Salinibacter ruber M8: SRM_00867
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Entry
SRM_00867 CDS
T01209
Symbol
metL
Name
(GenBank) Bifunctional aspartokinase/homoserine dehydrogenase II
KO
K12524
bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:
2.7.2.4
1.1.1.3
]
Organism
srm
Salinibacter ruber M8
Pathway
srm00260
Glycine, serine and threonine metabolism
srm00261
Monobactam biosynthesis
srm00270
Cysteine and methionine metabolism
srm00300
Lysine biosynthesis
srm01100
Metabolic pathways
srm01110
Biosynthesis of secondary metabolites
srm01120
Microbial metabolism in diverse environments
srm01230
Biosynthesis of amino acids
Module
srm_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
srm00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
SRM_00867 (metL)
00270 Cysteine and methionine metabolism
SRM_00867 (metL)
00300 Lysine biosynthesis
SRM_00867 (metL)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
SRM_00867 (metL)
Enzymes [BR:
srm01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
SRM_00867 (metL)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
SRM_00867 (metL)
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Gene cluster
GFIT
Motif
Pfam:
Homoserine_dh
AA_kinase
ACT_9
NAD_binding_3
ACT_7
ACT
MgtE_N
F420_oxidored
Motif
Other DBs
NCBI-ProteinID:
CBH23788
UniProt:
D5H6Y3
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All DBs
Position
complement(994511..996976)
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AA seq
821 aa
AA seq
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MESSAPASANWRVHKFGGTSLADPARIRHVADLLGARTPPVAVVVSAMSGVTDRLLALAE
KAHTDADGLADRLQSLRDDQRAVVTDLLDGDAAASVLRTLDQDLDDLADVLRATRLMGTA
PDTTRDLVAGYGELWSARVLGGVLRDRGLSAAVCDAREVLVVTHEEMGPVVDWDATQERF
ADWRAAHDAPDTIVATGFIATTPDGVPTTLGRNGSDHSAALFAALLEAEALTIWTDTDGV
MSADPQYVPDARRLDALSYEEAMEMAYFGAGVIHPRTLSPAVEHEIPITIRNTFAPDRPG
TRIHLNDDGASVVKGFSTIDDVALLNLEGSGMIGVPGIARRLFDALEDEGVSVILISQGS
SEHSICFAVPQAQAGVAREAAEHAFYAELDRGQLRTVELVPNCSILAVVGDQMAGTPGVA
ATFFGALGEASVNVRAVAQGSSERNISAVVDGDDARRALRAAHAGFYLSKRTLSIGVIGA
GNVGAALLDQIRTEAGRLRDQQDIDLRVRGIAASSRMLRAEQRLDLETWRADLSAGEATD
LDAFVDHVQTDYHPHTVIVDCTASASIARRYEDWLERGIHVVTPNKKANTDTWETYQALQ
TASQGPGPQYLYETTVGAGLPILQTLNSLTETGDQVHRIEGILSGTLSYLFNAFDGDRPF
SAILRQAKEEGFTEPDPRDDLSGMDVARKVVILAREMGVPLELEEVSVDGLVPEPLHDGP
VESFLDRLPEHDADMTKLLRDAQAENKVLRFVGGVTRDGDASVRLRRYPADHAFARINHT
DNIVRFQTDRYDETPLIVQGPGAGPQVTAAGVFADLLRLMS
NT seq
2466 nt
NT seq
+upstream
nt +downstream
nt
atggaatcgtccgcccctgcgtccgccaactggcgggttcacaagttcggcggcaccagc
