Streptomyces sp. RPA4-2: HEP85_28345
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Entry
HEP85_28345 CDS
T10422
Symbol
leuC
Name
(GenBank) 3-isopropylmalate dehydratase large subunit
KO
K01703
3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:
4.2.1.33
4.2.1.35
]
Organism
srpz Streptomyces sp. RPA4-2
Pathway
srpz00290
Valine, leucine and isoleucine biosynthesis
srpz00660
C5-Branched dibasic acid metabolism
srpz01100
Metabolic pathways
srpz01110
Biosynthesis of secondary metabolites
srpz01210
2-Oxocarboxylic acid metabolism
srpz01230
Biosynthesis of amino acids
Module
srpz_M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
Enzymes [BR:
srpz01000
]
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.33 3-isopropylmalate dehydratase
HEP85_28345 (leuC)
4.2.1.35 (R)-2-methylmalate dehydratase
HEP85_28345 (leuC)
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NCBI-ProteinID:
QIY64810
UniProt:
A0A6H1KMS6
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Position
6394957..6396393
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AA seq
478 aa
AA seq
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MGRTLAEKVWDDHVVRRAEGEPDLLFIDLHLLHEVTSPQAFDGLRQAGRPVRRLDLTIAT
EDHNTPTLDIDKPIADPVSRVQLETLRKNAADFGVRLHSLGDVEQGVVHVVGPQLGLTQP
GTTVVCGDSHTSTHGAFGALAFGIGTSQVEHVLATQTLPLARPRTMAITVDGELPEGVTA
KDLILAIIARIGTGGGQGYILEYRGSAIEKLSMEARMTICNMSIEAGARAGMIAPDETTF
AYLQGRAHAPEGEDWDAAVAYWKTLKTDEDAVFDAEVVIDGPSLAPFVTWGTNPGQGAPL
SASVPDPASYEDASERLAAEKALEYMGLTAGQPLRDIEVDTVFVGSCTNGRIEDLRAAAA
IVGGRKVAEGVRMLVVPGSARVGLQAVSEGLDVVFKEAGAEWRHAGCSMCLGMNPDQLAP
GERSASTSNRNFEGRQGKGGRTHLVSPQVAAATAVLGHLASPADLSDAPADRTPAGVR
NT seq
1437 nt
NT seq
+upstream
nt +downstream
nt
atgggtaggacactcgcggagaaggtctgggacgaccacgtcgtccggcgcgccgagggc
gagcccgacctcctcttcatcgatctgcacctgctgcacgaggtgaccagcccccaggcc
ttcgacggcctgcgtcaggcggggcgcccggtgcgccgtctcgacctcaccatcgccacc
gaggatcacaacaccccgaccctcgacatcgacaagcccatcgcggacccggtctcccgg
gtccagctggagacgctgcgcaagaacgcggccgacttcggtgtgcgcctgcactccctc
ggtgacgtcgagcagggagtcgtccacgtcgtgggaccgcagctgggcctgacccagccg
ggcaccaccgtggtctgcggcgactcgcacacctccacgcacggcgccttcggcgcgctg
gcgttcggcatcggcacctcgcaggtcgagcacgtgctggccacccagacgctgccgctg
gcccgccccaggaccatggccatcacggtcgacggcgagctgcccgagggcgtcaccgcg
aaggacctgatcctggcgatcatcgcccggatcggcaccggcggcggccagggctacatc
ctggaataccgcggctccgccatcgagaagctctcgatggaggcccgcatgaccatctgc
aacatgtcgatcgaggccggtgcccgcgcgggcatgatcgcccccgacgagacgaccttc
gcctacctccagggacgcgcccacgcgcccgagggcgaggactgggacgcggcggtcgcg
tactggaagacgctgaagacggacgaggacgcggtcttcgacgccgaggtcgtcatcgac
ggtccctcgctggccccgttcgtcacctggggcaccaaccccggccagggcgcgccgctt
tcggcgtccgtccccgacccggcttcgtacgaagacgcttcggagcgcctggccgccgaa
aaggccctggaatacatggggttgaccgccggacagccgctgcgcgacatcgaggtcgac
accgtcttcgtaggttcgtgcaccaacggtcgcatcgaggacctgcgggccgccgccgcg
atcgtcgggggccgcaaagtcgccgagggcgtacggatgctggtggtccccggctccgcc
cgggtcggcctgcaggccgtctccgagggcctggacgtggtcttcaaggaggccggcgcc
gaatggcggcacgcgggctgctcgatgtgtctgggcatgaaccccgaccagctggcaccc
ggtgagcgctccgcgtccacctccaaccgcaacttcgagggcaggcagggcaagggcggc
cgtacgcacctggtctccccgcaggtcgccgccgccaccgccgtgctgggccatctggcc
tcgccggccgacctgtccgacgcgcccgccgaccgtacgcccgctggagtccgataa
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