Serratia plymuthica S13: M621_02935
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Entry
M621_02935 CDS
T02716
Symbol
thrA
Name
(GenBank) bifunctional aspartokinase I/homoserine dehydrogenase I
KO
K12524
bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:
2.7.2.4
1.1.1.3
]
Organism
sry
Serratia plymuthica S13
Pathway
sry00260
Glycine, serine and threonine metabolism
sry00261
Monobactam biosynthesis
sry00270
Cysteine and methionine metabolism
sry00300
Lysine biosynthesis
sry01100
Metabolic pathways
sry01110
Biosynthesis of secondary metabolites
sry01120
Microbial metabolism in diverse environments
sry01230
Biosynthesis of amino acids
Module
sry_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
sry_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
sry_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
sry00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
M621_02935 (thrA)
00270 Cysteine and methionine metabolism
M621_02935 (thrA)
00300 Lysine biosynthesis
M621_02935 (thrA)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
M621_02935 (thrA)
Enzymes [BR:
sry01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
M621_02935 (thrA)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
M621_02935 (thrA)
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Ortholog
Paralog
GFIT
Motif
Pfam:
Homoserine_dh
AA_kinase
ACT_9
NAD_binding_3
ACT_7
ACT
DUF8747
Motif
Other DBs
NCBI-ProteinID:
AGP42914
UniProt:
S4YDW4
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All DBs
Position
626411..628870
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AA seq
819 aa
AA seq
DB search
MRVLKFGGTSVANAERFLRVADIMESNARQGQVATVLSAPAKITNHLVAMIEKTVAGQDI
LPNMSDAERIFADLLSGLAQALPGFEYDRLKTLVDQEFAQLKQVLHGVALLGQCPDSVNA
AIICRGEKLSIAIMEGVFRAKGFPVTVINPVEKLLAQGHYLESTVDIAESTLRIAAAAIP
ADHIVLMAGFTAGNDKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRTV
PDARLLKSMSYQEAMELSYFGASVLHPRTITPIAQFQIPCLIKNTSNPQAPGTLIGGENV
DSDTPVKGITNLNNMAMINVSGPGMKGMVGMAARVFAVMSRTGISVVLITQSSSEYSISF
CVPQSELQRARRALEDEFYLELKDGLLEPLDVMEKLAIISVVGDGMRTLRGISARFFSAL
ARANINIVAIAQGSSERSISVVVSNDSATTGVRVCHQMLFNTDQVIEVFVIGVGGVGGAL
IEQIYRQQPWLKQKHIDLRICGIANSRAMLTNVHGIALESWKEELAAAKEPFNLGRLIRL
VKEYHLLNPVIVDCTSSQAVADQYADFLADGFHVVTPNKKANTSSMNYYQQLRTAAAGSR
RKFLYDTNVGAGLPVIENLQNLLNAGDELTRFSGILSGSLSFIFGKLDEGMSLSAATLEA
KAKGFTEPDPRDDLSGMDVARKLLILAREAGYKLELGDIEVESALPPSFDASGDVETFLA
RLPELDKEYARNVANAAEQGKVLRYVGVIEDGRCQVRIDAVDGNDPLYKVKNGENALAFY
SRYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV
NT seq
2460 nt
NT seq
+upstream
nt +downstream
nt
atgcgagtgctgaaatttggcggaacttcggtagcgaatgcagaacgttttctgcgcgtt
gccgacatcatggaaagtaacgcacgtcagggacaggtagccacggtattgtccgcgcct
gcaaagatcaccaaccacttggtggcgatgattgaaaaaacggtggccgggcaagacatt
ctgccaaatatgagcgatgcggagcgcatcttcgccgacctgctgagcggcctggcgcag
gctctgccaggtttcgaatacgatcgcctgaagaccctggtcgatcaggagttcgcccaa
ctgaagcaggtgctgcacggcgtagcgctgctggggcaatgcccggacagcgtgaacgcg
gcgattatctgccgtggcgagaagctctccatcgccatcatggaaggcgtattccgcgcc
aaaggtttcccggtgacggtgatcaacccggtagagaaactgctggcgcaggggcattat
ctggagtcgaccgtagatatcgccgaatccacgttgcgcatcgccgccgcggctatccca
gcggatcacatcgtgctgatggccggttttaccgccggtaatgacaagggcgagctggtg
gtgttgggtcgtaacggttccgattactctgccgccgtactggccgcttgtctgcgcgcc
gactgttgcgagatctggaccgacgtagacggcgtttatacctgcgacccgcgcaccgtg
ccggacgccaggctgctgaagtcgatgtcgtaccaggaggcgatggagctttcttatttc
ggcgccagcgtgcttcacccccgtaccatcacaccgattgcccagttccaaatcccttgc
ctgatcaaaaacacctccaatccgcaggcccccggcacgctgatcggcggtgaaaacgtg
gatagcgataccccggtgaagggcatcaccaacctgaacaacatggcaatgatcaacgtc
tccggcccggggatgaagggcatggtcggcatggccgctcgggtgttcgccgtgatgtcg
cgcaccggtatttcggtcgtgctgattacccaatcctcttccgaatacagcatcagcttc
tgcgtgccgcagagcgagctgcagcgtgcgcgccgtgcgctggaagacgaattctatctt
gagctgaaagacggcttgctcgagccgctggacgtgatggagaagctggcgattatctct
gtcgtgggcgacggcatgcgcaccttgcgcggcatctcggcccgcttcttctccgcgctg
gcgcgcgccaatatcaacattgtcgccatcgcccagggctcgtcggagcgttccatctcg
gtggtggtcagcaacgattccgccaccaccggcgttcgcgtctgccaccagatgctgttc
aataccgatcaggtgattgaagtgtttgtcatcggcgtcggcggcgtcggcggtgccctg
atcgagcagatttatcgccagcagccgtggctgaagcaaaagcatatcgatctgcgcatc
tgcggtatcgccaattcccgagccatgctgaccaatgtgcacggtatcgctctggagagt
tggaaagaggaactggccgcggctaaagaaccgttcaatctgggccgcctcatccgtctg
gtgaaggagtatcacctgctgaacccggtgattgtcgactgtacctccagccaggcggtc
gccgaccaatacgcggatttcctggccgatggtttccacgtggtgacgccgaacaagaag
gccaacacctcgtcgatgaactactatcaacagctgcgcaccgccgctgccggctcacgc
cgcaagttcctgtacgacaccaacgtcggcgcgggtttgccggttatcgagaacctgcaa
aatctgctgaatgccggcgacgaactgacgcgtttctccggtatcctgtccggttcgctg
tcgtttattttcggcaagctggacgaaggcatgtcgctgtcggcggcgaccctggaggcc
aaggccaaagggttcaccgagccggatccgcgtgacgatctttccggcatggacgtggcc
cgcaagctgctgatcctggcccgcgaggcgggttacaagctggaactgggggacattgag
gtcgagtcggcgctgccgccgtcctttgacgcttccggtgatgtggaaaccttcctggcg
cgcttgccggagttggataaggaatacgcgcgcaacgtggctaacgccgccgagcagggc
aaggtgttgcgctacgtcggcgtgatcgaagatggccgctgtcaggtgcgcattgatgcg
gtagacggcaacgatccgttgtataaagtgaagaacggtgagaatgccctggccttctac
agccgttactatcagccattacctttggtgttgcgcggctacggcgccggtaatgatgtg
actgcggcgggggtatttgccgacctgttgcgcacactgtcatggaagttgggagtttaa
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