPELTASHSSARLLEEVVATERDEDKSLSHCSTYYYSVRLLPGQDPSCVWVGWVTSSFQQ QQQQQPAFDLDRVRTVTVTLGDQQGKVHESVKRCSCYMVCAAEAMNPSHSRSSGGLEIGC LVDTATGLLTFTANRKELDTYHQVEPCTRLYPAVFAKATSSDMFQFELGRIKFAMPVSAG MFRGERRNLVAQCPPRLHVQHLEPYHWLRVPDHSPRVEVTRMDERHGWRVQCDSLLQVMT LHIPEENRCVDILELSELDDLLTFHQHTLRLYSALCSHGNTHVAHAICSHVDQSQFFYAL QCRQMPGPLRDAYYALLSEVHLNGHAGARRAMTHEYIVPMTDDTRSVTLYNSHKRRHSLP GSVRSGSLWPRLHFSAPCFVRPERAAAADGGEPPADGRAGDVQQDSPAFPLERLKALLVE MLRRAVRAAGRCVRDPVGGSVELLLVPLLRLLHTLLLMGVYRGPDLRAALRLILPAVYIQ NWAIAEDEDEDEDEDEEELEMDADGDRDESLGGFPKQSLLQMKLPEAVKLQVCHLLEYLC DCQVRHRVEAVVAFADDFVARLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQIN LLLNFREEQLECPCPVEIQELLQEFHGDLTTHCGIEIDEDSETGDDGGLSVRGRLFGLVE KVASLKRRLSLCPLESVIAKPVSLRQMISDAMLRWAQEAPMAEPVLVRAVFGLLRRQYEG LSAQMAAPLLKAYCISPGSVEDTLALQSALGRLRSLLRIRMGRQEEALMIQGLGDIMNNK VFYQHPNLMRALGMHETVMEVMVNVLGEGESKEILFPKMVAHCCRFLCYFCRISRHNQKA MFDHLSYLLDNSNVGLASPSMRGSTPLDVAAASVMDNNELALALTESALEKVVQYLAGCG LRSCPLLLSKGYPDIGWNPVEGERYVDFLRFAVFCNGESVEENAYVVLRLLIRRPECFGP ALRGDGGDGLLATMEEAIRISADPKRDGRTAAYESNRTLDTINDEDDDLVHLGHAIMTFY SALIDLLGRCAPEMHLIEAGKGEAIRIRAILRSLIPLEDLVGVISIPLHLPALDTDGAVI EPDMSTVFCPDHKTAMVLFLDRVYGIPDQTFLMRLLNVGFLPDLQAALSMDSSDLASTDM ALALNRYLCTAALPLLTKCASLFGDSEAHHQLVDSLLQAVYRLSKGSVLTKAQRDAIEDC LLSICGKLRPSMVQPLLHCLVFDVPLLSDNTKMPLKLLANHYELSWKYYCLAGGYGGVGR ASVEELHLSRQLFWSTFSALAKKSYDADLFRLCLSCLGAVARAIPPDHLDPSCRGGLEET HLSLDTEGRFCPQPVDTSNVSIPEGLEFVVNKYAEHTHEKWSLDKFASGWVHGDQLCESS KVHPLLKPYRAQSEKDKESYRWAIKEKVKIMLVFGWTIERTKDGDALEVHNTAQRISQAL QLSFEGASTFSPKPIDMSNVTLSWDQYSMAEQLADSSHNMWAKRKQLELESKGGGSHPLL VPYDSLPAREKTRVRERAQDVLKFFHMNGYNVWRDRKPVECDSPAIACRFAYGVLQQALN YTDQAQGQLLELGQGSKSEQAPYEKQINFFVKVVLPLVDQYLKCHHCYFLSTSTDLLGNR GHASNKEKEMVTSLFCKLGALGRRRIALLGNDSPSVTSCLTTLASSLDARTVMKSAAESV RLSLCSFFEEAAADLELAAEILAQGPPPPTTRAQGRGAAGDSVAYTSEVLVPVLTALFQH TAQCQYGQDLIVDKVQVCCYRVLISLYSLGTSKNTYAERQRPEVGTCLAALTAAFPAAFL EPSLGEHGPFSPLNDVSSHAAEASHLLPSLHTALGEVEELVLAGSTARHTLLSRVTEVTL PLLCSYFSRWDGVEAAEGGSSSLGPEHSSTLLGHVLSIIHTHLGVADGAWMKRLAVVSQP IIGQAEPQLLKSHLLPLMEKLKKKAELVLMEEEHLKEGRGDTSEAELQIQEKFTVLVRDL YAFYPLLIPYVDLHRVSWLRELTPEAETLFSMVADIFIFWAKSHNFKWEEQNFVVQNEIN NMEFLVNISKYTRPTSKVGTDKGGVADKERSKVKRKGDRYSTHTSLIVAALKKLLPIGLS VCSAADHEVIAKAKAHLSQKDTEEEVREIIRRGLQRHNKDLFRGAWDLEELSVERVFGIA RVLFHLDQVERPHRKKKAVWNKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLLGYGKA WIEAEGHSFEDKLIEDLTVSMLIVYLLPGDEEEGGASHSDPLHQLITLFSQSAVTERSRL