Sardina pilchardus (sardine): 134069579 Help Entry 134069579         CDS       T10667                                  Symbol ryr2a Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism spil  Sardina pilchardus (sardine) Pathway spil04020   Calcium signaling pathway spil04260   Cardiac muscle contraction spil04261   Adrenergic signaling in cardiomyocytes spil04371   Apelin signaling pathway Brite Ion channels [BR:spil04040]  Voltage-gated cation channels   Ryanodine receptor    134069579 (ryr2a) Domain-containing proteins not elsewhere classified [BR:spil04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    134069579 (ryr2a) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 ODV-E18 Motif Other DBs NCBI-GeneID:  134069579 NCBI-ProteinID:  XP_062381549 LinkDB All DBs Position 22:28779771..28898942 Genome browser AA seq 4954 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCSATINKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEEKAEGTAQGGGHRTLLYGHAVLLRHSYSGMYLCC LSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYL HLSYGNDSLHVDAAFQQTLWSVAPICSGSEVAQGFLIGGDVLRLLHGHMDECLTVPSGEH GEEQRRTVHYEGGAVSTHARSLWRLETLRVAWSGSHTRWGQPFRLRHVTTGKYLSLMDDK SLLLMDKERADIKSTAFCFRSSKEKLDLGFKKEVDGMGVPEIKYGDSVCYIQHVDTCLWM TYQSMDAKCARMGGIQRKAIMHHEGHMDDGLSLSRSQHEESRTARVIRSTVFLFNIFIRG LDSLSKKGKVSTLDLPIESVSLSLEDLIGYFQPPEDHLEHEDKQNRLRALKNRQNLFQEE GMISLVLECIDRLHVYSSAAHFADVAGREAGEAWKSILNSLYELLAALIRGNRKNCAQFS GSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLD VLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTQLVNQVSSMRPNIFLGVSEGSAQYKK WYYELIVDHVDPFITAEATHLRMGWASTHGYSPYPGGGEGWGSNGVGDDLYSYGFDGLHL WSGCIARTVSSPIQHLLRTEDVVSCCLDLSAPSISFRINGQPVQGMFENFNSDGLFFPVV SFSAGVKVRFLLGGRHGEFKFLPPPNYAPCFEAVLPREKLRVEHTQEYKQDHGATRDLLG PTITLSQAAFTPIPVDTSQIVLTPHLERIREKLAENIHELWVMNKVELGWTYGMIRDDNK RQHPCLVEFSKLPEQERSYNLQMSVETLKTLLALGCHVGVADEHAVEKVKKLKLPSKYEL SSGYKPAPMDLGHIRLASAQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKSKRNPRL VPYVLLDERTKKSNKDSLREAVRTLLGYGYSLEAPDQDHASRADISNMSAERFRIFRAET TYGVNVGKWYFEFEVVTAGEMRVGWARPACLPDQELGSDEHAFVFDGFKAQRWHQGNEHF GRSWQPGDVVGCMVDMSEHTMMFTLNGEVLLDDSGSELAFKDFEIWEGFIPVCSLGVCQI GRMNFGKDVSTLKYFTICGLQEGFEPFAVNMNRDLTMWLSKRLPQFIPVPSNHEHIEVTR IDGTVESSPCLKVMQRSFGSQNSSSDIVFYRLSMPIECAEVFCKSPGSAVPSNGRFFSSK KDLDDLETESDFEVLMKSSHSHMGSNGPEKDTDEFNNHKDYNQEKPSKFKSRFMLKKTKP EFNTSQSSARLPEEVIAEAERDDSYLMQTSTYYYSVRIFPGQEPSSVWVGWVTSDFHQYD TAFQQDKVRTVTVTLGDEKGKVHESIKRSNCYMVWAGETTSPGQGRNNNGLEIGCQVDCV SGVLSFTSNGKELSTFYQVEPSTKLFPAVFAQATSPNVFQFELGSIKNVMPLSAGLFKSE RKNAVPQCPPRLHVQYLTPVLWSRVPNRFLRVEVARVSERLGWQVQCHEPLQFMSLHIPE ENRSVDILELTEQRELLKFHYHTLRLYSAVCALGNNRVAHALCSHVDESQLLYAIENKHM PGLLRTGYYDILIDIHLSSYATARLMMNSEFIVPMTEETKSITLFPDEQKKHGLPGIGLS