Streptococcus pneumoniae gamPNI0373 (virulent serotype 1): HMPREF1038_01652
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Entry
HMPREF1038_01652 CDS
T02334
Name
(GenBank) UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
spng
Streptococcus pneumoniae gamPNI0373 (virulent serotype 1)
Pathway
spng00300
Lysine biosynthesis
spng00550
Peptidoglycan biosynthesis
spng01100
Metabolic pathways
spng01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
spng00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
HMPREF1038_01652
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
HMPREF1038_01652
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
HMPREF1038_01652
Enzymes [BR:
spng01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
HMPREF1038_01652
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Mur_ligase
Motif
Other DBs
NCBI-ProteinID:
AFS43676
LinkDB
All DBs
Position
complement(1516799..1518172)
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AA seq
457 aa
AA seq
DB search
MKLTIHEIAQVVGAKNDISIFEDTQLEKAEFDSRLIGTGDLFVPLKGARDGHDFIETAFE
NGAAATLSEKEVANHPYILVDDVLTAFQQLAAYYLEKTAVDVFAVTGSNGKTTTKDMLAH
LLSTTYKTYKTQGNYNNEIGLPYTVLHMPEGTEKLVLEMGQDHLGDIHLLSELARPKTAI
VTLVGEAHLAFFKDRSEIAKGKMQIADGMASNSLLLAPADSIVEDYLPTDKKIVRFGQGA
ELEITDLVERKDSLTFKANFLEQALDLPVTGKYNATNAMISSYVALQEGVSEEQIRLAFQ
GLELTRNRTEWKKAANGADILSDVYNANPTAMKLILETFSAIPANEGGKKIAVLADMKEL
GVQSVQLHNQMILSLSPDVLDTVIFYGEDIAELAQLASQMFPIGHVYYFKKTEDQDQFED
LVKQVKESLGVHDQILLKGSNSMNLAKLVESLENEAK
NT seq
1374 nt
NT seq
+upstream
nt +downstream
nt
atgaaattaacaatccatgaaattgcccaagttgttggagccaaaaatgatatcagtatc
tttgaggacacccagttagaaaaagctgagtttgatagtcgtttgattggaactggagat
ttatttgtgccacttaaaggtgcgcgtgatggccatgactttattgaaacagcctttgaa
aatggtgcggcagcaaccctgtctgagaaagaggttgcaaatcatccctacattctagta
gatgatgttttgactgcctttcaacaactagctgcctactatcttgaaaaaacagctgtt
gatgtctttgcggttacgggttcaaatggcaagacaacgaccaaggatatgttagcgcat
ttactatcaacaacctacaagacctacaaaacacaaggaaactacaataacgagattggt
cttccctacacagttctccatatgcctgaagggacagaaaagttggtcttggagatgggg
caggaccacttgggcgatattcatctcttgtctgaattggctcgtccaaaaacagccatc
gtgaccttggttggagaagcccatttggcctttttcaaagatcgttcggaaatcgctaaa
gggaaaatgcaaattgcagatggcatggcttcgaattccttgctcttggcgccagcagat
tcgattgtagaggactacttgccaactgataaaaagatagttcgatttgggcaaggagca
gagttggaaattaccgacttggttgagcgcaaggatagtctgacatttaaggctaatttt
ttggaacaagcccttgatttgccagtgactggtaagtacaatgccaccaatgctatgatt
tcatcctatgttgccctgcaagaaggagtttcagaggagcaaatccgtttggccttccaa
ggtcttgaattgacgcgtaaccgtactgagtggaagaaagcagccaatggagcagacatc
ttgtcagatgtttacaatgccaatccaactgctatgaagctgattttagagaccttctct
gccattccagccaatgaaggtggcaagaaaattgcagtgttggcggatatgaaggaactt
ggtgtccagtctgttcaacttcataatcagatgattttgagcctttcgccagatgtgctt
gatactgttattttctacggagaagatattgctgaattagcccaacttgctagtcaaatg
ttcccaatcggacacgtttattacttcaagaaaacagaagaccaagaccaatttgaagac
ctagtcaagcaggtcaaagaaagccttggagtccacgaccaaatcctgctcaaaggctct
aactctatgaatctagccaagttggtagaaagtttagaaaatgaagccaagtga
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