QEDTLFMTFAEIMAESCHGDEEDEDEVKSFEEKEMEKQKLLYEQARLHERGAAEMVLQTI SASRGEKGPMVEATLKLGIAILNGGNTGVQQKMLEYLRHKRDVGFFQSLAGLMQSCSVLD LNAFERQNKAEGLGLVTEASSGDKVMADEELTCDLFRFLQLLCEGHNSGTPRIKRISLIF HFICNHSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDKMDEHGQRH FSKAVSVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQI DLLKDLMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSSNVELILRFFDMFLKLQV FTLSDAFKEYDPDRRGLISKKDIQRAMEGCQHFSSSEADFLLSCMETDESELLDYQAFVK RFHEPAKDIGFNVAVLLTNLSEHMPGDARLHTFLELAESVLRYFQPHLGRIEILGSAKRI ERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVDFCEDTIFEMQLAAQ ISGTDAGEDTAEKDEEEEEEAERGRPRETSFFSLASAMYVLLAPVHFLVMLTSLLSVRNL RKHLRKVTLKGLISSIFSFLWNILMGLAQMVFCVISVILHLLYLTFINGGIIETVGNMTL ADLVIDVPDPSLDEVTGLRLGLGDGVRQRLEPLSSQEDLSELELDLDLSAVSKDPQVLTD IFGLRLRKEGAKVRLISHDASAGLGHLLSASDELTDAAELKRKQKVLAFKTHDCEEKEEK ITEKADGEDDEKDKRPECRQRQRARQQRRSKQEEEDVQESALWKTFNSYQRRMLNCFARN FYNMRMLALFVAFAINFILLFYKVSSVAADEEDLEGSAWSHSPDDVSLEGPEPVADSDSD SDSDSDTASFVLEESSGYMAPCLRYLAIIHTLISFCSIIGYYCLKVPLVIFKREKEVARK LEFDGLYVTEQPSEDDIRGQWDRLVINTPSFPSNYWDKFVKRKVMDKYGDFYGLARISDL LGLDRAALDFSAQGMERRRPRRERELSALLSSIDMKYQIWKLGVVFTDNSFLYLAWYMCM SVLGHYNNFFFAAHLLDIAMGFKTLRTILTSVTHNGKQLVLTVGLLAVVVYLYTVVAFNF FRKFYNKSEDGEGQDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDESEFYRIVFDI TFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNEYFDTLPHGFETH TLQEHNLANYLFFVMYLINKDETEHTGQESYVWKMYQERCWEFFPVGDCFRKQYEDQLS NT seq 14940 nt NT seq  +upstreamnt  +downstreamnt atgactgaagcgggagaggtagaggatgaaattcaatttctgcgaacgaatgatgagctg gcgctgcgctgctccctgtcggcacagcagaggcagcagaagttctgcctggcagcggaa ggctttggctgccggctctgcttcctggagaccacgtccaactctaaaaatgttcccgtg gacctgtccgtctgcgtgtttgtgctggcccagtgtctgtcagtccgtgccctgcaggag atgctggccaaacagagtcaccggcagacaggggcggttgagatgggaagccaccgcact ctcctctacggccaggccgtactgctgcgtcatgcctacagtggaatgtacctatgctgt ttgtccacaacttactcttccactgataagctggcgtttgatgtagggctgcaagaggaa ataataggcgaggcatgctggtggaccgtgcaccctgcctccaagcagaggtctgaggga gagaaagtacgagttggggatgacttaatactcgtcagcgtctcctcagagcgatacctg catctgtcccagtctaactgtaccagctcaggggatgagattgggagtctgagggtggat gctgccttccagcagaccctgtggagtgtagcctccatttcctcaggaagtgcagtggct caagggtacctcaaaggaggggacacgttccgcctcctgcatggacacactgatgactgt ttaacggttccacctgtggaacatggagaagaggaacgcaggtcggtgtgctttgaagga ggttctacgtcatcggaggcccgttctctctggcggctggagaccatgcgtgtggcatgg agtgggagtcacacccactggggtcagtcgttccgcctgcgccatgttaccacagggatg tacctgagcctcacgcaggacaagggcttgagactgatagagagggagaaagccgacgcc