Streptococcus pneumoniae R6 (avirulent serotype 2): spr0046
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Entry
spr0046 CDS
T00060
Symbol
purL
Name
(GenBank) Phosphoribosylformylglycinamide synthetase
KO
K01952
phosphoribosylformylglycinamidine synthase [EC:
6.3.5.3
]
Organism
spr
Streptococcus pneumoniae R6 (avirulent serotype 2)
Pathway
spr00230
Purine metabolism
spr01100
Metabolic pathways
spr01110
Biosynthesis of secondary metabolites
Module
spr_M00048
De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:
spr00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
spr0046 (purL)
Enzymes [BR:
spr01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor
6.3.5.3 phosphoribosylformylglycinamidine synthase
spr0046 (purL)
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Gene cluster
GFIT
Motif
Pfam:
GATase_5
AIRS_C
FGAR-AT_linker
GATase_3
FGAR-AT_PurM_N-like
DJ-1_PfpI
Motif
Other DBs
NCBI-ProteinID:
AAK98850
UniProt:
Q8DRM6
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All DBs
Position
46493..50221
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AA seq
1242 aa
AA seq
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MMDKRIFVEKKADFQVKSESLVRELQHNLGLSSLKSIRIVQVYDVFDLAEDLFAPAEKHI
FSEQGTDHVLDEVSVQADLANYAFFAIESLPGQFDQRAASSQEALLLLGSSSDVTVNTAQ
LYLVNKDIDATELEAVKNYLLNPVDSRFKDITTGIAKQEFSESDKTIPKLTFFESYTAED
FARYKAEQGMAMEVDDLLFIQDYFKSIGRVPTETELKVLDTYWSDHCRHTTFETELKHID
FSASKFQKQLQSTYDKYIAMREELGRSEKPQTLMDMATIFGRYERANGRLDDMEVSDEIN
ACSVEIEVDVDGVKEPWLLMFKNETHNHPTEIEPFGGAATCIGGAIRDPLSGRSYVYQAM
RISGAGDITAPISETRAGKLPQQVISKTAAHGYSSYGNQIGLATTYVREYFHPGFVAKRM
ELGAVVGAAPKGNVVREKPEAGDVIILLGGKTGRDGVGGATGSSKVQTVESVETAGAEVQ
KGNAIEERKIQRLFRNGNVTRLIKKSNDFGAGGVCVAIGELADGLEIDLNKVPLKYQGLN
GTEIAISESQERMAVVVRPEDVDTFVAECNKENIDAVVVATVTEKPNLVMHWNGETIVDL
ERRFLDINGVRVVVDAKVVDKDVKLPEERQTSAETLESDTLTVLSDLNHASQKGLQTIFD
CSVGRSTVNHPLGGRYQLTPTEASVQKLPVQHGVTHTASVIAQGFNPYVAEWSPYHGAAY
AVIEATARLVAAGANWSKARFSYQEYFERMDKQAERFGQPVAALLGSIEAQIQLGLPSIG
GKDSMSGTFEELTVPPTLVAFGVTTADSRKVLSPEFKAVGENIYYIPGQALSAEIDFDLI
KKNFAQFEASQADHKVTSASAVKYGGVVESLALATFGNYIGAEVTLPELKTALTAQLGGF
VFTSPEEIAGVEKIGQTKADFTLTVNGVKLDGHKLDSAFQGTLEEVYPTEFTQAKELEEV
PAVASDVVIKAKEKVEKPVVYIPVFPGTNSEYDSAKAFEKEGAEVNLVPFVTLNEEAIVK
SVETMVDNIDKTNILFFAGGFSAADEPDGSAKFIVNILLNEKVRVAIDSFIARGGLIIGI
CNGFQALVKSGLLPYGNFEDANNTSPTLFYNDANQHVAKMVETRIANTNSPWLAGVQVGD
IHAIPVSHGEGKFVVTAEEFAELRDNGQIFSQYVDFNGKPSMDSKYNPNGSVHAIEGITS
KNGQIIGKMGHSERYEDGLFQNIPGNKDQHLFASAVKHFTGK
NT seq
3729 nt
NT seq
+upstream
nt +downstream
nt
ttgatggataaacgtatttttgttgaaaaaaaggctgattttcaggtcaagtcagagagt
ttggttagagagctccagcacaacttgggactgtcaagcttgaaaagtattcgtattgtg
caagtatatgatgtatttgacttggctgaggacttgtttgcacctgcagagaagcacatt
ttctctgagcagggaaccgaccatgttttagatgaagtatctgtgcaggcggatcttgct
aactatgctttctttgccattgaaagtctgccagggcagtttgaccagcgtgcagcttcg
tcacaggaagccttgcttttgttgggaagttcgagtgacgtgacagttaacacagcccaa
ctttacttggtgaataaagatattgatgcgactgagttggaagctgtcaaaaactacctg
ctcaatccagttgattctcgtttcaaggatatcacgacagggattgccaagcaggagttt
tcagagtcagacaagaccattccaaaattgactttctttgaaagctatacagcagaagac
tttgctcgctacaaggccgagcaagggatggccatggaagtggatgatttgctctttatc
caagactactttaagtcaatcgggcgcgtgccaactgagactgaactcaaggttttggac
