| Entry |
|
|---|
| Symbol |
huwe1
|
|---|
| Name |
(RefSeq) E3 ubiquitin-protein ligase HUWE1 isoform X1
|
|---|
| KO |
|
|---|
| Organism |
ssco Scomber scombrus (Atlantic mackerel)
|
|---|
| Pathway |
|
|---|
| Brite |
Enzymes [BR:ssco01000]
2. Transferases
2.3 Acyltransferases
2.3.2 Aminoacyltransferases
2.3.2.26 HECT-type E3 ubiquitin transferase
133988386 (huwe1)
Ubiquitin system [BR:ssco04121]
Ubiquitin ligases (E3)
HECT type E3
133988386 (huwe1)
|
|---|
| SSDB |
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| Position |
10:15427577..15472284
|
|---|
| AA seq |
4591 aa
MKVDRSKLKKTPTEAPADCRILIEKLKACSDEQLLVELHHIKTWNIGKCELYHWVDLLDR
FDGILCDAGQTVENMSWLLVCDRPDNGQLKALLLAVLNFTALLIEYSFSRHLYSSIEHLT
TLLASCDMQVVLSVLNLLYVFSKRSNYITRLGSDKRTPLLARLQHLAESWGGKENGFGLA
ECCRDLLMTKYPPSATTLHFEFYAEPGPEVKVERKTSSNTLHYIHIEQLDKISESPSEIM
ESLTVMYNIPKDKQTLLFTHIRLAHGFSNHKKRLQAVQARLHAISILVYSNALQESANSI
LYNGLIEELVDVLQITDKQLVDIKAASLRTLTSIVHLERTPKLSNIIDCTGTASYHGFLP
VLVRNCIQAMIDPLMEPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLG
DEQDQITFVTRAVRVVDLITNLDMAAFQSHSGLSIFICRLEHEVDLSRKECPFVIKPKIQ
RPSAAVESEDMDTDMEMSEVAMESSPGPSTSSGSRPEVDHRVQSGTANTPRAGMQCIPQR
AALLKSMLNFLKKAIQDPAFSDGIRHVMDGSLPTSLKHIISNAEYYGPSLFLLATEVVTV
FVFQEPSLLSSLQDNGLTDVMLHALLIKDVPATREVLGSLPNVFSALCLNARGLHSFVQC
QPFERLFKVLLSPDYLPAMRRRRSSDPLGDTASNLGSAVDELMRHQPTLKTDATTAIIKL
LEEICNLGRAPEYICQKPSIQKADGTVAVPPARSSHAAEEASSEDEEEEEALHTFSQQQG
EPESNRQSVPLELVVGTEERIPIPLMDYILNVMKFVESILSNNTTDDHCQEFVNQKGLLP
LVSILGLPNLPIDFPTSAACQAVAGVCKSILTLSHEPKVLQEGLCQLDSILTSLEPLHRP
IEVPGGSVLLRELANAGHVTDATLSARATPLLHALTAAHAYILMFVHTCRVGQSEIRAIS
VNQWGSQLGLSVLNKLSQLYCSLVWESTVLLSLCTPNSLPPGCEFGQADMQKLVPKEEKP
SGSTTTTTASGSRRTAESEAVSVDSSAGGLLEGMGLDGDTLAPMETDEPTATDPKTKSKL
TPAMATRIKQIKPLLSASSRLGRALAELFGLLVKLCVGSPVRQRRSHHATSTGTTPTPAA
RATASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSPMLFDERKYPYHLMLQKFF
CSGGHDALFETFNWALSMGGKVPVSEGLEHTDLPDGTGEFLDAWLMLVEKMVNPSTVLDS
PHSLPAKMPGVTPTMPQFSALRFLIVTQKAAFTCIRSLWNRKPLKVYGGRMAESMLAILC
HILRGEPVIQERLAKEREGTVRPDDEAASTGSLAPTGPPGASTTAGEAPTATGTTTAAPA
GGSADDSTNSTPRREPQVNQAQLTQLMDMGFSREHAMEALLNTSTMEQATEYLLTHPPPL
LGGAVRDLTMSEEDQMMRAIAMSLGQEVSMEQRSDSPEEAARRREEDDRRARERAEEEEA
RCLERFMEAEPLDPQELHTFTDSMLPGCFHLLDELPDTVYRLCDLLMTAIKRSGPEYRDL
ILGQVVHQVWEAADVLIKAAVPLTTSDTKTVSEWTRQMATLPQASKLATRILLLTLLFEE
LKLVCARVVENSGILDLLIKLLEVVQPCLQAAKEQKDIQTPKWITPVLLIIDFYEKMAVS
SKRRAQMNKYLQPNGNNWRWFDDRSGRWCSYSASNNSTIDTAWRAGESSVRFTAGRRRYT
VQFNTMVQVNEETGNRRPVMLTVQRVPRMPKTAKTGSITDSEREEGDRSKAEETQTDLDS