aaagccaccgcgttctgcttccgctcttcaaaggagaagctcgatattgtccagaggaag gatgtagatggaatgggcacggccgagataaagtatggagactcaatctgctttgttcag cacttggacagtggcctttggctcacttaccagactggtcagggaaagagaatggccggg gccccacgccaggccattctgcacctggagggccacatggacgacggcgtgactctgtcc cgctcccagagcgaggagtccagagctgctcagatcatcaggagctccgtccgcctcttc tcccgcttcatcagaggactggacgaccttggtcagagatctaacacactggctccagcg ctgccaattgccacggtccgcttgagtctgcaggatctcattagctacttccagcctcct gatgactaccagggtcaagaggaaagacagaacagcatgagggctctgaagaacagacag aacctcttccaagaggaggggataattggctatgcattagactgtattgatcgcctgcat gcgtacggcaacgctggccattttgctgaggcagcaggaagagaggcaggagaggaatgg gagtcgctcttgaactcactctatgagctcctggcatctttgatcaggggtaataggaat aattgcgcccagttttccgggtcactggagtggctgattggaaggctggagaagctagat gcctcctctgggattctggaggtgctacattgtgtccttgaagaaagccccgaggctctt aactttatcaaagagggacacatcaaatcgattatatctcttttggacaagcatggttgc aatcacaagattctagatgtgttgtgttcactgtgcgtgtgccatgggatggcagtacgc tccaaccaacatttcatctgtgagaatctgctcccggagagagacctgcttctgcagacc cgcctctgcaatcaagtcacgagtgtgaggcccaatctcttcctgtgcatgaatgaagac tcggctcagtgcaggaagtggtactttgagctggtcgtggagaaggcggagccatttgtc accgctgaacccactcacctgcgcgtgggttgggcctgcacggagggctaccacccctcc cccaccggtggacacggctggggttcgaatggagtcggcgatgacctctactcctatggc tttgatgggcttcagctatggtcaggtggtgttggccggagcgtgagctcacccagtcag cacctgctgagggaggatgacgtggtcagctgttgccttgaccttgccactctctgcatg tcattcagggtcaacggtctccccgtgcagggcatgtttgagaacttcagcacagacgga ctgctttttcctgtggccagtttctcagctggagtgaggatctgtttcctgttgggcggt cgtttcggggagtttaagttcctgccccctcctggtttctcgcccctgtccgaggctctt ctgccccgggtcaggtgcagggtggagccctgtctggacttcatgaggcagcgtgacagt cgccagcatgacctgctgggaccaagggtggcactgaagcctcccacctttactcccgtc cctgtggacaccagtcaggtggccttcccccctcagctggaacagattcgggagaagctt gctgagaacctccacgagctctggctcatcagtatggttgatcaaggctggatctacggg ccggtaaaagaagaaaataagaaacatcatccggatctggtcgagttttccaaactgcca gaccaagagaaaaatatgagccttcaggctgcacagcagacactcaggacactcctggct ctcggagtccatattgggctgtcagatgaccgtgctgatgagaaggtcaaatatgtccga ctctctaacaagtatgagctgtggaatgggtatcgaccctctcctgtcgatctgtctcac gtcaccctgaccgctgcccaggaggccatagtggaccgtctggcagagaatgaccacaac ctgtgggccaaagacaggatcagacaaggatggagctatgggccacagcaggatgtgaag ggcaagaggagtcctcacctggtgcccttctctctgctggacgagcggaggcagaggtcc ggcagtgaggctgtgagggacgctctgagcaccgtactggcctatggctacaccgtggag cccctggaccaggagcagagtaccctttccctggctgagaagttcagaatattccgtgtt gagcgctcctactctgtgcagagagggaagtggtactttgagtttgaggcagtgaccacg