Streptomyces reticuli: TUE45_00070
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Entry
TUE45_00070 CDS
T04246
Symbol
eryA_1
Name
(GenBank) Erythronolide synthase, modules 1 and 2
KO
K15670
rifamycin polyketide synthase modules 1, 2 and 3 [EC:
6.2.1.74
]
Organism
srw
Streptomyces reticuli
Pathway
srw01051
Biosynthesis of ansamycins
srw01052
Type I polyketide structures
Brite
KEGG Orthology (KO) [BR:
srw00001
]
09100 Metabolism
09109 Metabolism of terpenoids and polyketides
01052 Type I polyketide structures
TUE45_00070 (eryA_1)
01051 Biosynthesis of ansamycins
TUE45_00070 (eryA_1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01008 Polyketide biosynthesis proteins [BR:
srw01008
]
TUE45_00070 (eryA_1)
Enzymes [BR:
srw01000
]
6. Ligases
6.2 Forming carbon-sulfur bonds
6.2.1 Acid-thiol ligases
6.2.1.74 3-amino-5-hydroxybenzoate---[acyl-carrier protein] ligase
TUE45_00070 (eryA_1)
Polyketide biosynthesis proteins [BR:
srw01008
]
Polyketide synthase (PKS)
Modular type I PKS
cis-AT PKS
Rifamycin PKS
TUE45_00070 (eryA_1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ketoacyl-synt
Acyl_transf_1
Ketoacyl-synt_C
KR
AMP-binding
PP-binding
KAsynt_C_assoc
PKS_DH_N
Thiolase_N
adh_short
AMP-binding_C
PKS_DE
PS-DH
Epimerase
ACP_syn_III
Polysacc_synt_2
GDP_Man_Dehyd
Motif
Other DBs
NCBI-ProteinID:
CUW25360
LinkDB
All DBs
Position
I:78809..95824
Genome browser
AA seq
5671 aa
AA seq
DB search
MRSDLVTPLAVTLHEHALRIPEKVAFADDRRAVTYAELEARTRRLAGHLVRLGLRRGDRV
ALCLGNSVAMVEGYLAVVRAGGIGVPVNPRSAPAELEYLLADSGARFALAGASSAGTFLH
GVSPHGGSPEGVPPQGVVAEGTVPEGAIPEGAPRQGVSSAVPDMTVLVAGTTDVPAGAHA
YDELAVTDPGTPAPDDLGLDEVAWMFYTSGTTGRPKGVLSTQRNCLWSVAASYVPIPDLR
QDDRVLWPLPLFHSLSHIACVLSVTSVGATARITDGSSADDVLDLLRTERATFLAGVPTT
YHHLVATARRTGLSLPDLRIGLVGGAVTGSELRRSFEDTFGVPLVDAYGSTETCGAITMN
PPDGARVEGSCGLPVPGVDVRIVDPGTGDDVPTGQEGEVWVSGPNVMVGYHNSPEATRAA
LRDGWFRTGDLARRDEAGYFTVCGRLKDLIIRGGENIHPDEVEAVLRSAPGVADAGVAGA
AHDTLGEVPVAWLVPGPDGLDLDAVLDHCRARLSAYKIPERIHEAAGIPRTASGKIVRRL
LAAQPYWPRHTADGHHDALLTPAWLPAPARTGDRDDSDGGDGGARPAACAVVGEDTTGLV
DALRAAGVDAAVHPGLPSVPDTIPGPTLLLPPAPSADPFTEARLLIQQVTGGNAPEPLVV
LTRGATPAGDSAPDPAGAALWAAVRSLQADGHQRLTVVDLDTDRPDAATLLAAITSDEPQ
LAMRGEELLAPRLLRTPVDGRPRPAAPERPGTVVVTGTDTPAGAALAHHLATVHRATDLL
LVHAPGTTDGTDPDAWPAGTRARRVSTDATGLREALADAHPVSLAVHTADDPDLARTLDE
LLGDTGEFVTVTDGAATLGAPGDPDRAIRGALTEAVTHTRRLRAPAATLVWAAADDHDRL
ADLLAAFDILLAGRAPALFAPRPAPPDPSRPVPAILRALTEPPAGQARPDAAVTAALRAR
LTGLDARAQLALLEELVREQAAGVLHGPDAAPLPADRAFRDLGLTSVAVVALRDRLTEHT
GLRLPTTVAFDHPTPRELAAHLRAAVLGLDDTPARPERPAADTDPQEPIAIVGMACRLPG
GVNTPEELWQLLAAGRDAVSDFPADRGWDLDGLFAPDPDRPGTSYVDRGGFLPDAGRFDA
AFFGISPREALAMDPQQRLLLETSWEALERAGIDPHALKGTDVGVFAGVMGQGYGSGGEL
PAELEGFVTTGTASSVASGRISYVFGLEGPAVTVDTACSSSLVALHLAAQALRRGECSMA
LAGGATVMATPGTFVEFSRQRALAADGRCKSYADAADGTGWAEGAGVLVLERLSEARRQG
HRVLAVVRGSAINQDGASNGLTAPSGPSQQRVIRKALTDAGLTPADIDAVEGHGTGTTLG
DPIEAQALLATYGQGRERPLWLGSLKSNIGHTQAAAGVSGVIKMVQALRHGVLPATLHVD
APSSQVDWSAGAVELLTEERQWPETGRPRRAGVSSFGVSGTNAHVILEQAPEEPVVVRVP
QDGVVPLVVSAASEGSLAGQAERLAAFTGDTDASVADVAGALVRRRAVLSERAVVVAGSR
EEAVAGLGALARGESAPGLVTGAAGASGRTVLVFPGQGSQWPGMGRELLESSPVFAERIE