GAAVEMSAPKDDSSQLKETTSAPSSSLESDHSQGSDIVVQGLTEDMTTVLIRACVSMISV
PVDPDTLHATLRLCLRLTRNHHYAMMFAELKSTRMILGLTQSSGFNGFTPLVTLLFRHII
EDPATLRHTMEKVVRSAVTSGAGSTTSGVVSGSLGSREINYILRVLGPAACRNPECFAET
ASNCVRIALPAPRGAGTASDDEFENLRIKGPNAVQLVKTTPLKLSPLPSIPDTIKEVIYD
MLNALAAYHAPEEPERPEERAATVPGGQDLCQILQDVGDDVYQQYRLTRQGSDFDSQSAF
HINTQVFAADGGVAESSQSGTPQGEASTPEDMREEKKEQEGEKSTTSEEGKAAKVKGSKP
LMPTSTILRLLAELVRSYVGIATLIASYCYTAGQSELIKEDCSVLAFVLDHLLPHTQNSE
DKDTPALARLFLASLAAAGTGTDAQVALVNEVKAALSRALAMTEGAEKHARLQAVMCIIS
TIMESCPSTSSFYSTAAAKTQHNGMNNIIRLFLKKGLVNDLARVPHSLDLSSPNMANTVN
AALKPLETLSRIVNQPSSLFGGKGGSSKTKAEHDTVGTARDSNSNTQEQGESGEAEPVEG
NHRVQGTDSDLMDGETEGDTVVIAGQPEVLSTQAMQVENELVDLIDELLERDAGTVNSTI
IVGRSGEDESQEDVLMDEAPSNISQASTLQANREDSMNILEPEDEEHTQEEDSSGSNDDE
DSQDEEEEEEEEEEEDQDDEEGDEDDDDEGSEMELDEDFPDINAAPHIRFERFDRDDDLI
IEFDNMFSNNADIPPSPGNIPSSHPLMVRHADHGSLTLGVAGTSSRLAQGMGRSQRTLRQ
LTANSGHTIHVHYPGNRQPNPPLILQRLLGPSAAADILQLSSSLPLQSRGRARLLVGNED
VHIIARSDDELLDDFFHEQSSTGGQAGTLSSIPTALTRWTDECKVLDAESMHDCVAVVKV
PILQHLESLRDEELEERREKRRRQLAEEEESKQNERRASGAEQAREQTLQGSGLGTVNGA
ENTAEGEQAQGGTVSCLDPPRVSEGFLTAPPSGEVTPTTPAPHEQALVSLETAISQQVHQ
PIADLLLAESHASSLAALAGAGLPPLSTTDRPNSEAEASQMEMSPAPTIGERVGGGDGGG
ALDEGREASLSPDIVETSEPAVVGVSQLEGSPMDTSSPASATQEEAAQNPVQIATLSQEL
SGSGESGLTDRQTDAETGSNSVSSPGETMPRSDSADSQSQAIQEEPLPSTSNEEEDPLAG
ISLPEGVDPSFLAALPEDIRREVLQNQLGIRPPSRSPAATSLPTSTAPVLGGPGVTEVSP
EFLAALPPAIQEEVLAQQRAEQQRRELAQQPPQGDTPLDPVTFIQTLPSELRRSVLEDME
DSVLAVMPPDIAAEAAALRREQEARQRQLMHERLFGHSSSSALSAILRSPAFTSRLGSNR
GVQYTRLAVQRGGTFQMGGGTNHRPSSSSVDSLLRLRGRLLLDHEALSCLLVLLFVDEPK
LNTSRLHRVLRNLCYHSQTRGWVIRSLLSILQRSSESEVCVETSRLEDSRGKRSIQGSCG
GKGSATSSLSSSSSSSSSSSSSSLELLNRVESRSSSQLSWLSVSMDAALGCRTNIFQIQR
ASGRKHADRHSAGGSAGSGTLVGGMSGATAGVTCAGGGGSTVHIHPQAAPVVCRHVLDTL
IQLAKVFPSHFTQQRCKDLSASSSDLDSRLCSGSSGGGGGSRSGSQSQSNASSNASNTQN
SLGSSVVTPQSLGISTDFWDLLVKLDNMNVSRKGKASMKTVPLGGSAEAEGAQFSLETSP
LGQLMNMLSHPVIRRSSLLTEKLLRLLSLISIALPDNKATEVPAGHPTPQAANPSTATSS
GATAPVTTQGMASGGSIQPTVVGPGASVVAGAQGTSSGTSLAVSQTSSTAICIPTSTGTI
STGKQRGTTSSTESDNKMASTGLTEKQLQLSVEVLTSHSCSEEGLEDAANILLQLSRGDG
ATRDTVLRLLLSGARHLGYTLCKQIGTLLAELREYNLEQQRRAQADSHSPDAPEDSSLSG
RLKGKMTSRLASDGSGLPNNIRFDGSESVVIVAAQKRTLGGRELQLPCMSSLTSKTSTQK
FFLRVLQVIIQLREDTRRANKKAKQTGRLGSSSLGSASSIQAAVRQLEAEADAIIQMVRE
GQRARRLTQAPPPTASSASAAVTATAGSSVVAPHAPTGAAPPAGTAAAATSEVQSMSEAQ
AAQRDDSPMDVDQPSPLEQDPAPLDEEGNGQSENEERLPDLPLLSEQLLLDELWDMLGEC
LKELEESHDQHAVLVLQPAVEAFFLVHATERESKPPVRDTRESQLSHIKDEPPPLSPAPL
TPATPSSLDPFFSREPSSMHISSNLPPDTQKFLRFAETHRTVLNQILRQSTTHLADGPFA
VLVDYIRILDFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHRKSPEDMK
NRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNH
LSYFKFVGRVVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYPFFQGLVYLLEN
DVSTLGYELTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMKMTGAIRKQL
AAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKANTEYHKYQSSSIQIQWFWR
ALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFN
QLDLPAYESYEKLRHMLLLAIQECSEGFGLA |
|---|
| NT seq |
13776 nt +upstreamnt +downstreamnt
atgaaggtcgacagaagcaagttaaagaaaacccctacggaagctcctgctgactgcagg
atactaatagagaagctcaaggcatgcagtgatgagcaactactggttgaactgcaccac
atcaagacctggaatattggcaagtgtgagctgtaccactgggtggatctgctagaccgc
tttgatggcattctgtgtgatgcaggccagacagtggagaatatgtcatggctcctggtg
tgtgaccgtcccgacaatggacagctcaaagccctgcttctggcagtgctcaacttcaca
gctctgctcattgagtatagcttctccaggcacctgtacagctccatagagcacttaacc
accttgttagcgtcatgtgacatgcaggtggtcctgtctgtgctgaacctgctctatgtg
ttcagtaagcgctccaactacatcacaagactgggatctgacaaaaggacgcctctactg
gcccgtttgcaacacctggctgagagctggggaggaaaggagaatggctttggtctggct
gagtgctgcagggatctgcttatgacgaagtaccctcccagtgccaccaccctgcatttc
gagttttacgctgaaccaggcccagaggtcaaagtagagaggaagacaagcagtaataca
ctacactatattcacatcgagcagcttgacaagatttcagaaagcccatctgagatcatg
gagtcgctgacagtcatgtacaacatccctaaggacaagcagaccctgctcttcacacac
attcgactggcccatggtttctctaatcacaagaagaggctgcaggcagtgcaggcccga
cttcacgctatctctatattggtgtattcaaatgcactccaagagtcagccaacagtatt
ctgtataatggcttgatagaggagctggtggatgtattacagattacagacaaacagctt
gtggatatcaaggcagcatctctgcgcactttaacttcgattgtccatctggagaggaca
cccaagctttccaacatcatcgactgcacgggcactgcctcataccatggcttcctgcct
gtgttggtgcgcaactgtatacaagcaatgattgatcctctaatggaaccctacccacac
cagtttgcaactgcactcttctccttcctctaccatttggctagctatgatgctggaggg
gaagcccttgtctcctgtgggatgatggaagccctcctgaaggtaataaaatttctgggt
gatgagcaggaccagatcacctttgtgacacgagcagtgcgtgttgtggacctcatcacc
aaccttgatatggctgcctttcagtcccacagcggcctttccattttcatctgcaggcta
gagcatgaggtggacctgtctaggaaagagtgcccttttgtcatcaagccaaagattcag
aggcctagcgcagctgtggaatctgaggacatggatacagacatggagatgtcagaagtt
gccatggaaagcagccctggaccatcaacatcctctggttccagaccagaagtggaccac
cgagtgcagagcggcactgctaacacgcctcgtgcaggtatgcagtgtatcccccagagg
gcagctctgttaaagtcgatgctgaatttcttgaagaaagccatccaggatcctgccttt
tctgatggtatccgccatgtaatggacggttccttgcctacctcactcaagcacatcatc
agtaatgcagaatattatggcccttcactgttcctcttagccacagaggttgtgacggtg
tttgtgttccaggagccatcactgctttcctccctgcaggataatggtctcactgatgtc
