Streptomyces profundus: K4G22_20705
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Entry
K4G22_20705 CDS
T10233
Name
(GenBank) UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
sprf Streptomyces profundus
Pathway
sprf00300
Lysine biosynthesis
sprf00550
Peptidoglycan biosynthesis
sprf01100
Metabolic pathways
sprf01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
sprf00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
K4G22_20705
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
K4G22_20705
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
K4G22_20705
Enzymes [BR:
sprf01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
K4G22_20705
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Mur_ligase
Motif
Other DBs
NCBI-ProteinID:
UED86315
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Position
4749269..4750699
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AA seq
476 aa
AA seq
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MILTLAEIAAATGGTLHDTPDPQLRVTGTTSSDSRQIGPGGMFVALPGARVDGHDFVAQA
VTAGAVCVLAERPVGVPAIVVDDVATALGRLAQHVLTRTEAQVIAVTGSAGKTSTKDLLA
QVLAHHGVTVASPQSFNSKFGLPLTVLRAQENTRYLVLEMGARYQGDIAHLASLATPRIG
LVLNVGDAHLAMFGGRDQIAAAKGELVEALPPAAEGGVAVLNADDPRVAAMETRTPARVV
RFSAHPEREAEIRATSIELNAGRAAFTLHTPHGTAPVRLRGLGAHQVHNALAAAAGAHIL
GMATDQIAQALSEAEPKAQGRLEPLEQKRAGLTIINDAFNASPASMRAALHTLASIGTNR
RTIAVLGEMRELGDQALSTHADIGRLLGELAIDILVTVGTTNEVTTLATHAVTAHPNLRT
EATDTPDALLPLLKSLLQPGDVVLVKASRRVGLETFGQTLHSHLQDLEISAPDRRG
NT seq
1431 nt
NT seq
+upstream
nt +downstream
nt
gtgatcctgaccctcgccgagatcgcagccgcgaccggcggcaccctgcacgacaccccc
gacccccaactgagggtgaccgggaccacctcaagcgactcacgccagatcggcccaggc
ggcatgttcgtcgcactgcccggcgcccgcgtcgacggccacgacttcgtcgcccaggcg
gtcacggccggagccgtctgcgtgctggccgagcgcccggtcggcgtcccagccatcgtc
gtggacgatgtggccacggccctgggacgcctcgcgcaacacgtcctgacccgcaccgag
gcacaggtcatcgccgtgaccggctccgccggcaagaccagcaccaaagacctcctcgcc
caggtcctcgcccaccacggtgtcaccgtcgcctccccccagtcgttcaacagcaagttc
ggcctgcccctgaccgtcctgcgcgcccaggagaacacccgctacctggtgttggaaatg
ggcgcccgctaccagggcgacatcgctcacctggcatcgctggccaccccacggatcggc
ctcgtgctcaacgtcggtgatgcccaccttgcgatgttcggtggccgtgatcagatcgcg
gcggcgaagggcgagttggtcgaagccctgcctcctgccgccgaaggcggggtcgccgtc
ctcaacgccgacgaccctcgcgtcgcggccatggaaacccgcaccccagcccgcgtcgtc
cggttcagcgcacaccccgaacgcgaagcggagatccgcgcaacgagcatcgaactgaac
gccggccgcgccgcattcaccctccacacgccacacggcacagccccggtacgcttacgc
ggcttgggcgcccatcaggtccacaacgcgctggcagccgccgccggcgctcacatcctg
ggcatggccaccgaccagatcgcccaagccctgtccgaggcagaacccaaggcacaaggg
cgcctggaacccttggagcaaaagcgcgccggcctgacgatcatcaacgacgcgttcaac
gccagccccgcgtccatgcgggccgcactccacaccctcgcctccatcggcaccaaccgg
cgaaccatcgcggtcctgggagagatgcgggaactcggcgaccaggccctctcaacccac
gcggacatcggacgcctcctcggcgaactggccatcgacatcctcgtcaccgtcggcacc
accaacgaagtcaccaccctcgccacccacgccgtgaccgcccacccgaatctgcgcacc
gaggcaaccgatacccccgatgccctgctaccgctcctaaaatcgttgttgcagcctgga
gacgtcgtcctggtgaaggcgtcaagaagagtcggcctggagacattcggccaaaccctc
cactcacacctgcaagacctagaaatctcagctcccgaccgcagaggatga
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