ggggagatgaaggtgggctgggctcagtttggctgtaagcctgacctggagctgggctca gacgaccaggcctttgtttttgatggctgcaaggggcgtctctggcatcagggcagtgag cagctgggtcatgcttggcagatgggcgatatcgtgggctgcatgctggatcttgaccag tgcactatgatgttcacactaaacggggagcttttgctgaacgaccacggttccgagctc gctgccaaagactttgcggtccaagatggtttcatgcctgtatgcagtgtaggggtgaac caggtgggtcgtctacattttggccaacaggatgaccccctgcgttactttgctgtgtgt ggactccaggagggctaccagccattcgctcacaacatgagccgagacgttcctctgtgg atgagctggaaacagccccatttcacccctgttcctccagaccacggccacattcaggta actcgtcttgatgggacagtggaccgatcaccttgtttgaaggtgacacaaaaatcatcg gggtcaaagcagggcaccagtggcacagtcacctctgacattggctactaccgcctcagc ttgcccatcgagtgtgccgaggttttctcccggccagtagagggtgcagtcccctgcagc agcactgcttatcaccccaagtccaagagagtctccgaggagggggagacggactccgat tttgaggtcctgatgaagtcagctcgccggcacgctgtatgcgatgaactcaacccccac aaagactacggccaagaaaagccttccagactgaaacagcgttttatgttgaagcgacct aaaccagagctgaccgcaagccactcctcggcccgcctgctggaagaagtggtggccacc gagagggacgaggacaagagcctctcccactgctccacgtactactactccgtcaggctg ctgcctggtcaggatccctcctgcgtctgggtcggttgggtcacctccagcttccagcag cagcagcagcagcagccggccttcgacctggacagggttcgcacggtcactgtgacactt ggggatcaacagggcaaagttcacgaaagtgtaaagcgctgcagctgctacatggtgtgt gcggcggaggctatgaacccctctcacagtcgtagcagcggcggactagagatcggttgt ctcgtagacacagcaacaggactcctcaccttcactgccaatagaaaagagctggacacc taccatcaggtggagccctgcaccaggttgtatcctgccgtgtttgccaaagccacaagc tctgacatgtttcagtttgagctcggcaggattaagtttgcgatgcccgtgtcggcgggt atgtttcggggcgagaggagaaacctggtggcccagtgccccccgcggttacacgtgcag catctggagccctaccattggctacgcgtgcctgaccactcccccagggtggaggtgacg cgcatggacgagaggcatggctggagggtgcagtgcgacagcctgctgcaggtcatgacc cttcacatccctgaggagaacaggtgtgtggatattctcgagctgtcagagcttgatgac ctcctgaccttccaccagcacacccttcgtctgtactctgccctctgtagccatggcaac actcacgtggcgcacgccatctgcagccacgtggaccagtcgcagttcttctacgccctc cagtgccgccagatgcccggcccgctgcgcgacgcctactacgccctcctcagcgaggtc cacctcaacggccacgccggcgcccggcgggccatgacccacgagtacatcgtgcccatg acggacgacacgaggtccgtcacgctctacaacagccacaagaggcgccactcgctgccc ggcagcgtccgcagcggctccctgtggccccggctgcacttcagcgcgccctgcttcgtc cggcccgagcgggcggcggcggcggacggcggcgagcctccggcggacggcagggcaggg gacgtccagcaggacagcccggcgttcccgctggagcggctcaaggcgctgctggtggag atgctgcggagggccgtgcgcgcggcggggcggtgcgtgcgcgatcctgtagggggcagc gtggagctgctgctggtgcccctgctgcgcctgctgcacacgctgctcctcatgggggtg taccggggcccggacctgcgggcagctctccgactcatcctgcccgccgtctacatacag aactgggccatcgccgaggatgaggatgaggatgaggatgaggatgaggaagagttggag