atgctgcatgcccttctcatcaaagacgttcctgctactcgtgaggtattgggatctctc
cccaatgtgttcagtgccctgtgcctgaatgcaagaggactgcactcctttgttcagtgc
cagccctttgagcgcctcttcaaagtgcttttgtcccctgactacctgcctgccatgcga
cggcgacgcagctctgatccattgggtgacactgcatccaacttgggcagtgctgtagac
gagctcatgaggcaccaaccaactttgaagactgatgctactactgccattattaagtta
ctggaggagatctgcaacctaggtcgagcccctgagtacatctgccagaaaccttctatc
cagaaagctgatggcactgtggctgtgccaccagcacgctccagccatgctgccgaggaa
gcatcaagtgaggatgaagaggaagaggaggcccttcacacattcagccaacagcagggg
gaaccagagagcaacagacagtcagtgccacttgaactggtggtgggcactgaagagcgg
atacctattcctctaatggattatattctgaacgtgatgaagtttgttgaatccatacta
agcaacaataccacagacgaccattgtcaggagtttgtcaaccaaaagggattgctacct
ctggtttctatactgggcctgcccaacttgcccatagactttcccacttctgctgcctgc
caagctgtggctggtgtatgcaagtctatattgactctctcacatgagcctaaggtactc
caggagggcttgtgccaactggacagtatactgacgtctctggagccactacatcgacca
attgaggtgcctggaggatctgtccttctcagagagctggctaatgcgggccatgtaacc
gacgccaccttgtcagcccgtgccacaccactgctacatgcacttactgcagcgcacgcc
tacatcctcatgtttgtccatacttgcagagtaggacagagtgagatcagggctatctca
gtcaaccaatggggctctcagctgggtttgagtgttctcaacaagctcagtcagctctac
tgctccctggtttgggagagcaccgttctcctgtccctctgcactccgaacagtctgcct
ccaggctgtgagtttggccaggctgacatgcagaaactggtgcccaaagaggagaagcct
tctggcagcactacaacaacgacagcctctggctccaggagaactgcagagtctgaggca
gtgtctgtggattcatctgctggtggattgttggaaggcatgggtctagatggggacacc
ttggctcccatggagacggatgaacccactgcaacagaccctaagaccaagtccaaactt
accccagctatggccacccgcataaaacagattaaaccgctactatcggcttcatctcga
ctaggcagggctctggctgagctctttggcctgcttgtgaagctgtgtgtgggctcccct
gtacgacaacgccgctcccaccatgccacaagcacaggcactactcctacgcctgctgcc
cgggccactgcctctgccctcaccaagctcctcaccaagggcctgagttggcagccccca
ccttacacacccacccctcgatttaggctgactttcttcatctgctctgtgggcttcaca
tctcctatgctctttgatgagaggaagtatccctaccacctcatgctgcaaaagttcttc
tgctccggtggacacgatgccttatttgagacattcaactgggccttgtcaatgggtggt
aaggtgcctgtgtctgagggtttagagcatactgatctaccagatgggacaggagagttc
ctggatgcctggttaatgctggtggagaagatggtgaacccaagcactgtgctggactcc
cctcactccctgccagctaaaatgcctggggtcacacccaccatgccccagttcagtgcc
cttcggttcctcatagtcacccaaaaggctgcattcacctgcatccgcagtctgtggaat
agaaagccgctgaaggtgtatggaggcaggatggctgaatccatgctggcaatcctctgc
cacatcctgcgaggggagcctgttatccaggagcgcttggctaaagagagagaggggaca
gtgcgccccgatgatgaagcagcttccactggttctttggcaccaactgggccccctgga
gcatccacaacagctggagaggcaccaacagccactggaacaaccactgcagcgccagca
ggaggatcagctgatgattcaaccaattctactccccgccgtgagccccaggttaaccag
gctcagcttacacagctcatggatatgggtttctcaagagagcatgccatggaggcacta
