Streptomyces profundus: K4G22_21165
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Entry
K4G22_21165 CDS
T10233
Name
(GenBank) bifunctional folylpolyglutamate synthase/dihydrofolate synthase
KO
K11754
dihydrofolate synthase / folylpolyglutamate synthase [EC:
6.3.2.12
6.3.2.17
]
Organism
sprf Streptomyces profundus
Pathway
sprf00790
Folate biosynthesis
sprf01100
Metabolic pathways
sprf01240
Biosynthesis of cofactors
Brite
KEGG Orthology (KO) [BR:
sprf00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
K4G22_21165
Enzymes [BR:
sprf01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.12 dihydrofolate synthase
K4G22_21165
6.3.2.17 tetrahydrofolate synthase
K4G22_21165
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_C
Mur_ligase_M
Motif
Other DBs
NCBI-ProteinID:
UED88614
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Position
4849695..4851227
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AA seq
510 aa
AA seq
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MSGAEAEAKADAEANAESGEFDEIAAAERDRDPDLAVIEAGSRTLRALAGPPGGDLPTRP
DDPELDRALAEVEAELLARWPETKLDPSTARMTALMDVLGEPQRGYPAIHITGTNGKTTT
ARMIEALLGGFDLRTGRYSSPHVQSITERISVDGAPLSAERFVEAYQDIKPYLDLVDAAQ
EHRLSFFEVLTGMAYAAFADAPADVAVVEVGMGGSWDATNVIDGSVAVITPISLDHTARL
GDTPEQIAVEKAGIIKPGARVILAQQQIDAASVILRRAVAADATVAREGMEFGVLSREVA
VGGQLLTLRGLGGEYPEVFLPLHGAHMAHNAAVALAAVEAFFGVGDGRPAAPLDQEVVRA
AFAAVSSPGRLEAVRTSPTVLLDAAHNPGGALATADAVTEAFGFSRLIGVVGATEGKDVR
GLLEAFEPIFTEVVVTRNATQRALDVDALAALAVEVFGEERVQVEPRLDEAIEAAIGLAE
EEHEYAAAGVLITGSVITVGEARLLLKGGR
NT seq
1533 nt
NT seq
+upstream
nt +downstream
nt
ctgagcggcgctgaggcggaggcgaaggccgacgcggaagcgaacgccgagagcggggag
ttcgacgagatcgccgccgccgagcgggaccgcgatcccgatctcgcggtgatcgaggcg
ggcagtcgcaccctgcgggcgctggccgggccgcccggcggcgatctgcccacccgcccc
gacgacccggagctcgaccgcgcgctcgccgaggtcgaggccgagctgctcgcgcgctgg
ccggagaccaagctcgacccgtcaaccgcccggatgaccgccctgatggacgtgctgggg
gagccccagcgcggctacccggcgatccacatcaccgggaccaacggcaagaccaccacc
gcccgtatgatcgaggcgctgctcggcggcttcgacctgcgcaccggccgctacagcagc
ccgcatgtgcagtccatcaccgagcggatcagcgtggacggcgcccccctctccgccgag
cgcttcgtcgaggcataccaggacatcaagccctatctcgatctggtggacgccgcccag
gagcaccggctgtccttcttcgaggtgctgaccggcatggcctacgcggccttcgccgac
gccccggcggacgtcgccgtggtcgaggtgggcatgggcggcagctgggacgccaccaat
gtgatcgacggatcggtagccgtgatcaccccgatcagcctggaccacaccgcgcgcctg
ggggacacccccgagcagatcgcggtggagaaggccgggatcatcaagccgggcgcccgg
gtgatcctcgcccagcagcagatcgacgcggcctccgtgatcctgcgccgcgccgtcgcg
gcggacgccaccgtggccagggagggcatggagttcggggtgctctcccgcgaggtcgcc
gtcggcggccagctattgacgctccgcggcctcggcggcgagtaccccgaggtcttcctg
ccgctgcacggtgcgcacatggcgcacaacgccgcggtcgcgctggccgccgtggaggcg
ttcttcggcgtgggcgacgggcggccggcggcgccgctggaccaggaggtggtgcgggcc
gcgttcgccgccgtcagctccccgggacggctggaggcggtgcgcaccagccccaccgtg
ctgctggacgccgcgcacaacccgggcggcgcgctggccacggcggacgcggtcaccgag
gcgttcggtttcagccggctgatcggcgtggtgggggccaccgagggcaaggacgtgcgg
gggctgcttgaagccttcgagccgatcttcaccgaggtggtggtgaccaggaacgccacc
cagcgtgccctggacgtcgacgcgttggcggcgctggccgtggaggtgttcggcgaggag
cgggtgcaggtcgagccccgcctcgacgaggcgatcgaggcggccatcgggctggccgag
gaggaacacgagtacgccgccgccggcgtcctgatcaccggttcggtgatcacggtcggc
gaggccaggctgctgttgaagggcggacgttga
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