atggatgctgatggagacagagatgaaagtctgggaggcttccccaagcaaagtctactg cagatgaaactgcccgaggctgttaaactgcaagtgtgtcacttgctggagtacctgtgc gactgtcaggtgcgccacagagtggaggcggtggtggccttcgccgatgactttgtggcg cgtctccaggacaaccagcgcttccgctacaacgaggtcatgcaggcgctcaacatgtct gccgccctcacggcgcgcaagactaaagagttccgctctcctcctcaggagcagattaac ctgctgcttaatttccgtgaggagcagctggagtgcccgtgcccagtggagatccaggaa ctgctgcaggagttccacggtgatctcacgactcactgtggcatcgagattgacgaggac tcggagacgggggatgacgggggtctatccgtcaggggtcggctcttcggcctggtggag aaagtggccagcctcaagcgacggctctccctgtgtcccctggaatctgtcatcgccaag cctgtgtccctgcggcagatgatatcggatgccatgctgcgctgggcccaggaggcgccc atggcggagccggtgctggtgcgggccgtgttcgggctgctgcggcggcagtacgagggc ctgagcgcccagatggcggcgccgctgctcaaggcctactgcatcagcccgggctccgtg gaggacacgctggcgctccagagcgccctgggacgcctccgctccctgctccgcatccgc atgggccgccaggaggaggcgctcatgatccagggcctcggagacatcatgaataacaaa gtcttttatcagcacccaaacctgatgagagctctgggcatgcatgagactgtgatggag gtgatggtgaacgtcttaggagagggagaatctaaggaaattctgttccctaagatggtt gcccactgctgcagattcctctgttatttctgtcggattagccgacacaaccagaaggcc atgtttgaccatctcagctatctgttggacaacagcaatgttggactcgcttccccttcg atgcggggctccactcctctggatgtggccgctgcctctgtgatggataacaacgagctg gccctggcgctcaccgagtccgccctggagaaagtggtgcagtacctggcaggttgtggc ttgcggagctgtcccctgctgctgtctaagggctatcctgatattggctggaatccagtg gagggggagcgctacgtcgacttcctccgcttcgctgtcttctgtaacggggagagcgtt gaggagaatgcttatgtggtgctgaggttactgatccggcggccagagtgctttgggcct gccctacgcggggatggaggagacggtctcctagcaaccatggaggaagctatcaggatc tccgccgatccaaagcgagatggacgaacagcagcttacgagtccaacagaactcttgac acgatcaatgatgaagatgatgacctcgtccacctggggcatgcaatcatgacattctat tctgctcttattgacctgctgggtcgctgtgcccccgagatgcacctgattgaggctggg aaaggtgaggcgatccgaatccgagccatcctgaggtcactcatccctttggaggatctg gtgggggtcatcagcatccccctgcacctgcccgcgctggacacagatggcgcagtgatc gagccagacatgtccaccgtgttctgcccggaccataagaccgccatggttctgtttctg gaccgggtctacgggattccggaccagaccttcctgatgcgactgctgaacgttggcttc ctgccagacctccaagcggctctcagcatggactcctccgatctggccagcactgatatg gctctggcgctcaaccgctatctgtgcacggcagcgctgcccctcctcaccaagtgcgcg tccctgttcggcgactcggaggctcaccaccagctggtggactccctgctgcaggccgtc taccggctctccaagggcagcgtgctgaccaaggcccagcgagacgccatcgaggactgc ctcctgtctatctgcggcaaactgagaccctccatggtgcagcctctgttgcactgtcta gtgtttgatgttcctcttctgagtgacaacacaaagatgcccctcaagctgctggccaat cactacgagctcagctggaagtactactgtctggccggaggctatggaggcgtggggagg gcttcagtggaggagcttcacttgtccaggcagctgttttggagcaccttcagtgccctg