TSLRPRMRFSSPSFVGMDKSLSGDCFQYSPEFPLEILKTKTMEMLTEAVCEGSLHVRDPV GGSTEFLFVPLIKLFYTLLIMGVFHNGDLRIILQLIEPSVFSKEGKATSGPSHTAEGAAA SEKAEALRKEGGKVEGEQTAKVPKEGLLQMKLPEPVKLQMCHLLQYLCDCQVRHRIEAVV AFSDDFVANLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLGFKDEKQDC PCPDGIREQLLDFHQDLMTHCGIEQDDERLGEVDGDFTIRGRLMSLVEKVNNLKKKMADL PKKKKVKKPSTLQQLISETMVRWAQECVIEDPELVRAMFVLLHRQYDGIGGQVRALPKTY TINSVSVEDTINLLASLGQIRSLLSVRMGREEEKLMIRGLGDIMNNKVFYQHPNLMRALG MHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSS VGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVQYLAGCGLQSCMMLVSKGYP DIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAA MEEAINFSEDPCRDGPSPVAEASRTLSDSLEDEEDDTIHMGNAIMTFYSALIDLLGRCAP EMHLIHAGKGEAIRIRAILRSLIPIEDLEGVISIPFRMPTLAKDGSVVEPDMSAGFCPDH KAAMVLFLDRVYGIEDQNFLLHLLEVGFLPDLRAAASLDTPALSATDMALALNRYLCTAV LPLLTKCAPLFAGTEPYASLIDSLLHTVYRLSKGCCLTKAQRDAIEECLLAVCGKLRPSM MQHLLRRLVFDVPLLNEHTKMPLKLLTNHYERCWKYYCLSGGWGSFGAASDEELHLSRKL FWGIFDALSRKKYEHELFKLALPCLSAVAGALPPDYMESNYVAMMEKQSSMDAEGNFNPQ PVDTSNVVIPEKLDNFIIKFAEHSHERWSMDKLTKGWVHGDQLCEFTKTHPLLKPYKSLS EKDKEIYRGPIKESLKTILSWGWLIERTREGDTTSLHNRTRRISLSSQHSMEGTHGFSPR PIDMSNVTLSRDLHAMAELLAENYHNIWAKNKKSELEAKGGGSHPLLVPYDTLTAKEKSR DREKAQDILKFFQINGYTVSRAKKEQDLDTPSIEKRFAYTFLLQLITYVDQAHEHLLEFD ASNQPKGEKINDQQMKFFGKVVLPLVDQYFKNHHMYFLSTALHPISSGGHASNKEKEMVT SLFCKLGVLVRHRISLFGNDAASIVNCLHILGQTLDARTVMKTGLDTVKAALRAFFDNAA EDLEKTIENLQLGQFTHTRAQPKGVTQIINYTTVALLPVLSSLFEHITQNSFGEDIILDD IQVSCYRLLNSLYLLGTSKSIYVERQRPAIGECLAAFSGAFPVAFLEPQLNKCNSHSIYN VKTSRERTTLGLPAQVEEMCPLIPSLEKSLEEIMELAESGMCYTQMPHVMEVVLPMLCSY MSRWWEYGPENNPERAESCCTSLTSNHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQP IIGKAKPQLLKTHFLPLMEKLKKKAAIVLTDEENMKAEGRGEMSESELLILDEFTILVRD LYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEIFIFWAKSHNFKREEQNFVVQNEI NNMSFLITDTKSKMSKGCGSDQERKKMKKKGDRYSMQTSLIVAALKRLLPVGLNICAPGD QELIGLAKNRFSQKDTEAEVRETIRNNLHLQGKLEDPAIRWQMALYKDMPNRSEDTSDPE KTVERVLDIAHVLFHLDQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAV NLFLQGYLRSWIETEEHYFEDKLIEDLAKPGGEEPPEEDETTKHIDPLHQLIQLFSRTAL TEKCKLEEDALYMAYADIMAKSCHDEEDEDGEEVKSFEEKEMEKQKLLYQQARLHDRGAA EMVLQTISASKGEMGPMVASTLKLGIAGLNGGNSTVQQKMLDYLKDKKDVGFFQSLAGLM QSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNY LRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAINVAKQVF NTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIDLLKELMDLQKD MVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEYDP DGKGIISKRDFHKAMESHKHYTQSETDFLLSCVETDENETLDYEEFVERFHEPAKDIGFN VAVLLTNLSEHMPHDSRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSR TQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQMSDASERLASKE DTERGEKPEEESPEMGFFSVTTVRTALLALRYNVIVLMKVLSMKSLKKQVKRAKKMTLQD