ctcgccgacccggcccgcatccggcacgtggccgacctgctcggtgcccgcacccctccg
gtcgccgtcgttgtgtcggccatgagcggggtgaccgaccgcctgcttgccctcgccgag
aaggcccacaccgacgccgacggactggccgatcgccttcagtccctgcgcgacgatcag
cgggccgtggtgaccgatctgctggacggggacgccgccgcctccgtgctccgcacactg
gaccaggacctagacgacctggccgacgtgctccgggccacccgcctcatgggcacggcc
cccgacacgacccgcgacctcgtggccgggtacggcgagctgtggtccgcccgcgtgctc
gggggggtgctgcgtgatcgggggctgtcggccgccgtgtgcgacgcccgcgaggtgctc
gtcgtcacccacgaggagatgggcccggtggtcgactgggacgccactcaggaacggttt
gccgactggcgggccgcgcacgacgcccccgatacgatcgtcgccaccggctttatcgcc
accacgcccgacggggtgcccaccaccctcgggcggaacggctcggaccactccgccgcc
ctcttcgcggcgctgctggaggcggaggccctcacgatctggacggacaccgacggggtg
atgagtgccgacccgcagtacgtccccgacgcgcgccgcctcgatgccctctcctacgag
gaggccatggagatggcctacttcggggccggcgtcattcacccgcgcacgctgtcgccg
gccgtcgagcacgagatcccgatcacgatccgcaacacctttgcgccggaccggcccggc
acccgcattcacctcaacgacgacggcgcgtcggtcgtgaagggcttctccacgatcgac
gacgtggcccttctcaacctggagggcagcggcatgatcggggtgcccggcatcgcccgg
cgcctcttcgacgcgctggaggacgagggggtgtccgtcatcctgatctcgcagggcagc
tccgagcactcgatctgcttcgccgtgccccaggcccaggccggggtcgcccgcgaggcc
gccgagcacgccttctacgccgagctggaccgcggccagctccggacggtcgagctggtg
cccaactgcagcatcctcgccgtggtgggggaccaaatggccggcacgcccggcgtcgcc
gctaccttcttcggggccctgggcgaggccagcgtcaacgtgcgggccgtcgcccagggc
tcctcggagcgcaacatctccgccgtggtggacggggacgacgcccgccgcgccctacgg
gccgcccacgcgggcttttacctctcgaagcggaccctgtcgatcggcgtcattggcgcc
ggcaatgtcggcgcggccctgctcgaccagattcgcaccgaggccggccggctccgcgac
caacaggacatcgacctccgtgtgcgcggcatcgccgcgtcctcgcgcatgctccgggcc
gagcagcgcctcgacctcgaaacgtggcgggccgacttgtctgcgggggaggcgaccgac
ctcgacgccttcgtcgaccacgtacaaaccgactatcacccgcacacggtgatcgtcgac
tgcaccgccagcgcctccatcgcccggcgctacgaggactggctggagcgcggcatccac
gtggtgacgcccaacaagaaggcgaataccgacacgtgggagacgtaccaggccctacaa
accgcgagccaggggcccgggccccagtatttgtacgagacgaccgtgggggcgggcctg
cccatcctgcagaccctcaacagcctcaccgagacgggcgaccaggtgcaccggatcgag
ggcatcctctccggcacgctctcgtatctcttcaacgcgttcgacggcgaccggcccttc
tccgccattctccgtcaggccaaggaggagggctttaccgagcccgacccccgcgacgac
ctctccggcatggacgtggcccgcaaggtcgtcatcctggcgcgcgagatgggggtgccg
ctggagctggaggaagtgtccgtggacggactcgtgccggagcccctccacgacggcccg
gtcgagtcgtttctcgaccggctccccgagcacgacgcggacatgacgaaactcctccgg
gacgcccaggccgaaaacaaggtactccggtttgtgggcggcgtcacgcgggacggcgac
gcgtcggtgcgcctgcgccgctaccccgccgaccacgccttcgcccgcatcaaccacacg
gacaacatcgtccgcttccagacggaccggtacgacgagacgcccctgatcgtgcagggc
cccggtgccggtccccaggtcaccgcggcgggcgtctttgccgacctgctccgcttgatg
tcctga
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