ECARALEPWVDWDLRAVLRGEADLLDRVDVVQPASFAVMVGLAAVWASVGVVPDAVVGHS
QGEIAAACVAGALSLEDAARIVAVRSQVIAGELAGRGGMASVALPEAEAAERIAAWEGRV
EVAAVNSPSSSVIAGDAEALDEALAALEADGVRVRRVAVDYASHTRHVEAIEAALADAFA
DIHGQAPVVPFFSTVTGEWVREAGVLDGGYWYRNLRGQVRFGPAVASLLAEGHSVFIESS
AHPVLVQPVNEIVDEAESEAVVSGSLRREEGGPRRLLTSMAEVFVQGVAVDWTGVLPEGA
DGAQVDLPTYAFDHRHYWLKPAPAADATALGQTGSDHPLLGAVVGRPDSGGFMTTSRWSL
RSQPWLAEHVVGADAVLVPNAALVELAVRLGDEAGAPVVAELTVERPVVLPVRGGRAVQT
VVGGADGAGRRTVEVYSRADDSAPDDAWTRHAHGTLAPADPAAGGDLPADGPGVEVSLGE
PAGDADRYGVHPSLLDAAVRTALPAGTLAVTWRGVGLRASGATVVTVRSAGVAGEGTRFH
LSDPAGRTVLTVDAVLSEPFDPARAGLAEALTHDALFRVAWAELTLPAGDGTPSVVTVRG
AEDIGAGAADADVLLYAVDPTVTDPRTAVAAALAVLQAWLAEPALERAPLAVVTGADATD
LATAAVRGLLRSAQSEHPGRIVLVEYDGPGEAQDAEAAVRAALPGLLASGEPVVRVRATG
AEVPRLVRAETAAGESGVPQPGRALDPDGTVLITGGTGTLGALTARHLVTGHGVRRLLLL
SRRGPEADGAAMLRAELTALGATVTVAACDITDRDRLAAVLDAVPADHPLTAVLHTAGVL
DDGVVTALTPDRVDTVLRPKLDAALLLDELTRECDLAAFVLFSSAANVFGNPGQANYAAA
NAALDALAARRRAQGLPGVSLAWGYWERASGMTRHLGAADLHRNRRLGMAALSEAEGMAL
LDLALRPASGLPAAPVAAKLDLPALRAAARTAPVAPLLRGLAPTPRTPARAAGDHGDLRD
RLAALDPAAQLALLLDLVRRNAADVLGHGSADAVRADRAFKDAGFDSLTAVELRNRLATA
TGLTLPSAVVFDYPKPTALAEHLRVRLGGDTAAPAAAAGPAPAAPAASDEPIAIVAMACR
FPAGVHSPEDLWRVVADGVDAVTEFPADRGWDIDRLYDADPDKAGTTYVRHGAFLDDAPG
FDAAFFGISPNEALAMDPQQRLLLETSWEAFERAAIDPTGLGGRDIGVFVGVNSHDYTVR
MHHATDAEGFRLTGGSGSVVSGRVAYHFGFEGPAVTIDTACSSSLVALHLAAQALRNGEC
SMALAGGVMVMGNVETFIEFSRQRGLAPDGRCKAFADGADGTGWSEGVGVLLVERLSEAE
RQGHQVLAVIRGSAVNQDGASNGLTAPNGPSQQRVIRKALANAGLTPADVDAVEAHGTGT
VLGDPIEAQALLATYGQDREQPLWIGSVKSNLGHTQAAAGVAGVIKMVMAMRHGLLPRTL
HVDRPSTHVDWSAGAVEVLTEARAWPEAGRPRRAGVSAFGIGGTNAHLVLEQAPAADRTD
AADGAGSTDGVAGAGPVTDGRTAPLLFPVSARTAAGLRGQAGRLADWVADRAGTPLAATA
HALGTARAHLDHRAVVLAADREGLVTALRALAAGSADAGTVTGAPADGKLAFLFTGQGSQ
WAGMGRELAAAHPVFRDAFDAACAAVEQHLDGLAHPLSAVVSAEPGTEQAALLDQTLYTQ
GALFALETALFRLFTSWGVRPDLLAGHSIGEIAAAHAAGILDLADAGRLVAARGRLMQAL
PEGGAMIAVEATEDEVAPLLAQAAGTVGIAAVNGPRAVVLSGAEDAVLAVAARLAQDGHR
TRRLTVSHAFHSALMEPMLDELRAVAAGLRYRPGTLPVVSTLTGALDEDGMLATPEYWVD
QARHAVRFADAVTALRDQGVATHLELGPGGVLSAMALGTLGPDTRGCIGTLRRDTPEDTA
VRTALAELHVRGVPVDWTAVLGRPDPAVGPDLPTYAFQHQRYWVEGGTATDAEALGARSA
GHPLLGGVVEVPGEHGGTGVVLTGRLTGRSPGLYGGGERAVPAGVLLELLVRAGDETGGG
TVERISVDAPLVVPPHGDLQLRVFVDAPGPDGARAATVHSRPAGHEGAPWLRHARATLTP
GVPRHAFDLREWPEEPAEAGAPAGVRGLWRQDGRILADLVLPDELTDEAEAFTLHPVLLD
TALRVAAGAQDTVVSLTGCAALAVYAVGATELRARVSPAADGGHLVELADPDGRPVALLG
PLTLTAAEATATETGTAETAVPETGAPETAPAATAPARRVIRRGPAADGNELAARLAGLA
EAEQRRVLLDLVRESTAVVLGHRDADGFDEGQPFKNLGFDSLTAVKLRNRLHDFTGVALP
SSLVFDHPTPALLADHLRGELLGTRPEIPAPARRGTADPDEPIAIIAMSSRLPGGVNSPE
DLWQLVMDRRDAISGFPTDRDWDIDRLYHPDPAHPGTSYTRAGGFLHDAARFDAQLFGIS
PREALAMDPQQRLLLETSWEAMERAGIDPLSTRGQDVGVFTGIVHHDYVTRLRQVPEDVQ
GYTMTGTAASVASGRVSYVFGFEGPAVTVDTACSSSLVAMHLAAQALRGGECSLALAGGA
TVMATPDAFLEFSRQRGLSADGRCKAYSSTADGTGWAEGVGVVLLERLSDARRNGHRVLA
VLRGSAVNQDGASNGLTAPNGPSQQRVIRSALASAGLRPADVDAVEGHGTGTVLGDPIEV
QALLATYGQDRPADAPLWLGSVKSNIGHTQAAAGVAGVIKMVEAMRHGVLPPTLNVAEPT
AQVDWSAGAVELLTEARAWTRAGRPRRAAVSSFGASGTNAHVILEEAPDTEPVTRPTVPD
GVVPLVVSARSTAALAAQAGRLAAFVTDADAAPAEVAGALVTRRALLSERAVVVAGSRDE
TLAGLGALARGESSPLLVTGTVAGSGGPGRTVLVFPGQGSQWPGMGRELLETSPVFAERI
EQCARALEPWVDWDLKAVLRGEADLLDRVDVVQPASFAVNIALAAVWASVGVVPDAVVGH