MVMALAAFYWSVLIGLLHFAFSVSRGFFRIIYNTFLGGNLLEGTKTMKMSDLITSMPDPT QEEARGEVEEGGENKSIERPLTKEDLADLTVATDETELLSDIFGLDLRREGGQYKIMPHN PNASLTDLLNAPIPPPSPSPEPRRHQVKESLKEEKGGTEDIKPEPEKAEGERVEKVEDKE QLKPKQRVRQIHISKSDEPDLQESAFCKKIIVYQRKLLNYFARNFYNMRMLALFVAFAIN FILLFYKVSTSSAVIEEKEVFRSPVDAGLHWNPLGATPDRTMTVHFVLEESSGYMEPTLR ILAILHTVISFCCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRL VINTQSFPNNYWDKFVKRKVMDKYGEFYGHDRISELLGMDKAALDFSDAHEKRKPKKDSS LAAVINSIDLKYQIWKLGVVFTDNSFLYLAWYMTMSILGHYNNFFFAAHLLDIAMGFKTL RTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGESPDMKCDDMLTCY MFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGEL RDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFVMYLINKDETEH TGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14865 nt NT seq  +upstreamnt  +downstreamnt atggcagaaggaggagaaggcgaagatgaaattcagtttttgcgaaccgatgatgaagtg gtgctgcagtgctctgccaccatcaacaaagagcagcagaagctgtgtctggcagccgag ggctttgggaacagactctgctttcttgagtcgacttccaattcaaagaatgttccccca gacctgtctatatgtaccttcgtcctggaacagtcactctcagttcgcgcccttcaagag atgcttgccaacacagaggagaaagctgaggggactgcccagggtgggggacatcgtact ttactttacggacatgcagttctccttagacactcgtatagtggaatgtacctgtgttgt ttatcaacatcacgctcctcaacagacaaactagcatttgatgtaggtctgcaggaggac acaacaggtgaggcatgttggtggactattcatcctgcctctaaacaacggtcagaagga gagaaggtgcgcgttggtgatgacctcattctggtcagtgtctcttcagagcgctacttg cacctgtcgtatgggaatgacagtctgcatgtggatgcagccttccagcagaccctctgg agtgtggcccctatctgctcaggaagcgaggttgcacaaggcttcctgattggaggggat gtgctgcgcctgctccatggtcacatggacgagtgcctgacggtgccatctggagagcat ggagaggagcagcgcaggacagtgcactatgaggggggagctgtgtccactcatgcccgc tccctctggagactggagactctgcgagttgcatggagtggcagtcacactcgctggggc cagccctttcgtctccgccacgtaaccactgggaagtacctcagtcttatggatgacaag agcctactcctcatggacaaggagagggctgacatcaagtccacagctttctgtttccgc tcctccaaggaaaaactggacttgggcttcaagaaagaggttgatggcatgggtgtccct gagattaagtatggcgactctgtgtgctacatccagcatgttgatacatgtctgtggatg acctaccagtccatggatgctaaatgtgcacgaatgggtggaatacagagaaaggctata atgcatcatgagggtcacatggatgacggcctttcactgtcccgctctcagcatgaggag tcacgcaccgcccgcgtcatccgcagcacagtcttcctcttcaacatctttatcaggggt ctagattccttgagtaaaaaagggaaggtttccacactggacttgcccattgaatctgtc agcttgagcctagaggatctgattggctacttccagcctccagaggaccatttagaacac gaggacaaacaaaaccgtctccgtgcactgaagaatcgtcaaaacctattccaagaggag ggtatgattagtctggtgttagagtgcattgacaggctacatgtatatagcagtgcagcc cattttgctgatgtggcgggaagagaagctggggaagcttggaaatctatactaaactca ttatatgagctgctggctgccctcataaggggtaaccggaagaactgtgcccagttttca ggctctttggactggctgatcagtcgtttagaacgccttgaagcttcttctggtatacta gaagttttgcattgtgtcttggtggaaagtccggaagccttaaacataattaaggagggg cacatcaaatcgattatctctcttctggacaaacatgggcgtaaccataaggtgctggac