gccaagaagtcgtacgatgctgacttgttccggctgtgtttgtcctgccttggggcagtg gctcgggcgatcccacctgaccacctggaccccagctgcagggggggcctggaggagacc catctttctctggacacagagggacgcttctgtccgcagcccgtggacacctcaaatgtt tccattcccgagggactggagtttgtggtgaataaatatgctgagcacacacatgagaaa tggtctcttgacaagtttgccagtggttgggtccatggggaccagctttgtgagagttcc aaagttcatccccttctgaagccttatcgagcccagtcagagaaggacaaagagagctat cgctgggctataaaagagaaggtgaagataatgctggtgtttggttggaccatcgagaga accaaggatggagacgctttggaagtgcataatacagcacaaagaatatcacaggcctta cagctatcctttgaaggcgcttccactttcagtcccaaacccattgatatgagcaatgtg acattatcatgggaccagtattccatggcagagcagctggcggacagttcccataacatg tgggccaagaggaaacagctggagctggaatccaaaggaggcgggagtcatccactgctg gtgccgtatgactccttgcctgctcgcgagaagaccagagttcgagaaagagcacaggac gtcctcaagttcttccacatgaacggatacaacgtgtggagggacaggaagcctgtggag tgtgactctccagccatcgcctgtcgcttcgcttatggggtccttcagcaggctctgaac tacactgaccaggcccaggggcagctgctggagctgggacaaggatcaaaatctgaacag gctccttatgaaaagcaaatcaatttctttgtcaaggttgttttgcccttggttgatcag tatctgaagtgccatcactgttacttcctgtccacctcgacggatctccttggcaaccga gggcacgcatccaacaaggagaaagagatggttaccagtcttttctgcaagcttggggct cttgggaggcgaaggatagctctccttggaaacgattctccttccgtgacgagctgtctg accactttggcatcgtctttggatgcaaggaccgtgatgaagagtgctgcagagtcggtg cgtctctccctctgctccttctttgaggaggccgctgcagacctggagctggcggcggag atcctggctcagggccctcctccccccacgaccagagcccagggcaggggggcggcgggg gactccgtggcctacacctccgaggtcctggtccccgtcctcaccgctctcttccagcac accgcccagtgccagtacggccaggacctcatagtggataaagttcaagtctgctgctac cgagtcctaatcagcctgtattcacttggcacctccaaaaatacctacgcagagaggcag aggccggaggtggggacgtgtctggctgccctgacggctgcctttcctgctgccttcctg gagccgtctctgggtgagcacggccctttttcccccctgaatgatgtatcctctcatgct gcagaagccagtcatctcctcccctctctgcacacggctctgggggaggtggaggagctg gtgttggccggctcgaccgcacgtcacaccctgctgtcccgggtcaccgaggtgacgctg cccctgctctgcagctacttctcccggtgggacggcgtggaggcggccgaggggggcagc tcatctctcggccccgagcacagcagcactctgctgggccacgtcctctccatcatccac acgcacctgggggtggccgacggcgcctggatgaaacgcctggcagttgtgtctcagcca atcattggccaggcggaaccacagctactgaagagtcaccttctgcctctgatggagaag ttgaagaagaaggcggagttagttctcatggaggaggagcatttgaaggaggggaggggc gatacatcagaggcggagttacaaatccaagaaaagtttactgtgttagtccgtgacttg tatgctttttacccactactcattccctatgtggatttacacagagtgagctggttgaga gagttaactccagaggccgagacgcttttcagtatggtggccgacatcttcatcttttgg gctaagtctcataatttcaaatgggaggagcagaattttgtagttcagaatgaaattaac aacatggagttcctggtcaatattagcaagtacactaggcctacatcaaaggtgggtact