SQGEIAAACVAGALSLEDAARIVAVRSQVIAGELAGRGGMASVALPEAEAVVRIAAWDGR
VEVAAVNGPSSVVVAGDAEALDEALAALAADGVRVRRVAVDYASHTRHVEAIEGALEKAF
ADIRSQAPAVPFRSTVTGEWVREAGVLDGDYWYRNLRSQVRFGPAIAALLAEGHTVFVES
SAHPVLVQPVNEIFDEAADDNVRLRAVAAGSLRREEGGPRRLLASMAELFVKGVAVDWTG
VLPAEARDARPDLPTYAFDRQHYWLREAATGSDDAPAAEGAETDFWAAVEQADADSLARL
LDLAAADQRDALRTVVPLLADWRGRRRERSAAEKLRYHVTWRPLDQEGTGVPGGTWLAVV
PEAPAAADLVRELTAQGLHLVTLDVPLEAAAADAGRARLGERLSAVLAEHDVTGVLSLLA
LGGEQGPQDPVPLTAATLALVQALGDTGATQPLWCLTRGAVNTGIQDTVTAPAQAAVWGI
GRAAALERGDRWGGLIDLPATLDTRTVRHLLGALGHPGDDDQLAVRRSGVHTRRLLRKAA
PDPTAGPGWQPAGTVLVTGGAEGLGRHASLWLARSGARRLLVTTTAGAPEGALAALTAEV
AALGTGTTVVACADTDRTAIEGLLARTPEDEPLTAVVHTADIARTSTVDDTGVPDLTEVF
AAKVDTARWLAERFADTPLDAFVVFSSIAGIWGGGGQGTSGAANAVLDALVEWRRGHGHP
ATAIAWGALDEIGVGMDEDTLTQLRRRGVLPMAPQIAVTAFEQAVQAHEKAVTVVDMDWG
AFIPAFTSVRPGPLFADLPEAQEALRATQPDTENGDTTAGLVDSLRDVPEAEQNRILLRL
VCGHAATVLGHSGAESIGPLQAFQEVGFDSLAAVNLRNSLHVATGLRLPATLIFDYPTPD
ALVGYLRSELLRDADDGLDGREDDLRRALATVPLARFKEAGVLDTLLGLVDTEDAPASGT
PDAAAPAEDDETLIDAMDVADLVQRALGRTS
NT seq
17016 nt
NT seq
+upstream
nt +downstream
nt
gtgcgttccgacctggtcacaccgcttgcggtcacgctgcacgagcacgctctccgcatc
ccggagaaggtcgccttcgccgacgaccggcgcgcggtcacctacgcggagctggaggcg
cggacgcggcggctcgccggacatctcgtccgtctgggcctgcgccgcggggaccgggtg
gcgctctgcctcggcaactccgtcgcgatggtggaggggtatctcgcggtcgtgcgcgcc
ggcggcatcggtgtgccggtgaacccgcggtcggcgcccgccgagctggagtatctcctc
gccgacagcggggcgcggttcgccctcgccggggcgagcagtgcagggacgtttctgcac
ggggtgtctccgcacggggggtccccggaaggggtgcctccgcagggggtggttgcggag
gggacggttccggagggggcgattccggagggggcgcctcgccaaggggtgtcgtccgcc
gtcccggacatgaccgtcctggtggccggcaccacggacgtgccggccggcgcccacgcc
tacgacgagcttgcggtcaccgaccccggcacgcccgcccccgacgacctcggcctggac
gaggtggcctggatgttctacacgtccggcaccaccgggcgccccaagggcgtgctgtcc
acccagcgcaactgcctgtggtcggtcgccgccagctacgtacccatcccggacctgcgc
caggacgaccgggtgctgtggccgctgccgctcttccacagcctctcccacatcgcctgc
gtgctctccgtgacctccgtcggcgccaccgcccgcatcacggacggcagttccgccgac
gacgtcctggacctcctgcgcaccgagcgggccaccttcctcgccggcgtccccaccacc
taccaccacctcgtcgccaccgcccgccgcaccggactgtccctgcccgacctgcgcatc
gggctcgtcggcggcgcggtcaccggctccgagctgcgccgctccttcgaggacaccttc
ggcgtcccgctggtcgacgcctacggctccaccgagacctgcggcgcgatcaccatgaac
ccgcccgacggcgcccgcgtcgaaggctcctgcgggctgcccgtacccggcgtcgacgtc
cgcatcgtcgaccccggcaccggcgacgacgtgcccaccggacaggagggcgaggtctgg
gtcagcggccccaacgtcatggtcggctaccacaacagccccgaggcgacccgggccgcg
ctgcgcgacggctggttccgcaccggcgacctggcccgccgggacgaggccggctacttc
acggtctgcggccggctgaaggacctgatcatccgcggcggcgagaacatccaccccgac
gaggtcgaagcggtgctgcggagcgcccccggggtcgccgacgccggcgtcgccggcgcc
gcccacgacaccctgggcgaggtgcccgtcgcctggctggtcccgggaccggacggcctc
gacctcgacgccgtgctcgaccactgccgcgcccggctctccgcgtacaagatcccggag
cggatccacgaggccgccggcatcccgcgcaccgcctccgggaagatcgtccgccggctg
ctcgccgcccagccgtactggccccgccacacggccgacggccaccacgacgccctcctg
actccggcgtggctgcccgcgccggcccgcaccggcgaccgtgacgacagcgacggcggc
gacggcggcgcacgcccggccgcctgcgccgtggtcggcgaggacaccaccgggctggtc
gacgccttgcgcgcggccggggtggacgccgcagtccatcccggtctgccgtccgtgccg
gacacgatccccggtccgaccctcctgctgccgccggccccctccgccgaccccttcacc
gaggcccgcctcctcatccaacaggtgaccggcggaaacgccccggaaccgctggtggtc