gtgctgtgctccttgtgcgtgtgtcatggtgttgctgtgcgctccaaccagcacctcatc tgtgataacctcctaccaggccgagatctgctgctacagacgcagctggtcaaccaagtc agtagcatgaggcccaacatcttccttggtgtcagtgaaggctctgcccagtataagaag tggtactatgagctcattgtggaccatgtagatcccttcatcactgctgaagctacccat ctgcgaatgggctgggcctcgacacatggctattctccctacccaggaggaggggagggc tggggcagcaatggggttggtgatgacctgtactcgtatggctttgatgggctacatctg tggtcaggttgcattgcccgtactgtcagctcccctattcagcatcttttgcgcacagag gatgttgtcagctgctgcctggacctcagcgctcccagtatctcctttcgcatcaatggg cagccagtacagggcatgtttgagaacttcaactctgatgggctcttcttccctgtggtt agcttctcagcaggagtcaaggtgcgtttcctgttgggtggtcgtcatggtgagttcaaa ttcctaccaccgcccaactacgctccctgttttgaggctgtgctccccagagagaagttg cgagtggagcacactcaagagtataagcaggaccatggagctaccagggacttgctgggc cccacaatcaccctctcacaggctgccttcactcccataccagtggacactagccagatt gtgctgacacctcatttggaacggattcgtgagaagcttgctgaaaatatccatgagctt tgggtgatgaacaaggtagagcttggttggacatatggcatgattcgggatgacaacaag agacagcatccctgtctcgttgaattctcgaagcttccagaacaagaacgtagctacaat ctgcagatgtccgtggaaacactcaagacccttctggcactaggctgccatgttggtgtg gcagatgagcatgctgttgagaaagtcaagaagcttaagctcccctccaaatatgaactc tccagtggatacaaaccagcccctatggacctgggtcacattagacttgcctccgcccag gaggccatggtggacaagctggcagaaaatgcccacaatgtttgggcaagggaccggatt cgacagggctggacttatggcatccaacaggatgtaaagagcaagaggaacccacggctg gttccatatgtattgcttgatgaacgaaccaagaaatccaacaaggacagcttgcgagaa gcagtgcgtacactcctaggctacggatatagccttgaggctccagaccaagaccacgca tccagagcagacataagcaacatgtcagccgagaggtttcgtatcttccgtgctgagacg acatacggcgtgaacgtggggaagtggtactttgagtttgaagtggtgactgctggagag atgagggtaggttgggcccgaccagcttgcctgcctgaccaggaactgggctctgatgaa cacgcatttgtctttgatggcttcaaggcccaacggtggcaccaggggaatgaacatttt gggcgctcctggcagccaggagatgtggttggatgcatggtggacatgagtgaacacacc atgatgttcacactaaatggggaagtgttgcttgacgactctggctcagagcttgccttt aaagattttgaaatttgggaaggattcatccctgtgtgtagtctgggtgtgtgtcagatt ggccgcatgaactttggcaaggacgtaagcacattgaagtacttcacaatatgtggccta caagaaggttttgagccttttgctgtgaacatgaaccgagatttgaccatgtggttaagc aagaggctccctcagtttataccagtcccttcaaaccatgagcacattgaggtcacaagg atagatggcaccgtggagagctcaccgtgtctaaaggtcatgcagaggtcattcggctca cagaacagcagcagtgacatcgtcttttaccgcctcagtatgcccattgagtgcgccgag gtcttctgcaagtctccaggcagtgccgtgccctcgaatgggagattcttctcctccaag aaagacctggacgaccttgaaacagaatctgactttgaggtcttgatgaagagttcccat agtcacatgggctctaacggaccagagaaggacactgatgaattcaacaaccacaaggac tacaaccaggaaaagccatccaagttcaagtcaaggtttatgcttaaaaagacaaagcca gagttcaacaccagccagtcatcagcacgtctgccagaagaggtgatagcagaggctgaa agagatgactcttatcttatgcagacctcaacgtattactactctgtaaggatcttccct ggccaggaaccatcgagtgtgtgggtgggttgggttacatcagacttccatcagtatgac actgcctttcagcaagacaaggttaggactgttactgtgaccctgggggatgagaaaggc aaggtccatgagagcatcaagcgcagtaattgctacatggtatgggcaggcgagaccacc