acttactggtctgaccactgccgtcatacgacttttgagacagagttgaaacacatcgac
ttttcagcttctaaatttcaaaagcaattgcagtcaacctatgacaagtatattgccatg
cgcgaggagttaggtcggtctgaaaaaccacaaaccttgatggatatggcgactattttc
ggtcgttatgagcgtgctaacggacgattggatgatatggaagtctctgacgaaatcaat
gcctgctcagttgaaattgaagtggatgttgatggtgtcaaggaaccttggctcctcatg
tttaaaaatgaaacccacaaccatccaacagaaattgagccatttggtggagcggctacc
tgtatcggtggagctattcgtgatccgttgtcaggccgttcctatgtttaccaagccatg
cgtatttcaggtgctggtgatattacagcaccgatttcggaaactcgtgctgggaaattg
ccacaacaagtcatttctaaaacagcagctcatggttattcttcatatggtaaccagatt
gggcttgccacaacctacgttcgtgaatacttccacccaggctttgtagctaaacgtatg
gaacttggtgccgttgttggtgcggctcccaagggcaatgttgtccgtgaaaaacctgaa
gcaggtgatgtgatcatccttctcggaggtaaaacaggtcgtgatggtgtcggtggtgcg
acgggctcttctaaggttcaaacagttgagtctgtagagactgctggtgctgaggttcaa
aaaggaaatgccatcgaagaacgcaagattcagcgcctcttccgtaatggcaatgtcact
cgtctgatcaagaagtccaatgactttggggcaggcggtgtctgtgtggctatcggtgaa
ttggcagacggtcttgaaatcgacctcaacaaggtgcctcttaaataccagggcttgaat
ggtacagaaattgccatctctgaatcacaagaacggatggcggttgtggttcgtcctgaa
gatgtggataccttcgttgccgaatgtaacaaagaaaatattgatgctgttgtggtggcg
acagtaactgaaaaaccaaatcttgtcatgcactggaatggtgagacaatcgttgacttg
gagcgtcgtttccttgacatcaatggtgtgcgcgtggttgtcgatgccaaagttgtggac
aaggatgtcaaactcccagaagagcgtcaaacatctgctgaaacactggaatcagatacc
cttacggttctatctgacctcaaccatgcaagtcaaaaaggattacagactatctttgac
tgctctgttggacgctcaacggttaatcacccacttggtggtcgttaccaactcacacca
actgaggcatctgtgcagaaattgccagttcaacacggtgtgactcatactgcgtcggtc
attgctcaaggtttcaacccatatgtagctgaatggtctccataccacggtgctgcttat
gcggttatcgaagcaactgctcgtttggtggctgctggtgccaactggtccaaggctcgt
ttctcttaccaagaatatttcgagcgtatggacaagcaagcagagcgttttggtcagcca
gtagccgctcttctaggctctattgaagctcagattcaacttggcttgccatctatcggt
ggtaaggactccatgtctggtacctttgaagaattgaccgttccgccaaccttggttgcc
tttggggtgacgacggcagatagccgtaaggtgctctctccagaatttaaagctgttggg
gaaaatatctactacatcccaggtcaagccctctctgcagagattgattttgacttgatt
aagaaaaattttgctcagtttgaagcaagccaagctgaccataaagtgacatctgcatca
gctgtcaaatacggtggtgtagttgaaagtttggctcttgctacctttggaaactatatt
ggtgcagaggtgaccttgcctgaacttaaaacagctttgacagctcaattaggcggcttt
gtcttcacatctcctgaagaaattgctggagtagagaagattggacaaacgaaagcagac
tttacactgactgtcaacggtgtgaagctagatggacacaagcttgacagtgcatttcaa
gggacattggaagaagtttacccaacagaatttacccaagcgaaagaactagaagaagta
ccagctgtggcatcagatgttgtgattaaagccaaagaaaaggttgaaaaacctgtggtt
tacatcccagtctttccaggaaccaactcagaatatgattcagctaaggccttcgaaaaa
gaaggtgcagaggtcaatttggtgccattcgtgaccttgaatgaagaagctattgtcaag
tcagttgaaactatggttgacaatatcgacaagactaatattctcttctttgctggtgga
ttctcggctgcggatgaaccagatggttcagctaagtttatcgtcaatatcctgcttaat
gaaaaagtgcgtgtggctattgatagctttatcgcccgtggtggtttgattatcggtatt
tgtaatggattccaagccttagtcaaatcgggtctcctaccctacggaaactttgaagat
gctaacaatactagcccaaccctcttctacaatgatgccaaccaacacgtggccaagatg
gtggaaactcgcattgccaataccaactcaccatggttggctggtgtgcaagtgggcgat
atccacgctattcctgtttcgcacggtgaagggaagtttgtcgtgacggctgaggaattt
gcagagctccgtgacaatggacaaattttcagccaatacgttgactttaacggtaaacca
agtatggattctaagtacaatccgaatggttctgtccatgccatcgaaggaattaccagc
aagaatggtcaaatcatcggtaagatgggccattcagaacgttatgaggacggtcttttc
caaaatatcccaggcaataaagaccagcacctgttcgcgtcagcggttaaacatttcact
ggaaaataa
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