gataaagggggagtggcagataaagagaggagcaaggtgaagaggaagggcgaccgctac tccacgcacacctcgctcatcgtggccgccctgaagaaactgctccccatcggcctgagc gtctgctccgctgctgaccacgaggtcatagccaaggccaaggcccacctatcccagaag gacactgaggaggaggtcagagagatcatccgcaggggccttcagaggcacaataaggat ttattcagaggggcctgggatcttgaagagctcagtgtagagcgagtttttggcatagct cgtgtcttatttcacctggaccaggttgagaggccacacaggaaaaagaaggctgtgtgg aacaaactgctctccaagcagcgcaagagagctgtggtggcttgcttcagaatggcacct ctttacaacttacccaggcacagagcagtcaatctcttcctgctgggttatggtaaagcg tggattgaggcagagggccattcttttgaagataagctaatagaggatttgacggtaagc atgcttattgtgtacttattgccgggcgatgaggaagaggggggcgcgtctcactccgat cctctccaccaactcatcacactcttcagccagagtgctgtcacagagaggagcagactc caagaagacacgttgttcatgacctttgcagagatcatggctgagagttgccatggggac gaggaggatgaagatgaagtcaagtcatttgaggagaaggagatggagaagcagaagcta ctatacgagcaggccagactacacgagcgcggagctgccgagatggtgcttcagactatc agtgctagcaggggtgagaaaggccctatggtagaggctacgctaaagctgggaatagcc attcttaacggaggaaatacaggtgtgcaacagaaaatgctggaatacctgcggcacaag cgggacgtgggcttctttcagagcctggcaggcctcatgcagtcgtgcagcgtactggat ctcaacgcctttgagcggcagaacaaagcagagggactgggcctggtgacggaggcgagc tcaggggacaaggtaatggcagatgaggaactgacctgtgacctcttccgcttcctacag ctcctgtgcgagggacacaactcaggtacaccacgcataaaacggattagtttaatcttt cacttcatttgcaatcattcagattttcagaattacctccggactcaaactggcaacaac acaacagtgaacatcattatatccactgttgactacctcctcagggtacaggaatccatc agtgatttctactggtactattctgggaaagataagatggatgaacacggacaacggcat ttctctaaggccgttagtgttgccaagcaagtcttcaacaccctcaccgaatatattcag ggtccttgcacagggaatcagcagagtttggctcacagtcgattatgggatgcggttgtt ggattcctgcatgtgtttgctcatatgcaaatgaagctctcgcaggattctagtcagatt gatttgctgaaagacttgatggatttacagaaagacatggttgtgatgcttctctccatg ctggaaggaaatgttgtaaatggcacaattgggaaacagatggtggacatgttggtggaa tcctctagcaacgtggagctgatccttcgcttctttgacatgttccttaaactccaagtt ttcaccttgtctgatgcttttaaagagtacgaccccgaccgacgggggctcatctccaag aaggacatccagagggccatggagggctgccagcacttctcgtcctctgaggccgacttc ctgctctcctgcatggagacggacgagagcgagctgctggactaccaggcgtttgtgaag cggttccacgagccggccaaggacatcggctttaacgtggccgtgctcctcaccaacctg tccgagcacatgcctggcgatgcccgcctgcacaccttcctggagctggcagagagtgtt ctcaggtacttccagccccacctggggcgtatagagatcctggggagtgctaagcgcatt gagcgtgtttactttgagattagcgagtcgagccggactcagtgggagaagccccaggtg aaggagtccaaacgccagttcatctttgacgtcgtcaacgagggtggagagaaggagaag atggagctcttcgtggacttctgtgaggacaccatctttgaaatgcagctggccgcacag atctccggcacggacgctggcgaggacacggcagagaaggacgaggaggaagaggaggag