ctcacccggggagccacaccggccggcgacagcgcgcccgaccccgccggcgccgcgctg
tgggccgccgtacggtcgctccaggcggacgggcaccagcggctcaccgtcgtcgacctc
gacaccgaccgcccggacgcggcgaccctgctcgccgcgatcacctcggacgaaccgcaa
ctggccatgcgcggcgaagagttgctggcgccccggctgctgcgcacccccgtggacggc
cggccgcgccccgccgcccccgagcgccccggaaccgtcgtcgtcaccggcaccgacacg
cccgcaggcgccgcgctcgcccaccacctcgccaccgtgcaccgggccacggacctgctg
ctcgtccacgcgcccggtacgaccgacggcaccgacccggacgcctggcccgccggcacc
cgcgcccgccgggtcagcaccgacgccaccggtctgcgcgaggcgctggccgacgcccac
ccggtgagcctggccgtgcacaccgccgacgaccccgacctggcccgcacgctcgacgaa
ctcctcggcgacacaggtgagttcgtcaccgtcaccgacggcgccgccaccctgggcgcc
ccgggcgacccggaccgtgcgatacgcggcgccctcaccgaggccgtcacgcacacccgc
cggctgcgggcaccggccgccaccctcgtctgggccgccgccgacgaccacgaccgactc
gccgacctgctcgccgcgttcgacatcctgctcgccggccgggcccccgccctcttcgcc
ccccgcccggccccgcccgacccgtcccggccggtccccgcgatcctccgcgccctcacc
gagccgccggccgggcaggcccgccccgacgctgccgtcaccgccgccctgcgcgcacgc
ctgaccggcctcgacgcacgagcccaactggccctcctggaagagctggtccgtgagcag
gccgccggcgtcctgcacggccccgacgcggcccccctcccggccgaccgcgccttccgc
gacctcggcctgacctcggtcgccgtcgtcgccctgcgcgaccggctgaccgagcacacc
gggctgcgcctgcccaccaccgtggccttcgaccacccgaccccgcgggagctggcggcc
cacctgcgcgccgcggtcctcggcctggacgacaccccggcgcgccccgagcggccggcc
gcggacaccgacccgcaggaacccatcgccatcgtcggcatggcctgccgcctgcccggc
ggagtgaacaccccggaagaactctggcagttgctcgccgcgggccgggacgccgtgtcc
gacttcccggccgaccggggctgggacctcgacggcctgttcgccccggacccggaccgg
cccggcacctcctacgtcgaccggggcggcttcctcccggacgcaggccggttcgacgcc
gcgttcttcggcatctcgccgcgcgaggcgctggcgatggacccgcagcagcggctcctc
ctcgaaacgtcctgggaggcgctggagcgggccggcatcgacccccatgcgctgaagggc
acggacgtgggcgtgttcgccggcgtcatgggccagggctacggctccgggggcgaactc
cccgcggaactcgaaggcttcgtcaccaccggcaccgcctccagcgtggcctcgggccgc
atctcgtacgtcttcggactcgaaggccccgcggtcaccgtcgacaccgcctgctcctcc
tccctggtcgccctgcacctcgccgcccaggcgctgcggcgcggggagtgctccatggcc
ctggcaggcggcgccaccgtcatggccaccccgggcaccttcgtggagttctcccggcag
cgcgcgctggccgccgacggccgctgcaagtcgtacgccgacgccgccgacggcaccggc
tgggccgagggcgcgggcgtgctcgtcctggaacggctctcggaagcccgccgccagggg
catcgcgtgctcgccgtggtccggggcagcgcgatcaaccaggacggcgcctccaacggc
ctcaccgcccccagcggcccttcccaacagcgcgtgatccgcaaggccttgaccgacgcc
gggctgacaccggccgacatcgacgcggtggagggccacggcaccggtaccaccctcggc
gacccgatcgaggcgcaggcgctgctcgccacctatggccaggggcgtgaacggccgctg
tggctgggctcgttgaagtcgaacatcggccacacccaggccgccgcgggcgtgtccggc
gtgatcaagatggtgcaggcgctgcggcacggcgtcctgcccgccacgctgcacgtcgac
gccccctcctcccaggtcgactggtcggcgggcgccgtcgagctgctgaccgaggagcgg
cagtggccggagacggggcgtccgcgccgggccggtgtctcctccttcggcgtgagcggc
acgaacgcccacgtgatcctggagcaggcccccgaggagccggtggtcgtgcgggtgccg
caggacggtgtggtgccgctggtggtgtcggcggcgtcggagggttccctcgcgggtcag
gccgagcggctggccgcgttcaccggtgacaccgatgcgtctgtcgcggacgtcgcgggt
gcgctggtgcggcggcgggcggtgctgtcggagcgggctgtggtcgtggcggggtcgcgg
gaggaggcggtggccgggctgggcgcgctggcccggggggagtcggcgcccggtctggtg
acgggtgctgcgggggcgtcggggcggacggtgctggtgttcccggggcaggggtcgcag
tggccgggcatgggccgggagttgctggagtcctcgccggtgttcgcggagcggatcgag
gagtgcgcccgggcgttggagccgtgggtggactgggacctgcgggccgtcctgcgcggt
gaggccgatctgctggaccgtgtggacgtggtccagccggcaagcttcgcggtgatggtc