ctgaataccagcaccatggagcaggccacagagtacctgcttacacaccctccgccactt
cttggtggagcagtacgggacctgactatgtctgaagaggaccagatgatgagggccatt
gctatgtcacttgggcaagaggtcagcatggagcagcgctctgactctcctgaggaagca
gcacgtcgacgtgaggaggacgacagaagagccagggagcgggcagaggaggaggaggcc
cgctgcttggagcgcttcatggaggctgagccactggacccccaggagttgcataccttc
acagactccatgcttcctggctgcttccatcttctagatgagctgcctgacacagtctac
cgtctctgtgacttgctgatgactgccatcaagaggagtggcccagagtacagagacctc
atcctgggccaggtcgtccaccaggtgtgggaggcagctgacgtgctgatcaaggcggct
gtgcccctgactaccagtgacacaaagacagtgtctgagtggaccagacagatggccaca
ctgccccaggcctctaagctggcaactcgaattttgcttctcacgttgctctttgaggag
ctgaagcttgtctgtgccagagtggtcgagaacagtgggattcttgatttgctgattaag
ctgcttgaagttgtgcagccctgtctgcaggcagcaaaagaacagaaagacatccagaca
ccaaaatggatcacaccagtactgttgatcattgacttctatgagaagatggcagtctct
tcaaagcgcagagcccaaatgaacaagtatcttcagcccaatgggaataactggcgatgg
tttgatgaccgctcaggccgttggtgtagttacagtgcatcaaacaacagtaccattgat
acagcatggagggccggggagagcagtgtccgcttcacagctggacgccgaagatacact
gttcagtttaacaccatggtgcaggtaaatgaagagactggtaacaggaggccagtgatg
ttgacggtccagagagtgcctcgcatgcccaagactgccaagactggcagcattacagac
tccgagagagaagagggagacaggagcaaagcagaggaaacgcagactgacctagactct
ggggcagcagtggagatgagtgcgcctaaggatgattccagccagctgaaggagacaact
tctgccccctcatcttccctggagtccgaccactctcagggctccgatattgttgtacaa
ggcctgactgaggacatgaccactgttctcatccgtgcctgtgtcagtatgattagtgtg
cctgtggacccagacaccctccacgccacactacgtctctgtttgcgcctaacacgcaat
caccactatgctatgatgtttgctgagctgaagagcacacggatgattcttggcctgacg
cagagctccggcttcaatggcttcaccccgcttgttactctgttgttcagacacatcata
gaagatccagccacactccggcacaccatggagaaggtggtgaggtcagctgtgactagc
ggagcaggtagtactacctcaggagtggtgtctggcagccttggctccagggaaatcaac
tatatcctgcgtgtcctgggccctgctgcctgccgtaaccctgagtgctttgctgaaact
gccagcaattgtgtccgcattgccctgcctgcaccccgtggagctggcacagcctctgat
gatgagtttgaaaaccttcgaattaagggacccaatgctgtgcagctggtgaagacgacc
cctctgaaactgtcccccttaccctctatccctgatactatcaaggaggtcatctatgac
atgcttaatgctctggctgcctaccatgctcctgaagaacctgagcgtccagaagaacgt
gcggcaactgttcctggtggtcaagacctgtgccagatacttcaggatgttggtgacgat
gtttaccaacagtaccgactcacccggcagggtagcgactttgactcccagtctgcattc
catatcaatactcaagtgtttgctgctgatggaggtgtggccgagtcttcccagtctggc
acaccgcaaggagaagcctctacaccagaagacatgcgggaggaaaagaaagagcaagag
ggagagaagagtaccacgtcagaggaaggtaaagcagctaaagtaaagggaagcaagcct
ctaatgcctacctccaccatcctgagactgctggctgagctggtgcgctcttacgtgggc
atcgccacactaatcgcctcttactgctacactgctggacagtctgagctcattaaggag
gattgcagtgtcctggcctttgtgctcgaccacttgctgccccacacccagaactcagag
