Streptomyces sp. RPA4-2: HEP85_11705
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Entry
HEP85_11705 CDS
T10422
Symbol
murF
Name
(GenBank) UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
srpz Streptomyces sp. RPA4-2
Pathway
srpz00300
Lysine biosynthesis
srpz00550
Peptidoglycan biosynthesis
srpz01100
Metabolic pathways
srpz01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
srpz00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
HEP85_11705 (murF)
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
HEP85_11705 (murF)
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
HEP85_11705 (murF)
Enzymes [BR:
srpz01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
HEP85_11705 (murF)
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Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Mur_ligase
DUF561
Motif
Other DBs
NCBI-ProteinID:
QIY62221
UniProt:
A0A6H1KE01
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Position
complement(2681620..2683026)
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AA seq
468 aa
AA seq
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MIALSLAEIAAVVGGQTHDIPDPALQVTGPVVRDSREVEPGSLFVAFAGERVDGHDFARA
VVDAGAVAVLASRPVGVPAIVVEDVQTALGALARHVVERLGTTLVALTGSAGKTSTKDLI
AQVLRSKAPTVFTPGSLNNEIGLPLTALTATEETKYLVLEMGARGIGHIRYLADLTPPKI
GLVLNVGTAHIGEFGGREQIAQAKGELVEGLPEDGAAVLNADDPLVRAMASRTKARVVLF
GESGEADVRAENVRLTDLGQPAFRLHTPSGCSDVTMRLYGEHHVSNALAAAAVAHELGMS
ADEIARALSEAGSLSRWRMEVTERPDGVTVVNDAYNANPESMRAALRALVAMGRGRRTWA
VLGQMAELGDEALAEHDAIGRLAVRLNVSKLVAVGGREASWLQLGAYNEGSWGEESVHVS
DAQAAVDLLRSELRPGDVVLVKASRSVGLERVAQALLAGGAEGEVAAR
NT seq
1407 nt
NT seq
+upstream
nt +downstream
nt
gtgatcgccctctctctcgccgagatcgcagcagtcgtcggcgggcagacgcacgacata
ccggatccggcgctacaggtcaccggaccggtcgtcagagactcccgtgaagtggagcca
ggcagcctcttcgtcgccttcgccggcgagcgcgtggacggccacgacttcgcccgcgcg
gtcgtcgacgcgggcgcggtcgccgtactggcctcccggcccgtcggcgtgcccgcgatc
gtcgtcgaggacgtgcagacggccctcggcgccctcgcccgccatgtcgtcgaacggctc
ggcacgacgctcgtggccctcaccggctccgcgggcaagaccagcaccaaggacctgatc
gcccaggtcctgcggagcaaggcgccgaccgtcttcacgcccggttcgctcaacaacgag
atcggactgccgctgaccgccctgaccgccaccgaggagacgaagtacctcgtgctggag
atgggcgcccgcggcatcggccacatccgttacctcgcggatctcaccccgccgaaaatc
ggtctcgtcctcaacgtcggcaccgcccacatcggcgagttcggcggccgcgaacagatt
gcacaggcgaagggcgagctcgtcgagggcctccccgaggacggcgccgcggtcctcaac
gccgacgaccccctcgtccgcgccatggcgtcccggacgaaggcgcgggtggtgcttttc
ggagagtccggcgaagcggacgtacgcgccgagaacgtccgtctcacggacctcggacag
ccggcgttcaggcttcacacaccctccgggtgcagtgatgtgaccatgcgcctgtacggt
gagcaccacgtgtcgaacgcgctcgccgcggccgccgtcgcccatgagctgggcatgtcc
gcagacgagatcgcccgcgcgctctccgaggcgggctccctctcccgctggcggatggag
gtcaccgagcgcccggacggcgtgacggtcgtcaacgacgcctacaacgcgaatcccgag
tccatgcgagccgccctgcgcgcgctcgtggcgatggggcggggacgtcgtacgtgggcg
gtgctcggtcagatggccgagctcggggacgaggctctcgccgagcacgacgcgatcggg
cggctcgccgtccgactcaacgtcagcaagctcgtcgcggtcgggggcagggaagcgtcc
tggctccaactgggcgcatataacgagggttcgtggggtgaggagtcggtgcacgtgtcc
gacgcacaggcggctgtcgacctgctgcgcagcgagttgcgcccgggggacgtcgtgctc
gtgaaggcgtcccggtcggtcggtctcgaacgggtggcgcaggcgctgctcgcaggcggt
gccgagggtgaggttgctgcccgatga
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