Sus scrofa (pig): 100736908
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Entry
100736908 CDS
T01009
Symbol
FPGS
Name
(RefSeq) folylpolyglutamate synthase, mitochondrial isoform X1
KO
K01930
folylpolyglutamate synthase [EC:
6.3.2.17
]
Organism
ssc
Sus scrofa (pig)
Pathway
ssc00790
Folate biosynthesis
ssc01100
Metabolic pathways
ssc01240
Biosynthesis of cofactors
ssc01523
Antifolate resistance
ssc04981
Folate transport and metabolism
Brite
KEGG Orthology (KO) [BR:
ssc00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
100736908 (FPGS)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
100736908 (FPGS)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
100736908 (FPGS)
Enzymes [BR:
ssc01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.17 tetrahydrofolate synthase
100736908 (FPGS)
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Motif
Other DBs
NCBI-GeneID:
100736908
NCBI-ProteinID:
XP_020925027
UniProt:
A0A4X1U4T3
F1RS02
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Position
1:268281298..268309397
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AA seq
588 aa
AA seq
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MSRARSHLLAARFLAAVPSRGATTGVAARRGLSAWPAPQEPGMEYQEAVRTLNTLQTNAN
YLEQVKRQRGDPQTQLEAMKLYLARSGLQVEDLDQLNIIHITGTKGKGSTCAFAERILRS
YGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHRLDETKDDSSCVSMPSYFR
FLTLMAFHVFLQEKVDLAVMEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTGLLGDTMEKI
AWQKGGIFKCGVPAFTVPQPDAPLAVLRDRAQEISCPLYLCPPLEALEEGGPPLTLGLEG
EHQRSNAALALQLTHCWLQQKGHQDIGELKTSRPSLLGQLPLAPVFQPTSRMRHGLRDTE
WLGRTQVLRRGPLTWYLDGAHTTSSMQACVRWFRQALHRRERPSSGSEVRVLLFNSTGDR
DSAALLKLLQPCQFDYAVFCPNLTEMSSADNADQQNFTVTLDQVLLRCLAHQQHWSHLQE
EQASPGLWSTPSSEPGGPTSLLLAPHPPHTHSTSSLVFSCITHALQWISQGRDPVWQPPS
PPRSLLAHPVAGSGAIVLHEAAAIHVLVTGSLHLVGGVLKLLEPSLSQ
NT seq
1767 nt
NT seq
+upstream
nt +downstream
nt
atgtcgcgggcacgtagccacctgctcgcggctcgcttcctggcagcggttccttcgcgt
ggtgcaacaaccggggtcgcagcgaggcgagggttgagcgcgtggcccgcgccacaggag
cccggcatggagtatcaggaggctgtgcgcacactcaacaccctgcagaccaatgccaac
tacctggagcaggtgaagcgccagcggggtgacccccagacacagctggaagccatgaag
ctgtacttggcacggagtgggctgcaggtggaggacctggaccaactgaacattattcac
atcaccgggaccaaggggaagggctccacctgtgcctttgctgaacgcatcctccgaagc
tacggcctgaagacaggattctttagctctccccacctggtgcaggtgcgtgagcggatc
cgcatcaacggacagcccataagccctgagctcttcaccaagtacttctggcgcctctac
caccggctggacgagaccaaggatgacagcagctgtgtctccatgcccagctacttccgt
ttcctcacgctcatggctttccacgtcttccttcaagagaaggtagacctggcagtgatg
gaagtgggcatcggcggggcttacgactgcaccaacatcatcaggaagccggtcgtgtgc
ggggtctcctctcttggcatcgaccacactggccttctgggggacacgatggagaagatt
gcgtggcagaaagggggtatctttaagtgtggcgttcctgccttcaccgtgccccagcct
gatgcccccctggccgtgctgagggaccgtgctcaggagatctcatgtcccctctacctg
tgcccaccactagaagccttggaggaaggggggccaccgctgaccctgggcctggaggga
gagcaccagcggtccaatgccgccttggccttgcagctgacccactgctggctgcagcag
aagggccaccaggatattggggaactgaagacatccaggccaagcctcctgggacagttg
cccctggcacctgtgttccagcccacgtcccgcatgcgccatgggcttcgggacacggag
tggctgggccggacacaggtactgcggcgtgggccccttacctggtacctggacggtgcg
cacaccaccagcagcatgcaggcctgtgtgcgctggttccgccaggccctgcaccgccgc
gagaggccaagcagcgggtcggaggttcgagtcttgctcttcaactccaccggggaccgg
gattccgcggccctgctgaagctgctacagccctgccagtttgactatgccgttttctgc
cctaacctgacagagatgtcatccgcggataatgcagaccagcagaacttcacagtgaca
ctggaccaagtgctcctccgctgcctcgcacatcagcagcactggagccacctgcaggag
gagcaggccagcccaggcctctggagcacccccagctcagagcctggtgggcccacatcc
ctgctgctggcgccccacccaccccacacccacagcaccagctccctcgtcttcagttgc
atcacccacgccctgcagtggatcagccaaggccgggaccccgtctggcagccgcccagt
cccccacggagcctcctcgcccaccccgtggcaggcagcggggccatcgtactccacgag
gctgctgccatccacgtgctggtcacaggcagcctgcacctggtcggcggcgtcctgaag
ctgctggagccctccctgtcccagtag
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