gacaaggacaccccagccttggcacgtctcttcctggccagcctggcagctgccggcaca
ggcactgatgcccaggtggccctagtcaatgaggtgaaggctgcccttagtcgagcactc
gcgatgacggaaggtgcagaaaaacatgccagacttcaggcagtgatgtgcatcatcagc
accatcatggaatcatgtccctccacgtctagtttctatagcactgcagcagccaagacc
cagcacaatggcatgaataatatcataaggctctttctcaagaaaggactggtcaatgac
ttggcgcgtgtgcctcacagcttggatttgtccagtcccaacatggccaacacagtgaat
gctgccctgaagcctctggagactctgtctcgaattgttaaccagcccagcagtctgttc
gggggcaaaggaggctccagcaagaccaaggctgagcatgacactgtgggcactgccagg
gacagcaacagcaacactcaggaacaaggagagtcgggtgaggcagagccagtagagggc
aaccacagggtgcagggaacagacagcgacctgatggatggcgagacggaaggagacaca
gtggtcattgctggtcagccagaggttctcagcactcaggctatgcaggtagagaatgag
ttggtggatctgattgatgagcttctggaaagagacgctggtactgtcaacagcacaatt
atagtggggcgcagcggtgaggatgaatcacaagaggatgtgttgatggatgaggctccc
tccaatattagccaggcatccactcttcaggccaaccgggaagattccatgaatattctg
gaaccagaggatgaggaacacacgcaagaggaagattctagtggtagcaatgatgatgaa
gatagccaggatgaagaggaggaggaggaagaagaggaggaggaagatcaggatgatgaa
gaaggagatgaggatgatgacgatgaaggttcagagatggagttggatgaagatttccct
gacatcaatgctgcacctcacatccgcttcgaaaggtttgacagggatgatgacctcatc
atagagtttgacaacatgttctccaacaacgctgacatccctccctccccaggcaacatt
cccagttcccacccactgatggtgcgccatgctgaccacggttccctcaccctaggtgtg
gcaggcactagcagccgcctggcgcagggcatgggtcgcagccagcgaacactgcgccag
ctcactgccaacagtggacacaccatccatgtccactaccctggaaatcgccagcccaac
cctccactcatcctgcagagattgttgggtcccagtgcagcagcagacattttacaactg
tccagctctctgcctttgcaatcccgtggtcgagctcgccttttggtcggaaatgaggat
gtgcacatcattgcccgttctgatgatgagttgttggatgactttttccatgagcagagc
agcacagggggacaagcaggcactctctctagtattcccactgccttaactagatggaca
gatgagtgtaaagtgctggatgctgagagtatgcacgactgtgtagcagtggtgaaggtg
cctatcctgcagcatttggagagtctgcgagatgaggagctggaagagcgtagggagaag
cgaagaaggcagttggctgaggaggaggagtctaaacagaatgagaggagggcctctgga
gcagaacaggccagggaacagaccctgcagggttctggactggggacagtaaacggtgca
gaaaacactgcagagggtgagcaggctcagggtggcaccgtgtcatgtctggacccaccc
agggtctcagagggctttctcactgctccaccatctggagaggtcactcccaccacccct
gcccctcatgaacaagccctagtctccctggagactgcgatcagtcagcaggtccaccaa
ccaattgctgacttgctactggccgagtcgcatgccagctcactggctgctctggcaggg
gcaggccttccacccttgtcgacaactgacaggccaaacagtgaagcggaggcatctcag
atggaaatgtccccggcgcccacaatcggtgagagagtcggaggaggggatggaggagga
gcgttggatgaaggcagggaagcctccctaagtccagacatcgtggagacctcagagcct
gcagtagtgggtgtgtcacagcttgaggggtcacccatggataccagcagccctgcctct
gccactcaagaagaagctgctcaaaaccctgtccagattgccaccctgtctcaggagctg
tctggcagtggggagagtgggctgactgacaggcagactgatgcagagactggctccaac