agccctggtcagggtcgaaacaacaatggcctggagatcggttgccaggtggactgtgtc agtggtgtgcttagcttcaccagcaatggcaaagagctcagcaccttttaccaggttgag cccagcaccaagctgttccctgcagtgtttgctcaggccaccagccccaacgtgttccag tttgaactgggaagcataaagaatgtgatgcccttgtctgctggccttttcaaaagtgag cgtaaaaacgccgtgccacagtgccctccccggctgcatgtgcagtacctgacgcccgtg ctgtggagccgcgtgcccaaccgcttcttgagggtggaggtggcgcgcgtcagcgagcgc ctgggatggcaggtgcagtgccacgagcccctgcagttcatgtctctgcacatccccgag gagaacaggtcggtggatatcctggagctgacggagcagagggagctgctgaagttccac taccacaccctgcgcctctactcggccgtgtgcgcgctgggcaacaaccgcgtggctcat gctctctgcagccacgtggacgagtcccagctgctgtacgccatcgagaacaagcacatg cccggcctgctgcgcacgggctactacgacatcctcatcgacatccacctcagcagctac gccacggcgcggctcatgatgaacagcgagttcatcgtgcccatgacggaggagaccaag agcatcacgctcttccccgacgagcagaagaagcacggcctgccaggcatcggcctgagc acctccctgcggccgcgcatgcgcttctcctcgcccagcttcgtggggatggacaagagt ctcagcggcgactgtttccagtacagccccgagtttcctctggagatcctgaagaccaag accatggagatgctgactgaggctgtgtgtgagggcagtcttcatgtgcgagatcccgtc ggtggcagcacagagttcctgtttgtgccactaatcaaactcttctatacgttgctcatt atgggcgtcttccacaacggtgacctgcgaatcattctgcaactcattgagcctagtgtc ttctccaaggagggcaaggccacctctggcccaagccacacagcggagggtgcagcagct agtgagaaggccgaggcactgaggaaagaaggcgggaaggttgaaggagaacaaacagca aaggtgcccaaagaaggtctgctccagatgaagttgcctgagccagtcaagctccagatg tgtcatctgctgcagtacctgtgtgactgtcaggtgcgtcaccggattgaggccgtggta gccttctctgatgattttgtggcaaacctgcaagacaatcagcgtttccggtacaacgaa gtcatgcaagctctgaacatgtctgccgcacttacagctcgaaagaccaaagagtttcgc tcacctccccaggagcagataaacatgctgctaggcttcaaagatgaaaagcaggattgt ccctgccctgacggtatcagagagcagttgttggacttccaccaagacttaatgactcac tgcggaatcgagcaggatgatgagaggctcggtgaagtggatggagatttcacaatacgc ggtcgactgatgtctctggtggaaaaagtgaataatttgaaaaagaaaatggctgatctg cctaagaaaaaaaaagtcaagaaaccaagcactcttcagcagcttatctctgagacgatg gtgcgctgggcacaggaatgtgtgattgaggacccagagctggtcagagccatgtttgtg ctcttgcatcgtcagtatgacggtatagggggacaggtgcgtgccttgccgaagacctac accatcaactcagtgtctgtggaggacaccatcaacctgctggcctctctgggccagatc cgctctctactcagcgtcaggatgggccgagaagaggagaagctcatgattaggggcctg ggtgatattatgaacaacaaagttttctatcagcatccaaatctaatgagggccttgggc atgcatgagactgtgatggaagtcatggtgaatgtattgggaggtggagaatcaaaggaa attacctttcctaagatggtggccaactgctgtcgttttctttgctacttctgccgcatc agtagacaaaaccaaaaagcgatgtttgatcacctcagttacctgcttgagaacagtagc gtgggacttgcctctccttctatgcggggttcaactcctctggatgtggctgcggcctca gtgatggataacaatgagcttgccttggccctgagggaaccagacctcgagaaagtggtg cagtatttggctggctgtggactccagagttgcatgatgttagtctctaaaggctatcct gacatcggctggaaccctgttgaaggagagcgttacttggactttctgcggtttgcagtc ttttgcaatggagagagtgttgaggagaacgctaatgtggttgtgaggctcctgatccgg cgccctgaatgtttcggtcctgccttgagaggggagggagggaatggccttctggcggcc atggaagaggccatcaatttctcagaagacccctgcagggacggaccctcacctgtcgct