ggtctggctgctgtgtgggcgtccgtgggtgtggtgccggatgcggtggtgggtcactcg
cagggtgagatcgcggctgcgtgtgtcgccggtgcgctgtcgttggaggatgcggcgcgg
atcgtggccgtgcggagtcaggtgatcgcgggggagttggcgggccggggtggtatggcc
tcggtggcgttgccggaggcggaggcggcggagcggattgccgcgtgggaaggccgagtt
gaggtcgcggcggtcaacagtccttcctcctcggtgatcgccggtgacgccgaggcgttg
gacgaggcgttggccgcgttggaggccgacggcgtacgcgtgcgtcgggtggcggtggac
tacgcgtctcacacgcgccatgtggaggcgatcgaggcggcgttggcggacgcgttcgcg
gacatccacggtcaggcgccggtggtgccgttcttctccaccgtgaccggtgagtgggtc
cgcgaggcgggtgtcctggacggcggttactggtaccgcaatcttcgtggtcaggtgcgt
ttcggtccggcggtggcttcgctgctggccgaggggcattcggtgttcatcgagtccagt
gcccacccggtcctggtccagccggtgaacgagatcgtggacgaggcggagtccgaggcg
gtcgtcagcggttccctgcgccgcgaggagggcggcccccgacggctgctgacgtcgatg
gccgaggtgttcgtccagggtgtcgccgtcgactggaccggcgtgctgcccgagggcgcc
gatggtgcacaggtggatctgccgacgtacgcgttcgatcaccggcactactggctgaag
cccgcccccgcggcggacgcgaccgccctcggacagaccggtagcgatcaccctctgctc
ggggcggtcgtcgggcggccggactccggtgggttcatgacgacctcgcggtggtccctg
cggtcgcagccgtggctggccgagcacgtggtcggggccgacgcggtgctggtgccgaac
gcggccctggtggagctggcggtccggctcggtgacgaggccggcgcgccggtcgtggcg
gagctgaccgtcgagcggcccgtcgtactgccggtgcgtggcgggcgggccgtccagacc
gtggtgggcggggcggacggcgccggacggcgcacggtcgaggtctactcacgcgcggac
gactccgcgccggacgacgcctggacacggcacgcgcacggcaccctcgcgcccgccgac
ccggcggccggcggcgacctgcccgccgacgggccgggcgtcgaggtgagcctcggcgag
ccggccggggacgccgaccggtacggcgtccaccccagcctgctcgacgcggccgtgcgg
acggcgctgccggccgggaccctggcggtcacctggcgcggggtcggcctgcgggcgtcc
ggcgcgaccgtcgtcaccgtgcggtcggcgggggtcgcgggcgagggcacccggttccac
ctgagcgatccggccgggcggaccgtgctgaccgtggacgcggtgctgtccgaaccgttc
gacccggcgcgcgccggactcgccgaggcgctcacccacgacgcgctgttccgcgtcgcc
tgggcggagctgacgctgccggcgggtgacggcacgccgtccgtcgtcaccgtacggggc
gccgaggacatcggcgccggtgcggcggacgcggacgtcctgctgtacgccgtcgacccc
acggtgaccgatccgcgcacggcggtcgccgccgcgctcgccgtcctccaggcgtggctg
gccgaacccgccctggagcgggccccgctggccgtggtcaccggcgcggacgccaccgac
ctcgccacggccgccgtgcgggggctgctgcggtccgcgcagtccgagcaccccggccgg
atcgtgctggtcgagtacgacggcccgggcgaggcccaggacgccgaggcggcggtccgt
gccgcgctgcccggcctgctcgcctccggtgaaccggtggtccgcgtgcgggccacgggc
gccgaggtgccccggctggtccgggccgagacggcggcgggggagagcggtgtcccgcag
ccgggccgggcgctcgatccggacgggaccgtgctgatcaccggcggcaccggcacgctc
ggcgcgctgaccgcccggcacctggtcaccgggcacggcgtccgccgtctgctcctgctc
agccggcgcggccccgaggcggacggcgcggccatgctccgcgcggagctgaccgcgctg
ggcgccaccgtcaccgtcgccgcctgcgacatcaccgaccgggaccggctcgcggccgtc
ctggacgccgtacccgccgaccacccgctgaccgccgtcctgcacaccgccggagtcctg
gacgacggcgtggtcaccgcgctcaccccggaccgcgtcgacaccgtgctgcggcccaaa
ctggacgcggcgctgctgctggacgagctgacgcgggagtgcgacctcgcggcgttcgtg
ctgttctcctcggccgcgaacgtcttcggcaacccgggccaggccaactacgccgccgcc
aacgccgccctggacgcgctcgccgcgcgccgccgggcccaggggctgcccggcgtctcg
ctcgcctggggctactgggagcgggccagcggcatgacccggcacctcggcgccgccgac
ctgcaccgcaaccggcggctcggcatggccgcgctgtccgaggccgagggcatggcgctg
ctggacctcgccctgcggcccgcgagcgggctgcccgccgccccggtggccgccaaactg
gacctgcccgccctgcgcgcggcggcccgcaccgcgcccgtggcgccgctgctgcggggc
ctcgcgcccacgccgcgcacgccggcccgcgccgccggcgaccacggcgacctgcgggac
cgcctggccgcgctggacccggcggcccagctggccctgctgctggacctggtccggcgc
