Streptomyces rochei: SRO_4845
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Entry
SRO_4845 CDS
T06265
Name
(GenBank) bifunctional folylpolyglutamate synthase/dihydrofolate synthase
KO
K11754
dihydrofolate synthase / folylpolyglutamate synthase [EC:
6.3.2.12
6.3.2.17
]
Organism
srj
Streptomyces rochei
Pathway
srj00790
Folate biosynthesis
srj01100
Metabolic pathways
srj01240
Biosynthesis of cofactors
Brite
KEGG Orthology (KO) [BR:
srj00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
SRO_4845
Enzymes [BR:
srj01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.12 dihydrofolate synthase
SRO_4845
6.3.2.17 tetrahydrofolate synthase
SRO_4845
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_C
Mur_ligase_M
Motif
Other DBs
NCBI-ProteinID:
BBC96021
LinkDB
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Position
5341326..5342840
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AA seq
504 aa
AA seq
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MSDLPHENDQPDPLDPFEEIIEAETDRDPDLAVIEAGSRTLRTQGGAPQADVPARPEDPE
VDKALREVEAELATRWGETKLEPSVSRISALMDVLGDPQRSYPSIHITGTNGKTSTARMI
ECLLGAFELRTGRYTSPHVQSITERISLDGAPVSAERFIETYQDIKPYIEMVDAAQEYRL
SFFEVLTGMAYAAFADAPVDVAVVEVGMGGSWDATNVIDGDVAVVTPIGLDHTDRLGETT
GEIAGEKAGVIKQGATVILAQQPVDAAQVLLKKAVEVDATVAREGLEFGIVARQVAVGGQ
MLTLRGLGGEYPEVYLPLHGAHQAHNAAVALAAVEAFFGVGAQRAEPLDIDTVRKAFAAV
SSPGRLEVVRRSPTVVLDAAHNPAGAEATAEAVREAFDFTRLIGVVGASGDKNVRGLLEA
FEPIFAEVVVTQNSSHRAMDADELAAIAVEVFGDERVQVEPRLPDALEAAITLAEEEGEF
AGGGVLVTGSVITVGEARLLLGKG
NT seq
1515 nt
NT seq
+upstream
nt +downstream
nt
gtgagcgacctcccgcacgagaacgaccagcccgatcccctcgacccgttcgaggagatc
atcgaggccgagaccgaccgcgaccccgacctcgccgtcatcgaggcaggcagccgtacc
ctgcgtacccagggcggcgcgccgcaggccgatgtgcccgcgcggcccgaggacccggaa
gtcgacaaggcgctgcgcgaggtcgaggcggagctggcgacccgctggggcgagaccaag
ctggagccctcggtcagcaggatctccgcgctgatggacgtgctgggcgacccccagcgc
tcgtacccctcgatccacatcacgggtacgaacggcaagacctccaccgcccgcatgatc
gagtgcctgctcggcgccttcgagctgcgcaccggccgctacaccagcccccatgtgcag
tcgatcaccgagcggatcagcctggacggcgccccggtctccgccgagcgcttcatcgag
acgtaccaggacatcaagccgtacatcgagatggtggacgccgcccaggagtaccggctg
tccttcttcgaggtcctcaccggcatggcctacgccgccttcgcggacgcgccggtcgac
gtggccgtcgtggaggtcggcatgggcggctcctgggacgccaccaatgtgatcgacggc
gatgtcgccgtcgtcaccccgatcggcctggaccacaccgaccgcctcggcgagaccacc
ggcgagatcgccggcgagaaggccggcgtcatcaagcagggcgccaccgtcatcctggcc
cagcagcccgtggacgccgcccaggtgctgctgaagaaggccgtggaggtcgacgccacc
gtggcccgcgagggcctggagttcggcatcgtggcccgccaggtcgccgtcggcggacag
atgctcaccctgcgcggcctcggcggcgagtaccccgaggtctacctcccgctgcacggc
gcccaccaggcgcacaacgcggccgtggcgctcgccgccgtggaggccttcttcggcgtc
ggcgcccagcgtgccgagccgctggacatcgacaccgtccgcaaggcgttcgccgccgtc
tcctccccgggccgcctggaggtcgtacgacgctctcccaccgtcgtcctggacgccgcg
cacaacccggccggcgccgaggccaccgcagaggcggtgcgcgaggcgttcgacttcacg
cggctgatcggcgtggtcggcgcgagcggcgacaagaacgtgcgcgggctgctggaggcc
ttcgagccgatcttcgccgaggtcgtcgtcacccagaactccagccaccgcgccatggac
gcggacgaactggccgccatcgccgtcgaggtcttcggtgacgagcgggtccaggtcgaa
ccgaggctgcccgacgccctggaggccgcgatcacgctggccgaggaggagggcgagttc
gcgggcggcggtgtgctggtcaccggttccgtcatcacggtcggcgaggcccggctgctg
ctgggcaagggctga
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