Streptomyces sp. RPA4-5: HEP86_11630
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Entry
HEP86_11630 CDS
T10325
Name
(GenBank) UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
srpa Streptomyces sp. RPA4-5
Pathway
srpa00300
Lysine biosynthesis
srpa00550
Peptidoglycan biosynthesis
srpa01100
Metabolic pathways
srpa01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
srpa00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
HEP86_11630
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
HEP86_11630
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
HEP86_11630
Enzymes [BR:
srpa01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
HEP86_11630
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Ortholog
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Mur_ligase
Motif
Other DBs
NCBI-ProteinID:
QIY55053
UniProt:
A0A6H1JSW6
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All DBs
Position
complement(2573031..2574479)
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AA seq
482 aa
AA seq
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MISLSLAEIASIVGGQQHDIPDDGHRVTGPVVADSRAVCPGALFVAFAGERVDGHDFAHR
AVEAGAVAVLAARPLGVPAIVVDDVVAALGALARAVVARLGTTVVGLTGSAGKTSTKDLI
AQLLQRHGPTVWPEGNLNNEIGLPLTALRADETTRHLVLEMGARGVGHIRYLAGLTPPRI
GVVLNVGSAHIGEFGGREQIALAKGELVESLPSAEDGGVAVLNADDPYVRAMVPRTRART
ILFGEAAEADVRAENVRLTDLGQPAFTLRTPSGCSDVTMRLYGEHHVSNALAAAAVAHEL
GMPADEIASALSEAGTLSRWRMEVTERADGVRIVNDAYNANPESMRAALRALVAMGAAGK
ATGARTWAVLGEMAELGEESLAEHDAVGRLAVRLNVSKLVAVGGREAAWLDMGAKNEGSW
GEESVHVSDARAAVDLLRSELRPGDVVLVKASRSVGLERVAAALLDEGMLGATGAEGGAA
SR
NT seq
1449 nt
NT seq
+upstream
nt +downstream
nt
gtgatctccctgtcgctcgccgagatcgcgagcatcgtcggagggcagcagcacgacata
ccggacgacggccaccgggtgaccggaccggtcgtggccgactcccgtgcggtgtgcccc
ggcgcgctgttcgtggccttcgccggtgaacgcgtcgacggccacgacttcgcgcaccgc
gccgtcgaggccggcgcggtggccgtactggccgcccgccccctcggcgtccccgcgatc
gtcgtcgacgacgtggtcgccgcgctcggcgcgctcgcccgcgccgtcgtcgcacggctg
ggcaccaccgtcgtgggcctgaccggctcggccggcaagaccagcaccaaggacctgatc
gcccagctgctccagcgccacggcccgacggtctggcccgagggaaacctcaacaacgag
atcgggctgccgctgaccgcgctgcgcgccgatgagaccacccggcatctcgtcctggag
atgggcgcccgcggcgtcggccacatccgctacctcgccgggctgaccccgccgaggatc
ggcgtggtgctgaacgtcggcagtgcgcacatcggcgagttcggcggccgtgagcagatc
gccctggccaagggcgaactcgtcgagtcgctgccttcggccgaggacggcggcgtcgcg
gtgctcaacgccgacgacccgtacgtccgcgccatggtgccgcgcacccgggcccgcacg
atcctgttcggggaggccgcggaggccgacgtacgtgccgagaatgtccggctcacggat
cttggtcagcccgctttcacgcttcgcacaccctccgggtgcagcgatgtgaccatgcgg
ctgtacggtgagcaccacgtgtcgaacgcgctcgccgcggccgccgtagcccatgagttg
ggcatgcccgcagacgagatcgcctccgcgctctccgaagccggcacgctctcccgctgg
cgtatggaggtcaccgagcgcgcggacggcgtgcggatcgtcaacgacgcctacaacgcg
aatcccgagtccatgcgagcggcgctgcgtgcgctggtcgcgatgggcgcagccggcaag
gcgacgggcgctcgtacgtgggcggtgctcggtgagatggctgagctcggcgaggagtca
ctcgccgaacacgacgcggtcgggcggctggccgtccggctcaacgtcagcaagctcgtg
gcagtcggcggcagggaagcggcctggctcgacatgggcgccaagaacgagggttcgtgg
ggtgaggagtcggtgcacgtgtccgacgcgcgggcggcggtcgacctgttgcgcagcgag
ctgcggccgggagatgtcgtgctggtgaaggcgtccaggtcggtggggctggagcgggtg
gccgcagctttgctggacgagggcatgctgggcgccacgggcgctgagggtggagccgca
tcccgatga
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