aacgccgccgacgtgctcggccacggcagcgccgacgccgtccgtgccgaccgggccttc
aaggacgccgggttcgactcgctgaccgcggtggagctgcgcaaccggctggcgaccgcc
accgggctcaccctgccctcggccgtcgtcttcgactaccccaagccgaccgcgctcgcc
gagcacctgcgggtccggctcggcggtgacaccgccgccccggccgcggcggccggtccg
gcacccgccgcgcccgccgcgtccgacgagccgatcgcgatcgtcgcgatggcctgccgc
ttccccgccggggtgcacagccccgaggacctgtggcgggtcgtggccgacggggtcgac
gccgtcaccgagttccccgccgaccgcggctgggacatcgaccggctctacgacgccgac
cccgacaaggccggcacgacctacgtgcggcacggcgcgttcctggacgacgcgcccggc
ttcgacgccgccttcttcgggatctccccgaacgaggccctcgcgatggacccgcagcag
cggctgctgctggagacgtcctgggaggccttcgaacgcgccgcgatcgaccccaccggg
ctcggcggccgggacatcggcgtgttcgtcggtgtcaacagccacgactacaccgtgcgg
atgcaccacgcgaccgacgccgagggcttccggctcaccggcggctccggcagcgtcgtc
tccggccgcgtcgcctaccacttcggtttcgagggcccggccgtcacgatcgacaccgcc
tgctcctcctccctggtcgccctgcacctggccgcccaggcgctgcgcaacggggagtgc
tccatggcgctcgccggcggcgtgatggtgatgggcaacgtggagacgttcatcgagttc
tcccggcagcgcggcctcgcccccgacggccggtgcaaggcgttcgcggacggcgcggac
ggcaccggctggtccgagggcgtgggcgtgctgctggtcgagcggctctccgaggccgaa
cggcagggccaccaggtgctcgccgtgatccggggcagcgcggtcaaccaggacggcgcg
tccaacggcctgacggcacccaacggcccgtcccagcagcgcgtgatccgcaaggcgctg
gcgaacgccgggctgaccccggcggacgtggacgcggtcgaggcgcacggcaccggcacc
gtcctcggcgacccgatcgaggcacaggcactgctcgccacctacggccaggaccgcgaa
cagccgctgtggatcggttcggtgaagtcgaacctcgggcacacccaggccgcggccggt
gtcgccggggtcatcaagatggtcatggcgatgcggcacggcctgctgccccgcaccctg
cacgtggaccggccctccacgcacgtggactggtcggcgggcgcggtcgaggtgctcacc
gaggcccgcgcctggcccgaggccggccgcccgcgccgggccggcgtctccgccttcggc
atcggcggcaccaacgcccacctggtcctggagcaggcaccggcggccgacaggaccgac
gccgcggacggcgcgggcagcacggacggcgtcgccggcgcggggccggtcaccgacggc
cgtaccgccccgctcctcttccccgtctccgcccgcaccgccgccgggctgcgcgggcag
gccggccggctcgccgactgggtggcggaccgggccggtacgccgctcgcggccacggcc
cacgcgctcggcaccgcccgcgcccacctcgaccaccgcgcggtcgtcctggccgccgac
cgggaggggctcgtcaccgccctgcgcgcgctcgccgcgggcagcgccgacgcgggcacc
gtcaccggcgccccggccgacggcaagctcgccttcctgttcaccgggcagggcagccag
tgggccggcatgggccgcgaactcgccgccgcccacccggtgttccgcgacgccttcgac
gcggcctgcgccgccgtggaacagcacctggacggcctcgcccaccccctgagcgcggtg
gtgtccgccgagcccggaaccgaacaggccgccctgctcgaccagaccctctacacccag
ggcgcgctgttcgccctggagaccgccctgttccggcttttcacctcctggggcgtacgg
cccgacctcctcgcgggccactcgatcggcgagatcgccgccgcccacgccgccggcatc
ctggacctggcggacgccggtcgactggtcgcggcccggggccggctgatgcaggccctg
cccgagggcggcgcgatgatcgccgtggaggcgaccgaggacgaggtggcaccgctgctc
gcccaggccgccggcaccgtcgggatcgcggcggtcaacgggccgcgggccgtggtcctg
tccggcgccgaggacgccgtcctcgccgtcgccgcgcgcctcgcccaggacggccaccgc
acccgccggctgaccgtcagccacgccttccactccgcgttgatggagccgatgctcgac
gaactgcgcgccgtggccgccgggctccgctaccggccgggcaccctccccgtcgtctcc
acgctcaccggcgcactcgacgaggacgggatgctcgccacccccgagtactgggtggac
caggcccggcacgccgtgcggttcgccgacgccgtcaccgccctgcgcgaccagggcgtc
gccacccacctggaactggggcccggcggtgtcctcagcgccatggccctcggcaccctc
gggccggacacccgcggctgcatcggcacgctgcgccgggacacccccgaggacaccgcc
gtccgcaccgcgctcgccgaactgcacgtacggggcgtgccggtcgactggaccgccgtc
ctcggccgcccggaccccgccgtcgggcccgacctgcccacctacgccttccagcaccag
cggtactgggtggagggcggcaccgccaccgacgccgaggcgctcggcgcccggtccgcc
gggcacccgctgctgggcggcgtcgtcgaggtccccggcgagcacggcggcaccggcgtc
