Streptococcus pyogenes MGAS8232 (serotype M18): spyM18_0026
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Entry
spyM18_0026 CDS
T00079
Symbol
purL
Name
(GenBank) putative phosphoribosylformylglycinamidine synthase II
KO
K01952
phosphoribosylformylglycinamidine synthase [EC:
6.3.5.3
]
Organism
spm
Streptococcus pyogenes MGAS8232 (serotype M18)
Pathway
spm00230
Purine metabolism
spm01100
Metabolic pathways
spm01110
Biosynthesis of secondary metabolites
Module
spm_M00048
De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:
spm00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
spyM18_0026 (purL)
Enzymes [BR:
spm01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor
6.3.5.3 phosphoribosylformylglycinamidine synthase
spyM18_0026 (purL)
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Gene cluster
GFIT
Motif
Pfam:
GATase_5
AIRS_C
FGAR-AT_linker
GATase_3
FGAR-AT_PurM_N-like
DJ-1_PfpI
GATase
Motif
Other DBs
NCBI-ProteinID:
AAL96855
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Position
36781..40554
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AA seq
1257 aa
AA seq
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MSSYFPVAPLSDLVSYMNKRIFVEKKADFGIKSASLVKELTHNLQLTSLKDLRIVQVYDV
FNLAEDLLARAEKHIFSEQVTDRLLTEAEITAELDKVAFFAIEALPGQFDQRAASSQEAL
LLFGSDSQVKVNTAELYLVNKDIAEAELEAVKNYLLNPVDSRFKDITLPLEEQAFSVSDK
TIPNLDFFENYKADDFAAYKAEQGLAMEVDDLLFIQDYFKSIGRVPTETELKVLDTYWSD
HCRHTTFETELKNIDFSASKFQKQLQTTYDKYIAMRDELGRSEKPQTLMDMATIFGRYER
ANGRLDDMEVSDEINACSVEIEVDVDGVKEPWLLMFKNETHNHPTEIEPFGGAATCIGGA
IRDPLSGRSYVYQAMRISGAGDITTPIAETRAGKLPQQVISKTAAHGYSSYGNQIGLATT
YVREYFHPGFVAKRMELGAVVGAAPKENVVREKPEAGDVVILLGGKTGRDGVGGATGSSK
VQTVESVETAGAEVQKGNAIEERKIQRLFRDGEVTRLIKKSNDFGAGGVCVAIGELADGL
EIDLDKVPLKYQGLNGTEIAISESQERMSVVVRPSDVDAFIAACNKENIDAVVVATVTEK
PNLVMTWNGETIVDLERRFLDTNGVRVVIDAKVVDKDLTVPEARTTSAETLEADTLKVLS
DLNHASQKGLQTIFDSSVGRSTVNHPIGGRYQITPTESSVQKLPVQHGVTRTVSVMAQGY
NPYIAEWSPYHGAAYAVIEATARLVATGADWSRARFSYQEYFERMDKQAERFGQPVSALL
GSIEAQIQLGLPSIGGKDSMSGTFEGLTVPPTLVAFGVTTADSRKILSPEFKAAGENIYY
IPGQAISEDIDFDLIKANFSQFEAIQAQHKITAASAAKYGGVLESLALMTFGNRIGASVE
IAELDSSLTAQLGGFVFTSAEEIADAVKIGQTQADFTVTVNGNDLAGASLLAAFEGKFEE
VYPTEFEQADALEEVPAVVSDTVIKAKETIEKPVVYIPVFPGTNSEYDSAKAFEQVGASV
NLVPFVTLNEIAIAESVDTMVANIAKANIIFFAGGFSAADEPDGSAKFIVNILLNEKVRA
AIDSFIEKGGLIIGICNGFQALVKSGLLPYGNFEEAGETSPTLFYNDANQHVAKMVETRI
ANANSPWLAGVEVGDIHAIPVSHGEGKFVVSASEFAELRDNGQIWSQYVDFDGQPSMDSK
YNPNGSVNAIEGITSKNGQIIGKMGHSERWEDGLFQNIPGNKDQTLFASAVKYFTGK
NT seq
3774 nt
NT seq
+upstream
nt +downstream
nt
atgtcctcctattttccagtcgctcccttgtcggatttggtatcttatatgaataaacgt
atttttgttgagaaaaaggctgactttggcattaaatcggctagccttgtgaaagagttg
acacataatctacaactgacttctttgaaggacttgcgtattgtgcaggtttatgatgtc
ttcaatttggctgaggatttactggcgcgtgctgagaagcatattttctctgagcaggtg
acagaccgtcttttgacggaagctgaaatcactgcggagcttgataaggttgccttcttt
gccattgaggcgcttcctggtcaatttgaccaacgtgctgctagttcgcaagaagctttg
ctattatttggaagtgacagtcaggttaaggtcaatacagctgagctatacttggtcaat
aaggatattgcagaagcagagcttgaagccgttaagaactatcttttgaaccctgttgat
tcacgtttcaaggacattactttgccgcttgaagagcaggctttctctgtatctgataag
acgatccctaatcttgatttctttgaaaattataaagctgacgattttgcggcctataag
gcagagcagggcttggctatggaggtcgatgaccttctcttcatccaagattatttcaaa
