Sus scrofa (pig): 100522018
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Entry
100522018 CDS
T01009
Symbol
GCLC
Name
(RefSeq) glutamate--cysteine ligase catalytic subunit isoform X1
KO
K11204
glutamate--cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
ssc
Sus scrofa (pig)
Pathway
ssc00270
Cysteine and methionine metabolism
ssc00480
Glutathione metabolism
ssc01100
Metabolic pathways
ssc01240
Biosynthesis of cofactors
ssc04216
Ferroptosis
Module
ssc_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
ssc00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
100522018 (GCLC)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
100522018 (GCLC)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
100522018 (GCLC)
Enzymes [BR:
ssc01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
100522018 (GCLC)
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Gene cluster
GFIT
Motif
Pfam:
GCS
GCS2
Motif
Other DBs
NCBI-GeneID:
100522018
NCBI-ProteinID:
XP_003482212
Ensembl:
ENSSSCG00000001488
Vega:
OTTSUSG00000000762
UniProt:
A0A480K1F4
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Position
7:27209565..27253535
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AA seq
641 aa
AA seq
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MGLLSQGSPLSWEETQRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDH
ESKKVQLVLSGEELLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EDNMRKRRKEATSLLGENQALCTITSFPRLGCPGFTLPEYKPNPVEEGASKSLFFPDEAI
NKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFPEDDEAAKASKPDHIYMDA
MGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVI
SASVDDRTREERGLEPLKNNRYRISKSRYDSIDSYLSECGEKYNDIDLTKDEEIYEQLLQ
EGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDI
GWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMIAAQKRDAVL
QGMFYFRKDICKGGNAVVDGCGKATGSAEQAAVAAAAEYTLMSIDTIINGKEGVFPGLIP
ILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDE
MNYSLLLKCNQIANELCECPELLGPAFRKVKYSGSKIDASS
NT seq
1926 nt
NT seq
+upstream
nt +downstream
nt
atggggctgctgtcccagggctcgcccctgagctgggaggagacccagcgccacgccgac
cacgtgcgacggcacgggatcctccagttcctgcacatctaccacgccgtcaaggaccgg
cacaaggacgtgctcaagtggggcgacgaggtggaatacatgttggtatctttcgatcat
gaaagtaaaaaagtccagttggtcctgtctggagaggaacttcttgaaactctacaagaa
aagggggaaaggacaaacccaaaccatcctaccctttggagaccagagtatgggagctac
atgatcgaagggactcccggccagccgtacggagggaccatgtccgagttcaacacggtg
gaggacaatatgaggaaacgccgcaaagaggccacgtctttactgggggaaaaccaggct
ctctgcacaatcacttcatttcccagattaggctgcccggggttcacgctgcctgagtac
aagcccaaccccgtggaagaaggagcttccaagtccctcttctttccagacgaagcgata
aacaagcacccgcgtttcagtaccctaacaagaaacatccggcacaggagaggggagaaa
gttgtcatcaatgtcccaatatttaaggacaagaacacaccgtctccatttatagaaaca
tttcctgaggatgatgaagcagcgaaggcttctaagccggaccacatttacatggatgcc
atgggctttgggatgggcaattgctgtctccaggtaacgttccaagcctgcagcatctct
gaggccagatacctttatgatcagttggccactatctgcccaattgtcatggctttgagt
gctgcgtctcctttttaccgaggctatgtgtcagacattgattgtcgctggggcgtgatt
tctgcatctgtagatgatagaactcgggaggagagaggcctggagccattgaagaacaat
aggtataggatcagtaagtcccgatacgattcaatagacagttacttatctgagtgcggt
gagaaatacaatgacatcgacctgacgaaagacgaagaaatctacgaacagctgttgcag
gaaggcatcgatcatctcctggcccagcatgtggctcacctcttcatcagagacccgcta
actctgtttgaagagaaaatccacctggacgacgccaatgagtctgaccatttcgagaat
attcagtccacaaattggcagacgatgagattcaagcctcctcctccaaactccgacatt
gggtggagagtagaattccggcccatggaggtgcagttgacagacttcgagaactctgcg
tacgtggtgtttgtggtgctgctcaccagggtgatcctctcctacaaactggactttctc
atccctctgtcgaaggttgatgagaacatgatagcagcacagaagcgcgatgctgtcctg
cagggaatgttttatttcagaaaagatatttgcaaaggtggcaatgcggtggtggatggc
tgcggcaaggccacaggcagcgcggagcaggcggcggtggcggcagcggcagagtacaca
cttatgagcattgacaccatcatcaatggcaaggaaggggtattcccggggctgatcccc
atcctgaactcttacctggaaaacatggaggtggatgtagacaccagatgcagtatcctg
aactacctaaagctgattaagaagagggcgtcaggggaattgatgacagttgccagatgg
atgagggagtttatcgcaaaccatccggactacaagcaagacagtgtgataactgatgaa
atgaactatagcctccttttaaagtgtaaccagattgcaaacgaattatgtgaatgtcca
gagttacttggaccagcatttaggaaagtaaaatacagcggaagtaaaatcgacgcttct
agctag
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