Streptococcus pneumoniae TIGR4 (virulent serotype 4): SP_1670
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Entry
SP_1670 CDS
T00057
Symbol
murF
Name
(GenBank) UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
spn
Streptococcus pneumoniae TIGR4 (virulent serotype 4)
Pathway
spn00300
Lysine biosynthesis
spn00550
Peptidoglycan biosynthesis
spn01100
Metabolic pathways
spn01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
spn00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
SP_1670 (murF)
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
SP_1670 (murF)
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
SP_1670 (murF)
Enzymes [BR:
spn01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
SP_1670 (murF)
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Mur_ligase
Motif
Other DBs
NCBI-ProteinID:
AAK75749
UniProt:
A0A0H2URC3
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Position
complement(1569713..1571086)
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AA seq
457 aa
AA seq
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MKLTIHEIAQVVGAKNDISIFEDTQLEKAEFDSRLIGTGDLFVPLKGARDGHDFIETAFE
NGAAVTLSEKEVSNHPYILVDDVLTAFQSLASYYLEKTTVDVFAVTGSNGKTTTKDMLAH
LLSTRYKTYKTQGNYNNEIGLPYTVLHMPEGTEKLVLEMGQDHLGDIHLLSELARPKTAI
VTLVGEAHLAFFKDRSEIAKGKMQIADGMASGSLLLAPADPIVEDYLPTDKKVVRFGQGA
ELEITDLVERKDSLTFKANFLEQALDLPVTGKYNATNAMIASYVALQEGVSEEQIRLAFQ
DLELTRNRTEWKKAANGADILSDVYNANPTAMKLILETFSAIPANEGGKKIAVLADMKEL
GDQSVQLHNQMILSLSPDVLDTVIFYGENIAELAQLASQMFPIGHVYYFKKTEDQDQFED
LVKQVKESLGAHDQILLKGSNSMNLAKLVESLENEDK
NT seq
1374 nt
NT seq
+upstream
nt +downstream
nt
atgaaattaacaatccatgaaattgcccaagttgttggagccaaaaatgatatcagtatc
tttgaggacacccagttagaaaaagctgagtttgatagtcgtttgattggaactggagat
ttatttgtgccacttaaaggtgcgcgtgatggccatgactttattgaaacagcctttgaa
aatggtgcagcagtaaccttgtctgagaaagaggtctcaaatcatccttacattctagta
gatgatgttttgacagcctttcaatccttagcatcctactatcttgaaaaaacgactgtt
gatgtctttgctgttacaggttcaaatggcaagacaacgactaaggatatgttggcgcat
ttactgtcaacaagatacaagacctacaaaacacaaggcaattacaataatgagattggc
cttccttacacagttcttcatatgcctgaaggaacagaaaagttggttttggagatggga
caggatcacttgggcgatattcatctcttgtctgaattggctcgtccaaaaacagccatc
gtgaccttggttggagaagcccatttggcctttttcaaagaccgttcagagattgctaag
ggaaaaatgcaaattgcagacggaatggcttcaggttccttgcttttagcgccggctgac
cctatcgtagaggactatttgccaactgataaaaaggtggttcgttttgggcaaggggca
gagctggaaattactgacttggttgagcgcaaagatagtctgaccttcaaggccaatttc
ttagagcaagcccttgatttgccagtaactggcaagtacaatgcgacaaatgctatgatt
gcatcctatgttgccttgcaagaaggagtttcagaggagcaaattcgtttggccttccaa
gatcttgaattgacgcgtaaccgtaccgagtggaagaaagcagccaatggagcagatatc
ctgtcagatgtttacaatgccaatccaactgctatgaaactgattttagagactttctct
gccattccagccaatgaaggtggcaagaaaattgcagtgttggcggatatgaaggagctt
ggtgaccagtctgttcaacttcataatcagatgattttgagcctttctccagatgtgctt
gataccgtgattttctatggagaaaatattgctgaattagcccaattggccagtcaaatg
ttcccaatcggccacgtttactacttcaagaaaacagaagaccaggatcaatttgaagac
ctagtcaagcaggtcaaggaaagccttggagcccatgaccaaatcctgctcaaaggctct
aactctatgaatctagccaagttggtagaaagtttagaaaatgaagacaagtga
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