tcaatcggacgtgtgccaactgagactgagttgaaagttttggatacttactggtcagac
cactgccgtcacacaacctttgaaactgaattgaagaacattgatttttcagcttctaaa
ttccaaaaacaattgcagacaacttatgacaaatatatcgccatgcgtgatgagcttggt
cgttctgaaaagccacaaacacttatggatatggcgactatttttggtcgttatgagcgt
gccaacggtcgtctggacgatatggaagtctcagatgaaatcaatgcctgctcagttgag
attgaagtagatgttgatggtgtgaaagagccttggctcctcatgtttaagaatgagaca
cacaatcacccaacagaaattgagccattcggtggagcggcgacttgtatcggtggtgct
attcgtgacccattgtcaggacgttcatacgtttatcaggctatgcgtatttcaggcgca
ggcgatatcacgactccgattgcggaaacacgtgctggtaaattgccacaacaggttatt
tctaagactgcggcgcacggctattcttcatatggtaaccaaattggacttgcgacaact
tatgtgcgtgagtacttccaccctggcttcgtagccaaacgcatggagcttggagctgtg
gtcggagcggcacctaaggaaaatgtggttcgtgaaaaaccagaagcaggtgatgtggta
atcttgcttggtggtaaaacagggcgtgacggtgtcggcggtgcgacaggttcatctaag
gttcaaacggttgagtctgtggaaacagctggcgcagaggtacaaaaagggaatgccatc
gaagagcgtaagattcaacgtctcttccgtgatggtgaagtgactcgtctcatcaaaaaa
tcaaacgactttggtgctggtggtgtctgtgttgctatcggtgaattggctgacggtctt
gaaatcgatttggacaaggtcccacttaaataccaaggtcttaatggtactgaaattgca
atctcagaatctcaagagcgtatgtcagtcgttgttcgtccaagtgatgtggatgccttc
atcgcagcttgcaacaaggaaaatatcgatgccgttgtagttgcgacagttaccgagaaa
ccaaatcttgtcatgacttggaatggtgaaaccatcgttgacttggaacgccgtttcctt
gataccaacggtgtccgtgtcgttattgatgctaaagtcgttgacaaggacttgacagtt
ccagaagcacgcacaacatcagcagagacacttgaagcagatacgcttaaggtcttgtct
gacctcaaccacgctagtcaaaaaggtcttcaaactatctttgactcatctgttggtcgc
tcaaccgttaaccacccaatcggtggtcgttaccaaatcacaccgacagaaagttctgtt
caaaaattgccagttcaacatggtgtgacaagaacagtatctgttatggctcaaggttac
aatccttatattgctgagtggtcaccttaccacggtgctgcctatgctgtcattgaagcg
acagctcgcttggtagcaacgggtgctgactggtctcgtgcacgtttctcttaccaagag
tactttgagcgtatggataaacaggcagagcgttttggtcagccagtatcagctcttctt
ggttctattgaggctcagattcaacttggtttgccatcaatcggcggtaaggactctatg
tctggtactttcgaaggcttgacagtaccaccaaccttggtagctttcggtgtgacaaca
gcggacagccgcaagattctctctcctgagtttaaagcggctggcgaaaacatttactat
atcccaggtcaagctatttcagaagatattgattttgatcttatcaaggctaactttagc
cagtttgaggctattcaagctcaacataagattacagctgcctcagccgctaaatacggt
ggtgtcctagaaagtcttgctctcatgacttttggtaaccgtatcggtgcttctgttgaa
attgcagagcttgacagcagcttgacagctcaactcggaggttttgtctttacatcagct
gaggaaattgctgacgcggtaaaaatcggtcaaactcaggcagactttacagtcactgtc
aatggaaatgaccttgctggcgctagccttctagcagctttcgaaggcaaatttgaagag
gtttacccaacagaattcgaacaggcagacgctcttgaagaagttcctgctgtggtatca
gatactgttatcaaggctaaggaaacaattgaaaaaccagtggtttacattcctgtcttc
cctggtaccaactcagagtatgattcagctaaggcctttgaacaggttggagctagtgtc
aacttggtaccatttgtaaccttgaatgagattgctattgctgagtcagttgacactatg
gttgctaatattgctaaggcaaatatcatcttctttgctggaggcttctcagcagcggat
gaaccagatgggtctgctaagtttatcgtcaatatcttgcttaacgagaaggtccgcgca
gctattgacagcttcatcgaaaaaggtggccttatcattggtatctgtaatggtttccaa
gcccttgttaaatcaggtcttcttccatacggaaacttcgaggaagctggtgagacaagt
ccaactctcttctataacgatgcgaaccaacacgttgccaagatggttgagactcgtatc
gcaaatgccaactcaccttggttggcaggagttgaggtcggcgatattcacgccattcca
gtttcacacggtgaaggtaaatttgttgtcagcgcttctgaatttgcagagctaagagac
aatggtcaaatctggagccaatatgtggactttgacggacaaccatctatggattctaaa
tacaatccaaacggctctgtcaatgccatcgaagggattaccagcaagaatggtcaaatc
atcggtaagatgggacactcagaacgctgggaagacggactcttccaaaatatccctggt
aacaaagaccaaaccctctttgcaagtgctgtaaaatactttacagggaagtaa
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