gcagagcgaggaaggcccagagaaaccagtttcttttctctggcctcagcgatgtacgtt ctcctggctcccgtgcacttcctggtgatgctgacgtctctgctctccgtgaggaacctc cgaaagcatctgaggaaggtcaccttgaagggtctcatcagctccattttctcatttctc tggaacattctcatgggactggctcaaatggtcttttgcgtcatctccgtcatacttcat ttactctacctgaccttcatcaacggcggcattattgagacggttgggaacatgacactc gctgacctggtgatcgacgtccctgaccccagcctcgacgaggtcacagggttgcgtctg ggtttgggggatggagtccggcagcgcctggagcccctctcctcccaggaggacctgagt gagctggagctggatctggatctctccgccgtgtccaaagacccgcaggtcctcacagac atcttcggactgcgtctgagaaaggagggggccaaggtcagactcatatctcatgatgcc agcgcgggcctcggccatcttctctcggcctcggacgagcttactgacgctgctgaactc aaaagaaaacaaaaggtgctcgcattcaagacacacgactgtgaggaaaaggaagagaaa attactgaaaaagcagatggagaagacgatgagaaggacaagaggccagagtgcaggcag cgccagagagccaggcaacagcgccgctccaagcaggaggaagaggatgtccaggagtca gctctctggaaaaccttcaactcctatcagagaagaatgcttaattgctttgccaggaat ttttacaacatgcgaatgcttgccctgtttgtcgcatttgccatcaatttcatccttctg ttctataaggtgtcgtccgtggctgcggatgaagaggacctggagggctctgcctggtct cacagcccagatgatgtgagcctggaggggccggagccagtggcggactcagactccgac tccgactctgactcagacacggcctcctttgtcctggaggagagcagtggctacatggcg ccctgtctgcgctacctggccatcattcacaccctcatctctttctgctctatcatcggc tactactgtctgaaggttcccttggtgatttttaagcgggagaaggaagtagcccgcaag cttgaatttgatggcctgtacgtgacagagcagccctctgaggatgacatcagaggacag tgggacagactggtcatcaatacgccgtcatttccgagtaattattgggataagtttgtg aagaggaaggtgatggataaatatggggatttttacggcttggcgcggatcagcgacctg ctgggtctggatcgcgccgctctggacttcagcgcccagggcatggagcggaggaggccc cggagagagcgagagctctcggccctgttgagctccatcgacatgaagtaccagatatgg aaattgggtgtggtgttcactgataattctttcctctacctggcttggtacatgtgcatg tctgtcctcggccactataacaacttcttctttgcggctcacctgctggacatcgctatg ggctttaaaacgctgaggaccatcctcacgtctgtcacgcacaacggcaaacagctggtg ttgactgtggggctgctggctgtcgtggtctatctctacactgtggtggccttcaacttc ttccggaagttctacaataaaagcgaagacggcgaaggccaggatatgaaatgtgacgat atgctgacatgttatatgttccacatgtacgtgggggtgagagccggaggcggcatcggg gatgagatcgaggatcctgccggggacgagtccgagttctaccgcatcgttttcgacatc accttcttcttttttgttatagtcatcctgctggcaatcatacaaggtctcatcattgat gcattcggagagctgcgagatcagcaggagcaggtcaaagaggacatggagactaagtgc tttatctgtggcatcggtaatgagtactttgacacgctcccccatggatttgagacgcac acgctgcaggagcacaacctggccaactacctgttcttcgtgatgtacctcatcaacaag gacgagacagagcacacgggccaggaatcgtatgtatggaagatgtaccaggagcgttgc tgggaattcttcccagtgggagattgtttccgtaaacaatatgaggatcagctcagctaa

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