Salmonella enterica subsp. enterica serovar Paratyphi A ATCC9150: SPA0002
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Entry
SPA0002 CDS
T00219
Symbol
thrA
Name
(GenBank) aspartokinase I/homoserine dehydrogenase I
KO
K12524
bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:
2.7.2.4
1.1.1.3
]
Organism
spt
Salmonella enterica subsp. enterica serovar Paratyphi A ATCC9150
Pathway
spt00260
Glycine, serine and threonine metabolism
spt00261
Monobactam biosynthesis
spt00270
Cysteine and methionine metabolism
spt00300
Lysine biosynthesis
spt01100
Metabolic pathways
spt01110
Biosynthesis of secondary metabolites
spt01120
Microbial metabolism in diverse environments
spt01230
Biosynthesis of amino acids
Module
spt_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
spt_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
spt_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
spt00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
SPA0002 (thrA)
00270 Cysteine and methionine metabolism
SPA0002 (thrA)
00300 Lysine biosynthesis
SPA0002 (thrA)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
SPA0002 (thrA)
Enzymes [BR:
spt01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
SPA0002 (thrA)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
SPA0002 (thrA)
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Ortholog
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Gene cluster
GFIT
Motif
Pfam:
Homoserine_dh
AA_kinase
ACT_9
NAD_binding_3
ACT_7
ACT
Motif
Other DBs
NCBI-ProteinID:
AAV76041
UniProt:
A0A0H2WLI7
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All DBs
Position
337..2799
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AA seq
820 aa
AA seq
DB search
MRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNHLVAMIEKTIGGQDA
LPNISDAERIFSDLLAGLASAQPGFPLARLKMVVEQEFAQIKHVLHGISLLGQCPDSINA
ALICRGEKMSIAIMAGLLEARGHRVTVIDPVEKLLAVGHYLESTVDIAESTRRIAASQIP
ADHMILMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRQV
PDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNTGNPQAPGTLIGASSD
DDNLPVKGISNLNNMAMFSVSGPGMKGMIGMAARVFAAMSRAGISVVLITQSSSEYSISF
CVPQSDCARARRAMQDEFYLELKEGLLEPLAVTERLAIISVVGDGMRTLRGISAKFFAAL
ARANINIVAIAQGSSERSISVVVNNDDATTGVRVTHQMLFNTDQVIEVFVIGVGGVGGAL
LEQLKRQQTWLKNKHIDLRVCGVANSKALLTNVHGLNLDNWQAELAQANAPFNLGRLIRL
VKEYHLLNPVIVDCTSSQAVADQYADFLREGFHVVTPNKKANTSSMDYYHQLRFAAAQSR
RKFLYDTNVGAGLPVIENLQNLLNAGDELQKFSGILSGSLSFIFGKLEEGMSLSQATALA
REMGYTEPDPRDDLSGMDVARKLLILARETGRELELSDIVIEPVLPDEFDASGDVTAFMA
HLPQLDDAFAARVAKARDEGKVLRYVGNIEEDGVCRVKIAEVDGNDPLFKVKNGENALAF
YSHYYQPLPLVLRGYGAGNDVTAAGVFADLLRALSWKLGV
NT seq
2463 nt
NT seq
+upstream
nt +downstream
nt
atgcgagtgttgaagttcggcggtacatcagtggcaaatgcagaacgttttctgcgtgtt
gccgatattctggaaagcaatgccaggcaagggcaggtagcgaccgtactttccgccccc
gcgaaaattaccaaccatctggtggcgatgattgaaaaaactatcggcggtcaggatgct
ttgccgaatatcagcgatgccgaacgtattttttctgacctgctcgcaggacttgccagc
gcgcagccgggattcccgcttgcacggttgaaaatggttgtcgaacaagaattcgctcag
atcaaacatgttttgcatggtatcagcctgctgggtcagtgcccggacagcatcaacgcc
gcgctgatttgccgtggcgaaaaaatgtcgatcgcgattatggcgggacttctggaggcg
cgtgggcatcgcgtcacggtgatcgatccggtagaaaaactgctggcggtgggccattac
cttgagtctaccgtcgatatcgcggaatcgactcgccgtatcgccgccagccagatcccg
gccgatcacatgatcctgatggcgggctttactgccggtaatgaaaagggagaactggtg
gtgctgggccgtaatggttccgactattccgccgccgtgctggccgcctgtttacgcgct
gactgctgtgaaatctggactgacgtcgatggcgtgtatacctgtgacccgcgccaggtg
ccggacgccaggctgttgaaatcgatgtcctaccaggaagcgatggagctctcttacttc
ggcgccaaagtccttcaccctcgcaccataacgcctatcgcccagttccagatcccctgt
ctgattaaaaataccggcaatccgcaggcgccaggaacgctgatcggcgcgtccagcgac
gatgataatctgccggttaaagggatctctaaccttaacaacatggcgatgtttagcgtc
tccggcccgggaatgaaagggatgattgggatggcggcgcgtgttttcgccgccatgtct
cgcgccgggatctcggtggtgctcattacccagtcctcctctgagtacagcatcagcttc
tgtgtgccgcagagtgactgcgcgcgtgcccgccgtgcgatgcaggatgagttctatctg
gagctgaaagaggggctgctggagccgctggcggttactgagcggttggcgattatctct
gttgtcggcgacggtatgcgcacgctacgcggcatttcagcgaaattcttcgccgcgctg
gcgcgggccaatatcaatatcgtggcgatcgctcagggatcttctgagcgttccatttct
gtggtggtgaataacgacgatgccaccaccggcgtgcgggtaacgcaccagatgctgttc
aataccgatcaggtgattgaagtatttgtcattggcgtcggcggcgtcggcggcgcgcta
ctggaacagcttaaacgtcagcaaacctggttgaagaacaagcacatcgatctacgtgtg
tgcggcgtggcgaactcaaaggcgttgctaaccaatgtgcatggcctgaatctggacaac
tggcaggcggaactggcgcaagcgaacgcgccgttcaatctgggacgcttaattcgcctg
gtgaaagaatatcatctactcaatccggtgattgttgattgtacctccagtcaggcggtg
gccgaccagtatgccgacttcctgcgtgaaggattccatgtggtgacgccgaacaagaaa
gcgaacacctcgtcgatggactactaccatcagctacgtttcgccgccgcgcaatcacgg
cgcaaattcttgtatgacaccaacgtcggcgccggtttgccggtaatcgaaaacctgcaa
aacctgctgaatgcgggtgatgaactgcaaaaattttccggcattctttccgggtcgctc
tcttttattttcggtaaactggaagaggggatgagtctctcacaggcgaccgctctggcg
cgcgagatgggctataccgaacccgatccgcgcgacgatctttccggtatggatgtggcg
cgtaaactgttgatcctcgcccgcgagacgggtcgcgagctggagctttccgatatcgtg
attgaaccggtgttgccggacgagtttgacgcctccggcgatgtgaccgcctttatggcg
catctgccgcagcttgacgacgcgtttgccgcccgtgtggcgaaagctcgtgatgaaggt
aaggtattgcgctatgtgggcaatatcgaagaggatggcgtgtgccgcgtgaagattgcc
gaagttgatggtaacgatccgctcttcaaagtgaaaaacggtgaaaacgcgctggcgttc
tacagccactattatcagcccttgccgttggtgctgcgcggctacggcgcaggcaatgat
gtgacggcggcgggcgtgtttgccgatctgttacgggccctctcatggaagttaggagtt
taa
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