gaggccagcagaacactgagtgattctctggaggatgaggaagatgacaccatccacatg ggcaatgccatcatgaccttctactcggccctcattgacctgctgggccgctgtgctcct gagatgcatctgatccatgctgggaagggcgaagccatccggatcagagcaattctgcgc tctctgatccccattgaggaccttgagggggtcatcagcatcccatttcgtatgcccact ttggccaaagatggatcggttgtagagcctgacatgtcagcaggcttctgccctgaccac aaggcagccatggttcttttcttggatcgggtgtatgggattgaggatcagaatttcctg cttcacctcctggaagtgggcttcctgcctgaccttcgcgcagcggcatcacttgacaca ccagccctgagtgctacagatatggccctggccttgaaccgctacctgtgcacagctgtg ctgcctttgcttactaaatgtgccccactgtttgctggcacagagccttatgcctcgctc attgactctctgcttcacactgtgtaccgcctgtcaaagggctgctgcctaactaaggcc cagagggatgccatagaggagtgcttgctggctgtgtgtgggaaactgaggccctccatg atgcagcatttactcagaaggctggtgtttgatgtccccctgctgaacgaacacactaaa atgccccttaagctgttgaccaaccactatgagcgttgctggaagtactattgcctgtct ggaggctggggcagctttggagctgcctctgatgaagaactgcacctctccaggaagctg ttctgggggatttttgatgctttgtcaaggaagaagtacgagcacgagctgttcaagctg gctttgccctgcctaagtgctgttgccggagccttgccaccagactacatggagtccaac tatgtggccatgatggagaagcagtcctcgatggatgcagagggaaacttcaacccccag ccagttgatacttcaaacgtggttatccctgaaaaactggataatttcatcatcaaattt gctgagcattcccacgagaggtggtctatggataagcttaccaaaggctgggtgcatggt gaccagctatgtgaattcaccaagacacacccccttctaaaaccatacaaaagcttgtca gagaaggacaaagagatttatcggggtcccataaaggaatccctgaaaaccatcctgtca tggggctggctcattgagaggactcgagaaggcgacacaactagccttcacaaccgtaca cggcggatatctttatcaagtcagcattctatggaaggcactcacggattcagccctaga ccaatcgacatgagtaatgtgactctctctagagacttacacgccatggccgaactactt gcagaaaattatcataacatatgggccaagaataagaagtcggagcttgaagccaaaggt ggagggagtcatcctttgctggtgccctatgacactctaacggccaaagagaaatcaaga gacagagaaaaagcacaagacatcctgaagttctttcagataaatggttatactgtgtct agggctaaaaaggagcaggatcttgacacgccctccatagagaagcgatttgcttacacc ttcctactgcaactcatcacctatgtggaccaagcccatgaacatctgctggaatttgat gccagtaatcagccaaagggagaaaaaatcaatgaccagcagatgaagttttttggaaag gtggtcttaccccttgtggatcagtacttcaaaaatcatcatatgtacttcctgtccact gcattgcaccctattagcagtggtggccatgcctccaacaaagagaaagaaatggtgacg agcctcttctgcaaactcggagttcttgtcagacataggatatcactgtttggaaatgat gcggcttctattgtgaactgtctccacatactaggacaaacacttgatgccagaactgtg atgaagacaggtttggacaccgtgaaggcagcactgcgggcattctttgacaatgctgcc gaggacttggagaaaacgatagagaacctacaactaggccagttcactcacacccgtgct cagcctaagggagtaactcagatcatcaactacacaaccgtggcattgctgcctgtgctc tcctccctctttgagcatatcacacagaactcgtttggggaggatatcatacttgatgat attcaggtgtcatgctataggctacttaacagcctatatttactgggcactagcaaaagc atttatgttgaaagacagcgaccagccataggggaatgcctggcagctttttcaggagct ttccctgttgcctttttggaacctcaactcaacaaatgtaatagtcactccatttataat gtcaaaacctcaagggagagaacaactctgggactacctgctcaggtggaggaaatgtgt cctctcattccatcacttgagaagtccttggaagagatcatggagctagcggagtcaggc