gtcctcaccggccggctcaccggacgcagccccggcctgtacggcggcggggagcgggcg
gtaccggccggtgtgctgctggagctgctggtccgggccggcgacgagaccggcggcggc
accgtcgagcggatcagcgtcgacgcgcccctcgtcgtccccccgcacggcgacctccag
ctccgcgtcttcgtggacgcgcccggccccgacggggcgcgcgcggccaccgtgcacagc
cggccggccggacacgagggcgcaccgtggctccggcacgcccgcgccaccctgaccccc
ggcgtcccgcggcacgccttcgacctgcgcgagtggccggaggagcccgcggaggccggc
gccccggcgggggtgcgcgggctgtggcggcaggacggccggatcctcgccgacctcgtg
ctgccggacgaactcaccgacgaggccgaggcgttcaccctccatccggtactcctcgac
accgccctgcgggtcgcggccggggcccaggacacggtcgtctccctgaccgggtgcgcc
gccctcgccgtgtacgcggtcggcgccaccgagctgcgggcgcgcgtcagcccggccgcc
gacggcgggcacctggtggagctggccgaccccgacggtcggcccgtcgccctgctcggc
ccgctgacgctcacggccgccgaggccaccgccaccgaaaccggcacagcggagaccgcc
gtaccggaaaccggcgcaccggagaccgcacccgccgcgaccgcgcccgcccgccgtgtc
atccgccgcggaccggccgccgacggcaacgaactggccgcccggctggccgggctcgcc
gaggccgaacagcgccgggtcctgctggacctggtccgggagagcaccgcggtcgtcctc
ggccaccgggacgcggacggcttcgacgaggggcagccgttcaagaacctcggcttcgac
tcgctcaccgccgtcaaactccgcaaccggctgcacgacttcaccggcgtcgccctgccc
agcagcctcgtcttcgaccaccccaccccggccctgctcgccgaccacctgcgcggcgaa
ctcctcggcacccgcccggagatccccgcgcccgcccggcgcggcacggccgacccggac
gagccgatcgccatcatcgccatgagcagccggctgcccggcggcgtcaacagccccgag
gacctgtggcagctcgtcatggaccggcgcgacgccatctccggcttccccaccgaccgc
gactgggacatcgaccggctctaccaccccgacccggcccaccccggcaccagctacacc
cgggcgggcggcttcctgcacgacgccgcccggttcgacgcccagctcttcggcatctcg
ccgcgcgaggccctggccatggacccgcagcagcggctgctgctggagacttcctgggag
gccatggaacgcgcgggcatcgacccgctgtccacccgcggccaggacgtcggtgtgttc
accggcatcgtccaccacgactacgtgacccggctgcgccaggtccccgaggacgtccag
ggctacaccatgaccggtacggccgccagcgtggcctcgggccgggtgtcgtacgtcttc
ggcttcgaaggccccgcggtgaccgtggacacggcctgctcgtcctccctggtcgccatg
cacctcgcggcgcaggcgctgcggggcggcgagtgctccctcgccctcgccggcggcgcc
accgtcatggccacccccgacgccttcctggagttctcccggcagcgcggcctgtccgcc
gacggccgctgcaaggcgtactcctccaccgcggacggcaccggctgggccgagggcgtc
ggcgtggtcctgctggagcggctgtcggacgcgcgccgcaacggccaccgggtgctggcg
gtgctgcgcggcagcgcggtcaaccaggacggcgcctccaacggcctgaccgcccccaac
ggtccctcccagcagcgggtgatccgcagcgccctggcctccgccgggctgcggcccgcc
gacgtggacgcggtggagggccacggcaccggcaccgtcctcggcgacccgatcgaggtg
caggcgctgctggccacctacggccaggaccgacccgcggacgcgccgctgtggctcggc
tcggtgaagtcgaacatcggtcacacgcaggccgccgccggcgtcgccggggtgatcaag
atggtggaggcgatgcggcacggcgtcctgccgcccaccctgaacgtcgccgaacccacc
gcgcaggtggactggtcggcgggcgcggtggaactgctcaccgaggcccgcgcatggacc
cgcgccggccggccgcgccgggccgccgtctcctccttcggcgcgagcggcaccaacgcg
cacgtcatcctggaggaggcgcccgacaccgagccggtcacccggccgacggtccccgac
ggcgtcgtaccgctggtggtgtcggcccgcagcacggccgccctcgccgcccaggccggg
cgcctggcggcgttcgtcaccgacgcggacgccgcgccggccgaggtcgcgggtgccctc
gtcacccggcgggccctgctgtccgagcgggccgtggtcgtcgccggttcacgcgacgag
accctcgccgggctcggcgcgctggcccggggcgagagcagccccctgctcgtgaccgga
accgtcgccggctccggcggccccggcaggaccgtgctggtcttccccgggcagggttcc
cagtggccgggcatgggccgggaactgctggaaacctccccggtgttcgcggagcggatc
gagcagtgcgcccgggcgttggagccctgggtggactgggacctgaaggccgtcctgcgc
ggtgaggcagacctgctggaccgggtggacgtcgtgcagccggcgagcttcgccgtgaac
atcgccctggccgccgtctgggcctccgtcggggtcgtgccggacgcggtggtcggtcac