tcggtctcatcccctggagaaacgatgcccagaagtgacagtgcagacagccagtctcag
gccatccaggaagagccccttccatcaaccagcaatgaggaggaggacccacttgcaggc
atcagtctgccagagggtgtggatccctctttcctggcagcgcttcctgaggacatccgt
cgagaggtgctgcaaaatcagttgggaatcagaccaccctcccgttctcctgctgccacc
agcttgcctacctctactgcaccggtactgggaggaccaggggttacagaggtcagccct
gagttcctggcagccttgccacctgccatccaggaggaggttcttgcccagcaacgggcg
gaacagcaacgcagggagctagcccaacagcccccacaaggagacacccctctggatcca
gtcaccttcattcagacactgccctcagagctccgccgtagtgtcctggaggacatggaa
gacagtgtattggctgtgatgcccccagacattgctgctgaagcagcagcattgcgtaga
gagcaagaggcacgccagaggcaactgatgcatgagaggctgtttggtcatagctcatct
tcagccctatcagccatcttgcgctcaccagccttcaccagtcggttagggagcaatcgt
ggcgtccagtatacccgcctggctgtgcagagaggaggcacatttcagatgggtggagga
acaaatcacagaccatccagttccagtgtggattccttgttgcgtctgcgcggtcgattg
ctgctggaccacgaggccttgtcctgcttgctggtgttgctgtttgtggatgaaccgaag
ctcaacaccagtcgtctgcaccgtgtgctcaggaacctttgctaccattctcagactcgt
gggtgggtcattcgcagcctattatccatcctccaacgcagcagcgagagtgaggtgtgt
gtggagacctcacgtctagaagactctcgtggcaagaggagcatccagggaagctgtgga
ggaaaaggctctgccacttcctctctctcctcttcatcttcttcctcttcctcttcctca
tcttcctccctagagctactgaacagggtggagtctcgcagctccagccagctttcctgg
ctctctgtttctatggacgcagcattgggctgccggacaaacattttccagatccaacga
gcatcaggtagaaagcatgctgaccggcattcagctgggggttctgcaggatctggaaca
ctggtaggaggaatgtcaggggctactgcaggtgttacatgtgctggaggtggaggttcc
actgtccacatccacccacaagctgctccagtggtctgtcgacatgtgttggacacactc
atccagctagccaaggtattccccagccacttcacccagcagcgctgtaaggatctttca
gcatcatcttcagatctggactctcgtctttgttcaggctcctctggtggaggtgggggc
tccaggtcagggtcacagtctcaaagcaacgccagctccaatgcctccaacacccaaaac
tccttaggctcctctgtcgttactccccagtctctgggaatctccaccgatttttgggac
ctgctggtcaagctggacaacatgaatgttagccgcaagggaaaggcctctatgaagacg
gtgcctctggggggcagtgcagaggctgagggggcccaattcagcctggaaacctcccct
cttggccagctgatgaacatgctgtcccaccctgtaatcagacggagctccttgctcact
gaaaagctgctgcgcctgctctccctcatatccattgccctgcctgacaacaaggccaca
gaggtgcctgcgggacaccctactccacaggcagccaaccctagcacagcaaccagctca
ggagccacagccccagtcacaacacagggcatggcatcagggggctccatccagcccact
gtcgtaggcccgggagcctctgtggtagccggagcccagggtacatcctcagggacaagt
ctagcagtctcccagacatcctctacagcaatctgtatacccacgtccactggaacaatc
tccacagggaaacagaggggcactacgagcagtacagagagtgacaacaagatggcttca
actggactcacagagaaacagcttcagctgtctgtggaggtgttgacgtctcattcatgt
tcagaagagggtctggaggatgcagcaaatattttactgcagctctctagaggagacggc
gcaaccagggacactgtgctcagactgctgctcagtggagcaagacacctcggatacact
ctttgcaaacagatcggtacattactggctgaactaagagagtacaacttggagcagcag