atgtgctacacacagatgcctcatgtgatggaggtggtgctgcccatgttgtgcagctac atgtcccgctggtgggaatatgggccggagaacaaccctgagcgcgcagagagctgctgc acctcactcacatccaatcacatgaacacgctgctggggaacatcctgaaaataatctat aacaatctgggaattgatgaaggagcctggatgaagcggctggcagttttctctcagcct atcataggcaaggccaagcctcaacttttaaagacccatttcctacctttgatggagaaa ctgaagaagaaagccgccatcgttctgaccgatgaggagaatatgaaggccgaggggcgg ggagagatgtccgagtcggagcttctcatcctagatgagttcaccatccttgttcgggat ctatatgcgttctatcctctcctcatacgatttgtggattacaacagggcaaaatggctt aaagaacctaacccagaagcagaagagttattccgtatggtggcagaaatcttcatattt tgggcaaaatcacataacttcaaaagggaggagcaaaactttgttgttcagaatgagata aacaacatgtctttcctcattacggataccaaatcgaaaatgtcaaaaggatgtgggtca gaccaggagaggaaaaagatgaagaaaaaaggggaccgctactctatgcagacctctctt attgtagctgctctcaagaggctgctgcctgttggcctgaacatttgtgctccaggagat caggaactgattggactcgctaagaatcgcttctctcagaaagatactgaagcggaggtg cgagagactatacgcaacaatctccatcttcagggaaaactggaggatcctgctattcgc tggcagatggcactatataaagacatgcccaatagaagtgaggatacatcagacccggag aaaacagtggagagggtgcttgatattgcccatgtgctcttccacctggaccaggttgaa catccccagaggagtaagaaagcagtgtggcacaagctattgtctaagcagaggaagaga gcagtagtggcctgtttcaggatggcacccctttataacctgcccaggcaccgagcagtc aatctattcctgcagggttacttgagatcctggatagaaacagaggagcactactttgaa gacaagcttattgaggacttggccaaacctggaggagaggaaccccctgaggaagatgaa accaccaaacacatagaccccctgcaccagcttatccagttattcagtagaactgcactg accgagaaatgtaaactagaggaagacgctctctacatggcctacgcagatatcatggca aagagttgtcatgatgaagaggatgaagatggtgaggaagtgaaaagttttgaagaaaag gagatggaaaagcagaaactactttaccaacaggcacgattacatgaccgaggcgctgca gagatggtccttcaaactatcagtgcgagtaaaggggagatgggaccaatggttgcatcc acattaaagctggggattgccggactaaatggaggaaattccactgtgcaacagaaaatg ctggactatctgaaagataagaaagatgtgggcttttttcagagtctggcaggtctcatg cagtcctgcagtgttctagatctcaatgcattcgagagacaaaacaaagctgaaggcttg ggtatggtgactgaagaaggctcaggagagaaggtgatgcaagatgatgagttcacctgt gacctctttcgcttcctgcaacttctgtgtgaaggacataactcagatttccagaattat ctgagaacacagacaggaaacaacacaactgttaacatcattatatctacagttgactac ctcctcagagtccaggagtccatcagtgatttctattggtattattcggggaaagatgtc attgatgaacaggggcaacgcaatttctccaaagctatcaatgtagcaaagcaagtcttc aacacgctgactgagtatatacagggcccatgtacaggaaatcagcagagtctagcccat agtcgcttatgggatgcagtggttggctttctgcatgtgtttgctcatatgcagatgaag ctgtctcaggattctagccaaattgatttgctgaaggagttaatggatctccaaaaagac atggttgtgatgttgctatccatgttggaaggtaatgttgtgaatgggaccattggtaaa cagatggtggacatgctggtggaatcttccaacaatgtggagatgatactgaagtttttt gacatgttcctcaagcttaaagacctaacgtcctcagatgctttcaaagaatatgaccct gatgggaaagggattatctcaaagcgagatttccataaagcaatggagagtcacaaacac tacacacaatctgaaacagacttcctgctctcctgtgtagagacagatgagaatgagact cttgactatgaggagtttgtggaaaggttccatgaaccagccaaagacattggttttaat gtggctgtacttctaaccaacctttctgagcatatgccgcatgattcacgccttcagacc