tcgcagggcgagatcgccgccgcctgtgtcgccggcgcgctgtcgctggaggacgcggcg
cggatcgtcgccgtccgcagtcaggtgatcgccggtgagctggcgggccggggcgggatg
gcctcggtggcgctgcccgaggccgaggccgtcgtccggatcgccgcctgggacgggcgc
gtcgaggtcgccgccgtcaacgggccgtcgtcggtcgtggtcgccggagacgccgaggcg
ctggacgaggcgctcgccgcactcgcggccgacggcgtccgggtccgccgggtcgccgtg
gactacgcctcccacacccgccatgtcgaggcgatcgaaggggcgttggagaaggcgttc
gccgacatccgcagccaggcgcccgcggtgccgttccgctccaccgtcaccggcgagtgg
gtccgcgaggccggcgtcctcgacggcgactactggtaccggaacctgcgcagccaggtc
cgcttcggcccggccatcgccgccctcctcgccgagggccacacggtgttcgtcgagtcc
agcgcccaccccgtcctcgtccagcccgtgaacgagatcttcgacgaggccgccgacgac
aacgtccgcctccgcgccgtcgccgccggatcgctgcggcgcgaggaaggcggcccgcgg
cggctgctcgcgtcgatggccgagctgttcgtcaagggcgtcgccgtggactggacgggc
gtcctgcccgccgaggcccgcgacgcccgcccggacctgccgacgtacgccttcgaccgc
cagcactactggctgcgggaagcggcgaccggcagcgacgacgcccccgccgccgagggc
gccgagaccgacttctgggccgccgtcgaacaggccgacgccgactccctcgcccggctg
ctcgacctggccgcggccgaccagcgcgacgccctgcgcaccgtcgtccccctgctggcc
gactggcgcggccggcggcgcgagcggtcggcggccgagaagctgcgctaccacgtcacc
tggcgccccctcgaccaggaaggcaccggtgtccccggcgggacctggctggccgtcgta
ccggaagccccggccgcggccgatctggtccgggaactcaccgcgcagggactccacctg
gtcaccctggacgtcccgctggaggccgcggcggccgacgccggccgcgcccggctcggc
gagcgcctgtcggccgtcctcgccgaacacgacgtgaccggcgtgctgtcgctgctcgcc
ctcggcggcgaacagggcccgcaggaccccgtcccgctgaccgcggccaccctggcgctg
gtgcaggcgctcggcgacaccggggccacccagcccctgtggtgcctgacccggggcgcg
gtcaacaccggcatccaggacaccgtcaccgcgcccgcccaggccgccgtctggggcatc
ggccgggccgccgccctggaacgcggcgaccgctggggcggactgatcgacctgcccgcc
accctcgacacccgcaccgtccgccacctgctcggcgccctgggccaccccggcgacgac
gaccagctggccgtccgccggtccggggtgcacacccgccggctgctgcgcaaggccgcc
cccgacccgaccgccggccccggctggcagccggccggcaccgtcctggtgaccggcggc
gccgagggcctcggccggcacgcctccctgtggctcgcccgctccggcgcccgccgcctc
ctcgtcaccaccacggccggcgcccccgagggcgcgctcgccgcgctcaccgccgaggtg
gccgcgctcggcaccggcaccaccgtggtggcctgtgccgacaccgaccggaccgcgatc
gaggggctgctcgcccggacccccgaggacgagccgctcaccgccgtcgtgcacaccgcc
gacatcgcccgtaccagcaccgtggacgacaccggcgtccccgacctcaccgaggtgttc
gccgccaaggtcgacaccgcccgctggctcgccgaacggttcgccgacacccccctcgac
gcgttcgtggtgttctcctcgatcgccggcatctggggcggcggcgggcagggcacctcc
ggcgcggccaacgccgtcctcgacgccctcgtcgagtggcgccgcggccacggccacccg
gcgaccgccatcgcctggggcgccctggacgagatcggcgtcggcatggacgaggacacc
ctcacccagctccgccggcgcggtgtgctgccgatggccccgcagatcgccgtcaccgcc
ttcgaacaggccgtccaggcccacgagaaggccgtcacggtggtcgacatggactggggc
gccttcatccccgccttcacctcggtccggcccggcccgctcttcgccgacctgcccgaa
gcgcaggaggcactgcgggccacccagccggacaccgagaacggcgacaccaccgccggc
ctcgtggactccctgcgcgacgtccccgaggccgagcagaaccgcatcctgctccggctg
gtgtgcggacacgccgccaccgtcctcggccacagcggcgccgagagcatcggccccctc
caggccttccaggaggtcggcttcgactcgctcgccgccgtcaacctgcgcaacagcctg
cacgtggcgaccggcctgcggctgcccgccaccctcatcttcgactaccccacgccggac
gccctcgtcggctatctgcgctccgagctgcttcgggacgcggacgacgggctggacggg
cgggaggacgacctcaggcgagccctcgccaccgtccccctcgcccggttcaaggaggcc
ggcgtcctggacaccctgctcggcctcgtggacaccgaggacgccccggcgtccgggacg
cccgacgcggcggccccggccgaggacgacgagaccctgatcgacgccatggacgttgcc
gatctcgtgcagcgtgctctgggcaggacgagctga
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