Streptomyces profundus: K4G22_23780
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Entry
K4G22_23780 CDS
T10233
Symbol
leuC
Name
(GenBank) 3-isopropylmalate dehydratase large subunit
KO
K01703
3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:
4.2.1.33
4.2.1.35
]
Organism
sprf Streptomyces profundus
Pathway
sprf00290
Valine, leucine and isoleucine biosynthesis
sprf00660
C5-Branched dibasic acid metabolism
sprf01100
Metabolic pathways
sprf01110
Biosynthesis of secondary metabolites
sprf01210
2-Oxocarboxylic acid metabolism
sprf01230
Biosynthesis of amino acids
Module
sprf_M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
Enzymes [BR:
sprf01000
]
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.33 3-isopropylmalate dehydratase
K4G22_23780 (leuC)
4.2.1.35 (R)-2-methylmalate dehydratase
K4G22_23780 (leuC)
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NCBI-ProteinID:
UED86842
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Position
5439424..5440848
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AA seq
474 aa
AA seq
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MGRTLAEKVWDDHVVRRAEGEPDLLYIDLHLLHEVTSPQAFDGLRKSGRRVRRTDLTIAT
EDHNTPTLDIDKPIADPVSRTQLETLRKNCAEFGVRLHSLGDAEQGVVHVVGPQLGLTQP
GTTVVCGDSHTSTHGAFGALAFGIGTSQVEHVLATQTLPLAPFRTMAVTVTGELPAGVTA
KDLILAIIARIGTGGGQGYVIEYRGEAIEKLSMEARMTICNMSIEAGARAGMIAPDATTF
AYLRGRDHAPGGADWDEAVAYWQTLRTDDDAVFDHEVVIDGAELAPFVTWGTNPGQGAPL
SEAVPDPASYDDPSARLAAEKALEYMGLTAGQRLREIAIDTVFVGSCTNGRIEDLRSAAE
VLRGRQLAEGLRMLVVPGSVRVALQAVEEGLDKVFTAAGAEWRHAGCSMCLGMNPDQLSP
GERCASTSNRNFEGRQGKGGRTHLVSPQVAAATAITGRLASPADLADVPTPVEV
NT seq
1425 nt
NT seq
+upstream
nt +downstream
nt
atgggacggacactggcggagaaagtctgggacgaccatgtcgtccgacgggcggagggc
gagcccgacctgctgtacatcgacctccatctactgcacgaggtcaccagcccgcaggcg
ttcgacgggctgcgcaagagcggccgtcgggtgcgtcgcacggacctcaccatcgccacc
gaggaccacaacaccccgacgctggacatcgacaagccgatcgccgacccggtctccagg
acccagctggagaccctgcgcaagaactgcgccgagttcggggtccggctgcactcgctg
ggcgacgccgagcagggcgtcgtccatgtcgtcggcccgcagttgggattgacacagccg
ggaaccaccgtggtctgcggcgacagccacacctccacccacggcgccttcggcgcgctg
gccttcggcatcggcaccagccaggtggagcatgtgctggccacccagacgttgccgttg
gccccgttccggacgatggccgtcacggtgaccggcgaactgcccgccggcgtcaccgcc
aaggacctgatcctcgccatcatcgccaggatcggcacgggcggcggtcagggctatgtg
atcgagtaccggggcgaggccatcgagaagctctcgatggaggcccggatgaccatctgc
aacatgtcgatcgaggccggggccagggcgggcatgatcgcgcccgacgccaccaccttc
gcctatctgcgcggtcgggaccacgcccccgggggcgccgactgggacgaggccgtcgcc
tactggcagacgctgcgcaccgacgacgacgccgtcttcgaccacgaggtggtgatcgac
ggcgccgagctggcccccttcgtcacctggggcaccaacccgggccagggcgcgccgctc
tccgaggccgtgccggacccggcctcctacgacgaccccagcgcgcgtctcgccgccgag
aaggccctggagtacatgggtctcaccgccggccagcggctgcgggagatcgccatcgac
accgtcttcgtcggctcctgcaccaacggccggatcgaggatctgcgctcggccgccgag
gtgttgcgcggccgtcagctcgccgaagggctgcggatgctcgtggtgcccggctccgtt
cgggtcgcgctccaggcggtggaggaggggctcgacaaggtgttcacggccgccggcgcc
gagtggcggcacgccggctgttcgatgtgcctgggcatgaacccggaccaactctccccc
ggggagcgctgcgcctccacctccaaccgcaacttcgagggccggcagggcaagggtggt
cgtacgcacctggtctcgccgcaggtcgccgcagccaccgcgatcaccggccgtctcgcg
tccccagccgatctggccgatgtcccgacccccgtggaggtctga
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