ttcttggagttggctgagagtgtccttaattacttccagcctttcttgggccgcattgag atcatgggtagtgccaagcgtattgaacgtgtctactttgaaattagtgagtctagccgc acacagtgggagaagccacaggtaaaagagtccaaacgacagtttatctttgatgttgtc aacgaaggtggtgagaaggaaaagatggagctttttgtcaatttctgtgaagacaccatt tttgagatgcagcttgcagcacaaatgtcagatgctagtgagcgcttggccagcaaggag gacacagagcggggagaaaagcctgaggaggagagccctgagatgggcttcttctctgtt accactgtaaggacagcccttctagctctccgctataatgttatagtgttaatgaaagtg ctttccatgaagagcctgaagaaacaggtgaagagggccaagaaaatgacattgcaggac atggtaatggcacttgctgccttctactggagtgtgctgattggacttctgcattttgca tttagcgtctcacgtgggttcttccgtattatatacaacaccttccttgggggtaatctg ttggaaggtaccaagaccatgaaaatgtctgacctcataaccagcatgcctgacccaaca caggaggaggcgcgtggggaggttgaagaaggtggggaaaataaatcaattgagaggccc ttgacaaaggaggacttagccgacctcactgttgctacagatgaaacagaacttctttca gacatctttggcttagatttacgaagagaagggggacagtacaagataatgcctcacaat ccaaatgccagcctgactgacttattaaatgccccaatacctcctcctagtccctcccct gagcctagaagacatcaggttaaagaatcattaaaagaggaaaaagggggaacagaagac attaagccagagccagagaaagcagaaggagaacgtgtggagaaagtagaagataaggaa cagctcaagccaaagcagagggtcagacagatccacatctccaaatccgatgagccagac ctgcaggaatctgcattctgcaaaaaaatcattgtctaccagaggaagcttcttaactac tttgccaggaacttctacaacatgaggatgctggcattgtttgtggcctttgctatcaac ttcatccttctcttctataaggtgtctacatcttcagctgtgattgaggagaaggaggtg tttagaagcccagtagatgcaggcctgcactggaatcctctgggtgctacccctgatcgc accatgactgtgcattttgtccttgaggaaagtagtggctacatggagcctactctgcgc atccttgccatcctgcacacagtcatctctttctgctgcatcatagggtactactgcctg aaggttcccttggtaatcttcaagcgtgaaaaagaggtggctagaaagctggagtttgat ggcctgtatattactgagcagccttcagaggatgacatcaaaggccagtgggataggctg gtcatcaatactcagtcatttcctaataattactgggataagtttgtgaaaagaaaggtg atggacaagtatggtgagttctatgggcatgaccgcatcagtgagctgctggggatggac aaagctgcgctggacttcagtgatgcgcatgagaagaggaagcccaagaaggacagttca ttagctgctgtaatcaattccattgatttgaagtaccagatatggaaattgggagttgtc ttcacagacaattccttcctgtatctggcctggtacatgacaatgtccattctgggacac tacaataacttcttctttgcagctcacctcctggacatagccatgggtttcaagaccttg aggacaatcttgtcctctgttacccacaatggaaaacagttggtcctcacagttggctta cttgcagtagtggtttatctttacactgtggtggccttcaactttttccgcaaattctac aacaagagtgaggatggcgagtcaccagacatgaagtgtgatgacatgcttacatgctat atgttccacatgtacgttggtgtgagggcaggagggggcattggcgaccaaatagaggac ccagctggagatgaatacgagatttaccgtatcatctttgacatcaccttcttctttttt gttattgtcattctgctagccatcattcaaggtcttataattgatgcttttggtgaactg cgagaccaacaggaacaggtgaaggaagacatggagaccaaatgcttcatctgtggaata gggaatgattactttgatactgtacctcatggctttgaaacacataccctgcaggagcac aacttggcaaattatctattttttgtgatgtatctcattaataaagatgaaacagagcac accggacaggaatcatatgtctggaaaatgtaccaggaacggtgctgggaatttttccct gcaggagactgtttccgtaaacaatatgaagaccagctcaactag

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