KEGG   Sus scrofa (pig): 397601
Entry
397601            CDS       T01009                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
ssc  Sus scrofa (pig)
Pathway
ssc01521  EGFR tyrosine kinase inhibitor resistance
ssc01522  Endocrine resistance
ssc04010  MAPK signaling pathway
ssc04012  ErbB signaling pathway
ssc04068  FoxO signaling pathway
ssc04270  Vascular smooth muscle contraction
ssc04650  Natural killer cell mediated cytotoxicity
ssc04720  Long-term potentiation
ssc04726  Serotonergic synapse
ssc04730  Long-term depression
ssc04810  Regulation of actin cytoskeleton
ssc04910  Insulin signaling pathway
ssc04914  Progesterone-mediated oocyte maturation
ssc04928  Parathyroid hormone synthesis, secretion and action
ssc05010  Alzheimer disease
ssc05022  Pathways of neurodegeneration - multiple diseases
ssc05034  Alcoholism
ssc05160  Hepatitis C
ssc05161  Hepatitis B
ssc05200  Pathways in cancer
ssc05205  Proteoglycans in cancer
ssc05208  Chemical carcinogenesis - reactive oxygen species
ssc05210  Colorectal cancer
ssc05211  Renal cell carcinoma
ssc05212  Pancreatic cancer
ssc05213  Endometrial cancer
ssc05214  Glioma
ssc05215  Prostate cancer
ssc05218  Melanoma
ssc05219  Bladder cancer
ssc05220  Chronic myeloid leukemia
ssc05221  Acute myeloid leukemia
ssc05223  Non-small cell lung cancer
ssc05224  Breast cancer
ssc05225  Hepatocellular carcinoma
ssc05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:ssc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    397601 (ARAF)
   04012 ErbB signaling pathway
    397601 (ARAF)
   04068 FoxO signaling pathway
    397601 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    397601 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    397601 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    397601 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    397601 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    397601 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    397601 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    397601 (ARAF)
   04720 Long-term potentiation
    397601 (ARAF)
   04730 Long-term depression
    397601 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    397601 (ARAF)
   05205 Proteoglycans in cancer
    397601 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    397601 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    397601 (ARAF)
   05212 Pancreatic cancer
    397601 (ARAF)
   05225 Hepatocellular carcinoma
    397601 (ARAF)
   05226 Gastric cancer
    397601 (ARAF)
   05214 Glioma
    397601 (ARAF)
   05221 Acute myeloid leukemia
    397601 (ARAF)
   05220 Chronic myeloid leukemia
    397601 (ARAF)
   05218 Melanoma
    397601 (ARAF)
   05211 Renal cell carcinoma
    397601 (ARAF)
   05219 Bladder cancer
    397601 (ARAF)
   05215 Prostate cancer
    397601 (ARAF)
   05213 Endometrial cancer
    397601 (ARAF)
   05224 Breast cancer
    397601 (ARAF)
   05223 Non-small cell lung cancer
    397601 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    397601 (ARAF)
   05160 Hepatitis C
    397601 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    397601 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    397601 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    397601 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    397601 (ARAF)
   01522 Endocrine resistance
    397601 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ssc01001]
    397601 (ARAF)
Enzymes [BR:ssc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     397601 (ARAF)
Protein kinases [BR:ssc01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   397601 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 397601
NCBI-ProteinID: NP_999494
Ensembl: ENSSSCG00000012275
Vega: OTTSUSG00000004536
UniProt: O19004
LinkDB
Position
X:42078202..42090250
AA seq 606 aa
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRRQFYHSVQDLSGGSRQHETPSNRPLNEPL
TPQGPSSCTQHRDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSGLVQLTAQSFN
TDAAGNRGGGDGAPRGSPSPASVSSGRKSPHSKSPSEQRERKSLADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq 1821 nt   +upstreamnt  +downstreamnt
atggagccaccacggggcccccctgccaacggggccgagccgtcccgggcagtgggcacc
gtcaaagtgtacctgcccaacaagcagcgcacggtggtgactgtccgggatggcatgagt
gtctacgactctctggacaaggccctcaaggtgcgaggtctcaatcaggattgctgcgtg
gtctaccggctcatcaaggggcgaaagacagtcaccgcctgggacacggccattgccccc
ctggacggcgaggagctcattgtggaggtcctcgaagatgtccccctgaccatgcacaat
tttgtacggaagacattcttcagcctggccttttgtgacttctgccttaagtttctgttc
catggcttccgctgccaaacctgtggatacaagttccaccagcattgttcctccaaggtc
cccacagtttgtgtcgacatgagtaccaatcgccgacagttctaccacagtgtccaggat
ttgtccggaggctccagacagcatgagactccctcgaaccgccccctgaatgagccgcta
acccctcagggtcccagctcctgcacccagcaccgcgaccctgagcacttccccttccct
gccccggccaatgcccccctgcagcgcatccgctccacgtccacccccaacgtccacatg
gtcagcaccaccgcccccatggactccggcctggtccagctcactgcccagagtttcaac
actgatgctgctggtaatagaggtggtggcgacggagccccccgggggagccccagccca
gccagcgtgtcctcggggaggaagtccccacattccaagtcgccatctgagcagcgggag
cggaagtccttggccgacgacaagaagaaagtgaagaatctggggtaccgggactcgggc
tattactgggaggtgccccccagtgaggtgcagctgctgaagaggatcgggacgggctcg
tttggcaccgtgtttcgcgggcggtggcatggcgatgtggccgtgaaggtgctcaaggtg
gcccagcccacagccgagcaggcccaggccttcaagaacgagatgcaagtgctcaggaag
acgcggcacgtcaacatcttgctgttcatgggcttcatgacccggcccggctttgccatc
atcacacagtggtgcgagggctccagtctgtaccaccacctgcacgtggccgacacacgc
ttcgacatggtccagctcatcgatgtggcccggcagactgcccagggcatggactacctc
catgccaagaacatcattcaccgagatctcaagtctaacaacatcttcctacacgagggc
ctcacggtgaagatcggggacttcggcctggccacagtgaagacgcggtggagcggggcc
cagcccttggagcagccctcgggctccgtgctgtggatggcggctgaggtgatccggatg
caggacccgaacccctacagcttccagtctgacgtctatgcctatggggtggtgctctac
gagctcatgaccggctcgctgccttacagccacattggcagccgtgaccagattatcttc
atggtgggccgtggctatctgtccccggacctcagcaaaatctccagcaactgccccaag
gccatgcggcgcctgctgtctgactgcctcaagttccagcgggaggagcgacccctcttc
ccccagatcctggccacgattgagctgctgcagcggtcactccccaagattgagcggagt
gcctcggaaccctccttgcaccgaacccaggctgatgagttgcctgcctgcctactcagc
gcagcccgccttgtgccttag

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