agacgggcacaagcagattcacattcccctgatgcacctgaagattcctcgctctcaggc
agactgaagggcaagatgactagcaggttagccagtgatggctctgggctacccaataat
attaggttcgatgggtcggaaagtgtggtgattgtggctgcccagaagcgcaccctcggg
ggacgtgaactacaacttccctgtatgagctcgctaacctccaagacgtcaacgcagaag
tttttcctgcgagtgctgcaggtcattatccagcttcgtgaggacacacgacgggccaac
aaaaaagccaaacagacagggcgattaggctcatcaagtttgggctcagccagcagcatc
caggccgcggtgcgtcagctagaggctgaagctgacgccatcatccagatggtgagagag
ggtcagcgggcacgccggctcacacaggcccccccacccaccgcctcttctgcctctgcc
gccgtcacagccactgccggatcctcagtggtggcccctcatgcccccactggtgctgct
ccccctgctggcacagctgctgctgccacgtctgaagtgcagtcaatgtcagaagcccag
gcagcgcagagagatgactcgccaatggatgtggaccagccatctcctctagaacaggat
cctgcaccactggatgaagaaggaaacggccagtcagagaatgaggagagacttccagac
ctccctctgctcagcgagcagctgttgttggatgaattatgggacatgctcggggagtgc
ctgaaagagctggaggagtcccatgaccagcatgctgtactggttctccagcctgctgtg
gaggcgttcttcctggtccatgccacagagcgagagagcaaacctcctgtgagggacacc
cgggagagccaactgtctcacatcaaagatgagcctccaccactgtccccggcacccctt
acacctgctacaccttcatccctagacccattcttctccagggaaccatcctcgatgcac
atctcttcaaacttgccaccagacacccagaagttcctccgctttgccgaaactcaccgc
acagtgcttaaccagatcctgcgccagtccaccactcacttggctgatgggccttttgca
gtgctggttgactacatacgcatcctggactttgatgttaagaggaagtatttccgccag
gagctagagcgtctggatgaaggcctgaggaaggaggacatggctgtgcatgtgaggaga
gatcacgtgtttgaggactcctacagagagctgcatcgcaagagcccagaggacatgaag
aacaggctgtacatcgtgtttgaaggagaagagggccaggatgctggtggcctgctgagg
gaatggtacatgatcatctcccgagagatgttcaacccaatgtatgcgctgttccgcacg
tcgcccggcgatcgtgtgacttacaccatcaacccctcatcccactgcaaccccaaccac
ctcagctacttcaagtttgtgggtcgtgtggtggctaaggcagtctatgataaccggtta
ttggagtgctacttcacccgcagcttctacaagcacatcctgggcaagagtgtcaggtac
acagacatggagagcgaggactacccattcttccagggcttggtgtacttgttggagaac
gacgtgtccacactgggctacgagctgacattcagcacagaggtccaggagtttggggtg
tgtgaagtgagagacctcaagccaaatggagccaatatcctggtcacagaggaaaacaaa
aaagagtatgtgcatctggtttgccagatgaagatgacaggtgcaatccgcaagcagctg
gcagctttccttgagggattctacgagatcatccccaagaggctgatctccatcttcact
gagcaggagctggagctgctcatctctggcctgcccactattgacattgacgacctaaag
gccaacactgaatatcacaaataccagtccagctccatccagatccaatggttctggagg
gccttgcggtcctttgaccaggccgaccgggccaagttcctacagtttgtcactggcacg
tccaaggttccccttcagggtttcgctgctctggagggcatgaacggcatccagaagttc
cagatccaccgtgatgatcgctccactgaccgcctgccatctgctcatacctgctttaac
cagctggacctcccagcctatgagagctatgagaagctgagacatatgctgctgttggcc
attcaggaatgctcagagggattcggactggcttaa |
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